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Conserved domains on  [gi|1953292637|ref|XP_038542353|]
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protein lifeguard 2 isoform X4 [Canis lupus familiaris]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-300 2.25e-101

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 295.99  E-value: 2.25e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953292637 242 LYAGLGTIVFSLYLVMDVQLMVGGRHHhsDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10428   161 VYASLGALLFSLYLAVDTQLLMGGRKY--ELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-300 2.25e-101

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 295.99  E-value: 2.25e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953292637 242 LYAGLGTIVFSLYLVMDVQLMVGGRHHhsDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10428   161 VYASLGALLFSLYLAVDTQLLMGGRKY--ELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-298 2.09e-38

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 134.61  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  90 RAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRR-QVPANYILLGLFTVL 168
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKySSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1953292637 249 IVFSLYLVMDVQLMVGGRHHHSDLDpeeYVFAALNIYLDIINLFLFILQL 298
Cdd:pfam01027 160 LLFSGFILYDTQRIIKRYGEYGDYD---AILAALSLYLDFINLFLSLLRI 206
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-300 1.51e-33

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 122.60  E-value: 1.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  89 RRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACcGKLRRQVPANYILLGLFTVL 168
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 169 QGLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYA 244
Cdd:COG0670    98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953292637 245 GLGTIVFSLYLVMDVQLMVggrhhHSDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:COG0670   178 VAGVLLFSGLTLYDTQRIK-----HGYETNKQYIMAALSLYLDFINLFLSLLRLLG 228
PRK10447 PRK10447
FtsH protease modulator YccA;
156-303 6.19e-03

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 37.13  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 156 PANYILLGLFTVLQGLLLGAV-SVFYNA---EEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILL 231
Cdd:PRK10447   73 PTGILSAFAFTGFLGYILGPIlNTYLSAgmgDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVAN 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953292637 232 LFIRSYWLHLLYAGLGTIVFSLYLVMDVQLMVGGRHHHsdldpeeYVFAALNIYLDIINLFLFILQLVGLGR 303
Cdd:PRK10447  153 IFLQLPALHLAISAVFILISSGAILFETSNIIHGGETN-------YIRATVSLYVSLYNIFVSLLSILGFAS 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 82-300 2.25e-101

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 295.99  E-value: 2.25e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  82 PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRRQVPANYIL 161
Cdd:cd10428     1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 162 LGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHL 241
Cdd:cd10428    81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953292637 242 LYAGLGTIVFSLYLVMDVQLMVGGRHHhsDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10428   161 VYASLGALLFSLYLAVDTQLLMGGRKY--ELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 73-300 3.06e-55

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 178.95  E-value: 3.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  73 PDDSNNLAN-PFSDSWIRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFtyaILPAFFVVLIVLACCGKL 151
Cdd:cd10429    10 PDDFKYGTNvASAEPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWL---FLISLIGSLILLIALYWK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 152 RRQVPANYILLGLFTVLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLII-YGIL 230
Cdd:cd10429    87 RHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILlALIF 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 231 LLFIRSYWLHLLYAGLGTIVFSLYLVMDVQLMVggrHHHSdldPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10429   167 QFFPYSPTFELVYAGLGALLFSGYIVYDTQLIM---KRLS---PDEYILAAISLYLDIINLFLSILRILA 230
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 90-298 2.09e-38

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 134.61  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  90 RAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACCGKLRR-QVPANYILLGLFTVL 168
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKySSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1953292637 249 IVFSLYLVMDVQLMVGGRHHHSDLDpeeYVFAALNIYLDIINLFLFILQL 298
Cdd:pfam01027 160 LLFSGFILYDTQRIIKRYGEYGDYD---AILAALSLYLDFINLFLSLLRI 206
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 88-300 1.27e-34

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 124.45  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  88 IRRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVnawftyaiLPAFFVVLIVLAC-CGKLRRQVPANYILLGLFT 166
Cdd:cd06181     1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPA--------LMGLLTSMLALMAtAAMIRAKMPVNLILLFGFT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 167 VLQGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGL 246
Cdd:cd06181    73 GLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAV 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1953292637 247 GTIVFSLYLVMDVQLMVGGRHHhsdlDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd06181   153 GLVLFCGFLLYDTQLIIHKAEV----GPEDYINACISLYLDIINIFIRLLTILA 202
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 89-300 1.51e-33

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 122.60  E-value: 1.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  89 RRAFIIKVFLILSAQLVVTGAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLACcGKLRRQVPANYILLGLFTVL 168
Cdd:COG0670    19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 169 QGLLLGAVSVFY----NAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYA 244
Cdd:COG0670    98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953292637 245 GLGTIVFSLYLVMDVQLMVggrhhHSDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:COG0670   178 VAGVLLFSGLTLYDTQRIK-----HGYETNKQYIMAALSLYLDFINLFLSLLRLLG 228
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 89-300 1.45e-31

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 116.89  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  89 RRAFIIKVFLILSAQLVVTgAIVSVFLFWKGLKAWVLVNAWFTYAILPAFFVVLIVLAccGKLRRQVPANYILLGLFTVL 168
Cdd:cd10432     2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPALLLIAGSPLMWVLLIAELALVFGLSF--RINKMSVATALPLFFAFAAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 169 QGLLLGAVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAGLGT 248
Cdd:cd10432    79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGV 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1953292637 249 IVFSLYLVMDVQ-LMVGGRHHHSDLDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10432   159 LIFSGLIAYDTQrIKRMYEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 153-300 1.48e-13

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 68.00  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 153 RQVPANYILLGLFTVLQGLLLG-----AVSVFYNAEEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIY 227
Cdd:cd10433    56 RNSAWGIVLVFAFTGFMGYTLGpilnmYLALPNGGQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLA 135

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953292637 228 GILLLFIRSYWLHLLYAGLGTIVFSLYLVMDVQLMVGGrhhhsdlDPEEYVFAALNIYLDIINLFLFILQLVG 300
Cdd:cd10433   136 AVANIFLQIPALSLAISAAFVLFSSGFILYDTSRIIHG-------GETNYIMATVSLYVSIYNLFVSLLNLLG 201
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 94-298 1.17e-11

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 63.01  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637  94 IKVFLILSAQLVVT--GAIVSVFLFWKG-LKAWVLVNAWFTYAILPAFFvvlivlaccgklrRQVPANYILLGLFTVLQG 170
Cdd:cd10430    13 KKVYLTLAVALLAAavGAYVHMVINIGGlLTGLLSLGLSLWLAFTPSTG-------------KNEPKRLGLLLGFAFLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 171 L----LLGAVSVFyNAEEVLWATAATALVTLSLTLFALQTK-WDFTMLNGMLFVLLFVLIIYGILLLFIRSYWLHLLYAG 245
Cdd:cd10430    80 AslgpLLDLVIAI-NPSIIVTAFLGTAVIFACFSLAALLAKrREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELY 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1953292637 246 LGTIVFSLYLVMDVQLMVgGRHHHSDLDpeeYVFAALNIYLDIINLFLFILQL 298
Cdd:cd10430   159 LGLLVFCGFVLFDTQMII-EKAENGDRD---YIWHALDLFVDFVALFRRLLII 207
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 242-303 6.09e-03

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 37.75  E-value: 6.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953292637 242 LYAGLgtIVFSLYLVMDVQLMVggrhHHSDLDPEEYVF------AALNIYLDIINLFLFILQLVGLGR 303
Cdd:cd10431   200 LYGGL--VLFGGFLLYDTQKII----KRAETHPLYGVRkydpinASMSIYMDTINIFIRLVTILAGGG 261
PRK10447 PRK10447
FtsH protease modulator YccA;
156-303 6.19e-03

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 37.13  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953292637 156 PANYILLGLFTVLQGLLLGAV-SVFYNA---EEVLWATAATALVTLSLTLFALQTKWDFTMLNGMLFVLLFVLIIYGILL 231
Cdd:PRK10447   73 PTGILSAFAFTGFLGYILGPIlNTYLSAgmgDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVAN 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953292637 232 LFIRSYWLHLLYAGLGTIVFSLYLVMDVQLMVGGRHHHsdldpeeYVFAALNIYLDIINLFLFILQLVGLGR 303
Cdd:PRK10447  153 IFLQLPALHLAISAVFILISSGAILFETSNIIHGGETN-------YIRATVSLYVSLYNIFVSLLSILGFAS 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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