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Conserved domains on  [gi|1239934243|ref|XP_022283048|]
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protein lifeguard 1 isoform X3 [Canis lupus familiaris]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-253 1.74e-75

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 230.12  E-value: 1.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|..
gi 1239934243 242 LYAGLGTIVFSL 253
Cdd:cd10428   161 VYASLGALLFSL 172
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-253 1.74e-75

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 230.12  E-value: 1.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|..
gi 1239934243 242 LYAGLGTIVFSL 253
Cdd:cd10428   161 VYASLGALLFSL 172
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-253 4.77e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 102.25  E-value: 4.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  90 RAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRR-QVPANYILLGLFTVL 168
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKySSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159


                  ....*
gi 1239934243 249 IVFSL 253
Cdd:pfam01027 160 LLFSG 164
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-252 2.75e-21

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 90.24  E-value: 2.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  89 RRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACcGKLRRQVPANYILLGLFTVL 168
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 169 QGLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYA 244
Cdd:COG0670    98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177


                  ....*...
gi 1239934243 245 GLGTIVFS 252
Cdd:COG0670   178 VAGVLLFS 185
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-253 1.74e-75

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 230.12  E-value: 1.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170
                  ....*....|..
gi 1239934243 242 LYAGLGTIVFSL 253
Cdd:cd10428   161 VYASLGALLFSL 172
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 73-266 3.20e-39

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 137.73  E-value: 3.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  73 PDDSNNLAN-PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFtyaILPAFFVVLIVLACCGKL 151
Cdd:cd10429    10 PDDFKYGTNvASAEPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWL---FLISLIGSLILLIALYWK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 152 RRQVPANYILLGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLII-YGIL 230
Cdd:cd10429    87 RHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILlALIF 166

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1239934243 231 LLFIRSYWLHLLYAGLGTIVFSLEITAQKERVLHKV 266
Cdd:cd10429   167 QFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRL 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-253 4.77e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 102.25  E-value: 4.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  90 RAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRR-QVPANYILLGLFTVL 168
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKySSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159


                  ....*
gi 1239934243 249 IVFSL 253
Cdd:pfam01027 160 LLFSG 164
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 88-277 5.10e-24

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 96.71  E-value: 5.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  88 IRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVnawftyaiLPAFFVVLIVLAC-CGKLRRQVPANYILLGLFT 166
Cdd:cd06181     1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPA--------LMGLLTSMLALMAtAAMIRAKMPVNLILLFGFT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 167 VLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGL 246
Cdd:cd06181    73 GLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAV 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1239934243 247 GTIVFSLEITAQKERVLHKVQGARTHPI-HCL 277
Cdd:cd06181   153 GLVLFCGFLLYDTQLIIHKAEVGPEDYInACI 184
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-252 2.75e-21

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 90.24  E-value: 2.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  89 RRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACcGKLRRQVPANYILLGLFTVL 168
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 169 QGLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYA 244
Cdd:COG0670    98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177


                  ....*...
gi 1239934243 245 GLGTIVFS 252
Cdd:COG0670   178 VAGVLLFS 185
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 89-252 2.90e-20

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 86.85  E-value: 2.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  89 RRAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLAccGKLRRQVPANYILLGLFTVL 168
Cdd:cd10432     2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPALLLIAGSPLMWVLLIAELALVFGLSF--RINKMSVATALPLFFAFAAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:cd10432    79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGV 158


                  ....
gi 1239934243 249 IVFS 252
Cdd:cd10432   159 LIFS 162
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 153-264 2.65e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 52.97  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 153 RQVPANYILLGLFTVLQGLLLG-----AVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIY 227
Cdd:cd10433    56 RNSAWGIVLVFAFTGFMGYTLGpilnmYLALPNGGQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLA 135

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1239934243 228 GILLLFIRSYWLHLLYAGLGTIVFSLEITAQKERVLH 264
Cdd:cd10433   136 AVANIFLQIPALSLAISAAFVLFSSGFILYDTSRIIH 172
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 94-261 7.30e-04

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 39.90  E-value: 7.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243  94 IKVFLILSAQLVVT--GAIVSVFLFWKG-LKAWVLVNAWFTYAILPAFFvvlivlaccgklrRQVPANYILLGLFTVLQG 170
Cdd:cd10430    13 KKVYLTLAVALLAAavGAYVHMVINIGGlLTGLLSLGLSLWLAFTPSTG-------------KNEPKRLGLLLGFAFLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239934243 171 L----LLGAVSVFyNAEEVLWATAATALVTLSLTLFALQTK-WDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLH--LLY 243
Cdd:cd10430    80 AslgpLLDLVIAI-NPSIIVTAFLGTAVIFACFSLAALLAKrREYLYLGGLLSSALSILLLVSLANIFGGSKFLFqaELY 158

                         170       180
                  ....*....|....*....|..
gi 1239934243 244 AGL----GTIVFSLEITAQKER 261
Cdd:cd10430   159 LGLlvfcGFVLFDTQMIIEKAE 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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