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Conserved domains on  [gi|1958647231|ref|XP_038937925|]
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leucine-rich repeat LGI family member 4 isoform X2 [Rattus norvegicus]

Protein Classification

LRR 8 and EPTP domain-containing protein( domain architecture ID 10509911)

LRR (Leucine rich repeat) 8 and EPTP (Epitempin) domain-containing protein, similar to Homo sapiens leucine-rich glioma inactivated-1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 162-203 8.85e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 8.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958647231 162 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 203
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 207-246 1.27e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 35.91  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958647231 207 MFRLLQQLPSRGSHVFQPLLIASDQLAILGSDFAFSQVFR 246
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 162-203 8.85e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 8.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958647231 162 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 203
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 207-246 1.27e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 35.91  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958647231 207 MFRLLQQLPSRGSHVFQPLLIASDQLAILGSDFAFSQVFR 246
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 162-203 8.85e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 8.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958647231 162 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 203
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 207-246 1.27e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 35.91  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958647231 207 MFRLLQQLPSRGSHVFQPLLIASDQLAILGSDFAFSQVFR 246
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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