NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958804544|ref|XP_038940377|]
View 

disheveled-associated activator of morphogenesis 2 isoform X1 [Rattus norvegicus]

Protein Classification

formin homology family protein( domain architecture ID 10273102)

formin homology family protein is a cytoskeletal remodeling protein that may be involved a diverse array of cellular functions including the regulation of actin dynamics as well as the stability and organization of microtubules

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
587-1008 5.36e-127

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 392.40  E-value: 5.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  587 KKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQrhqgcmqegaqrergnvrdggtasrs 666
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRGTVWDKLDDESFELDGDLSELEELFSAKA-------------------------- 54
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  667 lpaaetndhrtekasrsmvsatgVKKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRRAILRMDEqE 746
Cdd:pfam02181   55 -----------------------KTKKNKKSEDKSSSKKKPKEVSLLDPKRAQNIAILLRKLKLPPEEIIQAILEGDE-D 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  747 DLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 826
Cdd:pfam02181  111 ALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAAS 190
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  827 QELTLSKRLKKMLEVVLAIGNFMNKGQ-RGGAYGFRVASLNKIADTKSSiDRNISLLHYLIMILEKHFPDILNMPSELLH 905
Cdd:pfam02181  191 EELRNSRKFKKLLELILALGNYMNDGTrRGQAKGFKLSSLLKLSDTKST-DNKTTLLHYLVKIIREKFPEVLDFSSELSH 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  906 LSKAAKVNLAELEKEVGALRRGLRAVEVELEYQRQQaRDPNDKFVPVMSDFITVSSFSFSELEEQLNEARDKFAKALAHF 985
Cdd:pfam02181  270 VKKAAKVNLEQLEKDVKQLERGLKKLERELELSALD-EHPDDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYF 348
                          410       420
                   ....*....|....*....|...
gi 1958804544  986 GEQDSKMQPDEFFGIFDTFLQAF 1008
Cdd:pfam02181  349 GEDPKETSPEEFFKILRDFLKEF 371
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
231-435 3.14e-63

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


:

Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 212.90  E-value: 3.14e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  231 GGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSlgrYRDEVNLKTAIMSFINAVLNAGageDNLEFRLHLRYEFLMLGIQ 310
Cdd:pfam06367    1 GGHEKVLEATLNFKEVCRERGRFQSLVGALDSS---ENDNVEYKVATMQFINALVNSP---EDLQFRLHLRSEFTALGLD 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  311 PVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMpYKR 390
Cdd:pfam06367   75 RILDKLRELENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLI-RDD 153
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958804544  391 NGGYFQQWQLLDRILQQIVLQDErgvDPDLAPLENFNVKNIVNML 435
Cdd:pfam06367  154 EEELPSYWKLLEELVSQIVLHRT---KPDPKFDERKNLEIDINRL 195
Drf_GBD super family cl05720
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
41-228 1.18e-48

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


The actual alignment was detected with superfamily member pfam06371:

Pssm-ID: 461886  Cd Length: 188  Bit Score: 171.35  E-value: 1.18e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   41 PIPNPEELNVCFAELVDELDLTDKNREAVFALPPEKKWQIYCSKK----KEQEDPNKL-----ATSWPEFYIDRINAmat 111
Cdd:pfam06371    2 PKPDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKstnfQKEGGGSKSdsesnETGSPEYYVKKLKD--- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  112 mqnlydtedeeTDKRSQVVEDLKTALRTQPMRFVTRFIELEGLSCLLNFLRGMDHATCESR----IHTSLIGCIKALMNN 187
Cdd:pfam06371   79 -----------DSISSKQLESLRVALRTQPLSWVRRFIEAQGLGALLNVLSKINRKKSQEEedldREYEILKCLKALMNN 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958804544  188 SQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCL 228
Cdd:pfam06371  148 KFGLDHVLGHPSSIDLLVQSLDSERLKTRKLVLELLTALCL 188
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
587-1008 5.36e-127

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 392.40  E-value: 5.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  587 KKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQrhqgcmqegaqrergnvrdggtasrs 666
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRGTVWDKLDDESFELDGDLSELEELFSAKA-------------------------- 54
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  667 lpaaetndhrtekasrsmvsatgVKKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRRAILRMDEqE 746
Cdd:pfam02181   55 -----------------------KTKKNKKSEDKSSSKKKPKEVSLLDPKRAQNIAILLRKLKLPPEEIIQAILEGDE-D 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  747 DLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 826
Cdd:pfam02181  111 ALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAAS 190
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  827 QELTLSKRLKKMLEVVLAIGNFMNKGQ-RGGAYGFRVASLNKIADTKSSiDRNISLLHYLIMILEKHFPDILNMPSELLH 905
Cdd:pfam02181  191 EELRNSRKFKKLLELILALGNYMNDGTrRGQAKGFKLSSLLKLSDTKST-DNKTTLLHYLVKIIREKFPEVLDFSSELSH 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  906 LSKAAKVNLAELEKEVGALRRGLRAVEVELEYQRQQaRDPNDKFVPVMSDFITVSSFSFSELEEQLNEARDKFAKALAHF 985
Cdd:pfam02181  270 VKKAAKVNLEQLEKDVKQLERGLKKLERELELSALD-EHPDDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYF 348
                          410       420
                   ....*....|....*....|...
gi 1958804544  986 GEQDSKMQPDEFFGIFDTFLQAF 1008
Cdd:pfam02181  349 GEDPKETSPEEFFKILRDFLKEF 371
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
588-1070 1.42e-71

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 243.80  E-value: 1.42e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   588 KRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQvfrILDLEDFEKMFSAYQRHQgcmqegaqrergnvrdggtaSRSL 667
Cdd:smart00498    1 KKEPKPKKKLKPLHWDKLNPSDLSGTVWDKIDEES---EGDLDELEELFSAKEKTK--------------------SASK 57
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   668 PAAETndhrtekasrsmvsatgvkkelgsteDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRRAILRMDEqED 747
Cdd:smart00498   58 DVSEK--------------------------KSILKKKASQEFKILDPKRSQNLAILLRKLHMSYEEIKEAILEGDE-DV 110
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   748 LAKDMLEQLLKFIPEKSDVDLLEEHKHE-IERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 826
Cdd:smart00498  111 LSVDLLEQLLKYAPTKEELKKLREYKEEdPEELARAEQFLLLISNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAAC 190
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   827 QELTLSKRLKKMLEVVLAIGNFMNKG-QRGGAYGFRVASLNKIADTKSSiDRNISLLHYLIMILEKHFpdilnmpsellh 905
Cdd:smart00498  191 EELRESKKFRKLLELILAIGNYMNGGsRRGQAYGFKLSSLLKLSDVKSA-DNKTTLLHFLVKIIRKKY------------ 257
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   906 lskaakvnlaelekevgalRRGLRAVEveleyqrqqarDPNDKFVPVMSDFITVSSFSFSELEEQLNEARDKFAKALAHF 985
Cdd:smart00498  258 -------------------LGGLSDPE-----------NLDDKFIEVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYY 307
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   986 GEQDSKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMESMLKEQ---REKERWQRQRKVLVGGALeesGEF 1062
Cdd:smart00498  308 GEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEEEEEERRKKLVKETTEYEQsssRQKERNPSMDFEVERDFL---GVL 384

                    ....*...
gi 1958804544  1063 DDLVSALR 1070
Cdd:smart00498  385 DSLLEELG 392
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
231-435 3.14e-63

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 212.90  E-value: 3.14e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  231 GGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSlgrYRDEVNLKTAIMSFINAVLNAGageDNLEFRLHLRYEFLMLGIQ 310
Cdd:pfam06367    1 GGHEKVLEATLNFKEVCRERGRFQSLVGALDSS---ENDNVEYKVATMQFINALVNSP---EDLQFRLHLRSEFTALGLD 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  311 PVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMpYKR 390
Cdd:pfam06367   75 RILDKLRELENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLI-RDD 153
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958804544  391 NGGYFQQWQLLDRILQQIVLQDErgvDPDLAPLENFNVKNIVNML 435
Cdd:pfam06367  154 EEELPSYWKLLEELVSQIVLHRT---KPDPKFDERKNLEIDINRL 195
Drf_GBD pfam06371
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
41-228 1.18e-48

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


Pssm-ID: 461886  Cd Length: 188  Bit Score: 171.35  E-value: 1.18e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   41 PIPNPEELNVCFAELVDELDLTDKNREAVFALPPEKKWQIYCSKK----KEQEDPNKL-----ATSWPEFYIDRINAmat 111
Cdd:pfam06371    2 PKPDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKstnfQKEGGGSKSdsesnETGSPEYYVKKLKD--- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  112 mqnlydtedeeTDKRSQVVEDLKTALRTQPMRFVTRFIELEGLSCLLNFLRGMDHATCESR----IHTSLIGCIKALMNN 187
Cdd:pfam06371   79 -----------DSISSKQLESLRVALRTQPLSWVRRFIEAQGLGALLNVLSKINRKKSQEEedldREYEILKCLKALMNN 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958804544  188 SQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCL 228
Cdd:pfam06371  148 KFGLDHVLGHPSSIDLLVQSLDSERLKTRKLVLELLTALCL 188
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
587-1008 5.36e-127

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 392.40  E-value: 5.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  587 KKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQrhqgcmqegaqrergnvrdggtasrs 666
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRGTVWDKLDDESFELDGDLSELEELFSAKA-------------------------- 54
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  667 lpaaetndhrtekasrsmvsatgVKKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRRAILRMDEqE 746
Cdd:pfam02181   55 -----------------------KTKKNKKSEDKSSSKKKPKEVSLLDPKRAQNIAILLRKLKLPPEEIIQAILEGDE-D 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  747 DLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 826
Cdd:pfam02181  111 ALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAAS 190
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  827 QELTLSKRLKKMLEVVLAIGNFMNKGQ-RGGAYGFRVASLNKIADTKSSiDRNISLLHYLIMILEKHFPDILNMPSELLH 905
Cdd:pfam02181  191 EELRNSRKFKKLLELILALGNYMNDGTrRGQAKGFKLSSLLKLSDTKST-DNKTTLLHYLVKIIREKFPEVLDFSSELSH 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  906 LSKAAKVNLAELEKEVGALRRGLRAVEVELEYQRQQaRDPNDKFVPVMSDFITVSSFSFSELEEQLNEARDKFAKALAHF 985
Cdd:pfam02181  270 VKKAAKVNLEQLEKDVKQLERGLKKLERELELSALD-EHPDDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYF 348
                          410       420
                   ....*....|....*....|...
gi 1958804544  986 GEQDSKMQPDEFFGIFDTFLQAF 1008
Cdd:pfam02181  349 GEDPKETSPEEFFKILRDFLKEF 371
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
588-1070 1.42e-71

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 243.80  E-value: 1.42e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   588 KRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQvfrILDLEDFEKMFSAYQRHQgcmqegaqrergnvrdggtaSRSL 667
Cdd:smart00498    1 KKEPKPKKKLKPLHWDKLNPSDLSGTVWDKIDEES---EGDLDELEELFSAKEKTK--------------------SASK 57
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   668 PAAETndhrtekasrsmvsatgvkkelgsteDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRRAILRMDEqED 747
Cdd:smart00498   58 DVSEK--------------------------KSILKKKASQEFKILDPKRSQNLAILLRKLHMSYEEIKEAILEGDE-DV 110
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   748 LAKDMLEQLLKFIPEKSDVDLLEEHKHE-IERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 826
Cdd:smart00498  111 LSVDLLEQLLKYAPTKEELKKLREYKEEdPEELARAEQFLLLISNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAAC 190
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   827 QELTLSKRLKKMLEVVLAIGNFMNKG-QRGGAYGFRVASLNKIADTKSSiDRNISLLHYLIMILEKHFpdilnmpsellh 905
Cdd:smart00498  191 EELRESKKFRKLLELILAIGNYMNGGsRRGQAYGFKLSSLLKLSDVKSA-DNKTTLLHFLVKIIRKKY------------ 257
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   906 lskaakvnlaelekevgalRRGLRAVEveleyqrqqarDPNDKFVPVMSDFITVSSFSFSELEEQLNEARDKFAKALAHF 985
Cdd:smart00498  258 -------------------LGGLSDPE-----------NLDDKFIEVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYY 307
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   986 GEQDSKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMESMLKEQ---REKERWQRQRKVLVGGALeesGEF 1062
Cdd:smart00498  308 GEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEEEEEERRKKLVKETTEYEQsssRQKERNPSMDFEVERDFL---GVL 384

                    ....*...
gi 1958804544  1063 DDLVSALR 1070
Cdd:smart00498  385 DSLLEELG 392
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
231-435 3.14e-63

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 212.90  E-value: 3.14e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  231 GGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSlgrYRDEVNLKTAIMSFINAVLNAGageDNLEFRLHLRYEFLMLGIQ 310
Cdd:pfam06367    1 GGHEKVLEATLNFKEVCRERGRFQSLVGALDSS---ENDNVEYKVATMQFINALVNSP---EDLQFRLHLRSEFTALGLD 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  311 PVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMpYKR 390
Cdd:pfam06367   75 RILDKLRELENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLI-RDD 153
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958804544  391 NGGYFQQWQLLDRILQQIVLQDErgvDPDLAPLENFNVKNIVNML 435
Cdd:pfam06367  154 EEELPSYWKLLEELVSQIVLHRT---KPDPKFDERKNLEIDINRL 195
Drf_GBD pfam06371
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
41-228 1.18e-48

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


Pssm-ID: 461886  Cd Length: 188  Bit Score: 171.35  E-value: 1.18e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544   41 PIPNPEELNVCFAELVDELDLTDKNREAVFALPPEKKWQIYCSKK----KEQEDPNKL-----ATSWPEFYIDRINAmat 111
Cdd:pfam06371    2 PKPDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKstnfQKEGGGSKSdsesnETGSPEYYVKKLKD--- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958804544  112 mqnlydtedeeTDKRSQVVEDLKTALRTQPMRFVTRFIELEGLSCLLNFLRGMDHATCESR----IHTSLIGCIKALMNN 187
Cdd:pfam06371   79 -----------DSISSKQLESLRVALRTQPLSWVRRFIEAQGLGALLNVLSKINRKKSQEEedldREYEILKCLKALMNN 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958804544  188 SQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCL 228
Cdd:pfam06371  148 KFGLDHVLGHPSSIDLLVQSLDSERLKTRKLVLELLTALCL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH