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Conserved domains on  [gi|1958803302|ref|XP_038939866|]
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DENN domain-containing protein 1C isoform X4 [Rattus norvegicus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 49-249 3.24e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.58  E-value: 3.24e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302   49 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 128
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  129 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 208
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803302  209 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 249
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 281-347 1.30e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.30e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  281 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 347
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-43 1.53e-11

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 60.81  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958803302    1 MQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGFCRL 43
Cdd:smart00800  43 PDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGFCLR 87
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 552-731 3.16e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 552 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 622
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 623 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 696
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803302 697 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 731
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 49-249 3.24e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.58  E-value: 3.24e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302   49 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 128
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  129 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 208
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803302  209 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 249
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 50-249 3.08e-37

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 137.70  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  50 CLCILSHLPWFEVFYKILNTVGDLLAQNQVteaEELLQNLQQHPYLGPGFsggPKTDSSItswsecgILPPALGNSKLLS 129
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIANLLYEVPF---PPPGRTQ-------KLKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 130 CFvaPDAAGLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 209
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958803302 210 HLLDYCCAPMPYLIGVHSSLAErVREKALEDVVVLNADSN 249
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 281-347 1.30e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.30e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  281 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 347
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-43 1.53e-11

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 60.81  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958803302    1 MQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGFCRL 43
Cdd:smart00800  43 PDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGFCLR 87
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 2-43 3.65e-09

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 53.38  E-value: 3.65e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958803302   2 QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 43
Cdd:pfam03456  19 DGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 313-364 2.15e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.96  E-value: 2.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958803302 313 FSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESRLEKLNageGFSDQFEQE 364
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 552-731 3.16e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 552 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 622
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 623 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 696
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803302 697 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 731
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-706 1.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  547 ASESCSSLPdipvgSPWQLEEDRRSQDPQLQSLPGDLSPLQDTPFSEVVSYSKNCPQPPSDISSLPTSSATSADPPSQRD 626
Cdd:PHA03247  2791 LSESRESLP-----SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  627 PGPSSSSKLDPTPSQSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQVLLSQACIQP 706
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 49-249 3.24e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 203.58  E-value: 3.24e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302   49 SCLCILSHLPWFEVFYKILNTVGDLLAQNQVTEaEELLQNLQQHPYLGPGfsgGPKTDSSItswsecgilppalgNSKLL 128
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPG---GSLVLVSL--------------GPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  129 SCFVAPDAAGLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLP 208
Cdd:smart00799  65 IELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILP 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958803302  209 PHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSN 249
Cdd:smart00799 143 ASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 50-249 3.08e-37

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 137.70  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  50 CLCILSHLPWFEVFYKILNTVGDLLAQNQVteaEELLQNLQQHPYLGPGFsggPKTDSSItswsecgILPPALGNSKLLS 129
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIANLLYEVPF---PPPGRTQ-------KLKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 130 CFvaPDAAGLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 209
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958803302 210 HLLDYCCAPMPYLIGVHSSLAErVREKALEDVVVLNADSN 249
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 281-347 1.30e-15

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 71.94  E-value: 1.30e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  281 GEGVSRLFLKAQALLFGGYRDALVCI---PGQPVTFSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESR 347
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELrkePGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-43 1.53e-11

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 60.81  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958803302    1 MQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGFCRL 43
Cdd:smart00800  43 PDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGFCLR 87
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 2-43 3.65e-09

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 53.38  E-value: 3.65e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958803302   2 QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 43
Cdd:pfam03456  19 DGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 313-364 2.15e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.96  E-value: 2.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958803302 313 FSEEAFLAQKPGAPlQAFHKKAVHLQLFKQFIESRLEKLNageGFSDQFEQE 364
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 552-731 3.16e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 552 SSLPDIPvgSPWQLEEDRRS---------QDPQLQSLPGDLSPLQdTPFSEVVSYSKNCPqPPSDISSLPTSSATSADPP 622
Cdd:pfam03154 143 STSPSIP--SPQDNESDSDSsaqqqilqtQPPVLQAQSGAASPPS-PPPPGTTQAATAGP-TPSAPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 623 SQRDPGPSSSSKLDPTPS----QSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQ-- 696
Cdd:pfam03154 219 NQTQSTAAPHTLIQQTPTlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQpf 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958803302 697 ---VLLSQACIQPLKELGAPTSyvSHVGKHQEPQDRQP 731
Cdd:pfam03154 299 pltPQSSQSQVPPGPSPAAPGQ--SQQRIHTPPSQSQL 334
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-706 1.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  547 ASESCSSLPdipvgSPWQLEEDRRSQDPQLQSLPGDLSPLQDTPFSEVVSYSKNCPQPPSDISSLPTSSATSADPPSQRD 626
Cdd:PHA03247  2791 LSESRESLP-----SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302  627 PGPSSSSKLDPTPSQSPCSRTLRVPTQPTPPKSQLLASTEPNSDTVQKLQPIQSPLCSQSKENPRNQPPQVLLSQACIQP 706
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 536-706 2.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 536 ASQSLDCCQQGASESCSSLPDIPVGSPWQleedRRSQDPQLQSLPGDLSPLQDTPFSEV-VSYSKNCPQPPSDISSLPTS 614
Cdd:pfam03154 294 PPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPApLSMPHIKPPPTTPIPQLPNP 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 615 SAtSADPPSQRDPGP-SSSSKLDPTPSQSPCSR-TLRVPTQPTPPKSQLLastePNSDTVQKlQPIQSPLCSQSKENP-- 690
Cdd:pfam03154 370 QS-HKHPPHLSGPSPfQMNSNLPPPPALKPLSSlSTHHPPSAHPPPLQLM----PQSQQLPP-PPAQPPVLTQSQSLPpp 443

                         170
                  ....*....|....*..
gi 1958803302 691 -RNQPPQVLLSQACIQP 706
Cdd:pfam03154 444 aASHPPTSGLHQVPSQS 460
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 545-709 5.11e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 545 QGASESCSSLPDIPVGSPWQLEEDRRSQDPQLQSlPGDLSPLQDTPFSEVVSYSkncpQPPSDISSLPTSSatsadPPSQ 624
Cdd:pfam03154 117 EGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPS-PQDNESDSDSSAQQQILQT----QPPVLQAQSGAAS-----PPSP 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 625 RDPGPSSSSKLDPTPSqspcsrTLRVPTQPTPPKSQLLASTEPnsdTVQKLQPIQSPLCSQSKENPRNQPPQVLL----- 699
Cdd:pfam03154 187 PPPGTTQAATAGPTPS------APSVPPQGSPATSQPPNQTQS---TAAPHTLIQQTPTLHPQRLPSPHPPLQPMtqppp 257

                         170
                  ....*....|.
gi 1958803302 700 -SQACIQPLKE 709
Cdd:pfam03154 258 pSQVSPQPLPQ 268
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 536-694 5.27e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 536 ASQSLDCCQQGASESCSSLPDIPVGSPwqleEDRRSQDPQLQSLPgdLSPLqdTPFSEVVSYSKNCPQPPSDISSLPTSS 615
Cdd:PLN03209  397 SSKSVDAVAKPAEPDVVPSPGSASNVP----EVEPAQVEAKKTRP--LSPY--ARYEDLKPPTSPSPTAPTGVSPSVSST 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803302 616 ATSADPPSQRDPGPSSSSKLDPTPSQSPCS-----RTLRVPTQPTP--PKSQLLASTEPNSDTVQKLQPIQSPLCSQSKE 688
Cdd:PLN03209  469 SSVPAVPDTAPATAATDAAAPPPANMRPLSpyavyDDLKPPTSPSPaaPVGKVAPSSTNEVVKVGNSAPPTALADEQHHA 548


                  ....*.
gi 1958803302 689 NPRNQP 694
Cdd:PLN03209  549 QPKPRP 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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