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Conserved domains on  [gi|672083990|ref|XP_008770474|]
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telomere repeats-binding bouquet formation protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

telomere repeats-binding bouquet formation protein 1( domain architecture ID 10184727)

telomere repeats-binding bouquet formation protein 1 (TERB1) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis

CATH:  1.20.58.1880
Gene Symbol:  TERB1
Gene Ontology:  GO:0003677|GO:0070197|GO:0045141
PubMed:  8882580|24413433
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 714-759 1.34e-20

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 212556  Cd Length: 46  Bit Score: 85.54  E-value: 1.34e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 672083990 714 FTKEEVNYLFHGVKKMGNHWNLILWSFPFQKGRRAIDLAHKYHKLI 759
Cdd:cd11658    1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHLC 46
 
Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 714-759 1.34e-20

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 85.54  E-value: 1.34e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 672083990 714 FTKEEVNYLFHGVKKMGNHWNLILWSFPFQKGRRAIDLAHKYHKLI 759
Cdd:cd11658    1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHLC 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 711-759 2.24e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 36.33  E-value: 2.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 672083990  711 RKNFTKEEVNYLFHGVKKMGNHWNLILWSFPfqkGRRAIDLAHKYHKLI 759
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLP---GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
711-760 3.38e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 3.38e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 672083990   711 RKNFTKEEVNYLFHGVKKMG-NHWNLILWSFPfqkGRRAIDLAHKYHKLIK 760
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP---GRTAEQCRERWRNLLK 48
 
Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 714-759 1.34e-20

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 85.54  E-value: 1.34e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 672083990 714 FTKEEVNYLFHGVKKMGNHWNLILWSFPFQKGRRAIDLAHKYHKLI 759
Cdd:cd11658    1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHLC 46
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 712-760 2.69e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.56  E-value: 2.69e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 672083990 712 KNFTKEEVNYLFHGVKKMGN-HWNLILWSFPFQKGRRAIDLAHKYHKLIK 760
Cdd:cd11660    1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFVNNRTSVDLKDKWRNLKK 50
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 711-759 2.24e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 36.33  E-value: 2.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 672083990  711 RKNFTKEEVNYLFHGVKKMGNHWNLILWSFPfqkGRRAIDLAHKYHKLI 759
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLP---GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
711-760 3.38e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 3.38e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 672083990   711 RKNFTKEEVNYLFHGVKKMG-NHWNLILWSFPfqkGRRAIDLAHKYHKLIK 760
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP---GRTAEQCRERWRNLLK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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