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Conserved domains on  [gi|1952685547|ref|XP_038302145|]
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leucine-rich repeat and death domain-containing protein 1 isoform X3 [Canis lupus familiaris]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-94 1.56e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDISDNAIREIPRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNL 81
Cdd:COG4886   148 LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                          90
                  ....*....|...
gi 1952685547  82 FSLKEINFDDNPL 94
Cdd:COG4886   228 TNLETLDLSNNQL 240
PRK15387 super family cl33133
type III secretion system effector E3 ubiquitin transferase SspH2;
15-175 1.18e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


The actual alignment was detected with superfamily member PRK15387:

Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  15 LKRLDISDNAIREIPRNIGELrslVSLNAYNNQISYLP--PSflclnDLQQLNLSGNNLTALPIGIHNLFSLKEINfddN 92
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSEL---CKLWAYNNQLTSLPtlPS-----GLQELSVSDNQLASLPTLPSELYKLWAYN---N 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  93 PLLRPPMEICKGKQLYTIVHYLQRADQRDEKILEkiLIIVANNIT---------ITNFKYLCQKLNLAISETDMSTKSPV 163
Cdd:PRK15387  373 RLTSLPALPSGLKELIVSGNRLTSLPVLPSELKE--LMVSGNRLTslpmlpsglLSLSVYRNQLTRLPESLIHLSSETTV 450

                         170
                  ....*....|....*..
gi 1952685547 164 S-----LSERVLQALHK 175
Cdd:PRK15387  451 NlegnpLSERTLQALRE 467
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-94 1.56e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDISDNAIREIPRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNL 81
Cdd:COG4886   148 LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                          90
                  ....*....|...
gi 1952685547  82 FSLKEINFDDNPL 94
Cdd:COG4886   228 TNLETLDLSNNQL 240
PLN03150 PLN03150
hypothetical protein; Provisional
 5-95 1.03e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNAIR-EIPRNIGELRSLVSLN-AYNNQISYLPPSFLCLNDLQQLNLSGNNLTA-LPIGIHN- 80
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDlSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAALGGr 513

                          90
                  ....*....|....*
gi 1952685547  81 LFSLKEINFDDNPLL 95
Cdd:PLN03150  514 LLHRASFNFTDNAGL 528
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-98 4.85e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 4.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   7 EELSNLTQLKRLDISDNAIREI----------------------------PRNIGEL-RSLVSLNAYNNQISYLPPsFLC 57
Cdd:cd21340    62 ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEP-LAP 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1952685547  58 LNDLQQLNLSGNNLT---ALPIGIHNLFSLKEINFDDNPLLRPP 98
Cdd:cd21340   141 LRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
13-71 1.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952685547  13 TQLKRLDISDNAIREI-PRNIGELRSLVSLNAYNNQISYLPP-SFLCLNDLQQLNLSGNNL 71
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
15-175 1.18e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  15 LKRLDISDNAIREIPRNIGELrslVSLNAYNNQISYLP--PSflclnDLQQLNLSGNNLTALPIGIHNLFSLKEINfddN 92
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSEL---CKLWAYNNQLTSLPtlPS-----GLQELSVSDNQLASLPTLPSELYKLWAYN---N 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  93 PLLRPPMEICKGKQLYTIVHYLQRADQRDEKILEkiLIIVANNIT---------ITNFKYLCQKLNLAISETDMSTKSPV 163
Cdd:PRK15387  373 RLTSLPALPSGLKELIVSGNRLTSLPVLPSELKE--LMVSGNRLTslpmlpsglLSLSVYRNQLTRLPESLIHLSSETTV 450

                         170
                  ....*....|....*..
gi 1952685547 164 S-----LSERVLQALHK 175
Cdd:PRK15387  451 NlegnpLSERTLQALRE 467
DEATH smart00005
DEATH domain, found in proteins involved in cell death (apoptosis); Alpha-helical domain ...
 125-211 6.56e-03

DEATH domain, found in proteins involved in cell death (apoptosis); Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers.


Pssm-ID: 214467 [Multi-domain]  Cd Length: 88  Bit Score: 34.69  E-value: 6.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  125 LEKILIIVANNITITNFKYLCQKLNLaiSETDM---STKSPVSLSERVLQALHKWKT-ESINLSLttaalrDQLTRALTM 200
Cdd:smart00005   4 TRQKLAKLLDHPLGLDWRELARKLGL--SEADIdqiRTEAPRDLAEQSVQLLRLWEQrEGKNATL------GTLLEALRK 75

                           90
                   ....*....|.
gi 1952685547  201 IGAYEIMDKIT 211
Cdd:smart00005  76 MGRDDAVELLR 86
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-94 1.56e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDISDNAIREIPRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNL 81
Cdd:COG4886   148 LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                          90
                  ....*....|...
gi 1952685547  82 FSLKEINFDDNPL 94
Cdd:COG4886   228 TNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-110 3.98e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDISDNAIREIPRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNL 81
Cdd:COG4886   125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                          90       100
                  ....*....|....*....|....*....
gi 1952685547  82 FSLKEINFDDNPLLRPPMEICKGKQLYTI 110
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETL 233
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-107 8.60e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 8.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   6 PEELSNLTQLKRLDISDNAIREIPRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNLFSLK 85
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                          90       100
                  ....*....|....*....|..
gi 1952685547  86 EINFDDNPLLRPPMEICKGKQL 107
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTNL 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-107 9.37e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 9.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNaireipRNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNLFSL 84
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                          90       100
                  ....*....|....*....|...
gi 1952685547  85 KEINFDDNPLLRPPMEICKGKQL 107
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTNL 184
PLN03150 PLN03150
hypothetical protein; Provisional
 5-95 1.03e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNAIR-EIPRNIGELRSLVSLN-AYNNQISYLPPSFLCLNDLQQLNLSGNNLTA-LPIGIHN- 80
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDlSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAALGGr 513

                          90
                  ....*....|....*
gi 1952685547  81 LFSLKEINFDDNPLL 95
Cdd:PLN03150  514 LLHRASFNFTDNAGL 528
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-94 2.24e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNAIR-EIPRNIGELRSLVSLN-AYNNQISYLPPSFLCLNDLQQLNLSGNNLTA-LPIGIHNL 81
Cdd:PLN00113  204 IPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSL 283

                          90
                  ....*....|...
gi 1952685547  82 FSLKEINFDDNPL 94
Cdd:PLN00113  284 QKLISLDLSDNSL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
2-173 3.89e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 3.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDIsdNAIREIPRNIGElrSLVSLNAYNNQISYLPPSFlcLNDLQQLNLSGNNLTALPigIHNL 81
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSI--NRITELPERLPS--ALQSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLP--AHLP 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  82 FSLKEINFDDNPLLRPPMEICKGkqLYTIVhylqrADQRDEKILE-------KILIIVANNITItnfkyLCQKLNLAISE 154
Cdd:PRK15370  304 SGITHLNVQSNSLTALPETLPPG--LKTLE-----AGENALTSLPaslppelQVLDVSKNQITV-----LPETLPPTITT 371

                         170
                  ....*....|....*....
gi 1952685547 155 TDMSTKSPVSLSERVLQAL 173
Cdd:PRK15370  372 LDVSRNALTNLPENLPAAL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-94 4.92e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNAIR-EIPRNIGELRSLVSLNAYNNQIS-YLPPSFLCLNDLQQLNLSGNNLTA-LPIGIHNL 81
Cdd:PLN00113  491 VPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNV 570

                          90
                  ....*....|...
gi 1952685547  82 FSLKEINFDDNPL 94
Cdd:PLN00113  571 ESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-98 4.85e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 4.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   7 EELSNLTQLKRLDISDNAIREI----------------------------PRNIGEL-RSLVSLNAYNNQISYLPPsFLC 57
Cdd:cd21340    62 ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEP-LAP 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1952685547  58 LNDLQQLNLSGNNLT---ALPIGIHNLFSLKEINFDDNPLLRPP 98
Cdd:cd21340   141 LRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
13-71 1.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952685547  13 TQLKRLDISDNAIREI-PRNIGELRSLVSLNAYNNQISYLPP-SFLCLNDLQQLNLSGNNL 71
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
15-175 1.18e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  15 LKRLDISDNAIREIPRNIGELrslVSLNAYNNQISYLP--PSflclnDLQQLNLSGNNLTALPIGIHNLFSLKEINfddN 92
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSEL---CKLWAYNNQLTSLPtlPS-----GLQELSVSDNQLASLPTLPSELYKLWAYN---N 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  93 PLLRPPMEICKGKQLYTIVHYLQRADQRDEKILEkiLIIVANNIT---------ITNFKYLCQKLNLAISETDMSTKSPV 163
Cdd:PRK15387  373 RLTSLPALPSGLKELIVSGNRLTSLPVLPSELKE--LMVSGNRLTslpmlpsglLSLSVYRNQLTRLPESLIHLSSETTV 450

                         170
                  ....*....|....*..
gi 1952685547 164 S-----LSERVLQALHK 175
Cdd:PRK15387  451 NlegnpLSERTLQALRE 467
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-156 1.36e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEeLSNLTQLKRLDISDNAIREIPrNIGELRSLVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNNLTALPIGIHNL 81
Cdd:COG4886   240 LTDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952685547  82 FSLKEINFDDNPLLRPPMEICKGKQLYTIVHYLQRADQRDEKILEKILIIVANNITITNFKYLCQKLNLAISETD 156
Cdd:COG4886   318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-94 8.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 8.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   7 EELSNLTQLKRLDISDNAIREIPrNIGELRSLVSLNAYNNQISYL--------------------PPSFLCLND------ 60
Cdd:cd21340    40 ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlpPGEKLTFDPrslaal 118

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952685547  61 ---LQQLNLSGNNLTALpIGIHNLFSLKEINFDDNPL 94
Cdd:cd21340   119 snsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
2-87 1.26e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.38  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSnltQLKRLDISDNAIREIPRnigeLRS-LVSLNAYNNQISYLPPSFLCLNDLQQLNLSGNnltalPIGIHN 80
Cdd:PRK15387  394 LTSLPVLPS---ELKELMVSGNRLTSLPM----LPSgLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN-----PLSERT 461


                  ....*..
gi 1952685547  81 LFSLKEI 87
Cdd:PRK15387  462 LQALREI 468
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-85 4.50e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   5 LPEELSNLTQLKRLDISDNAIR-EIPRNIGELRSLVSLNAYNNQIS-YLPPSFLCLNDLQQLNLSGNNLTA-LPIGIHNL 81
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGkIPVALTSL 331


                  ....
gi 1952685547  82 FSLK 85
Cdd:PLN00113  332 PRLQ 335
DEATH smart00005
DEATH domain, found in proteins involved in cell death (apoptosis); Alpha-helical domain ...
 125-211 6.56e-03

DEATH domain, found in proteins involved in cell death (apoptosis); Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers.


Pssm-ID: 214467 [Multi-domain]  Cd Length: 88  Bit Score: 34.69  E-value: 6.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547  125 LEKILIIVANNITITNFKYLCQKLNLaiSETDM---STKSPVSLSERVLQALHKWKT-ESINLSLttaalrDQLTRALTM 200
Cdd:smart00005   4 TRQKLAKLLDHPLGLDWRELARKLGL--SEADIdqiRTEAPRDLAEQSVQLLRLWEQrEGKNATL------GTLLEALRK 75

                           90
                   ....*....|.
gi 1952685547  201 IGAYEIMDKIT 211
Cdd:smart00005  76 MGRDDAVELLR 86
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-76 7.99e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.56  E-value: 7.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685547   2 LTRLPEELSNLTQLKRLDISDNAIRE--IPRNIGELRS---LVSLNAYNNQISYLPPSFLC-----LNDLQQLNLSGNNL 71
Cdd:cd00116   154 CEALAKALRANRDLKELNLANNGIGDagIRALAEGLKAncnLEVLDLNNNGLTDEGASALAetlasLKSLEVLNLGDNNL 233


                  ....*
gi 1952685547  72 TALPI 76
Cdd:cd00116   234 TDAGA 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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