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Conserved domains on  [gi|1394733478|ref|XP_025042857|]
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zinc finger B-box domain-containing protein 1 isoform X1 [Pelodiscus sinensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 134-176 2.03e-26

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


:

Pssm-ID: 380876  Cd Length: 43  Bit Score: 102.06  E-value: 2.03e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394733478 134 ACGQCENKNALLVCLECGEDYCGSCFAKVHQKGALKLHRMIPL 176
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
 
Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 134-176 2.03e-26

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380876  Cd Length: 43  Bit Score: 102.06  E-value: 2.03e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394733478 134 ACGQCENKNALLVCLECGEDYCGSCFAKVHQKGALKLHRMIPL 176
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
BBOX smart00336
B-Box-type zinc finger;
135-176 1.48e-05

B-Box-type zinc finger;


Pssm-ID: 197662 [Multi-domain]  Cd Length: 42  Bit Score: 42.71  E-value: 1.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1394733478  135 CGQCENKNALLVCLECGEDYCGSCFAKVHQKgalklHRMIPL 176
Cdd:smart00336   6 CDSHGDEPAEFFCEECGALLCRTCDEAEHRG-----HTVVLL 42
zf-B_box pfam00643
B-box zinc finger;
130-176 3.89e-05

B-box zinc finger;


Pssm-ID: 459886 [Multi-domain]  Cd Length: 42  Bit Score: 41.69  E-value: 3.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1394733478 130 VKGKACGQCENKNALLVCLECGEDYCGSCFAKVHQKgalklHRMIPL 176
Cdd:pfam00643   1 SKERLCPEHEEEPLTLYCNDCQELLCEECSVGEHRG-----HTVVPL 42
 
Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 134-176 2.03e-26

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380876  Cd Length: 43  Bit Score: 102.06  E-value: 2.03e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394733478 134 ACGQCENKNALLVCLECGEDYCGSCFAKVHQKGALKLHRMIPL 176
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
Bbox1 cd19757
B-box-type 1 zinc finger (Bbox1); The B-box-type zinc finger is a short zinc binding domain of ...
 135-176 6.60e-11

B-box-type 1 zinc finger (Bbox1); The B-box-type zinc finger is a short zinc binding domain of around 40 amino acid residues in length. It has been found in transcription factors, ribonucleoproteins and proto-oncoproteins, such as in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). The B-box-type zinc finger often presents in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain, in functionally unrelated proteins, most likely mediating protein-protein interactions. Based on different consensus sequences and the spacing of the 7-8 zinc-binding residues, the B-box-type zinc fingers can be divided into two groups, type 1 (Bbox1: C6H2) and type 2 (Bbox2: CHC3H2). This family corresponds to the type 1 B-box (Bbox1).


Pssm-ID: 380815 [Multi-domain]  Cd Length: 44  Bit Score: 57.89  E-value: 6.60e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394733478 135 CGQCENKNALLVCLECGEDYCGSCFAKVHQKG-ALKLHRMIPL 176
Cdd:cd19757     2 CDECEEREATVYCLECEEFLCDDCSDAIHRRGkLTRSHKLVPL 44
Bbox1_DUF2009 cd20208
B-box-type 1 zinc finger found in DUF2009 domain-containing proteins and similar proteins; ...
 135-176 2.80e-07

B-box-type 1 zinc finger found in DUF2009 domain-containing proteins and similar proteins; This group is composed of uncharacterized proteins containing a zinc finger B-box domain and a DUF2009 domain, and similar zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380909 [Multi-domain]  Cd Length: 43  Bit Score: 47.75  E-value: 2.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1394733478 135 CGQCENKNALLVCLECGEDYCGSCFAKVHQKGALKLHRMIPL 176
Cdd:cd20208     2 CIECEDQPAEVRCEECGDEFCEVCFQSQHRKGKRRLHSFRPV 43
BBOX smart00336
B-Box-type zinc finger;
135-176 1.48e-05

B-Box-type zinc finger;


Pssm-ID: 197662 [Multi-domain]  Cd Length: 42  Bit Score: 42.71  E-value: 1.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1394733478  135 CGQCENKNALLVCLECGEDYCGSCFAKVHQKgalklHRMIPL 176
Cdd:smart00336   6 CDSHGDEPAEFFCEECGALLCRTCDEAEHRG-----HTVVLL 42
zf-B_box pfam00643
B-box zinc finger;
130-176 3.89e-05

B-box zinc finger;


Pssm-ID: 459886 [Multi-domain]  Cd Length: 42  Bit Score: 41.69  E-value: 3.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1394733478 130 VKGKACGQCENKNALLVCLECGEDYCGSCFAKVHQKgalklHRMIPL 176
Cdd:pfam00643   1 SKERLCPEHEEEPLTLYCNDCQELLCEECSVGEHRG-----HTVVPL 42
Bbox2_TRIM23_C-IX_rpt1 cd19773
first B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and ...
 135-179 1.38e-04

first B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins; TRIM23, also known as ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, or RING finger protein 46 (RNF46), is an E3 ubiquitin-protein ligase belonging to the C-IX subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, two Bbox2, and a coiled coil region, as well as C-terminal ADP ribosylation factor (ARF) domains. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif. TRIM23 is involved in nuclear factor (NF)-kappaB activation. It mediates atypical lysine 27 (K27)-linked polyubiquitin conjugation to NF-kappaB essential modulator NEMO, also known as IKKgamma, which plays an important role in the NF-kappaB pathway, and this conjugation is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses. It also regulates adipocyte differentiation via stabilization of the adipogenic activator peroxisome proliferator-activated receptor gamma (PPARgamma) through atypical ubiquitin conjugation to PPARgamma. Moreover, TRIM23 interacts with and polyubiquitinates yellow fever virus (YFV) NS5 to promote its binding to STAT2 and trigger type I interferon (IFN-I) signaling inhibition.


Pssm-ID: 380831  Cd Length: 50  Bit Score: 40.01  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1394733478 135 CGQCENKNALLVCLECGEDYCGSCFAKVHQKGALKLHRMIPLQAK 179
Cdd:cd19773     5 CDENEDHEATLYCTVCSTNLCEECFTSTHSTKTLSKHRRVPLSEK 49
Bbox1_ANCHR-like cd19817
B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar ...
 135-172 2.61e-03

B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins; ANCHR, also termed MLL partner containing FYVE domain, or zinc finger FYVE domain-containing protein 19, is a key regulator of the abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. The family also includes zinc finger B-box domain-containing protein 1 (ZBBX), a B-box motif containing protein with unclear biological function. The B-box motif of this family shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380875  Cd Length: 45  Bit Score: 36.51  E-value: 2.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1394733478 135 CGQCeNKNALLVCLECGED-YCGSCFAKVHQKGALKLHR 172
Cdd:cd19817     4 CCIC-NEDASLRCHGCDGDlYCKRCFREGHDGFDRRDHR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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