NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958764976|ref|XP_017447618|]
View 

complement C5-like isoform X9 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 32-128 1.33e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


:

Pssm-ID: 465508  Cd Length: 101  Bit Score: 85.09  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976  32 YIISTPIVFRVGAPENVTVQAYGYTEAFDTTISVKSYPNKNVNYSSGTVELSPENKFQNSAILTIQAQELSEEQNWFSNV 111
Cdd:pfam17790   4 YLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGKQYV 83

                          90
                  ....*....|....*..
gi 1958764976 112 YSEVVSKHFSKLEIMPI 128
Cdd:pfam17790  84 YLQAKFPHFELEKVVLV 100
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 269-322 6.06e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


:

Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.11  E-value: 6.06e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958764976 269 KINEQASKYKHPVIKKCCYDGARYN-EHETCVQRAAHVTIGPNCVKAFSLCCEIA 322
Cdd:cd00017     1 KNSEKAAQYKDKELRKCCLDGMRENpMGQTCEERAAYITDGKECRKAFLECCVYA 55
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 134-228 6.73e-16

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 71.96  E-value: 6.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976 134 SLFVHTDKPVYTPEQPVKVAVYSVDDDLEPVTRTTV-LTFIDPEGSEVGIIGGRNG-TGIASFpDFKIPSNPKLGRWTIK 211
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVtLTVTDPDGNEVRRLPLTTDeFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 1958764976 212 AnYREDASTTGTTHFEV 228
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
 
Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 32-128 1.33e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


Pssm-ID: 465508  Cd Length: 101  Bit Score: 85.09  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976  32 YIISTPIVFRVGAPENVTVQAYGYTEAFDTTISVKSYPNKNVNYSSGTVELSPENKFQNSAILTIQAQELSEEQNWFSNV 111
Cdd:pfam17790   4 YLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGKQYV 83

                          90
                  ....*....|....*..
gi 1958764976 112 YSEVVSKHFSKLEIMPI 128
Cdd:pfam17790  84 YLQAKFPHFELEKVVLV 100
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 269-322 6.06e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.11  E-value: 6.06e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958764976 269 KINEQASKYKHPVIKKCCYDGARYN-EHETCVQRAAHVTIGPNCVKAFSLCCEIA 322
Cdd:cd00017     1 KNSEKAAQYKDKELRKCCLDGMRENpMGQTCEERAAYITDGKECRKAFLECCVYA 55
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 134-228 6.73e-16

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 71.96  E-value: 6.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976 134 SLFVHTDKPVYTPEQPVKVAVYSVDDDLEPVTRTTV-LTFIDPEGSEVGIIGGRNG-TGIASFpDFKIPSNPKLGRWTIK 211
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVtLTVTDPDGNEVRRLPLTTDeFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 1958764976 212 AnYREDASTTGTTHFEV 228
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 285-319 6.58e-11

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 56.51  E-value: 6.58e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958764976 285 CCYDGARYNE-HETCVQRAAHVTIGPNCVKAFSLCC 319
Cdd:pfam01821   1 CCLDGMKRNPmGRSCEQRAARIKEGPRCRKAFLQCC 36
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 285-319 3.36e-08

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 48.87  E-value: 3.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958764976  285 CCYDGARYN-EHETCVQRAAHVTIGPnCVKAFSLCC 319
Cdd:smart00104   1 CCADGMRLApMGETCEERAARINSGD-CRKAFLQCC 35
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 129-229 1.53e-07

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 53.16  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976  129 VYDNSSLFVHTDKPVYTPEQPVKVAVYSVDDDLEPVTRTTV-LTFIDPEGSEVG-IIGGRNGTGIASFpDFKIPSNPKLG 206
Cdd:COG2373    365 PPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLtLELTDPDGKEVRrQTLTLNEFGGYSF-SFPLPEDAPTG 443

                           90       100
                   ....*....|....*....|...
gi 1958764976  207 RWTIKAnYREDASTTGTTHFEVQ 229
Cdd:COG2373    444 TWRLEL-YVDPKPALGSKSFRVE 465
 
Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 32-128 1.33e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


Pssm-ID: 465508  Cd Length: 101  Bit Score: 85.09  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976  32 YIISTPIVFRVGAPENVTVQAYGYTEAFDTTISVKSYPNKNVNYSSGTVELSPENKFQNSAILTIQAQELSEEQNWFSNV 111
Cdd:pfam17790   4 YLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGKQYV 83

                          90
                  ....*....|....*..
gi 1958764976 112 YSEVVSKHFSKLEIMPI 128
Cdd:pfam17790  84 YLQAKFPHFELEKVVLV 100
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 269-322 6.06e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.11  E-value: 6.06e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958764976 269 KINEQASKYKHPVIKKCCYDGARYN-EHETCVQRAAHVTIGPNCVKAFSLCCEIA 322
Cdd:cd00017     1 KNSEKAAQYKDKELRKCCLDGMRENpMGQTCEERAAYITDGKECRKAFLECCVYA 55
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 134-228 6.73e-16

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 71.96  E-value: 6.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976 134 SLFVHTDKPVYTPEQPVKVAVYSVDDDLEPVTRTTV-LTFIDPEGSEVGIIGGRNG-TGIASFpDFKIPSNPKLGRWTIK 211
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVtLTVTDPDGNEVRRLPLTTDeFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 1958764976 212 AnYREDASTTGTTHFEV 228
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 285-319 6.58e-11

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 56.51  E-value: 6.58e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958764976 285 CCYDGARYNE-HETCVQRAAHVTIGPNCVKAFSLCC 319
Cdd:pfam01821   1 CCLDGMKRNPmGRSCEQRAARIKEGPRCRKAFLQCC 36
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 285-319 3.36e-08

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 48.87  E-value: 3.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958764976  285 CCYDGARYN-EHETCVQRAAHVTIGPnCVKAFSLCC 319
Cdd:smart00104   1 CCADGMRLApMGETCEERAARINSGD-CRKAFLQCC 35
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 129-229 1.53e-07

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 53.16  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764976  129 VYDNSSLFVHTDKPVYTPEQPVKVAVYSVDDDLEPVTRTTV-LTFIDPEGSEVG-IIGGRNGTGIASFpDFKIPSNPKLG 206
Cdd:COG2373    365 PPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLtLELTDPDGKEVRrQTLTLNEFGGYSF-SFPLPEDAPTG 443

                           90       100
                   ....*....|....*....|...
gi 1958764976  207 RWTIKAnYREDASTTGTTHFEVQ 229
Cdd:COG2373    444 TWRLEL-YVDPKPALGSKSFRVE 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH