NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1046880506|ref|XP_017447419|]
View 

probable ATP-dependent RNA helicase DHX35 isoform X1 [Rattus norvegicus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-546 4.27e-131

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 402.15  E-value: 4.27e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDAEKFRDFFNqnetsdPARdtcv 79
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDAERFARLLG------DAP---- 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  80 ILTVEGRTFPVDIFYL--QSPVPDYIKATVDTVVKIHQtEGDGDILAFLTGQEEvetvvsmlIEQARALARTGMKKHLRV 157
Cdd:COG1643   180 VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE--------IRRTAEALRGRLPPDTEI 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 158 LPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAG 237
Cdd:COG1643   251 LPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAG 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 238 RGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKD 317
Cdd:COG1643   331 RAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDAD 410

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 318 CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFvfpsnqksqatrvhRKFAveEGDHLTMLNVY 397
Cdd:COG1643   411 GRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------------RGAA--GSDLLARLNLW 473

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 398 EAFikhnkssQWCQEHFLNYKGLVRAATVRDQLKKLLvkfQVPKMSSEGDPDPVLRCIVSGFFAN-AARFHSTGAYRTIR 476
Cdd:COG1643   474 RRL-------REQQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAYPDRiARRRGEGGRYLLAR 543

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046880506 477 dDHELHIHPASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQ 546
Cdd:COG1643   544 -GRGAALFPGSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEWLEELAAHLIKRYSEPHWDKKRGRVV 610
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-546 4.27e-131

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 402.15  E-value: 4.27e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDAEKFRDFFNqnetsdPARdtcv 79
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDAERFARLLG------DAP---- 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  80 ILTVEGRTFPVDIFYL--QSPVPDYIKATVDTVVKIHQtEGDGDILAFLTGQEEvetvvsmlIEQARALARTGMKKHLRV 157
Cdd:COG1643   180 VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE--------IRRTAEALRGRLPPDTEI 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 158 LPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAG 237
Cdd:COG1643   251 LPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAG 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 238 RGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKD 317
Cdd:COG1643   331 RAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDAD 410

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 318 CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFvfpsnqksqatrvhRKFAveEGDHLTMLNVY 397
Cdd:COG1643   411 GRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------------RGAA--GSDLLARLNLW 473

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 398 EAFikhnkssQWCQEHFLNYKGLVRAATVRDQLKKLLvkfQVPKMSSEGDPDPVLRCIVSGFFAN-AARFHSTGAYRTIR 476
Cdd:COG1643   474 RRL-------REQQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAYPDRiARRRGEGGRYLLAR 543

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046880506 477 dDHELHIHPASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQ 546
Cdd:COG1643   544 -GRGAALFPGSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEWLEELAAHLIKRYSEPHWDKKRGRVV 610
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-528 1.13e-117

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 376.80  E-value: 1.13e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506    1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNEtsdpardtcvI 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAP----------I 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   81 LTVEGRTFPVDIFY-----LQSPVP-DYIKATVDTVVKIHQtEGDGDILAFLTGQEEVEtvvsmliEQARALARTGMKkH 154
Cdd:TIGR01967  236 IEVSGRTYPVEVRYrplveEQEDDDlDQLEAILDAVDELFA-EGPGDILIFLPGEREIR-------DAAEILRKRNLR-H 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  155 LRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQ 234
Cdd:TIGR01967  307 TEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQ 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  235 RAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGL 314
Cdd:TIGR01967  385 RKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGAL 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  315 DKD---CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHL 391
Cdd:TIGR01967  465 DDDeaePQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFL 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  392 TMLNVYEAF------IKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAAR 465
Cdd:TIGR01967  544 SRVNLWRHIeeqrqaLSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGM 623

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046880506  466 FHSTGAYRTIRdDHELHIHPASVLyAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 528
Cdd:TIGR01967  624 KDEKHEYDGAR-GRKFHIFPGSPL-FKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-528 4.22e-112

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 362.07  E-value: 4.22e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506    1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNEtsdpardtcvI 80
Cdd:PRK11131   173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAP----------I 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   81 LTVEGRTFPVDIFYlqSPV--------PDYIKATVDTVVKIhQTEGDGDILAFLTGQEEVEtvvsmliEQARALARTGMK 152
Cdd:PRK11131   243 IEVSGRTYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREGPGDILIFMSGEREIR-------DTADALNKLNLR 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  153 kHLRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASA 232
Cdd:PRK11131   313 -HTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASA 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  233 NQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALG 312
Cdd:PRK11131   390 NQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELG 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  313 GLDKDC-----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEE 387
Cdd:PRK11131   470 AITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKE 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  388 GDHLTMLNVYEAFIKHNK---SSQW---CQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFA 461
Cdd:PRK11131   549 SDFLAFVNLWNYLQEQQKalsSNQFrrlCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLS 628

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506  462 -----NAARFHSTGAyrtiRDDHeLHIHPASVLYaEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 528
Cdd:PRK11131   629 higmkDAEKQEYTGA----RNAR-FSIFPGSGLF-KKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 88-251 8.85e-77

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 239.74  E-value: 8.85e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  88 FPVDIFYLQSPV-----------PDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLieqaRALARTGMKKHLR 156
Cdd:cd18791     1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 157 VLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRA 236
Cdd:cd18791    77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156

                         170
                  ....*....|....*
gi 1046880506 237 GRGGRNRSGKCYRLY 251
Cdd:cd18791   157 GRAGRTRPGKCYRLY 171
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 304-393 1.30e-26

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 103.86  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 304 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSN------------ 371
Cdd:pfam04408   1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarr 79

                          90       100
                  ....*....|....*....|....*
gi 1046880506 372 -QKSQATRVHRKFAVE--EGDHLTM 393
Cdd:pfam04408  80 rRRAADEKARAKFARLdlEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 310-394 6.97e-25

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 98.11  E-value: 6.97e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  310 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNvfVFPSNQKSQATRVHRKFAVEEGD 389
Cdd:smart00847   1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPESD 77


                   ....*
gi 1046880506  390 HLTML 394
Cdd:smart00847  78 HLTLL 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-546 4.27e-131

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 402.15  E-value: 4.27e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDAEKFRDFFNqnetsdPARdtcv 79
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDAERFARLLG------DAP---- 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  80 ILTVEGRTFPVDIFYL--QSPVPDYIKATVDTVVKIHQtEGDGDILAFLTGQEEvetvvsmlIEQARALARTGMKKHLRV 157
Cdd:COG1643   180 VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE--------IRRTAEALRGRLPPDTEI 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 158 LPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAG 237
Cdd:COG1643   251 LPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAG 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 238 RGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKD 317
Cdd:COG1643   331 RAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDAD 410

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 318 CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFvfpsnqksqatrvhRKFAveEGDHLTMLNVY 397
Cdd:COG1643   411 GRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------------RGAA--GSDLLARLNLW 473

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 398 EAFikhnkssQWCQEHFLNYKGLVRAATVRDQLKKLLvkfQVPKMSSEGDPDPVLRCIVSGFFAN-AARFHSTGAYRTIR 476
Cdd:COG1643   474 RRL-------REQQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAYPDRiARRRGEGGRYLLAR 543

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046880506 477 dDHELHIHPASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQ 546
Cdd:COG1643   544 -GRGAALFPGSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEWLEELAAHLIKRYSEPHWDKKRGRVV 610
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-528 1.13e-117

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 376.80  E-value: 1.13e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506    1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNEtsdpardtcvI 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAP----------I 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   81 LTVEGRTFPVDIFY-----LQSPVP-DYIKATVDTVVKIHQtEGDGDILAFLTGQEEVEtvvsmliEQARALARTGMKkH 154
Cdd:TIGR01967  236 IEVSGRTYPVEVRYrplveEQEDDDlDQLEAILDAVDELFA-EGPGDILIFLPGEREIR-------DAAEILRKRNLR-H 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  155 LRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQ 234
Cdd:TIGR01967  307 TEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQ 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  235 RAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGL 314
Cdd:TIGR01967  385 RKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGAL 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  315 DKD---CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHL 391
Cdd:TIGR01967  465 DDDeaePQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFL 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  392 TMLNVYEAF------IKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAAR 465
Cdd:TIGR01967  544 SRVNLWRHIeeqrqaLSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGM 623

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046880506  466 FHSTGAYRTIRdDHELHIHPASVLyAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 528
Cdd:TIGR01967  624 KDEKHEYDGAR-GRKFHIFPGSPL-FKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-528 4.22e-112

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 362.07  E-value: 4.22e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506    1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNEtsdpardtcvI 80
Cdd:PRK11131   173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAP----------I 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   81 LTVEGRTFPVDIFYlqSPV--------PDYIKATVDTVVKIhQTEGDGDILAFLTGQEEVEtvvsmliEQARALARTGMK 152
Cdd:PRK11131   243 IEVSGRTYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREGPGDILIFMSGEREIR-------DTADALNKLNLR 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  153 kHLRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASA 232
Cdd:PRK11131   313 -HTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASA 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  233 NQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALG 312
Cdd:PRK11131   390 NQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELG 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  313 GLDKDC-----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEE 387
Cdd:PRK11131   470 AITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKE 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  388 GDHLTMLNVYEAFIKHNK---SSQW---CQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFA 461
Cdd:PRK11131   549 SDFLAFVNLWNYLQEQQKalsSNQFrrlCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLS 628

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506  462 -----NAARFHSTGAyrtiRDDHeLHIHPASVLYaEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 528
Cdd:PRK11131   629 higmkDAEKQEYTGA----RNAR-FSIFPGSGLF-KKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 88-251 8.85e-77

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 239.74  E-value: 8.85e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  88 FPVDIFYLQSPV-----------PDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLieqaRALARTGMKKHLR 156
Cdd:cd18791     1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 157 VLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRA 236
Cdd:cd18791    77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156

                         170
                  ....*....|....*
gi 1046880506 237 GRGGRNRSGKCYRLY 251
Cdd:cd18791   157 GRAGRTRPGKCYRLY 171
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 1-359 2.38e-63

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 221.72  E-value: 2.38e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDAEKFRDFFnqnetsdParDTCV 79
Cdd:PRK11664  103 ILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLIMSATLDNDRLQQLL-------P--DAPV 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  80 ILTvEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQaralartgMKKHLRVLP 159
Cdd:PRK11664  174 IVS-EGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASR--------VASDVLLCP 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 160 MYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRG 239
Cdd:PRK11664  245 LYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRA 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 240 GRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKDCR 319
Cdd:PRK11664  325 GRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGR 404

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1046880506 320 LTePLGMRIAEFPLNPMFAKMLLESGNFgcSQEILSIAAM 359
Cdd:PRK11664  405 LT-ARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAK 441
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 1-83 1.42e-51

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 174.58  E-value: 1.42e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVI 80
Cdd:cd17980   103 MLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETNDPSKDTATI 182


                  ...
gi 1046880506  81 LTV 83
Cdd:cd17980   183 LSV 185
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-67 1.33e-30

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 116.79  E-value: 1.33e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQ 67
Cdd:cd17917    87 ILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGG 153
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-66 6.50e-28

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 110.20  E-value: 6.50e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 66
Cdd:cd17973   115 MLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFD 180
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 1-66 5.87e-27

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 107.44  E-value: 5.87e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGD-----LRLIVASATLDAEKFRDFFN 66
Cdd:cd17978   101 MLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklspLKVIIMSATLDADLFSEYFN 171
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 304-393 1.30e-26

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 103.86  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 304 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSN------------ 371
Cdd:pfam04408   1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarr 79

                          90       100
                  ....*....|....*....|....*
gi 1046880506 372 -QKSQATRVHRKFAVE--EGDHLTM 393
Cdd:pfam04408  80 rRRAADEKARAKFARLdlEGDHLTL 104
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 1-65 1.22e-25

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 103.72  E-value: 1.22e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17971   106 MLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDAVKFSQYF 170
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 310-394 6.97e-25

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 98.11  E-value: 6.97e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  310 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNvfVFPSNQKSQATRVHRKFAVEEGD 389
Cdd:smart00847   1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPESD 77


                   ....*
gi 1046880506  390 HLTML 394
Cdd:smart00847  78 HLTLL 82
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-67 6.46e-24

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 98.73  E-value: 6.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQ 67
Cdd:cd17974   102 MLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAEKFSAFFDD 168
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-65 1.12e-21

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 92.14  E-value: 1.12e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17983   101 ILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADKFADFF 165
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 451-528 2.07e-21

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 88.46  E-value: 2.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 451 VLRCIVSGFFANAARF-HSTGAYRTIRDDHELHIHPASVLY--AEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 527
Cdd:pfam07717   1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFneKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  .
gi 1046880506 528 H 528
Cdd:pfam07717  81 H 81
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 2-63 1.76e-17

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 80.86  E-value: 1.76e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506   2 LVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGD----------LRLIVASATLDAEKFRD 63
Cdd:cd17982   106 LLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvkpLKLVIMSATLRVEDFTE 177
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 2-65 3.25e-17

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 79.51  E-value: 3.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046880506   2 LVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKI--QKKRG---DLRLIVASATLDAEKFRDFF 65
Cdd:cd17984   102 LLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqEKSPNrkeHLKVVVMSATLELAKLSAFF 170
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 1-66 3.39e-15

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 73.72  E-value: 3.39e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 66
Cdd:cd17981   108 IVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFN 173
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-65 6.51e-15

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 72.94  E-value: 6.51e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17977   104 MLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHLSSKLLSYY 168
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 1-66 1.13e-14

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 72.10  E-value: 1.13e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 66
Cdd:cd17989   101 ILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAERFSRHFN 166
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 1-67 1.33e-14

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 71.71  E-value: 1.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQ 67
Cdd:cd17979    98 LLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSGYFEG 164
HELICc smart00490
helicase superfamily c-terminal domain;
146-241 7.79e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 66.85  E-value: 7.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  146 LARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFmklraynprtaieclvvv 225
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------ 64

                           90
                   ....*....|....*.
gi 1046880506  226 PVSQASANQRAGRGGR 241
Cdd:smart00490  65 PWSPASYIQRIGRAGR 80
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 1-67 7.96e-14

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 69.94  E-value: 7.96e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQ 67
Cdd:cd17975   111 VLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLILMSATVDCEKFSSYFTH 177
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 1-61 5.43e-13

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 67.36  E-value: 5.43e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQK-KRGDLRLIVASATLDAEKF 61
Cdd:cd17990   101 VLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGDGL 162
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 107-241 1.28e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 64.15  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 107 VDTVVKIHQTEGDGDILAFLTGQEEVETvvSMLIEqaralartgmKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVA 186
Cdd:pfam00271   3 LEALLELLKKERGGKVLIFSQTKKTLEA--ELLLE----------KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVA 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506 187 TNVAETSITISGIVYVIDCGFmklrAYNPRTAIeclvvvpvsqasanQRAGRGGR 241
Cdd:pfam00271  71 TDVAERGLDLPDVDLVINYDL----PWNPASYI--------------QRIGRAGR 107
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-64 3.57e-12

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 64.92  E-value: 3.57e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDF 64
Cdd:cd17986   105 LLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAF 168
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 1-66 6.11e-11

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 61.39  E-value: 6.11e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 66
Cdd:cd17985   105 VLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATLNAELFSDYFN 170
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 12-252 4.25e-09

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 59.22  E-value: 4.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  12 LTKYSVVMLDEAHERTLYTDIAIGLLKkiqKKRGDLR-LIVASATL--DAEKFRDFFNqnetsDPArdtcvILTVEGRT- 87
Cdd:PHA02653  289 LFDYGTVIIDEVHEHDQIGDIIIAVAR---KHIDKIRsLFLMTATLedDRDRIKEFFP-----NPA-----FVHIPGGTl 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506  88 FPVDIFYL---QSPvPD---YIKATVDTVVKIHQT----EGDGDILaFltgqeeVETvVSMLIEQARALartgmKKHLRV 157
Cdd:PHA02653  356 FPISEVYVknkYNP-KNkraYIEEEKKNIVTALKKytppKGSSGIV-F------VAS-VSQCEEYKKYL-----EKRLPI 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 158 LPMY---AGLPSFEQM--KVF--ERVShsvrkVIVATNVAETSITISGIVYVIDCGfmklRAYNPRtaieclvvvP---- 226
Cdd:PHA02653  422 YDFYiihGKVPNIDEIleKVYssKNPS-----IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------Pfggk 483

                         250       260
                  ....*....|....*....|....*....
gi 1046880506 227 ---VSQASANQRAGRGGRNRSGKCYRLYT 252
Cdd:PHA02653  484 emfISKSMRTQRKGRVGRVSPGTYVYFYD 512
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 1-65 1.34e-08

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 54.80  E-value: 1.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506   1 MLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17976   106 VLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSATGDNQRLSRYF 170
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 1-66 3.11e-06

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 47.52  E-value: 3.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046880506   1 MLVREMMV-DPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 66
Cdd:cd17987   103 VLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALDVNLFIRYFG 169
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 16-65 4.29e-05

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 45.21  E-value: 4.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046880506  16 SVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17972   177 SHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 12-65 2.45e-04

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 42.10  E-value: 2.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046880506  12 LTKYSVVMLDEAHERTLYTDIAIGLLKK-IQKKRGDLRLIVASATLDAEKFRDFF 65
Cdd:cd17988   114 LTEYTHIILDEVHERDQELDFLLLVVRRlLRTNSRHVKIILMSATISCKEFADYF 168
PRK13766 PRK13766
Hef nuclease; Provisional
 103-256 9.74e-04

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 42.17  E-value: 9.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 103 IKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIE----------QARALARTGMKKHlrvlpmyaglpsfEQMKV 172
Cdd:PRK13766  349 LEKLREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKegikavrfvgQASKDGDKGMSQK-------------EQIEI 415

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880506 173 FERVSHSVRKVIVATNVAETSITISGIVYVIdcgFmklraYNPrtaieclvvVPvSQASANQRAGRGGRNRSGKCYRLYT 252
Cdd:PRK13766  416 LDKFRAGEFNVLVSTSVAEEGLDIPSVDLVI---F-----YEP---------VP-SEIRSIQRKGRTGRQEEGRVVVLIA 477


                  ....*...
gi 1046880506 253 E----EAF 256
Cdd:PRK13766  478 KgtrdEAY 485
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 182-251 1.02e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 38.07  E-value: 1.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506 182 KVIVATNVAETSITISGIVYVIDCGfmklraynprtaieclvvVPVSQASANQRAGRGGRN--RSGKCYRLY 251
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVIFFD------------------PPSSAASYIQRVGRAGRGgkDEGEVILFV 77
DEXDc smart00487
DEAD-like helicases superfamily;
1-69 2.05e-03

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 39.78  E-value: 2.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880506    1 MLVREMMVDPL-LTKYSVVMLDEAHERTLYTDIAIgLLKKIQKKRGDLRLIVASATL--DAEKFRDFFNQNE 69
Cdd:smart00487 115 RLLDLLENDKLsLSNVDLVILDEAHRLLDGGFGDQ-LEKLLKLLPKNVQLLLLSATPpeEIENLLELFLNDP 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH