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Conserved domains on  [gi|1958642064|ref|XP_038945386|]
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integral membrane transport protein UST5r isoform X2 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-334 4.15e-92

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 279.56  E-value: 4.15e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:cd17374    75 LAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQ 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlfh 160
Cdd:cd17374   155 LVVSVPFFLFFLYSWWLP-------------------------------------------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 tpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:cd17374   173 -----KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:cd17374   248 NIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYG 327
                         330
                  ....*....|....
gi 1958642064 321 GFSILNGFTVFLLP 334
Cdd:cd17374   328 VLPILAGLLALLLP 341
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
1-334 4.15e-92

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 279.56  E-value: 4.15e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:cd17374    75 LAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQ 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlfh 160
Cdd:cd17374   155 LVVSVPFFLFFLYSWWLP-------------------------------------------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 tpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:cd17374   173 -----KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:cd17374   248 NIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYG 327
                         330
                  ....*....|....
gi 1958642064 321 GFSILNGFTVFLLP 334
Cdd:cd17374   328 VLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
1-343 1.40e-67

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 221.43  E-value: 1.40e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:TIGR00898 167 TAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQ 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKnsgdnLTMEVVRTSMKRELEAAKARPSPRDLFH 160
Cdd:TIGR00898 247 LAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEKDLSSSKKQYSFLDLFR 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 TPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:TIGR00898 322 TPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLL 401
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:TIGR00898 402 LLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFG 481
                         330       340
                  ....*....|....*....|...
gi 1958642064 321 GFSILNGFTVFLLPETKNQPLPD 343
Cdd:TIGR00898 482 GLALLAGILTLFLPETKGVPLPE 504
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-334 3.33e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.74  E-value: 3.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   9 GFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMI---LAGLAFQFQNWHHLQLAMSV 85
Cdd:COG2271    93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALappLLGWLLAAFGWRAAFLILGL 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  86 PIFFFLILTRWLSesarWLIvtnkpqkglkelrkvahmngmknsgdNLTMEVVRTSMkreleaakarpsprdLFHTPILR 165
Cdd:COG2271   173 PGLLLALLRFWLL----ALA--------------------------YFLVYFALYGF---------------LTWLPTYL 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 166 KRICAMSFMRILFMLSIFGMSlhlqhlssnimllqfvvsasSLLFSVIGPYVFNRMGRR--ITQMVVMTLRGICILTAVF 243
Cdd:COG2271   208 VEVRGLSLAQAGLLLSLPFLA--------------------GIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLAL 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 244 VPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFYGG 321
Cdd:COG2271   268 LPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAA 345
                         330
                  ....*....|...
gi 1958642064 322 FSILNGFTVFLLP 334
Cdd:COG2271   346 LALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
1-302 8.10e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.66  E-value: 8.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMI---LAGLAFQFQNWH 77
Cdd:pfam07690  72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  78 HLQLAMSVPIFFFLILtrwlsesarWLIVTNKPQKGLKELRKVAHMNGMKNSGDNLtmevvrtsmkreleaakaRPSPRD 157
Cdd:pfam07690 152 AAFLILAILSLLAAVL---------LLLPRPPPESKRPKPAEEARLSLIVAWKALL------------------RDPVLW 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 158 LFHTPILRkricAMSFMRILFMLSIFGMSLHLQHLSSNIMLlqFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC 237
Cdd:pfam07690 205 LLLALLLF----GFAFFGLLTYLPLYQEVLGLSALLAGLLL--GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642064 238 ILT-AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAP 302
Cdd:pfam07690 279 ALGlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
1-334 4.15e-92

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 279.56  E-value: 4.15e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:cd17374    75 LAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQ 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlfh 160
Cdd:cd17374   155 LVVSVPFFLFFLYSWWLP-------------------------------------------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 tpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:cd17374   173 -----KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:cd17374   248 NIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYG 327
                         330
                  ....*....|....
gi 1958642064 321 GFSILNGFTVFLLP 334
Cdd:cd17374   328 VLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
1-343 1.40e-67

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 221.43  E-value: 1.40e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:TIGR00898 167 TAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQ 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKnsgdnLTMEVVRTSMKRELEAAKARPSPRDLFH 160
Cdd:TIGR00898 247 LAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEKDLSSSKKQYSFLDLFR 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 TPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:TIGR00898 322 TPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLL 401
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:TIGR00898 402 LLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFG 481
                         330       340
                  ....*....|....*....|...
gi 1958642064 321 GFSILNGFTVFLLPETKNQPLPD 343
Cdd:TIGR00898 482 GLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
1-334 2.61e-43

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 153.34  E-value: 2.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQ 80
Cdd:cd17446    73 MAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQ 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  81 LAMSVPIFFFLILTRWLsesarwlivtnkpqkglkelrkvAHMNgmknsgdnltmevvrtsmkreleaakarpsprdlfh 160
Cdd:cd17446   153 LAVSLPFFIFFLYSWWF-----------------------PRIT------------------------------------ 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 161 tpilrkriCAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT 240
Cdd:cd17446   174 --------FCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILA 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 241 AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:cd17446   246 NIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYG 325
                         330
                  ....*....|....
gi 1958642064 321 GFSILNGFTVFLLP 334
Cdd:cd17446   326 AAPILSGIAACFLP 339
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
8-334 1.12e-40

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 146.19  E-value: 1.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   8 VGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPI 87
Cdd:cd17317    72 SAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  88 FFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlfhtpilrKR 167
Cdd:cd17317   152 LLFLLLLWWLP-------------------------------------------------------------------RR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQE 247
Cdd:cd17317   165 TIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDD 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 248 MQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNG 327
Cdd:cd17317   245 ENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGG 324

                  ....*..
gi 1958642064 328 FTVFLLP 334
Cdd:cd17317   325 LLTLLLP 331
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
7-334 1.85e-28

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 113.29  E-value: 1.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   7 CVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVP 86
Cdd:cd17447    81 ASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLP 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  87 IFFFLILTRWlsesarwlivtnkpqkglkelrkvahmngmknsgdnltmeVVRTSMkreleaakarpsprdlfhtpilrk 166
Cdd:cd17447   161 CAPGIITWWW----------------------------------------VPKISL------------------------ 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 167 rICAMSFMRILFmlSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQ 246
Cdd:cd17447   177 -CTGIVWFGVAF--TYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPS 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 247 EMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILN 326
Cdd:cd17447   254 EFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLA 333

                  ....*...
gi 1958642064 327 GFTVFLLP 334
Cdd:cd17447   334 GGVAFLLP 341
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
1-334 1.01e-15

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 77.40  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAF-QFQNWHHL 79
Cdd:cd17378    74 MALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYlNGSSWRVL 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  80 QLAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlf 159
Cdd:cd17378   154 YFWTSIPALIYCILVYLFA------------------------------------------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 160 htpilrKRICAMsfMRILFMLSI--FGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC 237
Cdd:cd17378   173 ------RRLLAV--MVIGFGIGMvyYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGAS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 238 ILTAVFVPQEMQILRITVVTLAGAFSALS-FGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPW 316
Cdd:cd17378   245 CLLCFVLSIGGTTSLQIALELVGFFGAAGaFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSF 324
                         330
                  ....*....|....*...
gi 1958642064 317 IFYGGFSILNGFTVFLLP 334
Cdd:cd17378   325 GVFGVAILLLGLFALGLP 342
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
168-334 6.27e-13

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 69.03  E-value: 6.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMRILFMLSI----FGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVF 243
Cdd:cd17376   172 IPITTIMSLLLWMAIsvgyFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQL 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 244 VPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFS 323
Cdd:cd17376   252 VPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLT 331
                         170
                  ....*....|.
gi 1958642064 324 ILNGFTVFLLP 334
Cdd:cd17376   332 VLIGILTLFLP 342
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
2-334 3.39e-12

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 66.61  E-value: 3.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   2 AITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQL 81
Cdd:cd17379    74 GVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQL 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  82 AMSVPIFFFLILtrwlsesaRWLIVTnkpqkglkelrkvahmngmknsgdnltmevvrtsmkreleaakarpsprdlfHT 161
Cdd:cd17379   154 AVTLPNFLFLLY--------YWFIPK----------------------------------------------------HT 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 162 PILrkricamsfMRILFMLSIF--GMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICIL 239
Cdd:cd17379   174 FIL---------MYAWFTSAVVyqGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 240 TAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMI-LASYSPNLPWIF 318
Cdd:cd17379   245 ITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIV 324
                         330
                  ....*....|....*.
gi 1958642064 319 YGGFSILNGFTVFLLP 334
Cdd:cd17379   325 FGVLALVAGGLVLLLP 340
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-334 3.33e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.74  E-value: 3.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   9 GFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMI---LAGLAFQFQNWHHLQLAMSV 85
Cdd:COG2271    93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALappLLGWLLAAFGWRAAFLILGL 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  86 PIFFFLILTRWLSesarWLIvtnkpqkglkelrkvahmngmknsgdNLTMEVVRTSMkreleaakarpsprdLFHTPILR 165
Cdd:COG2271   173 PGLLLALLRFWLL----ALA--------------------------YFLVYFALYGF---------------LTWLPTYL 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 166 KRICAMSFMRILFMLSIFGMSlhlqhlssnimllqfvvsasSLLFSVIGPYVFNRMGRR--ITQMVVMTLRGICILTAVF 243
Cdd:COG2271   208 VEVRGLSLAQAGLLLSLPFLA--------------------GIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLAL 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 244 VPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFYGG 321
Cdd:COG2271   268 LPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAA 345
                         330
                  ....*....|...
gi 1958642064 322 FSILNGFTVFLLP 334
Cdd:COG2271   346 LALLAALLALLLL 358
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
180-334 5.45e-11

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 63.23  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 180 LSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRItVVTLA 259
Cdd:cd17375   187 LGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTI-VLSMT 265
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642064 260 GAFS-ALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 334
Cdd:cd17375   266 GKFAiAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
MFS_1 pfam07690
Major Facilitator Superfamily;
1-302 8.10e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.66  E-value: 8.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMI---LAGLAFQFQNWH 77
Cdd:pfam07690  72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  78 HLQLAMSVPIFFFLILtrwlsesarWLIVTNKPQKGLKELRKVAHMNGMKNSGDNLtmevvrtsmkreleaakaRPSPRD 157
Cdd:pfam07690 152 AAFLILAILSLLAAVL---------LLLPRPPPESKRPKPAEEARLSLIVAWKALL------------------RDPVLW 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 158 LFHTPILRkricAMSFMRILFMLSIFGMSLHLQHLSSNIMLlqFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC 237
Cdd:pfam07690 205 LLLALLLF----GFAFFGLLTYLPLYQEVLGLSALLAGLLL--GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642064 238 ILT-AVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAP 302
Cdd:pfam07690 279 ALGlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
Sugar_tr pfam00083
Sugar (and other) transporter;
61-341 1.10e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 56.51  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  61 FGSMILAGLAFQFQNWH-----HLQLAMSVPIFFFLIltrWLSESARWLIvtnkpQKGLKELRKVAHMNGMKNSGDNLTM 135
Cdd:pfam00083 153 LAYIFGLGLNKTSNSDGwriplGLQLVPALLLIIGLL---FLPESPRWLV-----EKGRLEEAREVLAKLRGVPDVDREL 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 136 EVVRTSMKRELEAAKArpSPRDLFHTPILRKRI---CAMSFMR-------ILFMLSIFGMSLHLqhlsSNIMLLQFVVSA 205
Cdd:pfam00083 225 DEIKDSLEAGQEAEKA--SWKELFSTKTRRQRLligVMLQIFQqltginaIFYYSTTIFENLGL----SDSFLVTIIVGV 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 206 SSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC--ILTAVFVPQE-----MQILRITVVTLAGAFSALSFG-VNRLHTNEL 277
Cdd:pfam00083 299 VNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICfvILGIVALLGVsksdwAGIVAIVFIALFIAFFAMGWGpVPWVIVSEL 378
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642064 278 LPTTLRATAIGVIGMFGN-SGFFLAPLFMILASYSPNLP-WIFYGGFSILNG-FTVFLLPETKNQPL 341
Cdd:pfam00083 379 FPLSVRSKAMALATAANWlANFLIGFLFPIITDAIGLGYtFFIFAGLLVLFIiFVFFFVPETKGRTL 445
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
145-337 2.44e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 145 ELEAAKARPSPRDLFHtPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIM--------LLQFVVSASSLLFSVIGPY 216
Cdd:COG2223   185 AGAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaatagLLAALFALLGALGRPLGGW 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 217 VFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNS 296
Cdd:COG2223   264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF-LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1958642064 297 GFFLAPLFM---ILASYSPNLPWIFYGGFSILNGFTVFLLPETK 337
Cdd:COG2223   343 GGFLGPLLFgalLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
163-330 2.79e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.92  E-value: 2.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 163 ILRKRICAMSFMRILFMLSIFGMSL--------HLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLR 234
Cdd:cd17316   174 LLRRRTLLLILLWFFISFGYYGLTTflptylqtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 235 GICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAP--LFMILASYSP 312
Cdd:cd17316   254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGG 333
                         170
                  ....*....|....*...
gi 1958642064 313 NLPWIFYGGFSILNGFTV 330
Cdd:cd17316   334 TGVPALILALLAIVALIV 351
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
220-334 3.26e-08

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 54.78  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 220 RMGRRITQMVVMTLRGICILTAVFVPQE-----MQILRITVVTLAGAFS-ALSFGVNRLHTNELLPTTLRATAIGVIGMF 293
Cdd:cd17377   233 WSGRRRTLAGFLFLGGIACLLVMFVPEKkdsgvFAVVNSTSLSLLGKLTiSAAFNIVYIYTSELYPTVVRNAGLGVCSMF 312
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958642064 294 GNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 334
Cdd:cd17377   313 SRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
73-341 3.49e-08

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 54.89  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  73 FQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKvahMNGMKNSGDNLTMEVvrTSMKRELEAAKAR 152
Cdd:cd17358   152 FLPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF---LRGKDADISKEAAEI--QEELAELEKEAKE 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 153 PSPRDLFHTPILRKRICAMSFMR----------ILFMLSIFGMSLHLqhLSSNIMLLqfVVSASSLLFSVIGPYVFNRMG 222
Cdd:cd17358   227 SSFSDLFQRKYLKPLVIGLGLMLfqqlsginavIFYASSIFDEAGSG--LDPNTATI--IIGVVQVVGTLVATLLVDRLG 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 223 RRITQMVVMTLRGI-CILTAVF-----VPQEMQILRI-TVVTLAGAFSALSFGVNRLH---TNELLPTTLRATAIGVIGM 292
Cdd:cd17358   303 RRPLLLVSAIGMGIgLLALGLYfylqeHGALLSSVSWlPLVGLVIYIISFSIGLGPLPwviMSEIFPAKIKGLAGSLVTL 382
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642064 293 FGNSGFFLAPL---FMILASYSPNLPWIFYG--GFSILngFTVFLLPETKNQPL 341
Cdd:cd17358   383 VNWLFAFIVTKtfpFLTLAWGASGTFWIFAGicGLALV--FVLLFVPETKGKSL 434
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
9-325 9.44e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.20  E-value: 9.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   9 GFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLA-----FQFQNWHHLQLAM 83
Cdd:cd06174    79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgilasSLGFGWRAVFLIA 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  84 SVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKvahmngmknsgdnltmevvrtsmkreleaakarpSPRDLFHTPI 163
Cdd:cd06174   159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLK----------------------------------LLKRVLKNPG 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 164 LRKRI----CAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRmGRRITQMVVMTLRGICIL 239
Cdd:cd06174   205 LWLLLlaifLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR-LIGRKPLLLIGLLLMALG 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 240 TAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL---FMILASYSPNLPW 316
Cdd:cd06174   284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLlagFLLAATFGLTGAF 363

                  ....*....
gi 1958642064 317 IFYGGFSIL 325
Cdd:cd06174   364 LVLAVLLLL 372
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
9-303 1.08e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 53.13  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   9 GFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMI---LAGLAFQFQNWHHL-QLAMS 84
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVggfLAGWLIPVFGWRSLfYVGGI 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  85 VPIFFFLILTRWLSESARWLIVtnkpQKGLKELRKVAHMNGMKNSGDNLTMEVVRTSMKRELEAAKARPSPRDLFHTPIL 164
Cdd:TIGR00895 180 APLLLLLLLMRFLPESIDFLVS----KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLL 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 165 RKRICAMSFMRIL------FMLSIFGMSLHLqhlsSNIMLlqFVVSASSLLFSVIGPYVFNRMGRRITqMVVMTLRGIcI 238
Cdd:TIGR00895 256 WLLYFMLLVGVYFltnwlpKLMVELGFSLSL----AATGG--ALFNFGGVIGSIIFGWLADRLGPRVT-ALLLLLGAV-F 327
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642064 239 LTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL 303
Cdd:TIGR00895 328 AVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPI 392
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
137-333 8.15e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 8.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 137 VVRTSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMRILFMLSIFGM----SLHLQHL----SSNIMLLQFVVSASSL 208
Cdd:cd17325   170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepflPLYAAELgglsPAQIGLLFGAQGLASA 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 209 LFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIG 288
Cdd:cd17325   250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL--LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642064 289 VIGMFGNSGFFLAPLF--MILASYSPNLPWIFYGGFSILNGFTVFLL 333
Cdd:cd17325   328 LFNTAFSLGMVLGPLLggFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-301 9.82e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 9.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTS----HKFLAMMSVIAPCAGSFGsMILAGLAFQFQNW 76
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPperrGRALGLLGAGLGLGPALG-PLLGGLLADLFGW 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  77 HHLQLAMSVPIFFFLILTRWLsesarwlivtnkpqkgLKELRKVahmngmknsgdnltmevvrtsmkrelEAAKARPSPR 156
Cdd:COG2814   164 RWVFLVNAVLALLALLLLLRL----------------LPESRPA--------------------------ARARLRGSLR 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 157 DLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQHL----SSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMT 232
Cdd:COG2814   202 ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlglsASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL 281
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642064 233 LRGICILTAVFVPQEMQILriTVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLA 301
Cdd:COG2814   282 LLALGLLLLALAGSLWLLL--LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
177-333 1.21e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.88  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 177 LFMLSIFGMSLhlqhlsSNIMLLQFVVSASSLLFSVIGPYV---FNRMGRRITQMVVMTLRGICILTAVFVPQEMqiLRI 253
Cdd:cd17319   204 TYLKQARGFSL------KQVGLLAAIPFLAGAIGMILGGRLsdrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV--VAV 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 254 TVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL---FMILASYSPNLPWIFYGGFSILNGFTV 330
Cdd:cd17319   276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLligYLVDATGSYTAAFLFLAAVALLAALLV 355

                  ...
gi 1958642064 331 FLL 333
Cdd:cd17319   356 LLL 358
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
1-338 1.99e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 49.57  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   1 MAITETCVGFASNFFIYCSL----RFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQF--- 73
Cdd:cd17357    88 LLVVSSLLMFLSKSAKSPELlifgRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSvlg 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  74 --QNWHHLQLAMSVPIFFFLILTRWLSESARWL-IVTNKPQKGLKELRKvahmngMKNSGDNLTMEVVRTSMKRELEAAK 150
Cdd:cd17357   168 teTLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKF------LRGIEDDVDQELEEIKKESEQMGDQ 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 151 ARPSPRDLFHTPILRKR---ICAMSFMRIL--------FMLSIFGMSLHLQHLSsniMLLQFVVSASSLLFSVIGPYVFN 219
Cdd:cd17357   242 KQVSLMQLLRDPSLRLPlllVLVVSASQQFsginaiffYSTFIFENAGFSPQLA---EWANLGIGIVNVLSTIVGPFLIE 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 220 RMGRR---ITQMVVMTLRGICILTAVFVP---QEMQILRITVVTLAGAFSALSFG-VNRLHTNELLPTTLRATAIGVIGM 292
Cdd:cd17357   319 KVGRRpllLISLSVCAVALLLMSVFLFLSeqnSWMSYGCIVAIFLFIFFFAIGLGpIPWFIGAELFPQAPRSAAQSLGSS 398
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642064 293 FGNSGFFLAPL-FMILASYSPNLPWIFYGGFSILNG-FTVFLLPETKN 338
Cdd:cd17357   399 VNWTSNFIVGMaFPPLQSIGGGFVFIIFAIPCALFLlYLYRYLPETKG 446
MFS_1 pfam07690
Major Facilitator Superfamily;
168-342 3.11e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQ- 246
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSl 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 247 -EMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFY--GGFS 323
Cdd:pfam07690  86 wLLLVLRV----LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLilAILS 161
                         170
                  ....*....|....*....
gi 1958642064 324 ILNGFTVFLLPETKNQPLP 342
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRP 180
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
9-336 4.95e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.07  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   9 GFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEW--TSHKFLAMMSVIAPCA-GSFGSMILAGLAFQFQNWHHLQLAM-- 83
Cdd:cd17371    82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYvpARHRGKALGYVQSGWAvGWLLATLLAALLFPLLPPEIAWRVLfl 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064  84 --SVPIFFFLILTRWLSESARWLIVTNKPQKGlkelrkvahmngmknsgdnltmevvrtsmkreleaaKARPSPRDLFHT 161
Cdd:cd17371   162 lgALPALLVLFIRRFVKEPPQWQAARAARRHF------------------------------------ADRPSLRELFSP 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 162 PILRKRI--------CAMSFMRILFMLSIFGMSLHlqHLSSNIMLLQFVVSAS-SLLFSVIGPYVFNRMGRRITQMVVMT 232
Cdd:cd17371   206 PLLRTTLlasllatgALGGYYGITTWLPSYLTGER--GLSFEGSAGYLVVTILgGFLGYLAGGFLADRIGRRNNFALFAL 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 233 LRGICILTAVFVPQEMQILRITVVTLaGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF--MILASY 310
Cdd:cd17371   284 GSAISILLYFFLPLSPTLILILGFPL-GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLvgFLATSG 362
                         330       340
                  ....*....|....*....|....*..
gi 1958642064 311 SPNLPWIFYGGFS-ILNGFTVFLLPET 336
Cdd:cd17371   363 SLGTAIAVFAAVYyIAGLVLALLLPET 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
165-337 1.48e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 165 RKRICAMSFMRILFMLSIFGMSLHL----QHLSSNIMLLQFVVSASSL---LFSVIGPYVFNRMGRRITQMVVMTLRGIC 237
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALpliaADLGASPAQAGLVVTAYLLgaaLGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 238 ILTAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF--MILASYSPNLP 315
Cdd:COG2814    89 SLLCALAPSLWLL--LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLggLLADLFGWRWV 166
                         170       180
                  ....*....|....*....|...
gi 1958642064 316 WIFYGGFSILNGF-TVFLLPETK 337
Cdd:COG2814   167 FLVNAVLALLALLlLLRLLPESR 189
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
168-333 6.85e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.49  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMrILFMLSIFGMSLHLQ-HLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVP 245
Cdd:COG2223    13 AFFLAFG-VWYLWSVLAPPLAEEfGLSaAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 246 QEMQILRITVvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFYGGFS 323
Cdd:COG2223    92 SYWLLLLLGL--LLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAplLIAAFGWRNAFLILGILL 169
                         170
                  ....*....|
gi 1958642064 324 ILNGFTVFLL 333
Cdd:COG2223   170 LVVAVLAWLF 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
168-340 8.50e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.10  E-value: 8.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMRIL-FMLSIFGMSLHLQHLSSNIMLLQFVVSASS---LLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVF 243
Cdd:cd17325     1 LSLALFLDMLgYGIIIPILPLYAESLGASVAQIGLIVAAYAlaqLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 244 V--PQEMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFY 319
Cdd:cd17325    81 AtsYWQLLLARF----LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGglLADALGYRAPFLVC 156
                         170       180
                  ....*....|....*....|..
gi 1958642064 320 GGFSILNG-FTVFLLPETKNQP 340
Cdd:cd17325   157 AALALLALvLALLLLPEPRPPP 178
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
168-341 1.60e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.88  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 168 ICAMSFMRILFMLSIFGMSLHL--QHLSSNIMLLQFVVSASSL---LFSVIGPYVFNRMGRRITQMVVMTLRGICILTAV 242
Cdd:COG0477    18 ALALGTFLEGLDFTIVNVALPSiaADLGASSAQLGWIVSAYLLgraIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 243 FVP--QEMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 320
Cdd:COG0477    98 LAPspELLIAARA----LQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
                         170       180
                  ....*....|....*....|...
gi 1958642064 321 G--FSILNGFTVFLLPETKNQPL 341
Cdd:COG0477   174 NapLGLLALVLRLRLPESRGLLL 196
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
219-334 2.39e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 42.84  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 219 NRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFG-VNRLHTNELLPTTLRATAIGVIGMFGNSG 297
Cdd:cd17445   230 DRFGRRGILLLAMTLTGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAAsLSILFAAEVIPTVIRGSGLGLIMALGSLG 309
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958642064 298 FFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 334
Cdd:cd17445   310 GLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
164-352 6.18e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 6.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 164 LRKRICAMSFMRILFMLSIFGMSLHL---QHLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICIL 239
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLhqqLGLSaSIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 240 TAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF-MILASYSPNLP-WI 317
Cdd:cd17329    81 LLGFAHSPWLF--AIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFRLLfLA 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958642064 318 FYGGFSILNGFTVFLLPETKNQPLPDCIHDIGNDW 352
Cdd:cd17329   159 AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
8-106 1.87e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 39.76  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064   8 VGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPI 87
Cdd:cd17443    83 VALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPL 162
                          90
                  ....*....|....*....
gi 1958642064  88 ffFLILTRWLSESARWLIV 106
Cdd:cd17443   163 --LLLLLYWCFPSRNGLIL 179
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
219-333 2.73e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.44  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 219 NRMGRRITQMVVMTLRGICILTaVFVPQEMQILrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGF 298
Cdd:cd17372   254 DRLGRKASMASMLFTCCIFLLL-LLICQSPFIL-TVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGA 331
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958642064 299 FLAPLF-MILASYSPNLPWIFYGGFSILNGFTVFLL 333
Cdd:cd17372   332 ILCPFIaQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
219-343 2.81e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 39.71  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 219 NRMGRRITQmvvmtLRGICILTAVFVPqeMQIL--------RITVVTLAGAFSalSFGVNR---LHTNELLPTTLRATAI 287
Cdd:TIGR00887 360 DIIGRKPIQ-----LMGFFILTVLFFV--LGFAynhlsthgFLAIYVLAQFFA--NFGPNAttfIVPGEVFPTRYRSTAH 430
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642064 288 GVIGMFGNSGFFLAPL-FMILASYS------PNLPW-----IFYGGFSILNGFTVFLLPETKNQPLPD 343
Cdd:TIGR00887 431 GISAASGKAGAIIGQFgFLYLAQHGdptkgyPTGIWmghvlEIFALFMFLGILFTLLIPETKGKSLEE 498
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
156-334 6.07e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 156 RDLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQ---HLSSNIM-LLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVM 231
Cdd:cd06173   202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKevlGGGAAGYgLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 232 TLRGICILTAVFVPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYS 311
Cdd:cd06173   282 LLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
                         170       180
                  ....*....|....*....|...
gi 1958642064 312 PNLPWIFYGGFSILNGFTVFLLP 334
Cdd:cd06173   360 LGLSAVFLLAGALLLLAALLLLL 382
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
176-333 8.05e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 8.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 176 ILFMLSIFgMSLHLQHLSSNIMLLQFVVSASSLLFSVI-GPYVFNRMGRRITQMVVMTLRGICILTAVFVPQemQILRIT 254
Cdd:cd17474   217 FLTYLPFL-LELLYGISPIIIGLLFAGWSVLLALGSLFvGRLLKKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLI 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 255 VVTLAGAFSALSF-GVNRLHTnELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLL 333
Cdd:cd17474   294 AIVLFGLGLGLNLpLLTTLVT-ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
194-335 8.89e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 37.94  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642064 194 SNIMLLQFVVSASSLLFSVIGPYVFNRMGRR-------ITQMVVMTLRGICILTAVfVPQEMQILRITVVTLAGAFSALS 266
Cdd:cd17315   214 TASILASIIVGVVNLLATLVAIRLVDKVGRRpllligfAGMAASLLLLAIAFLLPA-LAKAAGWLALLGILLYIAAFAMG 292
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642064 267 FG-VNRLHTNELLPTTLRATAIGV-IGMFGNSGFFLAPLFMI-LASYSPNLPWIFYGGFSILN-GFTVFLLPE 335
Cdd:cd17315   293 AGpVPWLLLSEIFPLRIRGKGMAIaTLVNWIFNFIVGLTFLImVSTIGLAGVFIFFAAVCLLAlVFVFFFVPE 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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