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Conserved domains on  [gi|1958803298|ref|XP_038939864|]
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DENN domain-containing protein 1C isoform X1 [Rattus norvegicus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 93-293 4.01e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.97  E-value: 4.01e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298   93 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 172
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  173 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 252
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803298  253 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-87 3.89e-18

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 79.69  E-value: 3.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298    9 PSAVFDWFFEAG-----RPNSLEEDPLILRKFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNR 80
Cdd:smart00800   1 PSRLFDYFVVVGldsdtGPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSR 80


                   ....*..
gi 1958803298   81 RFGFCRL 87
Cdd:smart00800  81 RYGFCLR 87
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 325-391 1.37e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.37e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  325 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 391
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 589-768 3.07e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 589 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 659
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 660 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 733
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803298 734 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 768
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 93-293 4.01e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.97  E-value: 4.01e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298   93 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 172
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  173 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 252
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803298  253 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 94-293 3.23e-37

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 137.70  E-value: 3.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  94 CLCILSHLPWFEVFYKILNTVGDLLAQNQVteaEELLQNLQQHPYLGPGFsggPKTDSSItswsecgILPPALGNSKLLS 173
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIANLLYEVPF---PPPGRTQ-------KLKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 174 CFvaPDAAGLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 253
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958803298 254 HLLDYCCAPMPYLIGVHSSLAErVREKALEDVVVLNADSN 293
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-87 3.89e-18

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 79.69  E-value: 3.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298    9 PSAVFDWFFEAG-----RPNSLEEDPLILRKFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNR 80
Cdd:smart00800   1 PSRLFDYFVVVGldsdtGPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSR 80


                   ....*..
gi 1958803298   81 RFGFCRL 87
Cdd:smart00800  81 RYGFCLR 87
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 325-391 1.37e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.37e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  325 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 391
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 29-87 2.45e-12

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 62.24  E-value: 2.45e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  29 PLILRKFPPDFQEQEAM-QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 87
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLpDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 357-408 4.27e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.19  E-value: 4.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958803298 357 FSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESRLEKLNageGFSDQFEQE 408
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 589-768 3.07e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 589 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 659
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 660 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 733
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803298 734 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 768
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
PHA03247 PHA03247
large tegument protein UL36; Provisional
 584-743 2.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  584 ASESCSSLPdipvgSPWQLEEDRRSQDPQLQSLPGDLSPLQDTPFSEVVSYSKNCPQPPSDISSLPTSSATSADPPSQRD 663
Cdd:PHA03247  2791 LSESRESLP-----SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  664 PGPSSSSKLDPTPSQSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQVLLSQACIQP 743
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 93-293 4.01e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.97  E-value: 4.01e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298   93 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 172
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  173 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 252
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803298  253 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 94-293 3.23e-37

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 137.70  E-value: 3.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  94 CLCILSHLPWFEVFYKILNTVGDLLAQNQVteaEELLQNLQQHPYLGPGFsggPKTDSSItswsecgILPPALGNSKLLS 173
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIANLLYEVPF---PPPGRTQ-------KLKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 174 CFvaPDAAGLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 253
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958803298 254 HLLDYCCAPMPYLIGVHSSLAErVREKALEDVVVLNADSN 293
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-87 3.89e-18

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 79.69  E-value: 3.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298    9 PSAVFDWFFEAG-----RPNSLEEDPLILRKFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNR 80
Cdd:smart00800   1 PSRLFDYFVVVGldsdtGPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSR 80


                   ....*..
gi 1958803298   81 RFGFCRL 87
Cdd:smart00800  81 RYGFCLR 87
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 325-391 1.37e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.37e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  325 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 391
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 29-87 2.45e-12

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 62.24  E-value: 2.45e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  29 PLILRKFPPDFQEQEAM-QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 87
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLpDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 357-408 4.27e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.19  E-value: 4.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958803298 357 FSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESRLEKLNageGFSDQFEQE 408
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 589-768 3.07e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 589 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 659
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 660 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 733
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803298 734 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 768
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
PHA03247 PHA03247
large tegument protein UL36; Provisional
 584-743 2.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  584 ASESCSSLPdipvgSPWQLEEDRRSQDPQLQSLPGDLSPLQDTPFSEVVSYSKNCPQPPSDISSLPTSSATSADPPSQRD 663
Cdd:PHA03247  2791 LSESRESLP-----SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298  664 PGPSSSSKLDPTPSQSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQVLLSQACIQP 743
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 573-743 2.20e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 573 ASQSLDCCQQGASESCSSLPDIPVGSPWQleedRRSQDPQLQSLPGDLSPLQDTPFSEV-VSYSKNCPQPPSDISSLPTS 651
Cdd:pfam03154 294 PPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPApLSMPHIKPPPTTPIPQLPNP 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 652 SAtSADPPSQRDPGP-SSSSKLDPTPSQSPCSR-TLRVPTQPTPPKSQLLastePNSDTVQKlQPIQSPLCSQSKENP-- 727
Cdd:pfam03154 370 QS-HKHPPHLSGPSPfQMNSNLPPPPALKPLSSlSTHHPPSAHPPPLQLM----PQSQQLPP-PPAQPPVLTQSQSLPpp 443

                         170
                  ....*....|....*..
gi 1958803298 728 -RNQPPQVLLSQACIQP 743
Cdd:pfam03154 444 aASHPPTSGLHQVPSQS 460
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 565-731 4.80e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 565 IKSGGQLRASQSLDCCQQGASESCSSLPDIPVGSPwqleEDRRSQDPQLQSLPgdLSPLqdTPFSEVVSYSKNCPQPPSD 644
Cdd:PLN03209  389 TPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVP----EVEPAQVEAKKTRP--LSPY--ARYEDLKPPTSPSPTAPTG 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 645 ISSLPTSSATSADPPSQRDPGPSSSSKLDPTPSQSPCS-----RTLRVPTQPTP--PKSQLLASTEPNSDTVQKLQPIQS 717
Cdd:PLN03209  461 VSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSpyavyDDLKPPTSPSPaaPVGKVAPSSTNEVVKVGNSAPPTA 540

                         170
                  ....*....|....
gi 1958803298 718 PLCSQSKENPRNQP 731
Cdd:PLN03209  541 LADEQHHAQPKPRP 554
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 582-746 5.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 582 QGASESCSSLPDIPVGSPWQLEEDRRSQDPQLQSlPGDLSPLQDTPFSEVVSYSkncpQPPSDISSLPTSSatsadPPSQ 661
Cdd:pfam03154 117 EGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPS-PQDNESDSDSSAQQQILQT----QPPVLQAQSGAAS-----PPSP 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803298 662 RDPGPSSSSKLDPTPSqspcsrTLRVPTQPTPPKSQLLASTEPnsdTVQKLQPIQSPLCSQSKENPRNQPPQVLL----- 736
Cdd:pfam03154 187 PPPGTTQAATAGPTPS------APSVPPQGSPATSQPPNQTQS---TAAPHTLIQQTPTLHPQRLPSPHPPLQPMtqppp 257

                         170
                  ....*....|.
gi 1958803298 737 -SQACIQPLKE 746
Cdd:pfam03154 258 pSQVSPQPLPQ 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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