|
Name |
Accession |
Description |
Interval |
E-value |
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1336-1662 |
3.13e-37 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 143.65 E-value: 3.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1336 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1413
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1414 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1493
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1494 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1573
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1574 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1653
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046699 1654 QTLRLLKCS 1662
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
349-515 |
1.02e-34 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 130.89 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 349 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 421
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 422 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 500
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046699 501 DEQKEEYFRKRISDQ 515
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
654-782 |
2.33e-34 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 128.18 E-value: 2.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 654 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 733
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046699 734 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 782
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
899-1197 |
3.25e-33 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 3.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 899 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 972
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 973 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1052
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1053 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1132
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 1133 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1197
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
266-340 |
1.11e-23 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
:
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.14 E-value: 1.11e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 266 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 340
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
831-963 |
1.21e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.21 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 831 LNRLLLVVKEATSALLSDCNLTERSCSALIKVLsSESSKLTFLDLSRNPIQDRGVELLSEGLKnENCKLENLGLSCCSIT 910
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1917046699 911 EEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLEdpHCKLKTLRL 963
Cdd:COG5238 362 DEGAIALAKYLEGNTT--LRELNLGKNNIGKQGAEALIDALQ--TNRLHTLIL 410
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1557-1773 |
3.38e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 67.51 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1557 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1636
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1637 KGVKLLIDLQKDPKyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRTQ 1712
Cdd:COG5238 223 EGAEILAEALKGNK-SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TLT 295
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917046699 1713 KLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1773
Cdd:COG5238 296 SLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
598-652 |
1.91e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
:
Pssm-ID: 465501 Cd Length: 57 Bit Score: 54.88 E-value: 1.91e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046699 598 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 652
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1336-1662 |
3.13e-37 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 143.65 E-value: 3.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1336 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1413
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1414 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1493
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1494 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1573
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1574 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1653
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046699 1654 QTLRLLKCS 1662
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
349-515 |
1.02e-34 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 130.89 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 349 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 421
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 422 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 500
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046699 501 DEQKEEYFRKRISDQ 515
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
654-782 |
2.33e-34 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 128.18 E-value: 2.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 654 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 733
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046699 734 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 782
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
899-1197 |
3.25e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 3.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 899 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 972
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 973 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1052
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1053 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1132
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 1133 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1197
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
873-1184 |
6.34e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 119.12 E-value: 6.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 873 LDLSRNPIQDRGVELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLe 952
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT--VTTLWLKRNPIGDEGAEILAEAL- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 953 dphCKLKTLrllspaaeevcdsltktlginpllqRELDLSGKIQDDSEMKKISDLLEDLHcRTQKLKLNNNSITEKGCAA 1032
Cdd:COG5238 233 ---KGNKSL-------------------------TTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSGNQIGAEGAIA 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1033 LSSALCSNPsHLIELDLSENKLGNSGVNQICSLLKNSNcTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKL 1112
Cdd:COG5238 284 LAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-LHSLDLSDNQI 360
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917046699 1113 ESSGVRQICSLLNNqHCKLQKLGLSDCSITEKGYADLASALKSNPssyLIELDLRGNYPGDTGVELIIDLLK 1184
Cdd:COG5238 361 GDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1420-1705 |
7.21e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 118.74 E-value: 7.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1420 IQELSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNPKcNLKIIILKTCALTEGSCSALANV 1499
Cdd:COG5238 153 GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1500 LnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNPsHLMELDLSGNKVGNSG 1579
Cdd:COG5238 232 L-KGNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEG 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1580 VKQLSDLLKNSNCLVqKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRLL 1659
Cdd:COG5238 309 AIALAEGLQGNKTLH-TLNLAYNGIGAQGAIALAKALQENTTLH--SLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLG 384
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1917046699 1660 KCSAAEDICNSLTKTLGKNPllLRELDLSGKIQGDSHMKQISHLLE 1705
Cdd:COG5238 385 KNNIGKQGAEALIDALQTNR--LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
266-340 |
1.11e-23 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.14 E-value: 1.11e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 266 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 340
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
831-963 |
1.21e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.21 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 831 LNRLLLVVKEATSALLSDCNLTERSCSALIKVLsSESSKLTFLDLSRNPIQDRGVELLSEGLKnENCKLENLGLSCCSIT 910
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1917046699 911 EEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLEdpHCKLKTLRL 963
Cdd:COG5238 362 DEGAIALAKYLEGNTT--LRELNLGKNNIGKQGAEALIDALQ--TNRLHTLIL 410
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1557-1773 |
3.38e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 67.51 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1557 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1636
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1637 KGVKLLIDLQKDPKyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRTQ 1712
Cdd:COG5238 223 EGAEILAEALKGNK-SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TLT 295
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917046699 1713 KLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1773
Cdd:COG5238 296 SLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
598-652 |
1.91e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 54.88 E-value: 1.91e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046699 598 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 652
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1506-1530 |
7.48e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.54 E-value: 7.48e-04
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1566-1773 |
1.39e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 42.73 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1566 MELDLSGNKVGNSGVKQLSDLLKNsnclVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPG--DKGVKLLI 1643
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1644 DlqkdpkyklqtlrllkcsaaedicnSLTKTLGknpllLRELDLSgkiqgdshmkqishlledshcrtqklkmnKSSITE 1723
Cdd:cd00116 75 Q-------------------------GLTKGCG-----LQELDLS-----------------------------DNALGP 95
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1724 EGCAALSSALCSnpSHLIELDLSDSKLGGSGLEKICGVLRNKQFKLLKLQ 1773
Cdd:cd00116 96 DGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLV 143
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1336-1662 |
3.13e-37 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 143.65 E-value: 3.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1336 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1413
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1414 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1493
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1494 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1573
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1574 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1653
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046699 1654 QTLRLLKCS 1662
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
349-515 |
1.02e-34 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 130.89 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 349 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 421
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 422 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 500
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046699 501 DEQKEEYFRKRISDQ 515
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
654-782 |
2.33e-34 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 128.18 E-value: 2.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 654 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 733
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046699 734 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 782
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
899-1197 |
3.25e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 3.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 899 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 972
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 973 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1052
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1053 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1132
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 1133 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1197
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
833-1141 |
4.49e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 131.32 E-value: 4.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 833 RLLLVVKEATSALLSDCNLTERSCSALIKVLSSESSkLTFLDLSRNPIQ--DRGVELLSEGLKNeNCKLENLGLSCCSIT 910
Cdd:cd00116 17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPS-LKELCLSLNETGriPRGLQSLLQGLTK-GCGLQELDLSDNALG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 911 EEGYAALALALKSnpsSLLIELDLRGNDPGDTGVKELTDLLEDPHCKLKTL----RLLSPAAeevCDSLTKTLGINPLLQ 986
Cdd:cd00116 95 PDGCGVLESLLRS---SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLvlgrNRLEGAS---CEALAKALRANRDLK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 987 rELDLS-GKIQDDSemkkISDLLEDL--HCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSENKLGNSGVNQIC 1063
Cdd:cd00116 169 -ELNLAnNGIGDAG----IRALAEGLkaNCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALA 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1917046699 1064 SLLKNSNCTLAKLNLSFCSITEEGCPFLSSaFCSNPSHLLELDLSKNKLESSGVRQICSLLNNQHCKLQKLGLSDCSI 1141
Cdd:cd00116 243 SALLSPNISLLTLSLSCNDITDDGAKDLAE-VLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDDSF 319
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1399-1714 |
9.75e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 124.78 E-value: 9.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1399 KIQGDSELQLLCSLLEDSHCKIQELSLSKCNITVESCAALASVLRLESSSVRkMDLSNNNLQ--DSGMLDLAGGLTNpKC 1476
Cdd:cd00116 4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKE-LCLSLNETGriPRGLQSLLQGLTK-GC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1477 NLKIIILKTCALTEGSCSALANVLNSkdAHLSELDLSNNNLEDSGVMQLCAGLKNPQSALEIMRLSKCNIGEEGCCALAS 1556
Cdd:cd00116 82 GLQELDLSDNALGPDGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1557 ALKLNPShLMELDLSGNKVGNSGVKQLSDLLKnSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGD 1636
Cdd:cd00116 160 ALRANRD-LKELNLANNGIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS--LEVLNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1637 KGVKLLIDLQKDPKYKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHCRTQ 1712
Cdd:cd00116 236 AGAAALASALLSPNISLLTLSLscndITDDGAKDLAEVL-----AEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELE 310
|
..
gi 1917046699 1713 KL 1714
Cdd:cd00116 311 SL 312
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
873-1184 |
6.34e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 119.12 E-value: 6.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 873 LDLSRNPIQDRGVELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLe 952
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT--VTTLWLKRNPIGDEGAEILAEAL- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 953 dphCKLKTLrllspaaeevcdsltktlginpllqRELDLSGKIQDDSEMKKISDLLEDLHcRTQKLKLNNNSITEKGCAA 1032
Cdd:COG5238 233 ---KGNKSL-------------------------TTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSGNQIGAEGAIA 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1033 LSSALCSNPsHLIELDLSENKLGNSGVNQICSLLKNSNcTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKL 1112
Cdd:COG5238 284 LAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-LHSLDLSDNQI 360
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917046699 1113 ESSGVRQICSLLNNqHCKLQKLGLSDCSITEKGYADLASALKSNPssyLIELDLRGNYPGDTGVELIIDLLK 1184
Cdd:COG5238 361 GDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1420-1705 |
7.21e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 118.74 E-value: 7.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1420 IQELSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNPKcNLKIIILKTCALTEGSCSALANV 1499
Cdd:COG5238 153 GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1500 LnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNPsHLMELDLSGNKVGNSG 1579
Cdd:COG5238 232 L-KGNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEG 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1580 VKQLSDLLKNSNCLVqKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRLL 1659
Cdd:COG5238 309 AIALAEGLQGNKTLH-TLNLAYNGIGAQGAIALAKALQENTTLH--SLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLG 384
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1917046699 1660 KCSAAEDICNSLTKTLGKNPllLRELDLSGKIQGDSHMKQISHLLE 1705
Cdd:COG5238 385 KNNIGKQGAEALIDALQTNR--LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
988-1314 |
4.26e-27 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 113.99 E-value: 4.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 988 ELDLSGKIQDDSEMKkisDLLEDLHCrTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSENKLGNSGVN-QICSLL 1066
Cdd:cd00116 2 QLSLKGELLKTERAT---ELLPKLLC-LQVLRLEGNTLGEEAAKALASALRPQPS-LKELCLSLNETGRIPRGlQSLLQG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1067 KNSNCTLAKLNLSFCSITEEGCPFLSSafCSNPSHLLELDLSKNKLESSGVRQICSLLNNQHCKLQKLGLSDCSITEKGY 1146
Cdd:cd00116 77 LTKGCGLQELDLSDNALGPDGCGVLES--LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1147 ADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDpNCKLKARFLK--TAAEKACDSLTEALgKNPLLLKELHLSG 1224
Cdd:cd00116 155 EALAKALRANRD--LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNnnGLTDEGASALAETL-ASLKSLEVLNLGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1225 KIQGDSEMKKISDLLKDSHCTTQKLKLNKCSITEEGCAALSSALCSNPSyLTELDLSENKLGNSGVKQICTLLNNQCCKL 1304
Cdd:cd00116 231 NNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES-LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
330
....*....|
gi 1917046699 1305 QKLKLTLCSI 1314
Cdd:cd00116 310 ESLWVKDDSF 319
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1394-1645 |
6.78e-25 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 109.88 E-value: 6.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1394 LDLSGKIQGDSELQLLCSLLEdSHCKIQELSLSKCNITVESCAALASVLRlESSSVRKMDLSNNNLQDSGMLDLAGGLTN 1473
Cdd:COG5238 185 VYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIGDEGAEILAEALK-GNKSLTTLDLSNNQIGDEGVIALAEALKN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1474 PKcNLKIIILKTCALTEGSCSALANVLnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCA 1553
Cdd:COG5238 263 NT-TVETLYLSGNQIGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1554 LASALKLNPShLMELDLSGNKVGNSGVKQLSDLLKNsNCLVQKLKVSDNNVKGEGYAALASALKSNpssHLIELDLRGND 1633
Cdd:COG5238 340 LAKALQENTT-LHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTN---RLHTLILDGNL 414
|
250
....*....|..
gi 1917046699 1634 PGDKGVKLLIDL 1645
Cdd:COG5238 415 IGAEAQQRLEQL 426
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1483-1751 |
1.40e-24 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 109.11 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1483 LKTCALTEGSCSALANVLNSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNP 1562
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNK 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1563 ShLMELDLSGNKVGNSGVKQLSDLLKNsNCLVQKLKVSDNNVKGEGYAALASALKSNPssHLIELDLRGNDPGDKGVKLL 1642
Cdd:COG5238 237 S-LTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNT--TLTSLDLSVNRIGDEGAIAL 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1643 ID-LQKDPkyKLQTLRLLKCSAAEDICNSLTKTLGKNPLLLReLDLSGKIQGDSHMKQISHLLEdSHCRTQKLKMNKSSI 1721
Cdd:COG5238 313 AEgLQGNK--TLHTLNLAYNGIGAQGAIALAKALQENTTLHS-LDLSDNQIGDEGAIALAKYLE-GNTTLRELNLGKNNI 388
|
250 260 270
....*....|....*....|....*....|
gi 1917046699 1722 TEEGCAALSSALCSNpsHLIELDLSDSKLG 1751
Cdd:COG5238 389 GKQGAEALIDALQTN--RLHTLILDGNLIG 416
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
341-935 |
1.49e-24 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 112.21 E-value: 1.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 341 VSEEDKPIRTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECQSLMKTINLFFPETQGL--RL 418
Cdd:COG5635 173 LELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLAEEASLEDLLAEALEKRGGEPEDAleRL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 419 TDQNKVLFILDGLDEcqLPLEFQKNEILNNVTkaapldavmtNLIKGnlLPSALIWITTRPAAAsmiPAECIDRVTEVR- 497
Cdd:COG5635 253 LRNGRLLLLLDGLDE--VPDEADRDEVLNQLR----------RFLER--YPKARVIITSRPEGY---DSSELEGFEVLEl 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 498 -GFNDEQKEEYFRKRI-SDQDLANKIIDHIRESRSLHIMCHIPVFCWISASVLQRileetaSEDTPKTLTQMYTCFL--I 573
Cdd:COG5635 316 aPLSDEQIEEFLKKWFeATERKAERLLEALEENPELRELARNPLLLTLLALLLRE------RGELPDTRAELYEQFVelL 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 574 FQTVQGNAKYIGKNALDIpwdEEGIRSLGKLAFQHLEKNSLIFYSSDLEA--CEISLSNISVYSGLctQETVRFH----- 646
Cdd:COG5635 390 LERWDEQRGLTIYRELSR---EELRELLSELALAMQENGRTEFAREELEEilREYLGRRKDAEALL--DELLLRTgllve 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 647 --DTVFSFVHLSIQEFLAAVFAYISLKNGTKNVLDHQSEsqESKKTEVIDLLktavdKALKSDHGHLDLFLRFLLGLSLE 724
Cdd:COG5635 465 rgEGRYSFAHRSFQEYLAARALVEELDEELLELLAEHLE--DPRWREVLLLL-----AGLLDDVKQIKELIDALLARDDA 537
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 725 SNEKLIRGLLTQTGSRSDcqkdiveYIKLKFKENPSPERSVNLFYCLNELNDDSLVKEIQSYMSSGRLSEAELSPAQWSA 804
Cdd:COG5635 538 AALALAAALLLALLLALA-------LLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLL 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 805 LVFVLLTSKEKLEVFELKKFIRSDECLNRLLLVVKEATSALLSDCNLTERSCSALIKVLSSESSKLTFLDLSRNPIQDRG 884
Cdd:COG5635 611 LLLLLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALAS 690
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 1917046699 885 VELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSSLLIELDLR 935
Cdd:COG5635 691 LLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLL 741
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
266-340 |
1.11e-23 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.14 E-value: 1.11e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046699 266 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 340
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
842-1086 |
1.08e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 103.33 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 842 TSALLSDCNLTERSCSALIKVLSsESSKLTFLDLSRNPIQDRGVELLSEGLKNeNCKLENLGLSCCSITEEGYAALALAL 921
Cdd:COG5238 211 TTLWLKRNPIGDEGAEILAEALK-GNKSLTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEGAIALAKAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 922 KSNPSslLIELDLRGNDPGDTGVKELTDLLEdphcKLKTLRLLSPAAEEV----CDSLTKTLGINPLLQReLDLSGkiqd 997
Cdd:COG5238 289 QGNTT--LTSLDLSVNRIGDEGAIALAEGLQ----GNKTLHTLNLAYNGIgaqgAIALAKALQENTTLHS-LDLSD---- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 998 dsemkkisdlledlhcrtqklklnnNSITEKGCAALSSALCSNPShLIELDLSENKLGNSGVNQICSLLKNSNctLAKLN 1077
Cdd:COG5238 358 -------------------------NQIGDEGAIALAKYLEGNTT-LRELNLGKNNIGKQGAEALIDALQTNR--LHTLI 409
|
....*....
gi 1917046699 1078 LSFCSITEE 1086
Cdd:COG5238 410 LDGNLIGAE 418
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1047-1360 |
1.83e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 102.56 E-value: 1.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1047 LDLSENKLGNSGVNQICSLLKNSNCTLakLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNN 1126
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNSVET--VYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1127 QHcKLQKLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDpncklkarflktaaekacdsl 1206
Cdd:COG5238 235 NK-SLTTLDLSNNQIGDEGVIALAEALKNNTT--VETLYLSGNQIGAEGAIALAKALQG--------------------- 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1207 tealGKNpllLKELHLSGKIQGDSEMKKISDLLKDSHcTTQKLKLNKCSITEEGCAALSSALCSNPSyLTELDLSENKLG 1286
Cdd:COG5238 291 ----NTT---LTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-LHSLDLSDNQIG 361
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1917046699 1287 NSGVKQICTLLNNQcCKLQKLKLTLCSITEEGYADLASALKSNSsshLIELDLRGNDPGDTGVKKLTDLQKDLK 1360
Cdd:COG5238 362 DEGAIALAKYLEGN-TTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1163-1515 |
2.13e-22 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 100.12 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1163 ELDLRGNYPGDTGVELIIDLLkdPNCKLKARFLKTAAEKACDSLTEALGKNPLLlKELHLSGKiqgdsEMKKISDLLKD- 1241
Cdd:cd00116 2 QLSLKGELLKTERATELLPKL--LCLQVLRLEGNTLGEEAAKALASALRPQPSL-KELCLSLN-----ETGRIPRGLQSl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1242 -----SHCTTQKLKLNKCSITEEGCAALSSALCSnpSYLTELDLSENKLGNSGVKQICTLLNNQCCKLQKLKLTLCSITE 1316
Cdd:cd00116 74 lqgltKGCGLQELDLSDNALGPDGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1317 EGYADLASALKSNSSshLIELDLRGNDPGDTGVKKLTDLQKDLKckltlrflntpdaekacdslikvleinplLLRELDL 1396
Cdd:cd00116 152 ASCEALAKALRANRD--LKELNLANNGIGDAGIRALAEGLKANC-----------------------------NLEVLDL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1397 SGKIQGDSELQLLCSLLEDShCKIQELSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNpKC 1476
Cdd:cd00116 201 NNNGLTDEGASALAETLASL-KSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAE-KE 278
|
330 340 350
....*....|....*....|....*....|....*....
gi 1917046699 1477 NLKIIILKTCALTEGSCSALANVLNSKDAHLSELDLSNN 1515
Cdd:cd00116 279 SLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1510-1772 |
6.18e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 97.94 E-value: 6.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1510 LDLSNNNLEDSGVMQLCAGLKNPQsaLEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGNKVGNSGVKQLSDLLKn 1589
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNS--VETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALK- 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1590 SNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRL----LKCSAAE 1665
Cdd:COG5238 234 GNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLsvnrIGDEGAI 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1666 DICNSLTKTlgknpLLLRELDLSGKIQGDSHMKQI-SHLLEDSHCRTQKLKMNKssITEEGCAALSSALCSNPShLIELD 1744
Cdd:COG5238 311 ALAEGLQGN-----KTLHTLNLAYNGIGAQGAIALaKALQENTTLHSLDLSDNQ--IGDEGAIALAKYLEGNTT-LRELN 382
|
250 260
....*....|....*....|....*...
gi 1917046699 1745 LSDSKLGGSGLEKICGVLRNKQFKLLKL 1772
Cdd:COG5238 383 LGKNNIGKQGAEALIDALQTNRLHTLIL 410
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
831-963 |
1.21e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.21 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 831 LNRLLLVVKEATSALLSDCNLTERSCSALIKVLsSESSKLTFLDLSRNPIQDRGVELLSEGLKnENCKLENLGLSCCSIT 910
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1917046699 911 EEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLEdpHCKLKTLRL 963
Cdd:COG5238 362 DEGAIALAKYLEGNTT--LRELNLGKNNIGKQGAEALIDALQ--TNRLHTLIL 410
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1557-1773 |
3.38e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 67.51 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1557 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1636
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1637 KGVKLLIDLQKDPKyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRTQ 1712
Cdd:COG5238 223 EGAEILAEALKGNK-SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TLT 295
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1917046699 1713 KLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1773
Cdd:COG5238 296 SLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
598-652 |
1.91e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 54.88 E-value: 1.91e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046699 598 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 652
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1506-1530 |
7.48e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.54 E-value: 7.48e-04
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1566-1773 |
1.39e-03 |
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Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 42.73 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1566 MELDLSGNKVGNSGVKQLSDLLKNsnclVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPG--DKGVKLLI 1643
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLL 74
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1644 DlqkdpkyklqtlrllkcsaaedicnSLTKTLGknpllLRELDLSgkiqgdshmkqishlledshcrtqklkmnKSSITE 1723
Cdd:cd00116 75 Q-------------------------GLTKGCG-----LQELDLS-----------------------------DNALGP 95
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1917046699 1724 EGCAALSSALCSnpSHLIELDLSDSKLGGSGLEKICGVLRNKQFKLLKLQ 1773
Cdd:cd00116 96 DGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLV 143
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