|
Name |
Accession |
Description |
Interval |
E-value |
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
175-344 |
3.17e-43 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 154.39 E-value: 3.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 175 QLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDrFQHVFFFSCRELA-QCKQLSLAELIAQGQEVPTAPTRQ----ILSRP 249
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSrSGNARSLADLLFSQWPEPAAPVSEvwavILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 250 EKLLFILDGIDEPAWVLEDQNPElcvhwsqaQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFS 329
Cdd:pfam05729 80 ERLLLILDGLDELVSDLGQLDGP--------CPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1958659559 330 EFERKDYFYKYFAKE 344
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
470-581 |
3.26e-27 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 106.99 E-value: 3.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 470 HLCLQEFFAAMSYILEDSEE-------AHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFP 542
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEksnplkeFFGLRKRESLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958659559 543 WETKLKLLQSI---IGEPFCQPCHLGLFHCLYENQEEELLTE 581
Cdd:pfam17776 81 SEIKQELLQWIkslIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
664-785 |
2.40e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 80.86 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 664 LFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGD 743
Cdd:cd00116 100 VLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958659559 744 NGVRQLCEGLRNpACNLSILRLDQASLSEQ-------VITELRALETKN 785
Cdd:cd00116 180 AGIRALAEGLKA-NCNLEVLDLNNNGLTDEgasalaeTLASLKSLEVLN 227
|
|
| NOD2_WH super family |
cl39286 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
414-468 |
3.48e-03 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
The actual alignment was detected with superfamily member pfam17779:
Pssm-ID: 465501 Cd Length: 57 Bit Score: 36.39 E-value: 3.48e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958659559 414 QLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLS-YSF 468
Cdd:pfam17779 2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKvYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
175-344 |
3.17e-43 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 154.39 E-value: 3.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 175 QLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDrFQHVFFFSCRELA-QCKQLSLAELIAQGQEVPTAPTRQ----ILSRP 249
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSrSGNARSLADLLFSQWPEPAAPVSEvwavILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 250 EKLLFILDGIDEPAWVLEDQNPElcvhwsqaQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFS 329
Cdd:pfam05729 80 ERLLLILDGLDELVSDLGQLDGP--------CPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1958659559 330 EFERKDYFYKYFAKE 344
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
470-581 |
3.26e-27 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 106.99 E-value: 3.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 470 HLCLQEFFAAMSYILEDSEE-------AHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFP 542
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEksnplkeFFGLRKRESLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958659559 543 WETKLKLLQSI---IGEPFCQPCHLGLFHCLYENQEEELLTE 581
Cdd:pfam17776 81 SEIKQELLQWIkslIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
171-532 |
1.35e-21 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 100.65 E-value: 1.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 171 EKKPQLVIIEGAAGIGKSTLARQV-KRAWDEGQLYRDRFqhVFFFSCRELAqcKQLSLAELIAQGQEVPTAPTRQILS-- 247
Cdd:COG5635 177 EAKKKRLLILGEPGSGKTTLLRYLaLELAERYLDAEDPI--PILIELRDLA--EEASLEDLLAEALEKRGGEPEDALErl 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 248 -RPEKLLFILDGIDEpawVLEDQNPELCVHWsqaqpvhtlLGSLLGKsiLPEASLMLTARTTALQKlvPSLGQPHRVEVL 326
Cdd:COG5635 253 lRNGRLLLLLDGLDE---VPDEADRDEVLNQ---------LRRFLER--YPKARVIITSRPEGYDS--SELEGFEVLELA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 327 GFSEFERKDYFYKYFAKERNTIIDF-NLIGSIPVLLTLCEVPWVCWLLCTclekQMQQGEVLSltsQTTTALCLKYLSL- 404
Cdd:COG5635 317 PLSDEQIEEFLKKWFEATERKAERLlEALEENPELRELARNPLLLTLLAL----LLRERGELP---DTRAELYEQFVELl 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 405 ---------TIPGQHLSTQ--LRTLCSLAAEGICQRRTLFSKSD--------LCKQGLAEDAIATFL-KIGVLQRQpSSL 464
Cdd:COG5635 390 lerwdeqrgLTIYRELSREelRELLSELALAMQENGRTEFAREEleeilreyLGRRKDAEALLDELLlRTGLLVER-GEG 468
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958659559 465 SYSFAHLCLQEFFAAmSYILEDSEEahgdmgndRTVETLVERYGRQNLFEapTVRFLLGLLNTREMRE 532
Cdd:COG5635 469 RYSFAHRSFQEYLAA-RALVEELDE--------ELLELLAEHLEDPRWRE--VLLLLAGLLDDVKQIK 525
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
664-785 |
2.40e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 80.86 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 664 LFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGD 743
Cdd:cd00116 100 VLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958659559 744 NGVRQLCEGLRNpACNLSILRLDQASLSEQ-------VITELRALETKN 785
Cdd:cd00116 180 AGIRALAEGLKA-NCNLEVLDLNNNGLTDEgasalaeTLASLKSLEVLN 227
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
656-782 |
1.77e-08 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 57.49 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 656 ISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGcRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELD 735
Cdd:COG5238 276 IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLD 354
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1958659559 736 LRLNDLGDNGVRQLCEGLRNpacNLSILRLDqasLSEQVITELRALE 782
Cdd:COG5238 355 LSDNQIGDEGAIALAKYLEG---NTTLRELN---LGKNNIGKQGAEA 395
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
728-754 |
1.07e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 1.07e-03
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
414-468 |
3.48e-03 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 36.39 E-value: 3.48e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958659559 414 QLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLS-YSF 468
Cdd:pfam17779 2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKvYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
175-344 |
3.17e-43 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 154.39 E-value: 3.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 175 QLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDrFQHVFFFSCRELA-QCKQLSLAELIAQGQEVPTAPTRQ----ILSRP 249
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSrSGNARSLADLLFSQWPEPAAPVSEvwavILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 250 EKLLFILDGIDEPAWVLEDQNPElcvhwsqaQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFS 329
Cdd:pfam05729 80 ERLLLILDGLDELVSDLGQLDGP--------CPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1958659559 330 EFERKDYFYKYFAKE 344
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
470-581 |
3.26e-27 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 106.99 E-value: 3.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 470 HLCLQEFFAAMSYILEDSEE-------AHGDMGNDRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREMENIFACKFP 542
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEksnplkeFFGLRKRESLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958659559 543 WETKLKLLQSI---IGEPFCQPCHLGLFHCLYENQEEELLTE 581
Cdd:pfam17776 81 SEIKQELLQWIkslIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
171-532 |
1.35e-21 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 100.65 E-value: 1.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 171 EKKPQLVIIEGAAGIGKSTLARQV-KRAWDEGQLYRDRFqhVFFFSCRELAqcKQLSLAELIAQGQEVPTAPTRQILS-- 247
Cdd:COG5635 177 EAKKKRLLILGEPGSGKTTLLRYLaLELAERYLDAEDPI--PILIELRDLA--EEASLEDLLAEALEKRGGEPEDALErl 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 248 -RPEKLLFILDGIDEpawVLEDQNPELCVHWsqaqpvhtlLGSLLGKsiLPEASLMLTARTTALQKlvPSLGQPHRVEVL 326
Cdd:COG5635 253 lRNGRLLLLLDGLDE---VPDEADRDEVLNQ---------LRRFLER--YPKARVIITSRPEGYDS--SELEGFEVLELA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 327 GFSEFERKDYFYKYFAKERNTIIDF-NLIGSIPVLLTLCEVPWVCWLLCTclekQMQQGEVLSltsQTTTALCLKYLSL- 404
Cdd:COG5635 317 PLSDEQIEEFLKKWFEATERKAERLlEALEENPELRELARNPLLLTLLAL----LLRERGELP---DTRAELYEQFVELl 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 405 ---------TIPGQHLSTQ--LRTLCSLAAEGICQRRTLFSKSD--------LCKQGLAEDAIATFL-KIGVLQRQpSSL 464
Cdd:COG5635 390 lerwdeqrgLTIYRELSREelRELLSELALAMQENGRTEFAREEleeilreyLGRRKDAEALLDELLlRTGLLVER-GEG 468
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958659559 465 SYSFAHLCLQEFFAAmSYILEDSEEahgdmgndRTVETLVERYGRQNLFEapTVRFLLGLLNTREMRE 532
Cdd:COG5635 469 RYSFAHRSFQEYLAA-RALVEELDE--------ELLELLAEHLEDPRWRE--VLLLLAGLLDDVKQIK 525
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
664-785 |
2.40e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 80.86 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 664 LFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGD 743
Cdd:cd00116 100 VLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958659559 744 NGVRQLCEGLRNpACNLSILRLDQASLSEQ-------VITELRALETKN 785
Cdd:cd00116 180 AGIRALAEGLKA-NCNLEVLDLNNNGLTDEgasalaeTLASLKSLEVLN 227
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
629-765 |
1.27e-14 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 75.85 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 629 RSLRLKGKGQQEYKLTAPAMVLYRWTpISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQpGCRLKTLWL 708
Cdd:cd00116 123 RGLRLLAKGLKDLPPALEKLVLGRNR-LEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDL 200
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659559 709 VDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVRQLCEGLRNPACNLSILRL 765
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSL 257
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
668-766 |
1.20e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 72.77 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 668 LKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVR 747
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQ 296
|
90
....*....|....*....
gi 1958659559 748 QLCEGLRNPACNLSILRLD 766
Cdd:cd00116 297 LLAESLLEPGNELESLWVK 315
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
630-788 |
1.81e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 63.14 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 630 SLRLKGKGQQEYKLTAPAMVLYRWTPISEASWKVLFSNLKCTRNLEELDLSGNPL--SYSAVRSLCTALrQPGCRLKTLW 707
Cdd:cd00116 9 LLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGL-TKGCGLQELD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 708 LVDCGLTSRCCSFLASMLSAHSrLAELDLRLNDLGDNGVRQLCEGLRNPACNLSILRLDQASLSEQVITELRALETKNPK 787
Cdd:cd00116 88 LSDNALGPDGCGVLESLLRSSS-LQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD 166
|
.
gi 1958659559 788 L 788
Cdd:cd00116 167 L 167
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
656-782 |
1.77e-08 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 57.49 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 656 ISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGcRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELD 735
Cdd:COG5238 276 IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLD 354
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1958659559 736 LRLNDLGDNGVRQLCEGLRNpacNLSILRLDqasLSEQVITELRALE 782
Cdd:COG5238 355 LSDNQIGDEGAIALAKYLEG---NTTLRELN---LGKNNIGKQGAEA 395
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
654-788 |
3.57e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 53.64 E-value: 3.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 654 TPISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALrQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAE 733
Cdd:COG5238 218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL-KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTS 296
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958659559 734 LDLRLNDLGDNGVRQLCEGLRNPAcNLSILRLDQASLSEQ-VITELRALEtKNPKL 788
Cdd:COG5238 297 LDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQgAIALAKALQ-ENTTL 350
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
673-766 |
3.89e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 53.26 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 673 NLEELDLSGNPLSYSAVRSLCTALRQpGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLRLNDLGDNGVRQLCEG 752
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259
|
90
....*....|....
gi 1958659559 753 LRNpacNLSILRLD 766
Cdd:COG5238 260 LKN---NTTVETLY 270
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
655-753 |
2.39e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.94 E-value: 2.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 655 PISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALrQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAEL 734
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL-QENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
|
90
....*....|....*....
gi 1958659559 735 DLRLNDLGDNGVRQLCEGL 753
Cdd:COG5238 382 NLGKNNIGKQGAEALIDAL 400
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
656-753 |
3.78e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.17 E-value: 3.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 656 ISEASWKVLFSNLKCTRNLEELDLSGNPLSYSAVRSLCTALRQPGcRLKTLWLVDCGLTSRCCSFLASMLSaHSRLAELD 735
Cdd:COG5238 332 IGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEALIDALQ-TNRLHTLI 409
|
90
....*....|....*...
gi 1958659559 736 LRLNDLGDNGVRQLCEGL 753
Cdd:COG5238 410 LDGNLIGAEAQQRLEQLL 427
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
728-754 |
1.07e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 1.07e-03
|
| COG3899 |
COG3899 |
Predicted ATPase [General function prediction only]; |
174-314 |
1.84e-03 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443106 [Multi-domain] Cd Length: 1244 Bit Score: 42.15 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 174 PQLVIIEGAAGIGKSTLARQVKRAWDEgqlyrdrfQHVFFFSCRelaqCKQLslaeliaqGQEVPTAPTRQILSRpekLL 253
Cdd:COG3899 311 GELVLVSGEAGIGKSRLVRELARRARA--------RGGRVLRGK----CDQL--------ERGVPYAPLAQALRA---LL 367
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958659559 254 FILDGIDEPAW--VLEDQNPELcvhwsqAQPVHTLLGSLLGKSILPEASLMLTARTT--ALQKLV 314
Cdd:COG3899 368 GQLPEDELAAWraRLLAALGAN------GRLLADLLPELELQPAPPELDPEEARNRLfrALLRLL 426
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
414-468 |
3.48e-03 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 36.39 E-value: 3.48e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958659559 414 QLRTLCSLAAEGICQRRTLFSKSDLCKQGLAEDAIATFLKIGVLQRQPSSLS-YSF 468
Cdd:pfam17779 2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKvYSF 57
|
|
| Dynamin_N |
pfam00350 |
Dynamin family; |
285-365 |
4.45e-03 |
|
Dynamin family;
Pssm-ID: 459775 [Multi-domain] Cd Length: 168 Bit Score: 38.75 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 285 TLLGSLLGKSILPEASLMLTARTTALQkLVPSLGQPHRVEVLGFSEFERKDY----FYKYFAKERNTIIDFNL-IGSIPV 359
Cdd:pfam00350 13 SVLNALLGRDILPRGPGPTTRRPTVLR-LGESPGASEGAVKVEYKDGEKKFEdfseLREEIEKETEKIAGTGKgISSEPI 91
|
....*.
gi 1958659559 360 LLTLCE 365
Cdd:pfam00350 92 VLEILS 97
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
658-777 |
4.84e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 40.16 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 658 EASWKVLFSNlkctRNLEELDLSGNPLSYSAVRSLCTALrQPGCRLKTLWLVDCGLTSRCCSFLASMLSAHSRLAELDLR 737
Cdd:COG5238 198 EELAEALTQN----TTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLS 272
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1958659559 738 LNDLGDNGVRQLCEGLRNpacNLSILRLDqasLSEQVITE 777
Cdd:COG5238 273 GNQIGAEGAIALAKALQG---NTTLTSLD---LSVNRIGD 306
|
|
| AAA_16 |
pfam13191 |
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
159-272 |
9.71e-03 |
|
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.
Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 37.87 E-value: 9.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659559 159 EIQDLFDPNLDTEkkPQLVIIEGAAGIGKSTLARQVKRAwdegqlYRDRFQHVFFFSCRELAqcKQLSLAELIAQGQEVP 238
Cdd:pfam13191 11 QLLDALDRVRSGR--PPSVLLTGEAGTGKTTLLRELLRA------LERDGGYFLRGKCDENL--PYSPLLEALTREGLLR 80
|
90 100 110
....*....|....*....|....*....|....
gi 1958659559 239 TAPTRQILSRPEKLLFILDGIDEPAWVLEDQNPE 272
Cdd:pfam13191 81 QLLDELESSLLEAWRAALLEALAPVPELPGDLAE 114
|
|
| |
