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Conserved domains on  [gi|1958790163|ref|XP_038935355|]
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solute carrier family 41 member 2 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 199-333 2.18e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 84.03  E-value: 2.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 199 VPALLGLKGNLEMTLASRLSTAVNVGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLSHSILLC 278
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958790163 279 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 333
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 413-510 7.33e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 56.68  E-value: 7.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 413 TPVINGIGGNLVAIQASRISTYLHLHSLpgelpeEPKgcsyPFRTFFGSGVNNKSAQVLLLFVIPGHLIFLYTIHLMKSG 492
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90
                  ....*....|....*...
gi 1958790163 493 HTSLTVVFVVvyLLAAVL 510
Cdd:pfam01769  71 VVGLALLLAV--LIALLL 86
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 199-333 2.18e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 84.03  E-value: 2.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 199 VPALLGLKGNLEMTLASRLSTAVNVGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLSHSILLC 278
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958790163 279 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 333
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
197-330 5.09e-14

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 70.66  E-value: 5.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 197 ILVPALLGLKGNLEMTLASRLSTAVNVG----KMDSPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLs 272
Cdd:COG1824    47 VLVPAFLGTRGNLGGILGARLSTALHLGllepRLRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTL- 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958790163 273 hsillcsssVATAFIASLLQGIIM----VGVIVGSKKTGINPDNVATPIAASFGDLITLAIL 330
Cdd:COG1824   126 ---------VGIALLAGLLLALLLivvtYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 413-510 7.33e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 56.68  E-value: 7.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 413 TPVINGIGGNLVAIQASRISTYLHLHSLpgelpeEPKgcsyPFRTFFGSGVNNKSAQVLLLFVIPGHLIFLYTIHLMKSG 492
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90
                  ....*....|....*...
gi 1958790163 493 HTSLTVVFVVvyLLAAVL 510
Cdd:pfam01769  71 VVGLALLLAV--LIALLL 86
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
382-519 4.92e-03

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 38.31  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 382 PVITAM-VISSIGGLILDTTVSDPNLV-GIVVYTPVINGIGGNLVAIQASRISTYLHLhslpGELPEEPKGCSYPFRTFF 459
Cdd:COG1824    16 PVLLVLaVGGIIAGLVLEGMEELLLAYpGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLEPRLRPDRRLLNNIL 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958790163 460 GSGVNNksaqvLLLFVIPGHLIFLYTIHLmksGHTS-----LTVVFVVVYLLAAVLQVFTLLWIA 519
Cdd:COG1824    92 ATLILA-----LLISPLIGVLAWLVAVLL---GRGSlglltLVGIALLAGLLLALLLIVVTYYVA 148
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 199-333 2.18e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 84.03  E-value: 2.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 199 VPALLGLKGNLEMTLASRLSTAVNVGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLSHSILLC 278
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958790163 279 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 333
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
197-330 5.09e-14

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 70.66  E-value: 5.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 197 ILVPALLGLKGNLEMTLASRLSTAVNVG----KMDSPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLs 272
Cdd:COG1824    47 VLVPAFLGTRGNLGGILGARLSTALHLGllepRLRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTL- 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958790163 273 hsillcsssVATAFIASLLQGIIM----VGVIVGSKKTGINPDNVATPIAASFGDLITLAIL 330
Cdd:COG1824   126 ---------VGIALLAGLLLALLLivvtYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 413-510 7.33e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 56.68  E-value: 7.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 413 TPVINGIGGNLVAIQASRISTYLHLHSLpgelpeEPKgcsyPFRTFFGSGVNNKSAQVLLLFVIPGHLIFLYTIHLMKSG 492
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90
                  ....*....|....*...
gi 1958790163 493 HTSLTVVFVVvyLLAAVL 510
Cdd:pfam01769  71 VVGLALLLAV--LIALLL 86
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
382-519 4.92e-03

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 38.31  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790163 382 PVITAM-VISSIGGLILDTTVSDPNLV-GIVVYTPVINGIGGNLVAIQASRISTYLHLhslpGELPEEPKGCSYPFRTFF 459
Cdd:COG1824    16 PVLLVLaVGGIIAGLVLEGMEELLLAYpGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLEPRLRPDRRLLNNIL 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958790163 460 GSGVNNksaqvLLLFVIPGHLIFLYTIHLmksGHTS-----LTVVFVVVYLLAAVLQVFTLLWIA 519
Cdd:COG1824    92 ATLILA-----LLISPLIGVLAWLVAVLL---GRGSlglltLVGIALLAGLLLALLLIVVTYYVA 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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