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Conserved domains on  [gi|1046880608|ref|XP_017447439|]
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ESF1 homolog isoform X1 [Rattus norvegicus]

Protein Classification

ESF1 family protein( domain architecture ID 1002617)

ESF1 family protein similar to Homo sapiens ESF1 pre-rRNA-processing protein homolog, which may constitute a novel regulatory system for basal transcription

Gene Ontology:  GO:0003723|GO:0006364

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5638 super family cl35032
Uncharacterized conserved protein [Function unknown];
293-827 3.85e-55

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG5638:

Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 201.55  E-value: 3.85e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 293 DLARGKGNVETS-SEDEDDLADLFPEEPGFEhawrELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVV 371
Cdd:COG5638   103 DPARGEGIISTSeSSDESREESEEEKANEIS----EKAGAVPEEGNPTKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKL 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 372 FSVKIYPSEFGKQRMKEEQIQGPVELLSIP----------------------EDAPEKDWASRE----KLRDYQFKRLKY 425
Cdd:COG5638   179 SKVKIYPSEFGKERMAAEHVQGPPRDIFTPadnqpssqkfgddnvfsdrdagEDALIEGDRGNEfdmvKLRQYQLERLRY 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 426 YYAVVECDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDAASEVDlTAYKPKYFTSAAMGTSTVEITWDE 505
Cdd:COG5638   259 YYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDSREVCTKAP-EKYEPRDFVTDALQHSKVKLSWDA 337
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 506 TDHERITTLNRKFKKDELLDMDFEAYLAsssedeeevEEAPEGEDGVSIEDGKTK-KSQKDDEEQIakyrqllqVIQEKE 584
Cdd:COG5638   338 EDPHRKDLCKEAFTDDGIRDKDFSAYTA---------SKLSDEDDDSVMESKMQKlFSEKEIDFGL--------NSELVD 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 585 KKGKENDMEMEIKWVPGLKESAEEMVKNKLEGkdkltpweqfLEKKKEKKRLKKKQKALAEEASEDEIPSDVDLNDpyfa 664
Cdd:COG5638   401 MSDDGENGEMEDTFTSHLPASNESESDDKLET----------TIEKLDRKLRERQENRKERQLKKTKDDSDVDLKD---- 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 665 eevKKIGIKKKSMKsakdgatSEEETELEKQKAEMALLVMDEEEDSKKHFNYDKIVEHQNLSKKKKKQLMKKKELLEDDF 744
Cdd:COG5638   467 ---KKESINKKNKK-------GKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGF 536
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 745 EVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARHREQKEERLiQAVERAQQDTGKPAQKQPMDPALSMLIK 824
Cdd:COG5638   537 VFDPKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIEQT-QDGKPELKIKKRKAEKGDQRQELDRIVK 615

                  ...
gi 1046880608 825 SVK 827
Cdd:COG5638   616 SIK 618
 
Name Accession Description Interval E-value
COG5638 COG5638
Uncharacterized conserved protein [Function unknown];
293-827 3.85e-55

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 201.55  E-value: 3.85e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 293 DLARGKGNVETS-SEDEDDLADLFPEEPGFEhawrELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVV 371
Cdd:COG5638   103 DPARGEGIISTSeSSDESREESEEEKANEIS----EKAGAVPEEGNPTKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKL 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 372 FSVKIYPSEFGKQRMKEEQIQGPVELLSIP----------------------EDAPEKDWASRE----KLRDYQFKRLKY 425
Cdd:COG5638   179 SKVKIYPSEFGKERMAAEHVQGPPRDIFTPadnqpssqkfgddnvfsdrdagEDALIEGDRGNEfdmvKLRQYQLERLRY 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 426 YYAVVECDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDAASEVDlTAYKPKYFTSAAMGTSTVEITWDE 505
Cdd:COG5638   259 YYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDSREVCTKAP-EKYEPRDFVTDALQHSKVKLSWDA 337
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 506 TDHERITTLNRKFKKDELLDMDFEAYLAsssedeeevEEAPEGEDGVSIEDGKTK-KSQKDDEEQIakyrqllqVIQEKE 584
Cdd:COG5638   338 EDPHRKDLCKEAFTDDGIRDKDFSAYTA---------SKLSDEDDDSVMESKMQKlFSEKEIDFGL--------NSELVD 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 585 KKGKENDMEMEIKWVPGLKESAEEMVKNKLEGkdkltpweqfLEKKKEKKRLKKKQKALAEEASEDEIPSDVDLNDpyfa 664
Cdd:COG5638   401 MSDDGENGEMEDTFTSHLPASNESESDDKLET----------TIEKLDRKLRERQENRKERQLKKTKDDSDVDLKD---- 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 665 eevKKIGIKKKSMKsakdgatSEEETELEKQKAEMALLVMDEEEDSKKHFNYDKIVEHQNLSKKKKKQLMKKKELLEDDF 744
Cdd:COG5638   467 ---KKESINKKNKK-------GKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGF 536
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 745 EVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARHREQKEERLiQAVERAQQDTGKPAQKQPMDPALSMLIK 824
Cdd:COG5638   537 VFDPKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIEQT-QDGKPELKIKKRKAEKGDQRQELDRIVK 615

                  ...
gi 1046880608 825 SVK 827
Cdd:COG5638   616 SIK 618
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
750-778 1.01e-07

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 48.48  E-value: 1.01e-07
                          10        20
                  ....*....|....*....|....*....
gi 1046880608 750 DARFQAMYTSHLFNLDPSDPNFKKTKAME 778
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFKKTNPMK 29
 
Name Accession Description Interval E-value
COG5638 COG5638
Uncharacterized conserved protein [Function unknown];
293-827 3.85e-55

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 201.55  E-value: 3.85e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 293 DLARGKGNVETS-SEDEDDLADLFPEEPGFEhawrELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVV 371
Cdd:COG5638   103 DPARGEGIISTSeSSDESREESEEEKANEIS----EKAGAVPEEGNPTKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKL 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 372 FSVKIYPSEFGKQRMKEEQIQGPVELLSIP----------------------EDAPEKDWASRE----KLRDYQFKRLKY 425
Cdd:COG5638   179 SKVKIYPSEFGKERMAAEHVQGPPRDIFTPadnqpssqkfgddnvfsdrdagEDALIEGDRGNEfdmvKLRQYQLERLRY 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 426 YYAVVECDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDAASEVDlTAYKPKYFTSAAMGTSTVEITWDE 505
Cdd:COG5638   259 YYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDSREVCTKAP-EKYEPRDFVTDALQHSKVKLSWDA 337
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 506 TDHERITTLNRKFKKDELLDMDFEAYLAsssedeeevEEAPEGEDGVSIEDGKTK-KSQKDDEEQIakyrqllqVIQEKE 584
Cdd:COG5638   338 EDPHRKDLCKEAFTDDGIRDKDFSAYTA---------SKLSDEDDDSVMESKMQKlFSEKEIDFGL--------NSELVD 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 585 KKGKENDMEMEIKWVPGLKESAEEMVKNKLEGkdkltpweqfLEKKKEKKRLKKKQKALAEEASEDEIPSDVDLNDpyfa 664
Cdd:COG5638   401 MSDDGENGEMEDTFTSHLPASNESESDDKLET----------TIEKLDRKLRERQENRKERQLKKTKDDSDVDLKD---- 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 665 eevKKIGIKKKSMKsakdgatSEEETELEKQKAEMALLVMDEEEDSKKHFNYDKIVEHQNLSKKKKKQLMKKKELLEDDF 744
Cdd:COG5638   467 ---KKESINKKNKK-------GKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGF 536
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880608 745 EVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARHREQKEERLiQAVERAQQDTGKPAQKQPMDPALSMLIK 824
Cdd:COG5638   537 VFDPKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIEQT-QDGKPELKIKKRKAEKGDQRQELDRIVK 615

                  ...
gi 1046880608 825 SVK 827
Cdd:COG5638   616 SIK 618
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
750-778 1.01e-07

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 48.48  E-value: 1.01e-07
                          10        20
                  ....*....|....*....|....*....
gi 1046880608 750 DARFQAMYTSHLFNLDPSDPNFKKTKAME 778
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFKKTNPMK 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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