NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958660190|ref|XP_038942481|]
View 

zinc finger protein ZFP2 isoform X1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-451 7.20e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 7.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190  76 WNSYGKGSNQNPKLMKSSRMFVRKKIYE------CDECGKSFSQSSSLLKHQRIHTGEKPYKCNV--CDKHFIERSSLTV 147
Cdd:COG5048     2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNaprpdsCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 148 HQRTHTGEKPYKCNecgKAFSQSMNLTVHQR----THTGEKPYQCKECGKAFRKNSSLIQHERIHTGEKPYKCNDCGKAF 223
Cdd:COG5048    82 HLRTHHNNPSDLNS---KSLPLSNSKASSSSlsssSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 224 TQSMN----------------------LTVHQRTHTGEKPYECNQCGKAFSQSMHLIVHQRSHTGEKPYECSECGKAFSK 281
Cdd:COG5048   159 VNTPQsnslhpplpanslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 282 SSTLTLHQRNHTGE-----------------------------------KPYKCNKCGKSFSQSTYLIEHQR--LHSG-- 322
Cdd:COG5048   239 SLLSQSPSSLSSSDssssasesprsslptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGes 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 323 VKPFEC--NQCGKAFSKNSSLTQHRRIHTGEKPYQCM--VCGKHFTGRS-----SLTVHQVIHTGEKPYECT--ECGKAF 391
Cdd:COG5048   319 LKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958660190 392 SQSAYLIEHQRIHTGEKPYECD--QCGKAFIKNSSLIVHQRIHTGEKPYKCNECGKSFSRST 451
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-451 7.20e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 7.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190  76 WNSYGKGSNQNPKLMKSSRMFVRKKIYE------CDECGKSFSQSSSLLKHQRIHTGEKPYKCNV--CDKHFIERSSLTV 147
Cdd:COG5048     2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNaprpdsCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 148 HQRTHTGEKPYKCNecgKAFSQSMNLTVHQR----THTGEKPYQCKECGKAFRKNSSLIQHERIHTGEKPYKCNDCGKAF 223
Cdd:COG5048    82 HLRTHHNNPSDLNS---KSLPLSNSKASSSSlsssSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 224 TQSMN----------------------LTVHQRTHTGEKPYECNQCGKAFSQSMHLIVHQRSHTGEKPYECSECGKAFSK 281
Cdd:COG5048   159 VNTPQsnslhpplpanslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 282 SSTLTLHQRNHTGE-----------------------------------KPYKCNKCGKSFSQSTYLIEHQR--LHSG-- 322
Cdd:COG5048   239 SLLSQSPSSLSSSDssssasesprsslptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGes 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 323 VKPFEC--NQCGKAFSKNSSLTQHRRIHTGEKPYQCM--VCGKHFTGRS-----SLTVHQVIHTGEKPYECT--ECGKAF 391
Cdd:COG5048   319 LKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958660190 392 SQSAYLIEHQRIHTGEKPYECD--QCGKAFIKNSSLIVHQRIHTGEKPYKCNECGKSFSRST 451
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 228 NLTVHQRTHTGEKPYECNQCGKAFSQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 128-176 2.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958660190 128 KPYkCNVCDKHFIERSSLTVHQRTHTgekpYKCNECGKAFSQSMNLTVH 176
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 5.21e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 132 CNVCdKHFIERSSLTVHQ-------------------RTHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086  410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 193 KAFRKNsSLIQHERIHTGEKPYKCNDCG---KAFTQSM-------NLTVHQRThTGEKPYECNQCGKAF---SQSMHLI- 258
Cdd:PLN03086  485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                  ....*
gi 1958660190 259 VHQRS 263
Cdd:PLN03086  563 VHQKS 567
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-451 7.20e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 7.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190  76 WNSYGKGSNQNPKLMKSSRMFVRKKIYE------CDECGKSFSQSSSLLKHQRIHTGEKPYKCNV--CDKHFIERSSLTV 147
Cdd:COG5048     2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNaprpdsCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 148 HQRTHTGEKPYKCNecgKAFSQSMNLTVHQR----THTGEKPYQCKECGKAFRKNSSLIQHERIHTGEKPYKCNDCGKAF 223
Cdd:COG5048    82 HLRTHHNNPSDLNS---KSLPLSNSKASSSSlsssSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 224 TQSMN----------------------LTVHQRTHTGEKPYECNQCGKAFSQSMHLIVHQRSHTGEKPYECSECGKAFSK 281
Cdd:COG5048   159 VNTPQsnslhpplpanslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 282 SSTLTLHQRNHTGE-----------------------------------KPYKCNKCGKSFSQSTYLIEHQR--LHSG-- 322
Cdd:COG5048   239 SLLSQSPSSLSSSDssssasesprsslptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGes 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 323 VKPFEC--NQCGKAFSKNSSLTQHRRIHTGEKPYQCM--VCGKHFTGRS-----SLTVHQVIHTGEKPYECT--ECGKAF 391
Cdd:COG5048   319 LKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958660190 392 SQSAYLIEHQRIHTGEKPYECD--QCGKAFIKNSSLIVHQRIHTGEKPYKCNECGKSFSRST 451
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-460 2.33e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 156 KPYKCNECGKAFSQSMNLTVHQRTHTGEKPYQC--KECGKAFRKNSSLIQHERIHTGEKPYKCNDCGK--AFTQSMNLTV 231
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 232 HQRTHTGEKPYECNQ-CGKAFSQSMHLIVHQRSHTGEKPYE-CSECGKAFSKSS-------------------TLTLHQR 290
Cdd:COG5048   112 SSSSNSNDNNLLSSHsLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 291 NHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNQCGKAFSK------NSSLTQHRRIHTGEKPYQCMVCGKHFT 364
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 365 GRSSLTVHQVIHTG-EKPYECTECGKAFSQSAYLIEHQR--IHTGE--KPYECD--QCGKAFIKNSSLIVHQRIHTGEKP 437
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                         330       340
                  ....*....|....*....|....*
gi 1958660190 438 YKC--NECGKSFSRSTNLTRHQRTH 460
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 228 NLTVHQRTHTGEKPYECNQCGKAFSQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 438-460 1.97e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.97e-04
                          10        20
                  ....*....|....*....|...
gi 1958660190 438 YKCNECGKSFSRSTNLTRHQRTH 460
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 2.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 200 SLIQHERIHTGEKPYKCNDCGKAFTQ 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 144 SLTVHQRTHTGEKPYKCNECGKAFSQ 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-195 2.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.92e-04
                          10        20
                  ....*....|....*....|....
gi 1958660190 172 NLTVHQRTHTGEKPYQCKECGKAF 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 3.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 424 SLIVHQRIHTGEKPYKCNECGKSFSR 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
408-461 5.53e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 5.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660190 408 KPYECDQCGKAFIKNSSLIVHQRIHTGEKPYKCN--ECGKSFSRSTNLTRHQRTHT 461
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 5.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.80e-04
                          10        20
                  ....*....|....*....|....
gi 1958660190 396 YLIEHQRIHTGEKPYECDQCGKAF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 8.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 256 HLIVHQRSHTGEKPYECSECGKAFSK 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 9.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1958660190 285 LTLHQRNHTGEKPYKCNKCGKSFSQ 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-139 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....
gi 1958660190 116 SLLKHQRIHTGEKPYKCNVCDKHF 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-364 1.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1958660190 340 SLTQHRRIHTGEKPYQCMVCGKHFT 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 214-236 2.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|...
gi 1958660190 214 YKCNDCGKAFTQSMNLTVHQRTH 236
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 102-124 2.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|...
gi 1958660190 102 YECDECGKSFSQSSSLLKHQRIH 124
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 158-180 2.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|...
gi 1958660190 158 YKCNECGKAFSQSMNLTVHQRTH 180
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 128-176 2.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958660190 128 KPYkCNVCDKHFIERSSLTVHQRTHTgekpYKCNECGKAFSQSMNLTVH 176
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 2.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958660190 368 SLTVHQVIHTGEKPYECTECGKAFSQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 154-237 3.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 154 GEKPYKCN--ECGKAFSQSMNLTVHqRTHtgekpyqcKECGKAFRKNSSLIQHERIHTGEKPYKCNDCGKAFTQSMNLTV 231
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958660190 232 HqRTHT 237
Cdd:COG5189   417 H-RKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 408-456 3.38e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 3.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958660190 408 KPYeCDQCGKAFIKNSSLIVHQRIHTgekpYKCNECGKSFSRSTNLTRH 456
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-372 4.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 294 GEKPYKCN--KCGKSFSQSTYLIEHqRLHSgvkpfecnQCGKAFSKNSSLTQHRRIHTGEKPYQCMVCGKHFTGRSSLTV 371
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1958660190 372 H 372
Cdd:COG5189   417 H 417
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 5.21e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 132 CNVCdKHFIERSSLTVHQ-------------------RTHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086  410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 193 KAFRKNsSLIQHERIHTGEKPYKCNDCG---KAFTQSM-------NLTVHQRThTGEKPYECNQCGKAF---SQSMHLI- 258
Cdd:PLN03086  485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                  ....*
gi 1958660190 259 VHQRS 263
Cdd:PLN03086  563 VHQKS 567
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 126-204 5.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660190 126 GEKPYKCNV--CDKHFIERSSLTVHQrthtgekpyKCNECGKAFSQSMNLTVHQRTHTGEKPYQCKECGKAFRKNSSLIQ 203
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1958660190 204 H 204
Cdd:COG5189   417 H 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 298-320 9.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.87e-03
                          10        20
                  ....*....|....*....|...
gi 1958660190 298 YKCNKCGKSFSQSTYLIEHQRLH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH