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Conserved domains on  [gi|1958797508|ref|XP_038937891|]
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GDNF family receptor alpha-like isoform X1 [Rattus norvegicus]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-330 2.23e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 251 CLEVTEACVGDVVCNAQLALYLKACTANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 323
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 1958797508 324 TLHSKPC 330
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 340-436 1.88e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 340 CLSVIHTCRNDELCRTYYRTFQTECWPHvagkcreDETCismlgkqdLTCSGSDSCRAAYLGTF------GTVLQVPCAC 413
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPS-------PESC--------SGCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 1958797508 414 RSITQgEEPLCMAFQHMLHSKSC 436
Cdd:pfam02351  66 KGSGN-QDEECEEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-330 2.23e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 251 CLEVTEACVGDVVCNAQLALYLKACTANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 323
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 1958797508 324 TLHSKPC 330
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 340-436 1.88e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 340 CLSVIHTCRNDELCRTYYRTFQTECWPHvagkcreDETCismlgkqdLTCSGSDSCRAAYLGTF------GTVLQVPCAC 413
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPS-------PESC--------SGCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 1958797508 414 RSITQgEEPLCMAFQHMLHSKSC 436
Cdd:pfam02351  66 KGSGN-QDEECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 340-436 4.78e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 56.11  E-value: 4.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508  340 CLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCRED--ETCISMLgkqdltcsGSDSCRAAYLGTfgTVLQVPCACRSit 417
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAY--------CGLALRPFYDDN--SSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 1958797508  418 qGEEPLCMAFQHMLHSKSC 436
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-330 7.22e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 52.64  E-value: 7.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508  251 CLEVTEACVGDVVCNAQLALYLKACTA---------NGNLCDVKHCQAAIRFFYQnmpfNTAQMLAFCDCA-QSDIPCQQ 320
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgeNSEACLRAYCGLALRPFYD----DNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 1958797508  321 SKETLHSKPC 330
Cdd:smart00907  77 FRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-330 2.23e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 251 CLEVTEACVGDVVCNAQLALYLKACTANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 323
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 1958797508 324 TLHSKPC 330
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 340-436 1.88e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508 340 CLSVIHTCRNDELCRTYYRTFQTECWPHvagkcreDETCismlgkqdLTCSGSDSCRAAYLGTF------GTVLQVPCAC 413
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPS-------PESC--------SGCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 1958797508 414 RSITQgEEPLCMAFQHMLHSKSC 436
Cdd:pfam02351  66 KGSGN-QDEECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 340-436 4.78e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 56.11  E-value: 4.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508  340 CLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCRED--ETCISMLgkqdltcsGSDSCRAAYLGTfgTVLQVPCACRSit 417
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAY--------CGLALRPFYDDN--SSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 1958797508  418 qGEEPLCMAFQHMLHSKSC 436
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-330 7.22e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 52.64  E-value: 7.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797508  251 CLEVTEACVGDVVCNAQLALYLKACTA---------NGNLCDVKHCQAAIRFFYQnmpfNTAQMLAFCDCA-QSDIPCQQ 320
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgeNSEACLRAYCGLALRPFYD----DNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 1958797508  321 SKETLHSKPC 330
Cdd:smart00907  77 FRRLFHSNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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