NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958660545|ref|XP_038942618|]
View 

nuclear receptor corepressor 1 isoform X18 [Rattus norvegicus]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 15502538)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|20084085
SCOP:  4000317

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.79e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.79e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660545  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.43e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
MDN1 super family cl34967
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 725-921 1.40e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5271:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 50.78  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  725 SQCESVASTVSAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNtEPVAELEATTDPAPCASPSS-------AV 797
Cdd:COG5271    447 EEADSLADEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEA-EEDAEAEADSDELTAEETSAddgadtdAA 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  798 PTTKPAESESVE--------AQVTDSASVETAEPMDVDHEECGAQGSS-VLDPPAPTKADSVDPEIQvpENTASKGEGDA 868
Cdd:COG5271    526 ADPEDSDEDALEdetegeenAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDE 603

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660545  869 KDRDLESASEKTEAR-----DEDLVVAEQMQRPEPQSDNDSSATCSADEDVDGEPERQ 921
Cdd:COG5271    604 AAEEEEADDDEADADadgaaDEEETEEEAAEDEAAEPETDASEAADEDADAETEAEAS 661
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.33e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 2072-2257 2.23e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2072 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2142
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2143 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2221
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660545 2222 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2257
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.79e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.79e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660545  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.43e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 649-692 1.39e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660545  649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
649-694 2.21e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660545   649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 694
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 725-921 1.40e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 50.78  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  725 SQCESVASTVSAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNtEPVAELEATTDPAPCASPSS-------AV 797
Cdd:COG5271    447 EEADSLADEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEA-EEDAEAEADSDELTAEETSAddgadtdAA 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  798 PTTKPAESESVE--------AQVTDSASVETAEPMDVDHEECGAQGSS-VLDPPAPTKADSVDPEIQvpENTASKGEGDA 868
Cdd:COG5271    526 ADPEDSDEDALEdetegeenAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDE 603

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660545  869 KDRDLESASEKTEAR-----DEDLVVAEQMQRPEPQSDNDSSATCSADEDVDGEPERQ 921
Cdd:COG5271    604 AAEEEEADDDEADADadgaaDEEETEEEAAEDEAAEPETDASEAADEDADAETEAEAS 661
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 756-922 3.68e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.82  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  756 VEAAKSSEDSsenAASRGN---TEPVAELEATTDPAPC-ASPSSAVPTTKPAESESVEAqVTDSASVETAEPMDVDHEEC 831
Cdd:PRK13108   273 ILAPKGREAP---GALRGSeyvVDEALEREPAELAAAAvASAASAVGPVGPGEPNQPDD-VAEAVKAEVAEVTDEVAAES 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  832 GAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDR---------DLESASEKTEARDEDLVVAEQMQRPEPQSDN 902
Cdd:PRK13108   349 VVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQvdaeaasaaPEEPAALASEAHDETEPEVPEKAAPIPDPAK 428

                          170       180
                   ....*....|....*....|
gi 1958660545  903 DSSATCSADEDVDGEPERQR 922
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.33e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
460-505 4.10e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.10e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660545   460 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 505
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 747-851 5.18e-04

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 5.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  747 EEENPEDSEVEAAKSSEDSSENAASRGNTE-PVAELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAepmd 825
Cdd:pfam14962   95 EKENVAEAEKASSEAPEVSVVEAEVVDAEEiPDATAAVIEEASACPGDVEAAPVETTAVGAETGPEVTDAATGETT---- 170

                           90       100
                   ....*....|....*....|....*.
gi 1958660545  826 vdheECGAQGSSVLDPPAPTKADSVD 851
Cdd:pfam14962  171 ----EVSAETTPEVTSAAPDEAVAID 192
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 462-501 5.44e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958660545  462 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 501
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2072-2257 2.23e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2072 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2142
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2143 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2221
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660545 2222 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2257
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.79e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.79e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660545  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.43e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 649-692 1.39e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660545  649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
649-694 2.21e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660545   649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 694
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 725-921 1.40e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 50.78  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  725 SQCESVASTVSAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNtEPVAELEATTDPAPCASPSS-------AV 797
Cdd:COG5271    447 EEADSLADEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEA-EEDAEAEADSDELTAEETSAddgadtdAA 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  798 PTTKPAESESVE--------AQVTDSASVETAEPMDVDHEECGAQGSS-VLDPPAPTKADSVDPEIQvpENTASKGEGDA 868
Cdd:COG5271    526 ADPEDSDEDALEdetegeenAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDE 603

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660545  869 KDRDLESASEKTEAR-----DEDLVVAEQMQRPEPQSDNDSSATCSADEDVDGEPERQ 921
Cdd:COG5271    604 AAEEEEADDDEADADadgaaDEEETEEEAAEDEAAEPETDASEAADEDADAETEAEAS 661
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 756-922 3.68e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.82  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  756 VEAAKSSEDSsenAASRGN---TEPVAELEATTDPAPC-ASPSSAVPTTKPAESESVEAqVTDSASVETAEPMDVDHEEC 831
Cdd:PRK13108   273 ILAPKGREAP---GALRGSeyvVDEALEREPAELAAAAvASAASAVGPVGPGEPNQPDD-VAEAVKAEVAEVTDEVAAES 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  832 GAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDR---------DLESASEKTEARDEDLVVAEQMQRPEPQSDN 902
Cdd:PRK13108   349 VVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQvdaeaasaaPEEPAALASEAHDETEPEVPEKAAPIPDPAK 428

                          170       180
                   ....*....|....*....|
gi 1958660545  903 DSSATCSADEDVDGEPERQR 922
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIR 448
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 735-919 8.64e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 48.09  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  735 SAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPVAELEATTDpapcaspsSAVPTTKPAESESVEaqvTD 814
Cdd:COG5271    645 SEAADEDADAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDDEE--------ETEEADEDAETASEE---AD 713

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  815 SASVETAEPMDVDHEECGAQGSSVLDPPA---PTKADSVDPEIQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAE 891
Cdd:COG5271    714 AEEADTEADGTAEEAEEAAEEAESADEEAaslPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAA 793

                          170       180
                   ....*....|....*....|....*...
gi 1958660545  892 qmqrPEPQSDNDSSATCSADEDVDGEPE 919
Cdd:COG5271    794 ----EEKEKVADEDQDTDEDALLDEAEA 817
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.33e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660545  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
460-505 4.10e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.10e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660545   460 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 505
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 747-851 5.18e-04

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 5.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  747 EEENPEDSEVEAAKSSEDSSENAASRGNTE-PVAELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAepmd 825
Cdd:pfam14962   95 EKENVAEAEKASSEAPEVSVVEAEVVDAEEiPDATAAVIEEASACPGDVEAAPVETTAVGAETGPEVTDAATGETT---- 170

                           90       100
                   ....*....|....*....|....*.
gi 1958660545  826 vdheECGAQGSSVLDPPAPTKADSVD 851
Cdd:pfam14962  171 ----EVSAETTPEVTSAAPDEAVAID 192
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 462-501 5.44e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958660545  462 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 501
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 720-919 7.37e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 45.01  E-value: 7.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  720 EERDVSQCESVASTVSAQEDED---IEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSA 796
Cdd:COG5271    566 DEPDEAEAETEDATENADADETeesADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDAS 645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545  797 VPTTKPAESESVEAQVTDSASVETAEPMDV-----DHEECGAQGSSVLDPPAPTKADSvDPEIQVPENTASKGEGDAKDR 871
Cdd:COG5271    646 EAADEDADAETEAEASADESEEEAEDESETssedaEEDADAAAAEASDDEEETEEADE-DAETASEEADAEEADTEADGT 724

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1958660545  872 DLESASEKTEARDEDLVVAEQMQRPEPQSDNDSSATcSADEDVDGEPE 919
Cdd:COG5271    725 AEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEE-AEEDDADGLEE 771
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 462-505 1.00e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660545  462 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 505
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2072-2257 2.23e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2072 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2142
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660545 2143 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2221
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660545 2222 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2257
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 650-697 2.81e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 2.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958660545  650 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 697
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH