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Conserved domains on  [gi|1958646998|ref|XP_038937096|]
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5'-deoxynucleotidase HDDC2 isoform X2 [Rattus norvegicus]

Protein Classification

HD domain-containing protein( domain architecture ID 10586555)

HD domain-containing protein may function as a metal dependent phosphohydrolase; similar to Homo sapiens 5'-deoxynucleotidase HDDC2, which catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)

CATH:  3.30.70.1370
EC:  3.1.-.-
Gene Ontology:  GO:0042578|GO:0046872
PubMed:  9868367
SCOP:  3000943

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 1-131 1.29e-32

HD domain; HD domains are metal dependent phosphohydrolases.


:

Pssm-ID: 432939  Cd Length: 163  Bit Score: 113.46  E-value: 1.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646998   1 MYRMAVMAMVTRD--DRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKEITQLLPEDLRKELYELWEE 78
Cdd:pfam13023  27 SWRMALMAMLLAEyaGPVDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEEREREAAERIFGLLPEDQGEELLALWDE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646998  79 YETQSSEEARFVKQLDQCEMILQASEYEDMENKPG--RLQDFYDSTAGKFS--HPEI 131
Cdd:pfam13023 107 FEARETPEAKFAKDLDKLEPLLQNLEYEGDSWAAFeaDLSQFYGRNSTILAegSPEL 163
 
Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 1-131 1.29e-32

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 432939  Cd Length: 163  Bit Score: 113.46  E-value: 1.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646998   1 MYRMAVMAMVTRD--DRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKEITQLLPEDLRKELYELWEE 78
Cdd:pfam13023  27 SWRMALMAMLLAEyaGPVDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEEREREAAERIFGLLPEDQGEELLALWDE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646998  79 YETQSSEEARFVKQLDQCEMILQASEYEDMENKPG--RLQDFYDSTAGKFS--HPEI 131
Cdd:pfam13023 107 FEARETPEAKFAKDLDKLEPLLQNLEYEGDSWAAFeaDLSQFYGRNSTILAegSPEL 163
YfbR COG1896
5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and ...
 1-125 1.18e-18

5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 441500  Cd Length: 162  Bit Score: 77.21  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646998   1 MYRMAVMAMV---TRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKEITQLLPEDLRKELYELWE 77
Cdd:COG1896    32 SWHVALIAHLladIANEGVDPERVAKMALLHDLVEIDTGDIPTPVKYANEAKKEIERAAAERLFGLLPEELREEFRALWD 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958646998  78 EYETQSSEEARFVKQLDQCEMILQASEYEDMENKPGRLQDFYDSTAGK 125
Cdd:COG1896   112 EFEAGETPEARFVKAADKLEALLQALEEIGAGNKENTFEQAYERLLKK 159
 
Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 1-131 1.29e-32

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 432939  Cd Length: 163  Bit Score: 113.46  E-value: 1.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646998   1 MYRMAVMAMVTRD--DRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKEITQLLPEDLRKELYELWEE 78
Cdd:pfam13023  27 SWRMALMAMLLAEyaGPVDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEEREREAAERIFGLLPEDQGEELLALWDE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958646998  79 YETQSSEEARFVKQLDQCEMILQASEYEDMENKPG--RLQDFYDSTAGKFS--HPEI 131
Cdd:pfam13023 107 FEARETPEAKFAKDLDKLEPLLQNLEYEGDSWAAFeaDLSQFYGRNSTILAegSPEL 163
YfbR COG1896
5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and ...
 1-125 1.18e-18

5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 441500  Cd Length: 162  Bit Score: 77.21  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958646998   1 MYRMAVMAMV---TRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKEITQLLPEDLRKELYELWE 77
Cdd:COG1896    32 SWHVALIAHLladIANEGVDPERVAKMALLHDLVEIDTGDIPTPVKYANEAKKEIERAAAERLFGLLPEELREEFRALWD 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958646998  78 EYETQSSEEARFVKQLDQCEMILQASEYEDMENKPGRLQDFYDSTAGK 125
Cdd:COG1896   112 EFEAGETPEARFVKAADKLEALLQALEEIGAGNKENTFEQAYERLLKK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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