H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium channel tetramerization domain-containing protein 16 (KCTD16) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-) receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. KCTD16 generates largely non-desensitizing receptor responses. It consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD16, which may not be involved in desensitization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971 160 DRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 239
Cdd:cd22219     1 DRKWGFITVGYRGSCTMGRESQADAKFRRVPRILVCGRIALAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046867971 240 LSECGFHMVACNSSVTASFVNQYTEDKIWSSYTEYVFYREP 280
Cdd:cd22219    81 LSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREP 121

H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium channel tetramerization domain-containing protein 16 (KCTD16) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-) receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. KCTD16 generates largely non-desensitizing receptor responses. It consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD16, which may not be involved in desensitization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971 160 DRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 239
Cdd:cd22219     1 DRKWGFITVGYRGSCTMGRESQADAKFRRVPRILVCGRIALAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046867971 240 LSECGFHMVACNSSVTASFVNQYTEDKIWSSYTEYVFYREP 280
Cdd:cd22219    81 LSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREP 121

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFSpkrdTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVV-LPDHFPERgR 105
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLE----LECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLhRPEEVCLD-E 75

                          90
                  ....*....|...
gi 1046867971 106 LKREAEYFQLPDL 118
Cdd:pfam02214  76 FLEEAEFYGLDEL 88

H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium channel tetramerization domain-containing protein 16 (KCTD16) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-) receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. KCTD16 generates largely non-desensitizing receptor responses. It consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD16, which may not be involved in desensitization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971 160 DRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 239
Cdd:cd22219     1 DRKWGFITVGYRGSCTMGRESQADAKFRRVPRILVCGRIALAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046867971 240 LSECGFHMVACNSSVTASFVNQYTEDKIWSSYTEYVFYREP 280
Cdd:cd22219    81 LSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREP 121

H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain is found in potassium channel tetramerization domain-containing proteins such as KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), KCTD12b, and KCTD16. They serve as auxiliary gamma-aminobutyric acid type B (GABA-B) receptor subunits that constitute receptor subtypes with distinct functional properties. KCTD12 and -12b generate desensitizing receptor responses while KCTD8 and -16 generate largely non-desensitizing receptor responses. They control GABA-B signaling and regulate the rise time and duration of G protein-coupled inwardly rectifying potassium (GIRK) currents, as well as enhance receptor expression levels. KCTD12 regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. Members of this family consist of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971 163 WGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDR-APERYTSRFYLKFKHLERAFDMLS 241
Cdd:cd22204     1 PGYITLGYRGTFAFGRDGQADVKFRKLARILVCGKVSLCREVFGDTLNESRDPDRgEPDRYTSRFFLKHNYLEQAFDQLA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1046867971 242 ECGFHMVACNSSVTASFV-NQYTEDKIWSSYTEYVFYR 278
Cdd:cd22204    81 EAGFRLVASCGSGTSGLPsAGDSEEKRWNHYTEFVFVR 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  23 FPEVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRdtANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPE 102
Cdd:cd18367     1 FPEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKN--RQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPE 78

                          90       100
                  ....*....|....*....|..
gi 1046867971 103 RGRLKREAEYFQLPDLVKLLAP 124
Cdd:cd18367    79 RERLKREAEYFQLPELVKALRA 100

H1 domain found in potassium channel tetramerization domain-containing protein 12; Potassium channel tetramerization domain-containing protein 12 (KCTD12), also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors associated with mood disorders. It regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. KCTD12 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971 162 KWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDMLS 241
Cdd:cd22217     1 RSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046867971 242 ECGFHMVACNSSVTASFV-NQYTEDKIWSSYTEYVFYRE 279
Cdd:cd22217    81 ESGFHMVACSSTGTCAFAsTDQSEDKIWTSYTEYVFCRE 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  22 SFPEVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRdtANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFP 101
Cdd:cd18396     1 PFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSRRA--ARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFP 78

                          90       100
                  ....*....|....*....|...
gi 1046867971 102 ERGRLKREAEYFQLPDLVKLLAP 124
Cdd:cd18396    79 EKERLLREAEYFQLGDLVKLLTP 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERG 104
Cdd:cd18365     1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTT----RDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYD 76

                          90
                  ....*....|....*...
gi 1046867971 105 RLKREAEYFQLPDLVKLL 122
Cdd:cd18365    77 LLLREADFYQIEPLIEAL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFspkrDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERG 104
Cdd:cd18375     1 ELVTLNVGGKKFTTRPSTLRRFPDSRLARML----DGKDQDFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDYN 76

                          90       100
                  ....*....|....*....|.
gi 1046867971 105 RLKREAEYFQLPDLVKLLAPE 125
Cdd:cd18375    77 RLAREAEFYGLYSLADLLSQN 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGRL 106
Cdd:cd18394     5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFPTA----RDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLL 80

                          90
                  ....*....|....*.
gi 1046867971 107 KREAEYFQLPDLVKLL 122
Cdd:cd18394    81 RKEADFYQIEPLIQCL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  23 FPEVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKrdtaNDLAKDSKGRFFIDRDGFLFRYILDYLRDrqvvlpDHFPE 102
Cdd:cd18366     2 FPEVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGR----HHIPKDSEGRYFIDRDGSYFGYILNFLRD------GDLPP 71

                          90       100
                  ....*....|....*....|
gi 1046867971 103 RGRLK---REAEYFQLPDLV 119
Cdd:cd18366    72 RERARavyKEAQYYGIGPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFspkrDTANDLAKDS-KGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGR 105
Cdd:cd18361     1 VHIDVGGHIYTSSLETLTKYPESRLGKLF----NGSIPIVLDSlKQHYFIDRDGKMFRHILNFLRTSKLLLPDDFTEFDL 76

                          90
                  ....*....|....*..
gi 1046867971 106 LKREAEYFQLPDLVKLL 122
Cdd:cd18361    77 LYEEARYYELQPMVKQL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLIS-IPHSLLWKMFSPKRDTANdlAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGR 105
Cdd:cd18368     3 IKLNVGGRIFTTTRSTLVKkEPDSMLARMFSDDSTWPS--SRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGV 80

                          90
                  ....*....|....*..
gi 1046867971 106 LKrEAEYFQLPDLVKLL 122
Cdd:cd18368    81 LE-EAKFFGIQSLIEIL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDhfPERG 104
Cdd:cd18363     2 DIINLNVGGKRFSTSRQTLTWIPDSFFTSLLSGRISSL----KDETGAIFIDRDPKLFSIILNYLRTKEIDLRN--VDIS 75

                  ....*....
gi 1046867971 105 RLKREAEYF 113
Cdd:cd18363    76 SLRHEAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFspkrDTANDLAKDS-KGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGR 105
Cdd:cd18387     5 VHIDVGGHMYTSSLATLTKYPESRIGRLF----DGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80

                          90
                  ....*....|....*..
gi 1046867971 106 LKREAEYFQL-PDLVKL 121
Cdd:cd18387    81 LYEEAKYFQLqPMLLEL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDtandLAKDSKGRFFIDRDGFLFRYILDYLRDrQVVLPDHFPERG 104
Cdd:cd18372     1 DVLRLNVGGCIYTARRESLCRFKDSMLSSMFSGRFP----LKLDESGACVIDRDGRLFKYLLDYLHG-ELQIPEDEQTRL 75

                          90
                  ....*....|..
gi 1046867971 105 RLKREAEYFQLP 116
Cdd:cd18372    76 ALQEEADYFGIP 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGRL 106
Cdd:cd18389     3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPDLDSD--KDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80

                          90
                  ....*....|....*.
gi 1046867971 107 KrEAEYFQLPDLVKLL 122
Cdd:cd18389    81 E-EAEFYNIASLVRLV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGRL 106
Cdd:cd18362     2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDPDLPSD--KDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVL 79

                  ....*..
gi 1046867971 107 KrEAEYF 113
Cdd:cd18362    80 E-EAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMfSPKRDTANDlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGRL 106
Cdd:cd18391     3 VRLNVGGTVFLTTRQTLCREQKSFLSRL-CQGEELQSD--RDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL 79

                          90
                  ....*....|....*.
gi 1046867971 107 KrEAEYFQLPDLVKLL 122
Cdd:cd18391    80 E-EAEFYNIGPLIRII 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDlakDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPERGrL 106
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTFP---NETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPD-L 76

                  ....*..
gi 1046867971 107 KREAEYF 113
Cdd:cd18187    77 REECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQvvLPDHFPERG 104
Cdd:cd18393     2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTL----KDETGAIFIDRDPTVFAPILNFLRTKE--LDPRGIHVS 75

                          90       100
                  ....*....|....*....|....*..
gi 1046867971 105 RLKREAEYFQLPDLV-KLLAPEEVKQS 130
Cdd:cd18393    76 LLLHEAQFYGITPLVrRLQLCEELDRS 102

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWKmfspkrdTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQV 94
Cdd:cd18373     1 FYFNVGGWIFSVPKSKLAQFPDSLLWK-------EASSLSESENTRLFIDRDGFTFRHVHYYLQTSKL 61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046867971  29 LNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDSK---GRFFIDRDGFLFRYILDYLR 90
Cdd:cd18424     3 INVGGSRFVLSQQVLSSHPETRLGKLAVSVRDSVLELCDDANfvdNEYFFDRSSQAFKYIMNYYK 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046867971  27 IELNVGGQVYFTRHSTLISIPHSLLWkmfSPKRDTANDlakDSKGRFFIDRDGFLFRYILDYLRDRQVvlpdHFP 101
Cdd:cd18380     2 IVINVSGRRFETWKNTLEKYPDTLLG---STEKEFFYD---DDTKEYFFDRDPEIFRHILNFYRTGKL----HYP 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWkmfSPKRDTANDlaKDSKGRFFiDRDGFLFRYILDYLRDRQVVLPDH 99
Cdd:cd18420    36 EKLIINVSGRRFETWRNTLEKYPDTLLG---SNEREFFYD--EETKEYFF-DRDPDIFRHILNYYRTGKLHYPKH 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046867971  26 VIELNVGGQVYFTRHSTLISIPHSLLWkmfSPKRDTandLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDH 99
Cdd:cd18418     1 LIVLNVSGTRFQTWRNTLERYPDTLLG---SSERDF---FYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRH 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046867971  25 EVIELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTA-----NDLAKDSKGRFFiDRDGFLFRYILDY 88
Cdd:cd18428     1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHSEEAilelcDDYSVADKEYYF-DRNPSLFRYVLNF 68