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Conserved domains on  [gi|1958646147|ref|XP_038934395|]
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phosphatidylinositide phosphatase SAC2 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5329 super family cl34984
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
50-566 6.42e-107

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5329:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 346.30  E-value: 6.42e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147   50 GVIGKIQLHSDLpwWLILIRQKALVGKLPGdHEVCKVTKIAVLSLSEM----EPQELELELCKKHHFginkpekivpspd 125
Cdd:COG5329     62 GVIGLIKLKGDI--YLIVITGASLVGVIPG-HSIYKILDVDFISLNNNkwddELEEDEANYDKLSEL------------- 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  126 dsKFLLKTftniksnvsapnkkkvkeskekeklerrlleellkmfmdsESFYYSLTYDLTNSVQRQSTGEKdgRPLWQKV 205
Cdd:COG5329    126 --KKLLSN----------------------------------------GTFYFSYDFDITNSLQKNLSEGL--EASVDRA 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  206 DDRFFWNKYMIQDL----SEIGTPD--VDFWIIPIIQGFVQIEELVVNYEPSdddksspetppqeatcvddihprfLVAL 279
Cdd:COG5329    162 DLIFMWNSFLLEEFinhrSKLSSLEkqFDNFLTTVIRGFAETVDIKVGGNTI------------------------SLTL 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  280 ISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCA 359
Cdd:COG5329    218 ISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDK 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  360 HFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPRLTYVSFDFHEHCRGMKFENVQTLTDAIHDIILDMKWCW 439
Cdd:COG5329    298 HFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFA 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  440 VDQAG--VICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLpvkCNRtYQIMWANNGDSISRQYAG 517
Cdd:COG5329    378 YDINEgkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPF---LQI-HRELWADNGDAISRLYTG 453
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1958646147  518 TAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG 566
Cdd:COG5329    454 TGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
hSac2 super family cl13842
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
593-671 1.50e-12

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


The actual alignment was detected with superfamily member pfam12456:

Pssm-ID: 463592  Cd Length: 115  Bit Score: 65.30  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  593 SHQELISQLLQSYMQLLLP-GDEKFHGGWALIDCDP------------------------SYDDEVDKVSQYQRRSLEDL 647
Cdd:pfam12456    5 SRPKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHwntlrslpeeervllltdkalyicKYDFNLEKVVQFERVPLNDI 84
                           90       100       110
                   ....*....|....*....|....*....|
gi 1958646147  648 EKIEIGP------EPTLFGKPKFSCMRLHY 671
Cdd:pfam12456   85 DRIQLGTyitstlSLAQRDERRNYGLRIHY 114
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
50-566 6.42e-107

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 346.30  E-value: 6.42e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147   50 GVIGKIQLHSDLpwWLILIRQKALVGKLPGdHEVCKVTKIAVLSLSEM----EPQELELELCKKHHFginkpekivpspd 125
Cdd:COG5329     62 GVIGLIKLKGDI--YLIVITGASLVGVIPG-HSIYKILDVDFISLNNNkwddELEEDEANYDKLSEL------------- 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  126 dsKFLLKTftniksnvsapnkkkvkeskekeklerrlleellkmfmdsESFYYSLTYDLTNSVQRQSTGEKdgRPLWQKV 205
Cdd:COG5329    126 --KKLLSN----------------------------------------GTFYFSYDFDITNSLQKNLSEGL--EASVDRA 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  206 DDRFFWNKYMIQDL----SEIGTPD--VDFWIIPIIQGFVQIEELVVNYEPSdddksspetppqeatcvddihprfLVAL 279
Cdd:COG5329    162 DLIFMWNSFLLEEFinhrSKLSSLEkqFDNFLTTVIRGFAETVDIKVGGNTI------------------------SLTL 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  280 ISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCA 359
Cdd:COG5329    218 ISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDK 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  360 HFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPRLTYVSFDFHEHCRGMKFENVQTLTDAIHDIILDMKWCW 439
Cdd:COG5329    298 HFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFA 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  440 VDQAG--VICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLpvkCNRtYQIMWANNGDSISRQYAG 517
Cdd:COG5329    378 YDINEgkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPF---LQI-HRELWADNGDAISRLYTG 453
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1958646147  518 TAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG 566
Cdd:COG5329    454 TGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
50-414 3.11e-99

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 315.67  E-value: 3.11e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147   50 GVIGKIQLHSDlpWWLILIRQKALVGKLPGdHEVCKVTKIAVLSLSemePQELELELCKKHHfginkpekivpsPDDSKF 129
Cdd:pfam02383    2 GILGLIRLLSG--YYLIVITKREQVGQIGG-HPIYKITDVEFIPLN---SSLSDTQLAKKEH------------PDEERL 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  130 LlktftniksnvsapnkkkvkeskekeklerrlleELLKMFMDSESFYYSLTYDLTNSVQRQSTGEKDGRplWQKVDDRF 209
Cdd:pfam02383   64 L----------------------------------KLLKLFLSSGSFYFSYDYDLTNSLQRNLTRSRSPS--FDSLDDRF 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  210 FWNKYMIQDLSEIGtPDVDFWIIPIIQGFVQIEELVVNYEPsdddksspetppqeatcvddihprFLVALISRRSRHRAG 289
Cdd:pfam02383  108 FWNRHLLKPLIDFQ-LDLDRWILPLIQGFVEQGKLSVFGRS------------------------VTLTLISRRSRKRAG 162
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  290 MRYKRRGVDKNGNVANYVETEQLIHV-----HNHTLSFIQTRGSVPVFWSQV-GYRYNPRPRLDKSEkETVDCFCAHFEE 363
Cdd:pfam02383  163 TRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDpNLKYKPKIQITRPE-ATQPAFKKHFDD 241
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958646147  364 QLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFN---NPRLTYVSFDFHEHCR 414
Cdd:pfam02383  242 LIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNqflPDKLRYTAFDFHHECK 295
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
593-671 1.50e-12

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 65.30  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  593 SHQELISQLLQSYMQLLLP-GDEKFHGGWALIDCDP------------------------SYDDEVDKVSQYQRRSLEDL 647
Cdd:pfam12456    5 SRPKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHwntlrslpeeervllltdkalyicKYDFNLEKVVQFERVPLNDI 84
                           90       100       110
                   ....*....|....*....|....*....|
gi 1958646147  648 EKIEIGP------EPTLFGKPKFSCMRLHY 671
Cdd:pfam12456   85 DRIQLGTyitstlSLAQRDERRNYGLRIHY 114
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
50-566 6.42e-107

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 346.30  E-value: 6.42e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147   50 GVIGKIQLHSDLpwWLILIRQKALVGKLPGdHEVCKVTKIAVLSLSEM----EPQELELELCKKHHFginkpekivpspd 125
Cdd:COG5329     62 GVIGLIKLKGDI--YLIVITGASLVGVIPG-HSIYKILDVDFISLNNNkwddELEEDEANYDKLSEL------------- 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  126 dsKFLLKTftniksnvsapnkkkvkeskekeklerrlleellkmfmdsESFYYSLTYDLTNSVQRQSTGEKdgRPLWQKV 205
Cdd:COG5329    126 --KKLLSN----------------------------------------GTFYFSYDFDITNSLQKNLSEGL--EASVDRA 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  206 DDRFFWNKYMIQDL----SEIGTPD--VDFWIIPIIQGFVQIEELVVNYEPSdddksspetppqeatcvddihprfLVAL 279
Cdd:COG5329    162 DLIFMWNSFLLEEFinhrSKLSSLEkqFDNFLTTVIRGFAETVDIKVGGNTI------------------------SLTL 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  280 ISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCA 359
Cdd:COG5329    218 ISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVTRSSEAAQSAFDK 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  360 HFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPRLTYVSFDFHEHCRGMKFENVQTLTDAIHDIILDMKWCW 439
Cdd:COG5329    298 HFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFA 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  440 VDQAG--VICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLpvkCNRtYQIMWANNGDSISRQYAG 517
Cdd:COG5329    378 YDINEgkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPF---LQI-HRELWADNGDAISRLYTG 453
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1958646147  518 TAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG 566
Cdd:COG5329    454 TGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
50-414 3.11e-99

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 315.67  E-value: 3.11e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147   50 GVIGKIQLHSDlpWWLILIRQKALVGKLPGdHEVCKVTKIAVLSLSemePQELELELCKKHHfginkpekivpsPDDSKF 129
Cdd:pfam02383    2 GILGLIRLLSG--YYLIVITKREQVGQIGG-HPIYKITDVEFIPLN---SSLSDTQLAKKEH------------PDEERL 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  130 LlktftniksnvsapnkkkvkeskekeklerrlleELLKMFMDSESFYYSLTYDLTNSVQRQSTGEKDGRplWQKVDDRF 209
Cdd:pfam02383   64 L----------------------------------KLLKLFLSSGSFYFSYDYDLTNSLQRNLTRSRSPS--FDSLDDRF 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  210 FWNKYMIQDLSEIGtPDVDFWIIPIIQGFVQIEELVVNYEPsdddksspetppqeatcvddihprFLVALISRRSRHRAG 289
Cdd:pfam02383  108 FWNRHLLKPLIDFQ-LDLDRWILPLIQGFVEQGKLSVFGRS------------------------VTLTLISRRSRKRAG 162
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  290 MRYKRRGVDKNGNVANYVETEQLIHV-----HNHTLSFIQTRGSVPVFWSQV-GYRYNPRPRLDKSEkETVDCFCAHFEE 363
Cdd:pfam02383  163 TRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDpNLKYKPKIQITRPE-ATQPAFKKHFDD 241
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958646147  364 QLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFN---NPRLTYVSFDFHEHCR 414
Cdd:pfam02383  242 LIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNqflPDKLRYTAFDFHHECK 295
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
593-671 1.50e-12

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 65.30  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646147  593 SHQELISQLLQSYMQLLLP-GDEKFHGGWALIDCDP------------------------SYDDEVDKVSQYQRRSLEDL 647
Cdd:pfam12456    5 SRPKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHwntlrslpeeervllltdkalyicKYDFNLEKVVQFERVPLNDI 84
                           90       100       110
                   ....*....|....*....|....*....|
gi 1958646147  648 EKIEIGP------EPTLFGKPKFSCMRLHY 671
Cdd:pfam12456   85 DRIQLGTyitstlSLAQRDERRNYGLRIHY 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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