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Conserved domains on  [gi|1958646987|ref|XP_038937062|]
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A-kinase anchor protein 7 isoforms delta and gamma isoform X2 [Rattus norvegicus]

Protein Classification

AKAP7 2'5' RNA ligase-like domain-containing protein( domain architecture ID 12106234)

AKAP7 (A-kinase anchoring protein 7) 2'5' RNA ligase-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 126-275 1.90e-48

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 159.74  E-value: 1.90e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646987 126 PNYFLSIPITNKKITAGIKVLQNSILRQDNRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 204
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646987 205 LTLPFHGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGESRT-FKPHLTFMKLSKAPMLWKK 275
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAK 157
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 126-275 1.90e-48

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 159.74  E-value: 1.90e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646987 126 PNYFLSIPITNKKITAGIKVLQNSILRQDNRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 204
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646987 205 LTLPFHGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGESRT-FKPHLTFMKLSKAPMLWKK 275
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAK 157
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 128-262 1.04e-04

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 41.94  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646987 128 YFLSIPItNKKITAGIKVLQNSILRQDN-RLTKAmvgdGSFHITLLVMQLLNEDEV----NIGTDALLELKPFveeileg 202
Cdd:COG1514     3 LFIALPP-PEELREALAALRARLKAAPGgRWVRP----ENLHLTLAFLGEVDEERLealaEALARAAAGAPPF------- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958646987 203 khlTLPFHGIGTFQGQVG---FVKLADGDhvsALLEIAETAKRTFQEKGiLAGESRTFKPHLT 262
Cdd:COG1514    71 ---ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT 126
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 126-275 1.90e-48

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 159.74  E-value: 1.90e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646987 126 PNYFLSIPITNKKITAGIKVLQNSILRQDNRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 204
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646987 205 LTLPFHGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGESRT-FKPHLTFMKLSKAPMLWKK 275
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAK 157
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 128-262 1.04e-04

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 41.94  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646987 128 YFLSIPItNKKITAGIKVLQNSILRQDN-RLTKAmvgdGSFHITLLVMQLLNEDEV----NIGTDALLELKPFveeileg 202
Cdd:COG1514     3 LFIALPP-PEELREALAALRARLKAAPGgRWVRP----ENLHLTLAFLGEVDEERLealaEALARAAAGAPPF------- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958646987 203 khlTLPFHGIGTFQGQVG---FVKLADGDhvsALLEIAETAKRTFQEKGiLAGESRTFKPHLT 262
Cdd:COG1514    71 ---ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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