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Conserved domains on  [gi|1958668676|ref|XP_038945360|]
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transmembrane protein 132B isoform X1 [Rattus norvegicus]

Protein Classification

transmembrane protein 132( domain architecture ID 12174329)

transmembrane protein 132 (TMEM132) such as Rattus norvegicus TMEM132D, also called mature oligodendrocytes transmembrane protein (MOLT), that may serve as a cell-surface marker for oligodendrocyte differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 369-711 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 532.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  369 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVLESVECRSADEDVVKVSNTCDSIFVNGKEMKSKVGTIVNFTHQHFTSQV 448
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  449 EITVWVPRLPLQIEISDTELSQIKGWRIPVASN-RRPTRESDDEEDEEKKGRGCTLQYQHALVRVLTQFVSESPDLGQLT 527
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNkRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  528 YMLGPDWQFDITDLVTEFVKVEEPKIAQLQDGRILAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTITELGVQLVAG 607
Cdd:pfam16070  161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  608 LSLSLQPHRADKRAIISTVSAQDVLQAPQQEAIVSSWILFSDGSVTPLDIYEPKDFSVTVSSLDEMVVSIQPNLQTRWPI 687
Cdd:pfam16070  241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                          330       340
                   ....*....|....*....|....
gi 1958668676  688 VVAEGEGQGPLIKLEMSISESCQK 711
Cdd:pfam16070  321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-108 6.98e-60

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 200.53  E-value: 6.98e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676    1 MRNASLQARSATLFIHRAQSPPAINASYGPFSVEKTVPWDFLLTPTPFGNMERFPFNWRLKSHILDSSIFSNRPKVQTLF 80
Cdd:pfam15705   22 MRNSSLQSRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFNWKLRAHILDSRVYSSRPKVQVLF 101

                           90       100
                   ....*....|....*....|....*...
gi 1958668676   81 YVTGMGWDENDPGDDLPCVKMFAFPEAR 108
Cdd:pfam15705  102 YIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 807-888 3.22e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 154.37  E-value: 3.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  807 TSFPTQGKLPESNN--PGDLTMTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 884
Cdd:pfam15706    1 TNFPAQTDAPNNNGesEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                   ....
gi 1958668676  885 LGNE 888
Cdd:pfam15706   81 LGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 369-711 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 532.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  369 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVLESVECRSADEDVVKVSNTCDSIFVNGKEMKSKVGTIVNFTHQHFTSQV 448
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  449 EITVWVPRLPLQIEISDTELSQIKGWRIPVASN-RRPTRESDDEEDEEKKGRGCTLQYQHALVRVLTQFVSESPDLGQLT 527
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNkRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  528 YMLGPDWQFDITDLVTEFVKVEEPKIAQLQDGRILAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTITELGVQLVAG 607
Cdd:pfam16070  161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  608 LSLSLQPHRADKRAIISTVSAQDVLQAPQQEAIVSSWILFSDGSVTPLDIYEPKDFSVTVSSLDEMVVSIQPNLQTRWPI 687
Cdd:pfam16070  241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                          330       340
                   ....*....|....*....|....
gi 1958668676  688 VVAEGEGQGPLIKLEMSISESCQK 711
Cdd:pfam16070  321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-108 6.98e-60

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 200.53  E-value: 6.98e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676    1 MRNASLQARSATLFIHRAQSPPAINASYGPFSVEKTVPWDFLLTPTPFGNMERFPFNWRLKSHILDSSIFSNRPKVQTLF 80
Cdd:pfam15705   22 MRNSSLQSRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFNWKLRAHILDSRVYSSRPKVQVLF 101

                           90       100
                   ....*....|....*....|....*...
gi 1958668676   81 YVTGMGWDENDPGDDLPCVKMFAFPEAR 108
Cdd:pfam15705  102 YIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 807-888 3.22e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 154.37  E-value: 3.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  807 TSFPTQGKLPESNN--PGDLTMTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 884
Cdd:pfam15706    1 TNFPAQTDAPNNNGesEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                   ....
gi 1958668676  885 LGNE 888
Cdd:pfam15706   81 LGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 369-711 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 532.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  369 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVLESVECRSADEDVVKVSNTCDSIFVNGKEMKSKVGTIVNFTHQHFTSQV 448
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  449 EITVWVPRLPLQIEISDTELSQIKGWRIPVASN-RRPTRESDDEEDEEKKGRGCTLQYQHALVRVLTQFVSESPDLGQLT 527
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNkRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  528 YMLGPDWQFDITDLVTEFVKVEEPKIAQLQDGRILAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTITELGVQLVAG 607
Cdd:pfam16070  161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  608 LSLSLQPHRADKRAIISTVSAQDVLQAPQQEAIVSSWILFSDGSVTPLDIYEPKDFSVTVSSLDEMVVSIQPNLQTRWPI 687
Cdd:pfam16070  241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                          330       340
                   ....*....|....*....|....
gi 1958668676  688 VVAEGEGQGPLIKLEMSISESCQK 711
Cdd:pfam16070  321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-108 6.98e-60

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 200.53  E-value: 6.98e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676    1 MRNASLQARSATLFIHRAQSPPAINASYGPFSVEKTVPWDFLLTPTPFGNMERFPFNWRLKSHILDSSIFSNRPKVQTLF 80
Cdd:pfam15705   22 MRNSSLQSRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFNWKLRAHILDSRVYSSRPKVQVLF 101

                           90       100
                   ....*....|....*....|....*...
gi 1958668676   81 YVTGMGWDENDPGDDLPCVKMFAFPEAR 108
Cdd:pfam15705  102 YIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 807-888 3.22e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 154.37  E-value: 3.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668676  807 TSFPTQGKLPESNN--PGDLTMTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 884
Cdd:pfam15706    1 TNFPAQTDAPNNNGesEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                   ....
gi 1958668676  885 LGNE 888
Cdd:pfam15706   81 LGRE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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