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Conserved domains on  [gi|1958660033|ref|XP_038942419|]
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rRNA methyltransferase 1, mitochondrial isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPOUT_MTase super family cl38912
SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) ...
 144-214 1.06e-40

SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, also known as class IV methyltransferase family, is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot. Members of the SPOUT superfamily that have been characterized functionally are involved in post-transcriptional RNA modification by catalyzing methylation of the 2-OH group of ribose, the N-1 atom of guanosine 37 in tRNA, or the N-3 atom of uridine 1498 in 16S rRNA.


The actual alignment was detected with superfamily member cd18105:

Pssm-ID: 476814  Cd Length: 158  Bit Score: 136.88  E-value: 1.06e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAMRA 214
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKE 71
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 50-214 6.65e-39

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 135.71  E-value: 6.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  50 LFGVSPCLLALRAaRRHVARLLLQAGkagLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLRPRPC 129
Cdd:COG0566    29 AEGRHAVEEALKA-GREIEELLVTEG---ALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYADL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 130 DEAADTSSGDDpqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFL 209
Cdd:COG0566   105 EDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADAL 181


                  ....*
gi 1958660033 210 QAMRA 214
Cdd:COG0566   182 EELKE 186
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 144-214 1.06e-40

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 136.88  E-value: 1.06e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAMRA 214
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKE 71
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 50-214 6.65e-39

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 135.71  E-value: 6.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  50 LFGVSPCLLALRAaRRHVARLLLQAGkagLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLRPRPC 129
Cdd:COG0566    29 AEGRHAVEEALKA-GREIEELLVTEG---ALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYADL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 130 DEAADTSSGDDpqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFL 209
Cdd:COG0566   105 EDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADAL 181


                  ....*
gi 1958660033 210 QAMRA 214
Cdd:COG0566   182 EELKE 186
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 47-213 4.42e-28

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 106.66  E-value: 4.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  47 LERLFGVSPCLLALRAARRhvarllLQAGKAGLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLRP 126
Cdd:TIGR00186   1 QEYLYGKNAVLEALLNQQR------VFILKGLESKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 127 RPCDEAADTS-SGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDL 205
Cdd:TIGR00186  75 KDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNL 152


                  ....*...
gi 1958660033 206 ASFLQAMR 213
Cdd:TIGR00186 153 SRTITKLK 160
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
86-215 1.94e-18

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 81.17  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  86 LLRVAEARGIPVLRPRRQKLDALCGYQVHQGVcmeVSRLRP-RPCDEA---ADTSSGDDPqqLWLVLEGIQDPRNLGAVM 161
Cdd:PRK11181   39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGI---IARVKPgRQLQENdlpDLLASLEQP--FLLILDGVTDPHNLGACL 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958660033 162 RSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLAsflQAMRAL 215
Cdd:PRK11181  114 RSADAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLA---RTMRML 164
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 146-211 6.03e-15

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 69.48  E-value: 6.03e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958660033 146 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSC-PLTPVVSKASAGAMEVMDVFASPDLASFLQA 211
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKD 70
SpoU_sub_bind pfam08032
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 50-125 1.43e-13

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 429793 [Multi-domain]  Cd Length: 74  Bit Score: 63.80  E-value: 1.43e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660033  50 LFGVSPCLLALRAARRhVARLLLQAGKAGLQGEraELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLR 125
Cdd:pfam08032   2 IYGRHAVLEALKSGPE-IKKLYLTEGRRDPRLK--ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
SpoU_sub_bind smart00967
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 50-122 2.85e-11

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 214943 [Multi-domain]  Cd Length: 70  Bit Score: 57.55  E-value: 2.85e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660033   50 LFGVSPCLLALRAARRhVARLLLQAGkagLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVS 122
Cdd:smart00967   1 IEGRHAVEEALKSGRR-IKELYLTEG---RAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVK 69
PRK10864 PRK10864
putative methyltransferase; Provisional
 110-173 4.28e-04

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 40.92  E-value: 4.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958660033 110 GYQVHQGVCMEVSRlrpRPCDEAADTSSGDDPQQLWLVLEGIQDPRNLGAVMRSAYFLGVDRVI 173
Cdd:PRK10864  168 GTEHHGGVCFLIKK---RNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRSCAHFGVKGVV 228
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 144-214 1.06e-40

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 136.88  E-value: 1.06e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAMRA 214
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKE 71
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 50-214 6.65e-39

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 135.71  E-value: 6.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  50 LFGVSPCLLALRAaRRHVARLLLQAGkagLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLRPRPC 129
Cdd:COG0566    29 AEGRHAVEEALKA-GREIEELLVTEG---ALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYADL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 130 DEAADTSSGDDpqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFL 209
Cdd:COG0566   105 EDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADAL 181


                  ....*
gi 1958660033 210 QAMRA 214
Cdd:COG0566   182 EELKE 186
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 47-213 4.42e-28

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 106.66  E-value: 4.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  47 LERLFGVSPCLLALRAARRhvarllLQAGKAGLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLRP 126
Cdd:TIGR00186   1 QEYLYGKNAVLEALLNQQR------VFILKGLESKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 127 RPCDEAADTS-SGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDL 205
Cdd:TIGR00186  75 KDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNL 152


                  ....*...
gi 1958660033 206 ASFLQAMR 213
Cdd:TIGR00186 153 SRTITKLK 160
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 144-213 5.12e-26

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 98.61  E-value: 5.12e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAMR 213
Cdd:cd18103     1 LLLILDGITDPHNLGAIIRSAEAFGVDGVIIPKRRSAPLTPTVAKASAGALEHLPIARVTNLARALEELK 70
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 144-214 1.13e-18

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 79.39  E-value: 1.13e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAMRA 214
Cdd:cd18095     1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKE 71
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
86-215 1.94e-18

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 81.17  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033  86 LLRVAEARGIPVLRPRRQKLDALCGYQVHQGVcmeVSRLRP-RPCDEA---ADTSSGDDPqqLWLVLEGIQDPRNLGAVM 161
Cdd:PRK11181   39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGI---IARVKPgRQLQENdlpDLLASLEQP--FLLILDGVTDPHNLGACL 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958660033 162 RSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLAsflQAMRAL 215
Cdd:PRK11181  114 RSADAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLA---RTMRML 164
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 146-211 6.03e-15

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 69.48  E-value: 6.03e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958660033 146 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSC-PLTPVVSKASAGAMEVMDVFASPDLASFLQA 211
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKD 70
SpoU_sub_bind pfam08032
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 50-125 1.43e-13

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 429793 [Multi-domain]  Cd Length: 74  Bit Score: 63.80  E-value: 1.43e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660033  50 LFGVSPCLLALRAARRhVARLLLQAGKAGLQGEraELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSRLR 125
Cdd:pfam08032   2 IYGRHAVLEALKSGPE-IKKLYLTEGRRDPRLK--ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
SpoU_sub_bind smart00967
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 50-122 2.85e-11

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 214943 [Multi-domain]  Cd Length: 70  Bit Score: 57.55  E-value: 2.85e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660033   50 LFGVSPCLLALRAARRhVARLLLQAGkagLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVS 122
Cdd:smart00967   1 IEGRHAVEEALKSGRR-IKELYLTEG---RAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVK 69
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 146-193 7.68e-07

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 47.15  E-value: 7.68e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958660033 146 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGA 193
Cdd:cd18109     3 LALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGS 50
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 146-241 1.37e-06

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 46.69  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660033 146 LVLEGIQDPRNLGAVMRSAYFLGVDRV-ITSRRNScplTPVVSKASAGAMEVMDVFASPDLASFLQAMRAlvcpRGFSPP 224
Cdd:cd18092    19 VVLENVHDPHNASAVLRTCDAFGVQDVhVIEPKNK---FKKNRGVAMGADKWLDVHRHDSTEECLAALKE----QGYRIV 91

                          90
                  ....*....|....*..
gi 1958660033 225 ASCslpFCPDATCLPAL 241
Cdd:cd18092    92 ATS---LSPDAVPLDEL 105
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 144-210 1.01e-05

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 44.11  E-value: 1.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660033 144 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVF--ASPDLASFLQ 210
Cdd:cd18104     1 LILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGAVFTLPVAeaSSEETLAWLK 69
PRK10864 PRK10864
putative methyltransferase; Provisional
 110-173 4.28e-04

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 40.92  E-value: 4.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958660033 110 GYQVHQGVCMEVSRlrpRPCDEAADTSSGDDPQQLWLVLEGIQDPRNLGAVMRSAYFLGVDRVI 173
Cdd:PRK10864  168 GTEHHGGVCFLIKK---RNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRSCAHFGVKGVV 228
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 146-193 3.85e-03

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 36.85  E-value: 3.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958660033 146 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGA 193
Cdd:cd18106     3 VICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGA 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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