T-cell surface glycoprotein CD3 delta chain isoform X1 [Rattus norvegicus]
Protein Classification
ITAM domain-containing protein( domain architecture ID 10490289)
ITAM domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ITAM | pfam02189 | Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ... |
73-92 | 2.25e-06 | ||
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains. : Pssm-ID: 426646 Cd Length: 20 Bit Score: 40.44 E-value: 2.25e-06
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| Name | Accession | Description | Interval | E-value | ||
| ITAM | pfam02189 | Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ... |
73-92 | 2.25e-06 | ||
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains. Pssm-ID: 426646 Cd Length: 20 Bit Score: 40.44 E-value: 2.25e-06
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| ITAM | smart00077 | Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ... |
73-93 | 1.00e-04 | ||
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. Pssm-ID: 128390 Cd Length: 21 Bit Score: 36.21 E-value: 1.00e-04
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| Name | Accession | Description | Interval | E-value | ||
| ITAM | pfam02189 | Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ... |
73-92 | 2.25e-06 | ||
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains. Pssm-ID: 426646 Cd Length: 20 Bit Score: 40.44 E-value: 2.25e-06
|
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| ITAM | smart00077 | Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ... |
73-93 | 1.00e-04 | ||
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. Pssm-ID: 128390 Cd Length: 21 Bit Score: 36.21 E-value: 1.00e-04
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| Blast search parameters | ||||
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