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Conserved domains on  [gi|1958791399|ref|XP_038935832|]
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xaa-Pro aminopeptidase 3 isoform X2 [Rattus norvegicus]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
173-410 2.78e-118

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 344.56  E-value: 2.78e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 173 IKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLGIIKTSKESAFK 332
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEIVE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 333 --AARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITVEPGIYIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPL 406
Cdd:cd01087   160 sgAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239

                  ....
gi 1958791399 407 ILSA 410
Cdd:cd01087   240 NLTR 243
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
15-127 5.93e-43

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 147.39  E-value: 5.93e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399   15 DHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQscsgKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGA 94
Cdd:smart01011  20 GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGGGKSTLFVPPRDPEDELWDGPRLGLEEA 95
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958791399   95 IALTGVDDAYPLEEFQHLLPKLRAETNMVWYDW 127
Cdd:smart01011  96 KEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLL 128
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
173-410 2.78e-118

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 344.56  E-value: 2.78e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 173 IKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLGIIKTSKESAFK 332
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEIVE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 333 --AARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITVEPGIYIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPL 406
Cdd:cd01087   160 sgAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239

                  ....
gi 1958791399 407 ILSA 410
Cdd:cd01087   240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
2-420 3.57e-87

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 271.98  E-value: 3.57e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399   2 ALVHKEAQGHSGtdhtvVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQSCSGKQlpsHKAMLFVPRRDPGR 81
Cdd:PRK10879   12 ALLAKMQPGSAA-----LIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTH---NHSVLFNRVRDLTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  82 ELWDGPRSGTDGAIALTGVDDAYPLEEFQHLLPKLRAETNMVWydwmkpsHAQLHSDYMQPLTEAkATSKNKVRSVQHL- 160
Cdd:PRK10879   84 EIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLLNGLDVVY-------HAQGEYAYADEIVFS-ALEKLRKGSRQNLt 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 161 -----------IQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGN 229
Cdd:PRK10879  156 apatltdwrpwVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSYNTIVGSGE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 230 RSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMM 309
Cdd:PRK10879  236 NGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 310 LTLMGQKLKDLGIIKTSKES--AFKAARKYCPHHVGHYLGMDVHDTPD--MPRSLPLQPGMVITVEPGIYIPEgDTDAPE 385
Cdd:PRK10879  316 VRIMVSGLVKLGILKGDVDQliAENAHRPFFMHGLSHWLGLDVHDVGVygQDRSRILEPGMVLTVEPGLYIAP-DADVPE 394
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1958791399 386 KFRGLGVRIEDDVVVTQDSPLILSADCPKEVNDIE 420
Cdd:PRK10879  395 QYRGIGIRIEDDIVITETGNENLTASVVKKPDEIE 429
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
152-419 3.55e-76

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 238.95  E-value: 3.55e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 152 NKVRSVQHLIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRS 231
Cdd:COG0006    58 RELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENA 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 232 NTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYsmmlT 311
Cdd:COG0006   138 AIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVD----A 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 312 LMGQKLKDLGIiktskesafkaaRKYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITVEPGIYIPEgdtdapekfrG 389
Cdd:COG0006   213 AARDVLAEAGY------------GEYFPHGTGHGVGLDVHEGPQIspGNDRPLEPGMVFTIEPGIYIPG----------I 270
                         250       260       270
                  ....*....|....*....|....*....|
gi 1958791399 390 LGVRIEDDVVVTQDSPLILSaDCPKEVNDI 419
Cdd:COG0006   271 GGVRIEDTVLVTEDGAEVLT-RLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
174-401 1.31e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 200.93  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 174 KRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFE-FECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCE-SSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMgqklKDLGIIktskesaf 331
Cdd:pfam00557  81 VGAEyDGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL----EEAGLG-------- 147
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958791399 332 kaarKYCPHHVGHYLGMDVHDTPDMPRS---LPLQPGMVITVEPGIYIPEGDTdapekfrglGVRIEDDVVVT 401
Cdd:pfam00557 148 ----EYFPHGLGHGIGLEVHEGPYISRGgddRVLEPGMVFTIEPGIYFIPGWG---------GVRIEDTVLVT 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
15-127 5.93e-43

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 147.39  E-value: 5.93e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399   15 DHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQscsgKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGA 94
Cdd:smart01011  20 GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGGGKSTLFVPPRDPEDELWDGPRLGLEEA 95
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958791399   95 IALTGVDDAYPLEEFQHLLPKLRAETNMVWYDW 127
Cdd:smart01011  96 KEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLL 128
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
13-124 1.02e-41

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 143.42  E-value: 1.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  13 GTDHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQscsGKQLPSHKAMLFVPRRDPGRELWDGPRSGTD 92
Cdd:pfam05195  13 PPNSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLE---GGDIDSGKETLFVPPKDPEDEIWDGPRLGPE 89
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958791399  93 GAIALTGVDDAYPLEEFQHLLPKLRAETNMVW 124
Cdd:pfam05195  90 EAKELFGVDEVYPIDELDEVLPKLLKGRDTVY 121
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
173-410 2.78e-118

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 344.56  E-value: 2.78e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 173 IKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLGIIKTSKESAFK 332
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEIVE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 333 --AARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITVEPGIYIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPL 406
Cdd:cd01087   160 sgAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239

                  ....
gi 1958791399 407 ILSA 410
Cdd:cd01087   240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
2-420 3.57e-87

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 271.98  E-value: 3.57e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399   2 ALVHKEAQGHSGtdhtvVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQSCSGKQlpsHKAMLFVPRRDPGR 81
Cdd:PRK10879   12 ALLAKMQPGSAA-----LIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTH---NHSVLFNRVRDLTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  82 ELWDGPRSGTDGAIALTGVDDAYPLEEFQHLLPKLRAETNMVWydwmkpsHAQLHSDYMQPLTEAkATSKNKVRSVQHL- 160
Cdd:PRK10879   84 EIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLLNGLDVVY-------HAQGEYAYADEIVFS-ALEKLRKGSRQNLt 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 161 -----------IQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGN 229
Cdd:PRK10879  156 apatltdwrpwVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSYNTIVGSGE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 230 RSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMM 309
Cdd:PRK10879  236 NGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 310 LTLMGQKLKDLGIIKTSKES--AFKAARKYCPHHVGHYLGMDVHDTPD--MPRSLPLQPGMVITVEPGIYIPEgDTDAPE 385
Cdd:PRK10879  316 VRIMVSGLVKLGILKGDVDQliAENAHRPFFMHGLSHWLGLDVHDVGVygQDRSRILEPGMVLTVEPGLYIAP-DADVPE 394
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1958791399 386 KFRGLGVRIEDDVVVTQDSPLILSADCPKEVNDIE 420
Cdd:PRK10879  395 QYRGIGIRIEDDIVITETGNENLTASVVKKPDEIE 429
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
152-419 3.55e-76

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 238.95  E-value: 3.55e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 152 NKVRSVQHLIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRS 231
Cdd:COG0006    58 RELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENA 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 232 NTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYsmmlT 311
Cdd:COG0006   138 AIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVD----A 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 312 LMGQKLKDLGIiktskesafkaaRKYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITVEPGIYIPEgdtdapekfrG 389
Cdd:COG0006   213 AARDVLAEAGY------------GEYFPHGTGHGVGLDVHEGPQIspGNDRPLEPGMVFTIEPGIYIPG----------I 270
                         250       260       270
                  ....*....|....*....|....*....|
gi 1958791399 390 LGVRIEDDVVVTQDSPLILSaDCPKEVNDI 419
Cdd:COG0006   271 GGVRIEDTVLVTEDGAEVLT-RLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
174-401 1.31e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 200.93  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 174 KRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFE-FECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCE-SSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMgqklKDLGIIktskesaf 331
Cdd:pfam00557  81 VGAEyDGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL----EEAGLG-------- 147
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958791399 332 kaarKYCPHHVGHYLGMDVHDTPDMPRS---LPLQPGMVITVEPGIYIPEGDTdapekfrglGVRIEDDVVVT 401
Cdd:pfam00557 148 ----EYFPHGLGHGIGLEVHEGPYISRGgddRVLEPGMVFTIEPGIYFIPGWG---------GVRIEDTVLVT 207
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
173-405 6.85e-48

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 162.68  E-value: 6.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 173 IKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIysmmltlmgqklkDlgiiktskesafK 332
Cdd:cd01092    81 FGAIYDGYCSDITRTVAV-GEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEV-------------D------------K 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 333 AAR---------KYCPHHVGHYLGMDVHDTPD-MPRS-LPLQPGMVITVEPGIYIPEgdtdapekfRGlGVRIEDDVVVT 401
Cdd:cd01092   135 AARdvieeagygEYFIHRTGHGVGLEVHEAPYiSPGSdDVLEEGMVFTIEPGIYIPG---------KG-GVRIEDDVLVT 204

                  ....
gi 1958791399 402 QDSP 405
Cdd:cd01092   205 EDGC 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
15-127 5.93e-43

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 147.39  E-value: 5.93e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399   15 DHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQscsgKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGA 94
Cdd:smart01011  20 GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGGGKSTLFVPPRDPEDELWDGPRLGLEEA 95
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958791399   95 IALTGVDDAYPLEEFQHLLPKLRAETNMVWYDW 127
Cdd:smart01011  96 KEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLL 128
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
13-124 1.02e-41

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 143.42  E-value: 1.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  13 GTDHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQscsGKQLPSHKAMLFVPRRDPGRELWDGPRSGTD 92
Cdd:pfam05195  13 PPNSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLE---GGDIDSGKETLFVPPKDPEDEIWDGPRLGPE 89
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958791399  93 GAIALTGVDDAYPLEEFQHLLPKLRAETNMVW 124
Cdd:pfam05195  90 EAKELFGVDEVYPIDELDEVLPKLLKGRDTVY 121
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
173-401 1.75e-36

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 132.58  E-value: 1.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 173 IKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGAdILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 252
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 253 GGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLtlmgQKLKDLGiiktskesafk 332
Cdd:cd01066    80 LGGVYDGYHADLTRTFVI-GEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAR----EVLEEHG----------- 143
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958791399 333 aARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITVEPGIYIPEGDtdapekfrglGVRIEDDVVVT 401
Cdd:cd01066   144 -LGPNFGHRTGHGIGLEIHEPPVLKAgdDTVLEPGMVFAVEPGLYLPGGG----------GVRIEDTVLVT 203
PRK09795 PRK09795
aminopeptidase; Provisional
164-416 2.98e-30

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 120.04  E-value: 2.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 164 LRLIKSPAEIKRMQIAGKL--TSEAFIETMFAskAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQ 241
Cdd:PRK09795  124 LRQIKTPEEVEKIRLACGIadRGAEHIRRFIQ--AGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDK 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 242 LIKDGEMVLLDGGCESSCYVSDITRTWPVNGRfTAPQAE-----LYEAVLEIQKACLTLCSPGTSLENIysmmltlmgqk 316
Cdd:PRK09795  202 IVAAGEFVTLDFGALYQGYCSDMTRTLLVNGE-GVSAEShplfnVYQIVLQAQLAAISAIRPGVRCQQV----------- 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 317 lkDLGIIKTSKESAFKaarKYCPHHVGHYLGMDVHDTPDM-PR-SLPLQPGMVITVEPGIYIPEgdtdapekfRGlGVRI 394
Cdd:PRK09795  270 --DDAARRVITEAGYG---DYFGHNTGHAIGIEVHEDPRFsPRdTTTLQPGMLLTVEPGIYLPG---------QG-GVRI 334
                         250       260
                  ....*....|....*....|..
gi 1958791399 395 EDDVVVTQDSPLILSAdCPKEV 416
Cdd:PRK09795  335 EDVVLVTPQGAEVLYA-MPKTV 355
PRK13607 PRK13607
proline dipeptidase; Provisional
165-412 1.53e-23

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 101.89  E-value: 1.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 165 RLIKSPAEIKRMQIAGKLTSEAFIetmfASKapvdEAFLYAKFEFECRAR-------GADILAYPPVVAGGNRSNTLHYV 237
Cdd:PRK13607  159 RAYKTDYELACMREAQKIAVAGHR----AAK----EAFRAGMSEFDINLAyltatgqRDNDVPYGNIVALNEHAAVLHYT 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 238 KNNQLiKDGEM--VLLDGGCESSCYVSDITRTW--PVNGRFtapqAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLM 313
Cdd:PRK13607  231 KLDHQ-APAEMrsFLIDAGAEYNGYAADITRTYaaKEDNDF----AALIKDVNKEQLALIATMKPGVSYVDLHIQMHQRI 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 314 GQKLKDLGIIKT-SKESAFKA--ARKYCPHHVGHYLGMDVHDT--------------PDMPRSL----PLQPGMVITVEP 372
Cdd:PRK13607  306 AKLLRKFQIVTGlSEEAMVEQgiTSPFFPHGLGHPLGLQVHDVagfmqddrgthlaaPEKHPYLrctrVLEPGMVLTIEP 385
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958791399 373 GIYIPEG--------------DTDAPEKFR--GlGVRIEDDVVVTQDSPLILSADC 412
Cdd:PRK13607  386 GLYFIDSllaplregpfskhfNWQKIDALKpfG-GIRIEDNVVVHENGVENMTRDL 440
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
186-402 9.43e-15

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 72.98  E-value: 9.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 186 AFIETMFASKAPVDEAFLYAKFEfECRARGADI--LAYPPVVAGGNRSNTLHY---VKNNQLIKDGEMVLLDGGcesSCY 260
Cdd:cd01085    18 AWLEQEVPKGETITELSAADKLE-EFRRQQKGYvgLSFDTISGFGPNGAIVHYsptEESNRKISPDGLYLIDSG---GQY 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 261 V---SDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSP----GTSLENIYSMMLtlmgqklkdlgiiktskesaFKA 333
Cdd:cd01085    94 LdgtTDITRTVHL-GEPTAEQKRDYTLVLKGHIALARAKFPkgttGSQLDALARQPL--------------------WKA 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958791399 334 ARKYcPH---H-VGHYLGmdVHDTP----DMPRSLPLQPGMVITVEPGIYIpegdtdaPEKFrglGVRIEDDVVVTQ 402
Cdd:cd01085   153 GLDY-GHgtgHgVGSFLN--VHEGPqsisPAPNNVPLKAGMILSNEPGYYK-------EGKY---GIRIENLVLVVE 216
PRK05716 PRK05716
methionine aminopeptidase; Validated
167-409 2.61e-09

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 57.45  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 167 IKSPAEIKRMQIAGKLTSEAFIETMFASKAPV------DEAFLYAkfefecRARGAdI---LAYPP-----------VVA 226
Cdd:PRK05716    5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVttkeldRIAEEYI------RDQGA-IpapLGYHGfpksictsvneVVC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 227 ggnrsntlHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVngrftAPQAELYEAVLEIQKACLTLcspgtSLENIY 306
Cdd:PRK05716   78 --------HGIPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV-----GEISPEDKRLCEVTKEALYL-----GIAAVK 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 307 SmmltlmGQKLKDLG--IIKTSKESAFKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQPGMVITVEPgiYIPE 378
Cdd:PRK05716  140 P------GARLGDIGhaIQKYAEAEGFSVVREYC----GHGIGRKFHEEPQIPhygapgDGPVLKEGMVFTIEP--MINA 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1958791399 379 GDTDAPE---------KFRGLGVRIEDDVVVTQDSPLILS 409
Cdd:PRK05716  208 GKREVKTlkdgwtvvtKDGSLSAQYEHTVAVTEDGPEILT 247
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
167-410 2.02e-08

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 54.63  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 167 IKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGAdilayppvvaggnRSNTLHY---------- 236
Cdd:COG0024     3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGA-------------IPAFLGYygfpksicts 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 237 --------VKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRfTAPQAElyeAVLEIQKACLTL----CSPGTslen 304
Cdd:COG0024    70 vnevvvhgIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-GE-VSPEAR---RLVEVTEEALYAgiaaAKPGN---- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 305 iysmmltlmgqKLKDLG-IIKTSKESA-FKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQPGMVITVEPGIYi 376
Cdd:COG0024   141 -----------RLGDIGhAIQSYAESNgYSVVREFV----GHGIGREMHEEPQVPnygrpgRGPRLKPGMVLAIEPMIN- 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958791399 377 pEGDTDapekfrglgVRIEDD------------------VVVTQDSPLILSA 410
Cdd:COG0024   205 -AGTPE---------VKVLDDgwtvvtkdgslsaqfehtVAVTEDGPEILTL 246
CDC68-like cd01091
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in ...
221-408 1.11e-07

Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.


Pssm-ID: 238524 [Multi-domain]  Cd Length: 243  Bit Score: 52.35  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 221 YPPVV-AGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAELYEAVLEIQKACLTLCSPG 299
Cdd:cd01091    65 YPPIIqSGGNYDLLKSSSSSDKLLYHFGVIICSLGARYKSYCSNIARTFLIDP--TSEQQKNYNFLLALQEEILKELKPG 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 300 TSLENIYSMMLTLMGQKLKDLgiiktskesafkaaRKYCPHHVGHYLGMDVHDT-----PDMPRSlpLQPGMVITVEPGI 374
Cdd:cd01091   143 AKLSDVYQKTLDYIKKKKPEL--------------EPNFTKNLGFGIGLEFRESsliinAKNDRK--LKKGMVFNLSIGF 206
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958791399 375 YIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPLIL 408
Cdd:cd01091   207 SNLQNPEPKDKESKTYALLLSDTILVTEDEPAIV 240
PRK15173 PRK15173
peptidase; Provisional
160-375 3.71e-06

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 48.56  E-value: 3.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 160 LIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILA-YPPVVAGGNRSNTLhyVK 238
Cdd:PRK15173   88 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrFHLISVGADFSPKL--IP 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 239 NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTlmgqklk 318
Cdd:PRK15173  166 SNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTME------- 237
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958791399 319 dlgIIKTSKESAFKaaRKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIY 375
Cdd:PRK15173  238 ---VIKKSGLPNYN--RGHLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYY 289
PRK14575 PRK14575
putative peptidase; Provisional
160-375 6.25e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 48.16  E-value: 6.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 160 LIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILA-YPPVVAGGNRSNTLhyVK 238
Cdd:PRK14575  171 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrFHLISVGADFSPKL--IP 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 239 NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTlmgqklk 318
Cdd:PRK14575  249 SNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTME------- 320
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958791399 319 dlgIIKTSKESAFKaaRKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIY 375
Cdd:PRK14575  321 ---VIKKSGLPNYN--RGHLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYY 372
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
235-409 1.03e-05

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 46.72  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 235 HYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAElyeAVLEIQKACLTLcspgtSLENIysmmltLMG 314
Cdd:cd01086    68 HGIPDDRVLKDGDIVNIDVGVELDGYHGDSARTFIVGE--VSEEAK---KLVEVTEEALYK-----GIEAV------KPG 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 315 QKLKDLG--IIKTSKESAFKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQPGMVITVEPgiYIPEGDTDapek 386
Cdd:cd01086   132 NRIGDIGhaIEKYAEKNGYSVVREFG----GHGIGRKFHEEPQIPnygrpgTGPKLKPGMVFTIEP--MINLGTYE---- 201
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958791399 387 frglgVRIEDD------------------VVVTQDSPLILS 409
Cdd:cd01086   202 -----VVTLPDgwtvvtkdgslsaqfehtVLITEDGPEILT 237
PRK07281 PRK07281
methionyl aminopeptidase;
342-410 4.28e-05

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 45.22  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 342 VGHYLGMDVHDTPDMP------RSLPLQPGMVITVEPGIYIP--EGDTDAPEKFR------GLGVRIEDDVVVTQDSPLI 407
Cdd:PRK07281  197 VGHGVGPTMHEEPMVPnygtagRGLRLREGMVLTIEPMINTGtwEIDTDMKTGWAhktldgGLSCQYEHQFVITKDGPVI 276

                  ...
gi 1958791399 408 LSA 410
Cdd:PRK07281  277 LTS 279
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
167-408 8.82e-05

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 43.67  E-value: 8.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 167 IKSPAEIKRMQIAGKLTSEAfIETMFASKAP---VDEAFLYAKfEFECR--ARGADILAYP----------PVVAggnrs 231
Cdd:PRK12896   10 IKSPRELEKMRKIGRIVATA-LKEMGKAVEPgmtTKELDRIAE-KRLEEhgAIPSPEGYYGfpgstcisvnEEVA----- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 232 ntlHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVngrftAPQAElyeavlEIQKacltLCSPGTSleniySMMLT 311
Cdd:PRK12896   83 ---HGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAV-----GPVSE------EAEK----LCRVAEE-----ALWAG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 312 LM----GQKLKDLG--IIKTSKESAFKAARKYCPHHVGHYL--GMDV--HDTPDMPRSLpLQPGMVITVEPgiYIPEGDT 381
Cdd:PRK12896  140 IKqvkaGRPLNDIGraIEDFAKKNGYSVVRDLTGHGVGRSLheEPSVilTYTDPLPNRL-LRPGMTLAVEP--FLNLGAK 216
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958791399 382 DAPE---------KFRGLGVRIEDDVVVTQDSPLIL 408
Cdd:PRK12896  217 DAETlddgwtvvtPDKSLSAQFEHTVVVTRDGPEIL 252
PRK14576 PRK14576
putative endopeptidase; Provisional
160-409 1.41e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 43.85  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 160 LIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEfecrargADILAYPP--------VVAGGNRS 231
Cdd:PRK14576  170 LFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFK-------AAVMSFPEtnfsrfnlISVGDNFS 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 232 NTLhyVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSmmlt 311
Cdd:PRK14576  243 PKI--IADTTPAKVGDLIKFDCGIDVAGYGADLARTF-VLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFD---- 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 312 lmgqklKDLGIIKTSKESAFKaaRKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYipegdtdapekfrGLG 391
Cdd:PRK14576  316 ------STMAVIKTSGLPHYN--RGHLGHGDGVFLGLEEVPFVSTQATETFCPGMVLSLETPYY-------------GIG 374
                         250       260
                  ....*....|....*....|.
gi 1958791399 392 V---RIEDDVVVTQDSPLILS 409
Cdd:PRK14576  375 VgsiMLEDMILITDSGFEFLS 395
PRK12318 PRK12318
methionyl aminopeptidase;
162-374 1.63e-04

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 43.27  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 162 QHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPV-----DEafLYAKFEFECRARGADI----LAYPPVVAGGNRSN 232
Cdd:PRK12318   38 QYDIIIKTPEQIEKIRKACQVTARILDALCEAAKEGVttnelDE--LSRELHKEYNAIPAPLnygsPPFPKTICTSLNEV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 233 TLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIysmmltl 312
Cdd:PRK12318  116 ICHGIPNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMI-GEVSEIKKKVCQASLECLNAAIAILKPGIPLYEI------- 187
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 313 mGQKLKDLgiiktskesafkAARKYCP---HHVGHYLGMDVHDTPDMPR-----SLPLQPGMVITVEPGI 374
Cdd:PRK12318  188 -GEVIENC------------ADKYGFSvvdQFVGHGVGIKFHENPYVPHhrnssKIPLAPGMIFTIEPMI 244
COG5406 COG5406
Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and ...
246-419 1.21e-03

Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics];


Pssm-ID: 227693 [Multi-domain]  Cd Length: 1001  Bit Score: 41.15  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  246 GEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLG--II 323
Cdd:COG5406    270 GDVVLLSIGIRYNGYCSNMSRTILTDP--DSEQQKNYEFLYMLQKYILGLVRPGTDSGIIYSEAEKYISSNGPELGpnFI 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399  324 KTskesafkaarkycphhVGHYLGMDVHD-----TPDMPRSlpLQPGMVITvepgIYIPEGDTDAPEKFRGLGVRIEDDV 398
Cdd:COG5406    348 YN----------------VGLMIGIEFRSsqkpfNVKNGRV--LQAGCIFN----ISLGFGNLINPHPKNNYALLLIDTE 405
                          170       180
                   ....*....|....*....|.
gi 1958791399  399 VVTQDSPLILSaDCPKEVNDI 419
Cdd:COG5406    406 QISLSNPIVFT-DSPKAQGDI 425
PRK12897 PRK12897
type I methionyl aminopeptidase;
312-409 2.05e-03

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 39.63  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958791399 312 LMGQKLKDLGIIKTS--KESAFKAARKYcphhVGHYLGMDVHDTPDM------PRSLPLQPGMVITVEP----GIYIPEG 379
Cdd:PRK12897  138 VIGNRVGDIGYAIESyvANEGFSVARDF----TGHGIGKEIHEEPAIfhfgkqGQGPELQEGMVITIEPivnvGMRYSKV 213
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958791399 380 DTD--APEKFRG-LGVRIEDDVVVTQDSPLILS 409
Cdd:PRK12897  214 DLNgwTARTMDGkLSAQYEHTIAITKDGPIILT 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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