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Conserved domains on  [gi|1958668196|ref|XP_038945140|]
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intraflagellar transport protein 22 homolog isoform X3 [Rattus norvegicus]

Protein Classification

Rab family GTPase( domain architecture ID 11437803)

Rab family GTPase similar to human intraflagellar transport protein 22 homolog (IFT22), also called Rab-like protein 5, which is a small GTPase-like component of the intraflagellar transport (IFT) complex B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
1-66 2.00e-06

GTPase SAR1 family domain [General function prediction only];


:

Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 43.43  E-value: 2.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668196   1 MLKAKILFVGPCESGKTVLAN-FLTESSDITEYNPTQGVRILEFENPHvtsnnKGTGCEFELWDCGG 66
Cdd:COG1100     1 MGEKKIVVVGTGGVGKTSLVNrLVGDIFSLEKYLSTNGVTIDKKELKL-----DGLDVDLVIWDTPG 62
 
Name Accession Description Interval E-value
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
1-66 2.00e-06

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 43.43  E-value: 2.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668196   1 MLKAKILFVGPCESGKTVLAN-FLTESSDITEYNPTQGVRILEFENPHvtsnnKGTGCEFELWDCGG 66
Cdd:COG1100     1 MGEKKIVVVGTGGVGKTSLVNrLVGDIFSLEKYLSTNGVTIDKKELKL-----DGLDVDLVIWDTPG 62
Roc pfam08477
Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial ...
 5-66 3.63e-04

Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organization, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.


Pssm-ID: 462490 [Multi-domain]  Cd Length: 114  Bit Score: 36.72  E-value: 3.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958668196   5 KILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFEnpHVTSNNKGTGCEFELWDCGG 66
Cdd:pfam08477   1 KVVLLGDSGVGKTSLLKRFVDDTFDPKYKSTIGVDFKTKT--VLENDDNGKKIKLNIWDTAG 60
RocCOR cd09914
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein ...
 3-66 2.28e-03

Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein family is characterized by a superdomain containing a Ras-like GTPase domain, called Roc (Ras of complex proteins), and a characteristic second domain called COR (C-terminal of Roc). A kinase domain and diverse regulatory domains are also often found in Roco proteins. Their functions are diverse; in Dictyostelium discoideum, which encodes 11 Roco proteins, they are involved in cell division, chemotaxis and development, while in human, where 4 Roco proteins (LRRK1, LRRK2, DAPK1, and MFHAS1) are encoded, these proteins are involved in epilepsy and cancer. Mutations in LRRK2 (leucine-rich repeat kinase 2) are known to cause familial Parkinson's disease.


Pssm-ID: 206741 [Multi-domain]  Cd Length: 161  Bit Score: 35.00  E-value: 2.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958668196   3 KAKILFVGPCESGKTVLANFLTESsditEYNP----TQGVRILEFENPhvtsNNKGTGCEFELWDCGG 66
Cdd:cd09914     1 EAKLMLVGQGGVGKTSLCKQLIGE----KFDGdessTHGINVQDWKIP----APERKKIRLNVWDFGG 60
 
Name Accession Description Interval E-value
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
1-66 2.00e-06

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 43.43  E-value: 2.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668196   1 MLKAKILFVGPCESGKTVLAN-FLTESSDITEYNPTQGVRILEFENPHvtsnnKGTGCEFELWDCGG 66
Cdd:COG1100     1 MGEKKIVVVGTGGVGKTSLVNrLVGDIFSLEKYLSTNGVTIDKKELKL-----DGLDVDLVIWDTPG 62
Roc pfam08477
Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial ...
 5-66 3.63e-04

Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organization, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.


Pssm-ID: 462490 [Multi-domain]  Cd Length: 114  Bit Score: 36.72  E-value: 3.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958668196   5 KILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFEnpHVTSNNKGTGCEFELWDCGG 66
Cdd:pfam08477   1 KVVLLGDSGVGKTSLLKRFVDDTFDPKYKSTIGVDFKTKT--VLENDDNGKKIKLNIWDTAG 60
RocCOR cd09914
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein ...
 3-66 2.28e-03

Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein family is characterized by a superdomain containing a Ras-like GTPase domain, called Roc (Ras of complex proteins), and a characteristic second domain called COR (C-terminal of Roc). A kinase domain and diverse regulatory domains are also often found in Roco proteins. Their functions are diverse; in Dictyostelium discoideum, which encodes 11 Roco proteins, they are involved in cell division, chemotaxis and development, while in human, where 4 Roco proteins (LRRK1, LRRK2, DAPK1, and MFHAS1) are encoded, these proteins are involved in epilepsy and cancer. Mutations in LRRK2 (leucine-rich repeat kinase 2) are known to cause familial Parkinson's disease.


Pssm-ID: 206741 [Multi-domain]  Cd Length: 161  Bit Score: 35.00  E-value: 2.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958668196   3 KAKILFVGPCESGKTVLANFLTESsditEYNP----TQGVRILEFENPhvtsNNKGTGCEFELWDCGG 66
Cdd:cd09914     1 EAKLMLVGQGGVGKTSLCKQLIGE----KFDGdessTHGINVQDWKIP----APERKKIRLNVWDFGG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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