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Conserved domains on  [gi|1958656767|ref|XP_038941245|]
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FAD-linked sulfhydryl oxidase ALR isoform X1 [Rattus norvegicus]

Protein Classification

Erv1/Alr family FAD-linked sulfhydryl oxidase( domain architecture ID 6790)

Erv1/Alr family FAD-linked sulfhydryl oxidase catalyzes disulfide bond formation, similar to Homo sapiens FAD-linked sulfhydryl oxidase ALR and Arabidopsis thaliana FAD-linked sulfhydryl oxidase ERV1

CATH:  1.20.120.310
EC:  1.8.3.2
Gene Ontology:  GO:0016972|GO:0050660|GO:0016971
SCOP:  4002787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Evr1_Alr super family cl02107
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 225-290 3.78e-24

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


The actual alignment was detected with superfamily member COG5054:

Pssm-ID: 470469  Cd Length: 181  Bit Score: 96.48  E-value: 3.78e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656767 225 KRDIKFREDCPQDREELGRNTWAFLHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRK 290
Cdd:COG5054    66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQK 131
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 225-290 3.78e-24

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 96.48  E-value: 3.78e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656767 225 KRDIKFREDCPQDREELGRNTWAFLHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRK 290
Cdd:COG5054    66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQK 131
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 243-290 5.19e-21

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 85.36  E-value: 5.19e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958656767 243 RNTWAFLHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRK 290
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQK 48
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 225-290 3.78e-24

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 96.48  E-value: 3.78e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656767 225 KRDIKFREDCPQDREELGRNTWAFLHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRK 290
Cdd:COG5054    66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQK 131
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 243-290 5.19e-21

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 85.36  E-value: 5.19e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958656767 243 RNTWAFLHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRK 290
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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