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Conserved domains on  [gi|672087058|ref|XP_008771305|]
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X-linked retinitis pigmentosa GTPase regulator isoform X5 [Rattus norvegicus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 78-398 2.73e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 222.93  E-value: 2.73e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058  78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 157
Cdd:COG5184    3 VAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 158 GLGDTDDRDTFHQIGFFTPsdiIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLKNKSNVCIPHEVTVG-KPISWISCG 236
Cdd:COG5184   81 GDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 237 YYHSAFVTTDGELYTFGEPENGKLGLPNQllINHRSPQRVLGIPDkVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLG 315
Cdd:COG5184  158 GYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 316 TFLFETSePKIIDRIKDqkISHISCGENHT-ALMTDiGLMYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLkfTVQLIAC 394
Cdd:COG5184  235 TTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLS--GVVAVAA 306


                 ....
gi 672087058 395 GGCH 398
Cdd:COG5184  307 GSSH 310
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 78-398 2.73e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 222.93  E-value: 2.73e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058  78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 157
Cdd:COG5184    3 VAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 158 GLGDTDDRDTFHQIGFFTPsdiIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLKNKSNVCIPHEVTVG-KPISWISCG 236
Cdd:COG5184   81 GDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 237 YYHSAFVTTDGELYTFGEPENGKLGLPNQllINHRSPQRVLGIPDkVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLG 315
Cdd:COG5184  158 GYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 316 TFLFETSePKIIDRIKDqkISHISCGENHT-ALMTDiGLMYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLkfTVQLIAC 394
Cdd:COG5184  235 TTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLS--GVVAVAA 306


                 ....
gi 672087058 395 GGCH 398
Cdd:COG5184  307 GSSH 310
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
93-139 2.86e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 2.86e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672087058   93 KLYMFGSNNWGQLGLGSKSAISKPTCIKALKPEKVKLAACGRNHTLV 139
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 78-398 2.73e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 222.93  E-value: 2.73e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058  78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 157
Cdd:COG5184    3 VAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 158 GLGDTDDRDTFHQIGFFTPsdiIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLKNKSNVCIPHEVTVG-KPISWISCG 236
Cdd:COG5184   81 GDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 237 YYHSAFVTTDGELYTFGEPENGKLGLPNQllINHRSPQRVLGIPDkVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLG 315
Cdd:COG5184  158 GYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 316 TFLFETSePKIIDRIKDqkISHISCGENHT-ALMTDiGLMYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLkfTVQLIAC 394
Cdd:COG5184  235 TTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLS--GVVAVAA 306


                 ....
gi 672087058 395 GGCH 398
Cdd:COG5184  307 GSSH 310
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 78-379 1.20e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 218.69  E-value: 1.20e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058  78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCIKALKPekVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 157
Cdd:COG5184   53 VAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 158 GLGDTDDRDTFHQIGffTPSDIIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLKNKSNVCIPHEVTVGKPISWISCGY 237
Cdd:COG5184  131 GDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAAGG 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 238 YHSAFVTTDGELYTFGEPENGKLGLPNQLliNHRSPQRVLGiPDKVIQVACGGGHT-VVLTEKVVYAFGLGQFGQLGLGT 316
Cdd:COG5184  209 DHSCALKSDGTVWCWGSNSSGQLGDGTTT--DRATPVQVAG-LTGVVAIAAGGSHTcALKSDGTVWCWGDNSYGQLGDGT 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672087058 317 FLFETSePKIIDRIKDqkISHISCGENHT-ALMTDiGLMYTFGDGRHGKLGLGmeNFTNQFFPT 379
Cdd:COG5184  286 TTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 127-401 5.64e-52

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 184.02  E-value: 5.64e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 127 VKLAAcGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIGFFTPsdiIKQLSAGANTSAALTEDGKLFMWGDNS 206
Cdd:COG5184    1 TQVAA-GGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 207 EGQIGLKNKSNVCIPHEVTVGKPISWISCGYYHSAFVTTDGELYTFGEPENGKLGLPNQLliNHRSPQRVLGIPDKVIQV 286
Cdd:COG5184   77 YGQLGDGTTTDRTTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTT--NRLTPVQVDAGLSGVVAI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087058 287 ACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLfETSEPKIIDRIKDqkISHISCGENHT-ALMTDiGLMYTFGDGRHGK 364
Cdd:COG5184  155 AAGGYHTCALKSDgTVWCWGANSYGQLGDGTTT-DRPTPVQVGGLSG--VVAVAAGGDHScALKSD-GTVWCWGSNSSGQ 230

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 672087058 365 LGLGmeNFTNQFFPTLCSNFLkfTVQLIACGGCHMLV 401
Cdd:COG5184  231 LGDG--TTTDRATPVQVAGLT--GVVAIAAGGSHTCA 263
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
93-139 2.86e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 2.86e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672087058   93 KLYMFGSNNWGQLGLGSKSAISKPTCIKALKPEKVKLAACGRNHTLV 139
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
246-296 4.94e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.99  E-value: 4.94e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672087058  246 DGELYTFGEPENGKLGLPNQllINHRSPQRVLGIPD-KVIQVACGGGHTVVL 296
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT--ENVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
196-243 8.79e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.22  E-value: 8.79e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 672087058  196 DGKLFMWGDNSEGQIGLKNKSNVCIPHEVT--VGKPISWISCGYYHSAFV 243
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEglSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
301-348 4.89e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.22  E-value: 4.89e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 672087058  301 VYAFGLGQFGQLGLGTFlFETSEPKIIDRIKDQKISHISCGENHTALM 348
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
180-209 3.05e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.81  E-value: 3.05e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 672087058  180 IKQLSAGANTSAALTEDGKLFMWGDNSEGQ 209
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
352-398 1.53e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 1.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672087058  352 GLMYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLKFTVQLIACGGCH 398
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDH 46
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
144-193 3.30e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.43  E-value: 3.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 672087058  144 GGVYAAGGNNEGQLGLGDTDDRDTFHQIGFFTPSDIIkQLSAGANTSAAL 193
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVV-QVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
127-156 3.72e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 3.72e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 672087058  127 VKLAACGRNHTLVSTDTGGVYAAGGNNEGQ 156
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
233-258 1.40e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 672087058  233 ISCGYYHSAFVTTDGELYTFGEPENG 258
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
283-311 2.57e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.64  E-value: 2.57e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 672087058  283 VIQVACGGGHTVVLTE-KVVYAFGLGQFGQ 311
Cdd:pfam13540   1 VVSVAAGDNHTLALTSdGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
78-104 3.41e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.26  E-value: 3.41e-05
                          10        20
                  ....*....|....*....|....*..
gi 672087058   78 LSCGDEHTAIVTGNNKLYMFGSNNWGQ 104
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
335-363 2.18e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.94  E-value: 2.18e-04
                          10        20
                  ....*....|....*....|....*....
gi 672087058  335 ISHISCGENHTALMTDIGLMYTFGDGRHG 363
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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