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Conserved domains on  [gi|1720400188|ref|XP_030107804|]
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novel KRAB box and zinc finger, C2H2 type domain containing protein isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
54-130 1.38e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400188  54 YESCSQRHQIKHNGEKH------HDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--NQCGKAFARSDDLQKHKRTH 121
Cdd:COG5048   267 TASSQSSSPNESDSSSEkgfslpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346


                  ....*....
gi 1720400188 122 TGEKPYECK 130
Cdd:COG5048   347 TSISPAKEK 355
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
54-130 1.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400188  54 YESCSQRHQIKHNGEKH------HDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--NQCGKAFARSDDLQKHKRTH 121
Cdd:COG5048   267 TASSQSSSPNESDSSSEkgfslpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346


                  ....*....
gi 1720400188 122 TGEKPYECK 130
Cdd:COG5048   347 TSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-137 7.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....*
gi 1720400188 113 DLQKHKRTHTGEKPYECKQCGKAFA 137
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
54-130 1.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400188  54 YESCSQRHQIKHNGEKH------HDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--NQCGKAFARSDDLQKHKRTH 121
Cdd:COG5048   267 TASSQSSSPNESDSSSEkgfslpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346


                  ....*....
gi 1720400188 122 TGEKPYECK 130
Cdd:COG5048   347 TSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-137 7.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....*
gi 1720400188 113 DLQKHKRTHTGEKPYECKQCGKAFA 137
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-134 1.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720400188  71 HDCNQCGKAFKRRSDLQIHKRTHTGEKPYECNQ--CGKAFARSDDLQKHKRTHTGEKPYECKQCGK 134
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
85-110 1.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720400188  85 DLQIHKRTHTGEKPYECNQCGKAFAR 110
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
RPL43A COG1997
Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 78-140 4.01e-03

Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal protein L37AE/L43A is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441600  Cd Length: 87  Bit Score: 34.52  E-value: 4.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720400188  78 KAFKRRSDLQIHKRthtgeKPYECNQCGKafarsddlQKHKRTHTGekPYECKQCGKAFAGSS 140
Cdd:COG1997    21 KLRKRVADIEEKMR-----AKHTCPECGS--------KRVKRVATG--IWECRKCGYKFAGGA 68
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 99-121 5.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 32.66  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|...
gi 1720400188  99 YECNQCGKAFARSDDLQKHKRTH 121
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-140 5.66e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 36.21  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720400188  97 KPYECNQCGKAFARSDDLQKHKRTHTGEKPYECKQCGKAFAGSS 140
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-119 8.32e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 35.44  E-value: 8.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720400188  48 CGKAFAYESCSQRHQIKHNGEKHHDCN--QCGKAFKRRSDLQIHKRTHTGEKPYECNQCGKaFARSDDLQKHKR 119
Cdd:COG5048   394 CIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 95-150 8.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 35.46  E-value: 8.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720400188  95 GEKPYECN--QCGKAFARSDDLQKHK-------RTH------------TGEKPYECKQCGKAFAGSSGLQCHkRSHT 150
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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