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Conserved domains on  [gi|1958659244|ref|XP_038942153|]
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NAD-dependent protein deacetylase sirtuin-7 isoform X2 [Rattus norvegicus]

Protein Classification

SIR2 family protein( domain architecture ID 1222)

SIR2 family protein similar to NAD-dependent deacetylase that catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

PubMed:  7498786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIR2 super family cl00195
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 114-234 1.51e-46

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


The actual alignment was detected with superfamily member cd01410:

Pssm-ID: 444738  Cd Length: 206  Bit Score: 156.31  E-value: 1.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 114 VCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKV 193
Cdd:cd01410    97 VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKDTIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958659244 194 lkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 234
Cdd:cd01410   169 ---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-101 7.94e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244    7 LSRSERKAAERVRRLREEQ-----QRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCD 81
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLeeleaQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                           90       100
                   ....*....|....*....|
gi 1958659244   82 DPEELRRKVRELAGAVRSAR 101
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLN 399
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 114-234 1.51e-46

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 156.31  E-value: 1.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 114 VCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKV 193
Cdd:cd01410    97 VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKDTIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958659244 194 lkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 234
Cdd:cd01410   169 ---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 88-246 3.01e-13

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 68.28  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSARhlvvytgagistvCTSCipNREYVRVFDVTERtalhrhltGRTCHKCGTQLRDTIVHFGErgtlgq 167
Cdd:PRK00481  111 KNVIELHGSLLRAR-------------CTKC--GQTYDLDEYLKPE--------PPRCPKCGGILRPDVVLFGE------ 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 168 PLN---WEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 244
Cdd:PRK00481  162 MLPelaIDEAYEALEEADLFIVIGTSLVV---YPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVE 238


                  ..
gi 1958659244 245 EL 246
Cdd:PRK00481  239 EL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 115-244 1.78e-10

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 60.17  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 115 CTSC---IPNREYVRVFDVTErtalhrhltGRTCHKCGTQLRDTIVHFGERGtlgQPLNWEAATEAASKADTILCLGSSL 191
Cdd:COG0846   126 CTKCgkrYDLEDVLEDLEGEL---------PPRCPKCGGLLRPDVVWFGEML---PEEALERALEALAEADLFLVIGTSL 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958659244 192 KVlkkYP--RLWCMTKppSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 244
Cdd:COG0846   194 VV---YPaaGLPEYAK--RAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 88-194 2.10e-06

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 47.25  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSARhlvvytgagistvCTSCIPNREYVRVFDVTERTALHRhltgrtCHKCGTQLRDTIVHFGErgtlGQ 167
Cdd:pfam02146  95 KKVVELHGSFAKAR-------------CVSCHQKYTGETLYERIRPEKVPH------CPQCGGLLKPDIVFFGE----NL 151

                          90       100
                  ....*....|....*....|....*..
gi 1958659244 168 PLNWEAATEAASKADTILCLGSSLKVL 194
Cdd:pfam02146 152 PDKFHRAYEDLEEADLLIVIGTSLKVY 178
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-101 7.94e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244    7 LSRSERKAAERVRRLREEQ-----QRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCD 81
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLeeleaQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                           90       100
                   ....*....|....*....|
gi 1958659244   82 DPEELRRKVRELAGAVRSAR 101
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLN 399
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 11-91 1.11e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  11 ERKAAERVRRLREEQQRE--RLRQV--SRILRKAAAERSA----EEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDD 82
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREveRRRKLeeAEKARQAEMDRQAaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAME 373


                  ....*....
gi 1958659244  83 PEELRRKVR 91
Cdd:pfam17380 374 ISRMRELER 382
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
12-93 5.06e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  12 RKAAERVRRLREE--QQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVcddpEELRRK 89
Cdd:COG4372    41 DKLQEELEQLREEleQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA----EELQEE 116


                  ....
gi 1958659244  90 VREL 93
Cdd:COG4372   117 LEEL 120
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 114-234 1.51e-46

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 156.31  E-value: 1.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 114 VCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKV 193
Cdd:cd01410    97 VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKDTIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958659244 194 lkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 234
Cdd:cd01410   169 ---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
 114-234 1.21e-29

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 112.28  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 114 VCTSCipNREYVRVFDVtertALHRHLTGRTCHKCGTQLRDTIVHFGERGtlgqPLNWEAATEAASKADTILCLGSSLKV 193
Cdd:cd01407   111 RCTKC--GKEYPRDELQ----ADIDREEVPRCPKCGGLLRPDVVFFGESL----PEELDEAAEALAKADLLLVIGTSLQV 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958659244 194 lkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 234
Cdd:cd01407   181 ---YPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 114-234 1.14e-19

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 85.86  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 114 VCTSCIPNREYVRVFDVTERtalhrhltgRTCHKCGTQLRDTIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKV 193
Cdd:cd00296   115 RCTSCGKEYPRDEVLEREKP---------PRCPKCGGLLRPDVVDFGEALPKE---WFDRALEALLEADLVLVIGTSLTV 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958659244 194 lkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDW--AALKLHGK 234
Cdd:cd00296   183 ---YPAARLLLRAPERGAPVVIINREPTPADALkkADLVILGD 222
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 88-246 3.01e-13

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 68.28  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSARhlvvytgagistvCTSCipNREYVRVFDVTERtalhrhltGRTCHKCGTQLRDTIVHFGErgtlgq 167
Cdd:PRK00481  111 KNVIELHGSLLRAR-------------CTKC--GQTYDLDEYLKPE--------PPRCPKCGGILRPDVVLFGE------ 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 168 PLN---WEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 244
Cdd:PRK00481  162 MLPelaIDEAYEALEEADLFIVIGTSLVV---YPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVE 238


                  ..
gi 1958659244 245 EL 246
Cdd:PRK00481  239 EL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 115-244 1.78e-10

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 60.17  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 115 CTSC---IPNREYVRVFDVTErtalhrhltGRTCHKCGTQLRDTIVHFGERGtlgQPLNWEAATEAASKADTILCLGSSL 191
Cdd:COG0846   126 CTKCgkrYDLEDVLEDLEGEL---------PPRCPKCGGLLRPDVVWFGEML---PEEALERALEALAEADLFLVIGTSL 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958659244 192 KVlkkYP--RLWCMTKppSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 244
Cdd:COG0846   194 VV---YPaaGLPEYAK--RAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
 88-234 1.87e-10

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 59.69  E-value: 1.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSArhlvvytgagistVCTSCipNREYvrvfDVTERTALHRHLTGRtCHKCGTQLRDTIVHFGErgTLGQ 167
Cdd:cd01413   102 KNVIELHGTLQTA-------------YCVNC--GSKY----DLEEVKYAKKHEVPR-CPKCGGIIRPDVVLFGE--PLPQ 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958659244 168 PLnWEAATEAASKADTILCLGSSLKVlkkYP--RLWCMTKppSRRPKLYIVNLQWTPKDDWAALKLHGK 234
Cdd:cd01413   160 AL-LREAIEAAKEADLFIVLGSSLVV---YPanLLPLIAK--ENGAKLVIVNADETPFDYIADLVIQDK 222
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 88-243 2.12e-08

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 53.75  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSARhlvvytgagistvCTSCipnrEYVRVFDVTE-RTALHRhltgrtCHKCGTQLRDTIVHFGERgtlg 166
Cdd:cd01412    98 RNVIELHGSLFRVR-------------CSSC----GYVGENNEEIpEEELPR------CPKCGGLLRPGVVWFGES---- 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659244 167 QPLNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLM 243
Cdd:cd01412   151 LPLALLEAVEALAKADLFLVIGTSGVV---YPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 88-194 2.10e-06

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 47.25  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  88 RKVRELAGAVRSARhlvvytgagistvCTSCIPNREYVRVFDVTERTALHRhltgrtCHKCGTQLRDTIVHFGErgtlGQ 167
Cdd:pfam02146  95 KKVVELHGSFAKAR-------------CVSCHQKYTGETLYERIRPEKVPH------CPQCGGLLKPDIVFFGE----NL 151

                          90       100
                  ....*....|....*....|....*..
gi 1958659244 168 PLNWEAATEAASKADTILCLGSSLKVL 194
Cdd:pfam02146 152 PDKFHRAYEDLEEADLLIVIGTSLKVY 178
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
 145-242 7.20e-05

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 43.39  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 145 CHKCGTQLRDTIVHFGErgTLGQPLNwEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYI-----VNLQ 219
Cdd:cd01408   143 CPRCGGLVKPDIVFFGE--SLPSRFF-SHMEEDKEEADLLIVIGTSLKV---APFASLPSRVPSEVPRVLInrepvGHLG 216

                          90       100
                  ....*....|....*....|...
gi 1958659244 220 WTPKDdwaaLKLHGKCDDVMRLL 242
Cdd:cd01408   217 KRPFD----VALLGDCDDGVREL 235
PRK05333 PRK05333
NAD-dependent protein deacetylase;
145-248 2.06e-04

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 42.36  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 145 CHKCGTQLRDTIVHFGE-----RGtlgqplnwEAATEAASKADTILCLGSSLKVLKKYPrlWCMTKPPSRRPkLYIVNLQ 219
Cdd:PRK05333  182 CPACGGILKPDVVFFGEnvpreRV--------AAARAALDAADAVLVVGSSLMVYSGYR--FCVWAAQQGKP-IAALNLG 250

                          90       100
                  ....*....|....*....|....*....
gi 1958659244 220 WTPKDDWAALKLHGKCDDVMRLLMDELGL 248
Cdd:PRK05333  251 RTRADPLLTLKVEASCAQALAALVARLGL 279
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
 144-239 2.53e-04

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 41.90  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244 144 TCHKCGTQLRDTIVHFGE---RGTLgqplnwEAATEAASKADTILCLGSSLKVLKKYpRLwCMTKPPSRRPkLYIVNLQW 220
Cdd:cd01409   171 ECERCGGVLKPDVVFFGEnvpRDRV------VTAAARLAEADALLVLGSSLMVYSGY-RF-VLAAAEAGLP-IAIVNIGP 241

                          90
                  ....*....|....*....
gi 1958659244 221 TPKDDWAALKLHGKCDDVM 239
Cdd:cd01409   242 TRADHLATLKVDARCGEVL 260
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-101 7.94e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244    7 LSRSERKAAERVRRLREEQ-----QRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCD 81
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLeeleaQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                           90       100
                   ....*....|....*....|
gi 1958659244   82 DPEELRRKVRELAGAVRSAR 101
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLN 399
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 11-91 1.11e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  11 ERKAAERVRRLREEQQRE--RLRQV--SRILRKAAAERSA----EEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDD 82
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREveRRRKLeeAEKARQAEMDRQAaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAME 373


                  ....*....
gi 1958659244  83 PEELRRKVR 91
Cdd:pfam17380 374 ISRMRELER 382
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
12-93 5.06e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  12 RKAAERVRRLREE--QQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVcddpEELRRK 89
Cdd:COG4372    41 DKLQEELEQLREEleQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA----EELQEE 116


                  ....
gi 1958659244  90 VREL 93
Cdd:COG4372   117 LEEL 120
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 7-78 7.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 7.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958659244   7 LSRSERKAAERVRRLRE-EQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEE 78
Cdd:COG1196   248 LEELEAELEELEAELAElEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 11-101 7.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  11 ERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKV 90
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL 388

                          90
                  ....*....|.
gi 1958659244  91 RELAGAVRSAR 101
Cdd:COG1196   389 LEALRAAAELA 399
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 11-101 7.36e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 36.56  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659244  11 ERKAAERVRRLREEQQRERLRQVSriLRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKV 90
Cdd:pfam05672  33 ERLEKEEEERLRKEELRRRAEEER--ARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKA 110

                          90
                  ....*....|.
gi 1958659244  91 RELAGAVRSAR 101
Cdd:pfam05672 111 REEAERQRQER 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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