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Conserved domains on  [gi|1046861367|ref|XP_017455199|]
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protocadherin-9 isoform X1 [Rattus norvegicus]

Protein Classification

protocadherin( domain architecture ID 10182726)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 777-1000 1.21e-79

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 260.83  E-value: 1.21e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  777 TAGNASYIYDLIRRTMETPLDRNI-GDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVR-CRHA--SRFKAAQrsKQ 852
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGK--KQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  853 GAEWMSPNQENKQNKKK------KRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAeleeqsigrfdwgpAPPT 926
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI--------------TLPT 144

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046861367  927 TFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDhFSASECSSQG 1000
Cdd:pfam08374  145 TFKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGDSLSKGSSQSSD-YSYSECSYKY 217
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-671 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  576 HFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNEN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  654 PRSSTAKVTINVMDVNDN 671
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 258-354 1.94e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFgaqVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 337
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  338 TP--ARATVTINVTDVNDN 354
Cdd:cd11304     80 PPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 473-568 1.38e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTP 550
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  551 PLQSQAAVIVTVLDENDN 568
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 146-248 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 3.82e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  146 VINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDiveTPEGEkwpqLIVQQNLDREQKDTYVMKIK 223
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSID---PSTGE----ITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*
gi 1046861367  224 VEDGGTPQKSSTAILQVTVSDVNDN 248
Cdd:cd11304     74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 370-465 3.34e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 3.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP---FHLKAvydNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  447 PSLNQTALVRVKLEDENDN 465
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 687-776 3.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 3.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  687 VPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPkALHT 766
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSS 84

                           90
                   ....*....|
gi 1046861367  767 LVLVFLYVND 776
Cdd:cd11304     85 TATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-138 1.53e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   29 TIREELPENVPIGNIPkdLNISHINAATGTSASLVYRLVSKaGDAPLVKVSSSTGEIFTTSnRIDREKLCagasyaeene 108
Cdd:cd11304      1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAK-PLDREEQS---------- 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1046861367  109 cFFELEVVIL---PNDFFRLIKIKIIVKDTNDN 138
Cdd:cd11304     67 -SYTLTVTATdggGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 777-1000 1.21e-79

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 260.83  E-value: 1.21e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  777 TAGNASYIYDLIRRTMETPLDRNI-GDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVR-CRHA--SRFKAAQrsKQ 852
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGK--KQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  853 GAEWMSPNQENKQNKKK------KRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAeleeqsigrfdwgpAPPT 926
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI--------------TLPT 144

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046861367  927 TFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDhFSASECSSQG 1000
Cdd:pfam08374  145 TFKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGDSLSKGSSQSSD-YSYSECSYKY 217
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-671 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  576 HFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNEN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  654 PRSSTAKVTINVMDVNDN 671
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 258-354 1.94e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFgaqVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 337
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  338 TP--ARATVTINVTDVNDN 354
Cdd:cd11304     80 PPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 473-568 1.38e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTP 550
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  551 PLQSQAAVIVTVLDENDN 568
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-673 3.88e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 3.88e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   595 TVTDEDAGENKAVTLSILNDNEN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   673 P 673
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 146-248 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 3.82e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  146 VINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDiveTPEGEkwpqLIVQQNLDREQKDTYVMKIK 223
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSID---PSTGE----ITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*
gi 1046861367  224 VEDGGTPQKSSTAILQVTVSDVNDN 248
Cdd:cd11304     74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 492-570 6.21e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 6.21e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   492 SATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNS 569
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   570 P 570
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
258-349 3.97e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 3.97e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYifgAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 337
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1046861367  338 TP--ARATVTINVT 349
Cdd:pfam00028   79 PPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 275-356 9.50e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 9.50e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   275 HATDADIGSNAEIRYIFgaqVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVN 352
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 1046861367   353 DNPP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
577-665 2.14e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 2.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  577 FQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNE--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPP 654
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1046861367  655 RSSTAKVTINV 665
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
477-563 2.92e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 2.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  477 SVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQS 554
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1046861367  555 QAAVIVTVL 563
Cdd:pfam00028   84 TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 370-465 3.34e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 3.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP---FHLKAvydNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  447 PSLNQTALVRVKLEDENDN 465
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 165-250 3.48e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.48e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   165 SATDPDTGFNGVQHYELLNGqSVFGLDIVETPEGEkwpqLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 1046861367   245 VNDNRP 250
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 687-776 3.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 3.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  687 VPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPkALHT 766
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSS 84

                           90
                   ....*....|
gi 1046861367  767 LVLVFLYVND 776
Cdd:cd11304     85 TATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 387-467 4.44e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 4.44e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   467 P 467
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
147-242 6.72e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 6.72e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  147 INISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGqSVFGLDIVETPEGEkwpqLIVQQNLDREQKDTYVMKIKVED 226
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 1046861367  227 GGTPQKSSTAILQVTV 242
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 702-776 5.77e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 5.77e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   702 AVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL------EEKPaptdvgLHRLVVNISDLGYPkALHTLVLVFLYVN 775
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTtkpldrEEQP------EYTLTVEATDGGGP-PLSSTATVTITVL 74


                    .
gi 1046861367   776 D 776
Cdd:smart00112   75 D 75
Cadherin pfam00028
Cadherin domain;
687-761 2.83e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 2.83e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046861367  687 VPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEkpaPTDV---GLHRLVVNISDLGYP 761
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTK---PLDResiGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
370-460 3.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSL 449
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1046861367  450 NQTALVRVKLE 460
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-138 1.53e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   29 TIREELPENVPIGNIPkdLNISHINAATGTSASLVYRLVSKaGDAPLVKVSSSTGEIFTTSnRIDREKLCagasyaeene 108
Cdd:cd11304      1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAK-PLDREEQS---------- 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1046861367  109 cFFELEVVIL---PNDFFRLIKIKIIVKDTNDN 138
Cdd:cd11304     67 -SYTLTVTATdggGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-117 6.38e-07

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 48.29  E-value: 6.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   28 YTIREELPENVPIGNIPKDLNIShinaaTGTSASLVYRLVSKaGDAPLVKVSSSTGEIFtTSNRIDREKLCAGASyaeen 107
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLE-----VGELAARGARVVSK-GNKQYFQLNPETGDLL-LNEKLDREELCGSTE----- 71

                           90
                   ....*....|
gi 1046861367  108 ECFFELEVVI 117
Cdd:pfam08266   72 PCVLHFQVLL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 56-140 1.55e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 1.55e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367    56 TGTSASLVYRLVSkAGDAPLVKVSSSTGEIFTTSnRIDREKLCagasyaeenecFFELEVVILPNDFFRL---IKIKIIV 132
Cdd:smart00112    7 SGENGKVTYSILS-GNDDGLFSIDPETGEITTTK-PLDREEQP-----------EYTLTVEATDGGGPPLsstATVTITV 73


                    ....*...
gi 1046861367   133 KDTNDNAP 140
Cdd:smart00112   74 LDVNDNAP 81
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 777-1000 1.21e-79

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 260.83  E-value: 1.21e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  777 TAGNASYIYDLIRRTMETPLDRNI-GDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVR-CRHA--SRFKAAQrsKQ 852
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGK--KQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  853 GAEWMSPNQENKQNKKK------KRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAeleeqsigrfdwgpAPPT 926
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI--------------TLPT 144

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046861367  927 TFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDhFSASECSSQG 1000
Cdd:pfam08374  145 TFKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGDSLSKGSSQSSD-YSYSECSYKY 217
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-671 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  576 HFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNEN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  654 PRSSTAKVTINVMDVNDN 671
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 258-354 1.94e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFgaqVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 337
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  338 TP--ARATVTINVTDVNDN 354
Cdd:cd11304     80 PPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 473-568 1.38e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.38e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTP 550
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1046861367  551 PLQSQAAVIVTVLDENDN 568
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-673 3.88e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 3.88e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   595 TVTDEDAGENKAVTLSILNDNEN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   673 P 673
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 146-248 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 3.82e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  146 VINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDiveTPEGEkwpqLIVQQNLDREQKDTYVMKIK 223
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSID---PSTGE----ITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*
gi 1046861367  224 VEDGGTPQKSSTAILQVTVSDVNDN 248
Cdd:cd11304     74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 492-570 6.21e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 6.21e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   492 SATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNS 569
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   570 P 570
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
258-349 3.97e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 3.97e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYifgAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 337
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1046861367  338 TP--ARATVTINVT 349
Cdd:pfam00028   79 PPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 275-356 9.50e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 9.50e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   275 HATDADIGSNAEIRYIFgaqVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVN 352
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 1046861367   353 DNPP 356
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
577-665 2.14e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 2.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  577 FQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNE--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPP 654
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1046861367  655 RSSTAKVTINV 665
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
477-563 2.92e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 2.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  477 SVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQS 554
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1046861367  555 QAAVIVTVL 563
Cdd:pfam00028   84 TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 370-465 3.34e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 3.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP---FHLKAvydNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1046861367  447 PSLNQTALVRVKLEDENDN 465
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 165-250 3.48e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.48e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   165 SATDPDTGFNGVQHYELLNGqSVFGLDIVETPEGEkwpqLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 1046861367   245 VNDNRP 250
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 687-776 3.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 3.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  687 VPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPkALHT 766
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSS 84

                           90
                   ....*....|
gi 1046861367  767 LVLVFLYVND 776
Cdd:cd11304     85 TATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 387-467 4.44e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 4.44e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1046861367   467 P 467
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
147-242 6.72e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 6.72e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  147 INISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGqSVFGLDIVETPEGEkwpqLIVQQNLDREQKDTYVMKIKVED 226
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 1046861367  227 GGTPQKSSTAILQVTV 242
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 702-776 5.77e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 5.77e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   702 AVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL------EEKPaptdvgLHRLVVNISDLGYPkALHTLVLVFLYVN 775
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTtkpldrEEQP------EYTLTVEATDGGGP-PLSSTATVTITVL 74


                    .
gi 1046861367   776 D 776
Cdd:smart00112   75 D 75
Cadherin pfam00028
Cadherin domain;
687-761 2.83e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 2.83e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046861367  687 VPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEkpaPTDV---GLHRLVVNISDLGYP 761
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTK---PLDResiGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
370-460 3.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSL 449
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1046861367  450 NQTALVRVKLE 460
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-138 1.53e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   29 TIREELPENVPIGNIPkdLNISHINAATGTSASLVYRLVSKaGDAPLVKVSSSTGEIFTTSnRIDREKLCagasyaeene 108
Cdd:cd11304      1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAK-PLDREEQS---------- 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1046861367  109 cFFELEVVIL---PNDFFRLIKIKIIVKDTNDN 138
Cdd:cd11304     67 -SYTLTVTATdggGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-117 6.38e-07

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 48.29  E-value: 6.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367   28 YTIREELPENVPIGNIPKDLNIShinaaTGTSASLVYRLVSKaGDAPLVKVSSSTGEIFtTSNRIDREKLCAGASyaeen 107
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLE-----VGELAARGARVVSK-GNKQYFQLNPETGDLL-LNEKLDREELCGSTE----- 71

                           90
                   ....*....|
gi 1046861367  108 ECFFELEVVI 117
Cdd:pfam08266   72 PCVLHFQVLL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 56-140 1.55e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 1.55e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367    56 TGTSASLVYRLVSkAGDAPLVKVSSSTGEIFTTSnRIDREKLCagasyaeenecFFELEVVILPNDFFRL---IKIKIIV 132
Cdd:smart00112    7 SGENGKVTYSILS-GNDDGLFSIDPETGEITTTK-PLDREEQP-----------EYTLTVEATDGGGPPLsstATVTITV 73


                    ....*...
gi 1046861367   133 KDTNDNAP 140
Cdd:smart00112   74 LDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 473-568 5.30e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 5.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  473 VIELSVSENNRRGLYLTTI-SATDEDSGKNADIVYQlGPNA--SFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGT 549
Cdd:cd00031      1 IPDGSAVEGRSRGSFRVSIpTDLIASSGEIIKISAA-GKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                           90
                   ....*....|....*....
gi 1046861367  550 PPLQSQAAVIVTVLDENDN 568
Cdd:cd00031     80 NVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-354 4.70e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 37.71  E-value: 4.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861367  261 IPENAPVGTSVIQLHATDA-DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA-SDGSST 338
Cdd:cd00031      2 PDGSAVEGRSRGSFRVSIPtDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSLGANV 81

                           90
                   ....*....|....*..
gi 1046861367  339 PARATV-TINVTDVNDN 354
Cdd:cd00031     82 PQTSSVfSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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