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Conserved domains on  [gi|1958646488|ref|XP_038935619|]
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serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [Rattus norvegicus]

Protein Classification

phosphatase 2A regulatory subunit B56 family protein( domain architecture ID 12024732)

phosphatase 2A regulatory subunit B56 family protein functions as a regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulating substrate specificity, subcellular localization, and responsiveness to phosphorylation

CATH:  1.25.10.10
Gene Ontology:  GO:0007165|GO:0019888|GO:0000159
PubMed:  7592815
SCOP:  4001530

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 69-260 1.10e-103

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


:

Pssm-ID: 460264  Cd Length: 404  Bit Score: 306.85  E-value: 1.10e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488  69 PASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENP- 147
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488 148 ---EFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKF 224
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958646488 225 LGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILG 260
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILG 196
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 69-260 1.10e-103

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 306.85  E-value: 1.10e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488  69 PASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENP- 147
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488 148 ---EFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKF 224
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958646488 225 LGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILG 260
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILG 196
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 69-260 1.10e-103

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 306.85  E-value: 1.10e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488  69 PASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENP- 147
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646488 148 ---EFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKF 224
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958646488 225 LGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILG 260
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILG 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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