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Conserved domains on  [gi|1958642068|ref|XP_038945458|]
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integral membrane transport protein UST5r isoform X4 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-285 1.97e-71

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 224.86  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   1 MMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmkns 80
Cdd:cd17374   124 LAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------------------------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  81 gdnltmevvrtsmkreleaakarpsprdlfhtpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLL 160
Cdd:cd17374   173 ------------------------------------KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVP 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 161 FSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGV 240
Cdd:cd17374   217 ARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGL 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642068 241 IGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17374   297 NSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-285 1.97e-71

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 224.86  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   1 MMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmkns 80
Cdd:cd17374   124 LAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------------------------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  81 gdnltmevvrtsmkreleaakarpsprdlfhtpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLL 160
Cdd:cd17374   173 ------------------------------------KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVP 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 161 FSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGV 240
Cdd:cd17374   217 ARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGL 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642068 241 IGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17374   297 NSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-294 4.80e-59

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 197.16  E-value: 4.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  11 SFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKnsgdnLTMEVVR 90
Cdd:TIGR00898 226 SLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  91 TSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFN 170
Cdd:TIGR00898 301 LSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLID 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 171 RMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFF 250
Cdd:TIGR00898 381 RLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSI 460

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642068 251 LAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLPETKNQPLPD 294
Cdd:TIGR00898 461 ISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
121-285 1.16e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 121 AMSFMRILFMLSIFGMSLHL-------QHLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRR--ITQMVVMTLRGICIL 190
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLptylvevRGLSlAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 191 TAVFVPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWI 268
Cdd:COG2271   264 LLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFL 341

                         170
                  ....*....|....*..
gi 1958642068 269 FYGGFSILNGFTVFLLP 285
Cdd:COG2271   342 LLAALALLAALLALLLL 358
Sugar_tr pfam00083
Sugar (and other) transporter;
12-292 1.76e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 58.44  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  12 FGSMILAGLAFQFQNWH-----HLQLAMSVPIFFFLIltrWLSESARWLIvtnkpQKGLKELRKVAHMNGMKNSGDNLTM 86
Cdd:pfam00083 153 LAYIFGLGLNKTSNSDGwriplGLQLVPALLLIIGLL---FLPESPRWLV-----EKGRLEEAREVLAKLRGVPDVDREL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  87 EVVRTSMKRELEAAKArpSPRDLFHTPILRKRI---CAMSFMR-------ILFMLSIFGMSLHLqhlsSNIMLLQFVVSA 156
Cdd:pfam00083 225 DEIKDSLEAGQEAEKA--SWKELFSTKTRRQRLligVMLQIFQqltginaIFYYSTTIFENLGL----SDSFLVTIIVGV 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 157 SSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC--ILTAVFVPQE-----MQILRITVVTLAGAFSALSFG-VNRLHTNEL 228
Cdd:pfam00083 299 VNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICfvILGIVALLGVsksdwAGIVAIVFIALFIAFFAMGWGpVPWVIVSEL 378

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642068 229 LPTTLRATAIGVIGMFGN-SGFFLAPLFMILASYSPNLP-WIFYGGFSILNG-FTVFLLPETKNQPL 292
Cdd:pfam00083 379 FPLSVRSKAMALATAANWlANFLIGFLFPIITDAIGLGYtFFIFAGLLVLFIiFVFFFVPETKGRTL 445
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-285 1.97e-71

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 224.86  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   1 MMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmkns 80
Cdd:cd17374   124 LAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------------------------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  81 gdnltmevvrtsmkreleaakarpsprdlfhtpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLL 160
Cdd:cd17374   173 ------------------------------------KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVP 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 161 FSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGV 240
Cdd:cd17374   217 ARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGL 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642068 241 IGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17374   297 NSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-294 4.80e-59

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 197.16  E-value: 4.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  11 SFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKnsgdnLTMEVVR 90
Cdd:TIGR00898 226 SLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  91 TSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFN 170
Cdd:TIGR00898 301 LSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLID 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 171 RMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFF 250
Cdd:TIGR00898 381 RLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSI 460

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642068 251 LAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLPETKNQPLPD 294
Cdd:TIGR00898 461 ISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-285 4.74e-32

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 121.53  E-value: 4.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   1 MMSVIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSesarwlivtnkpqkglkelrkvahmngmkns 80
Cdd:cd17317   114 FVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP------------------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  81 gdnltmevvrtsmkreleaakarpsprdlfhtpilrKRICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLL 160
Cdd:cd17317   163 ------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIP 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 161 FSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGV 240
Cdd:cd17317   207 AYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGL 286

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642068 241 IGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17317   287 CSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 11-285 3.23e-28

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 111.74  E-value: 3.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  11 SFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLsesarwlivtnkpqkglkelrkvAHMNgmknsgdnltmevvr 90
Cdd:cd17446   132 TLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWF-----------------------PRIT--------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  91 tsmkreleaakarpsprdlfhtpilrkriCAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFN 170
Cdd:cd17446   174 -----------------------------FCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMS 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 171 RMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFF 250
Cdd:cd17446   225 YLGRRPTQAAALILAGIMILANIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGI 304

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1958642068 251 LAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17446   305 VAPLVKMLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 4-285 2.13e-23

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 98.26  E-value: 2.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   4 VIAPCAGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWlsesarwlivtnkpqkglkelrkvahmngmknsgdn 83
Cdd:cd17447   127 VLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWW------------------------------------ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  84 ltmeVVRTSMkreleaakarpsprdlfhtpilrkrICAMSFMRILFmlSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSV 163
Cdd:cd17447   171 ----VPKISL-------------------------CTGIVWFGVAF--TYYGISFNISGFGLNVYLTQFIYGAIELPAKL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 164 IGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGM 243
Cdd:cd17447   220 LAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSF 299

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642068 244 FGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17447   300 IARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 117-285 2.19e-14

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 72.78  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 117 KRICAMsfMRILFMLSI--FGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVF 194
Cdd:cd17378   173 RRLLAV--MVIGFGIGMvyYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFV 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 195 VPQEMQILRITVVTLAGAFSALS-FGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGF 273
Cdd:cd17378   251 LSIGGTTSLQIALELVGFFGAAGaFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVA 330

                         170
                  ....*....|..
gi 1958642068 274 SILNGFTVFLLP 285
Cdd:cd17378   331 ILLLGLFALGLP 342
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 119-285 2.72e-13

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 69.42  E-value: 2.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 119 ICAMSFMRILFMLSI----FGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVF 194
Cdd:cd17376   172 IPITTIMSLLLWMAIsvgyFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 195 VPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFS 274
Cdd:cd17376   252 VPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLT 331

                         170
                  ....*....|.
gi 1958642068 275 ILNGFTVFLLP 285
Cdd:cd17376   332 VLIGILTLFLP 342
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 131-285 2.16e-11

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 64.00  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 131 LSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRItVVTLA 210
Cdd:cd17375   187 LGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTI-VLSMT 265

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642068 211 GAFS-ALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17375   266 GKFAiAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
121-285 1.16e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 121 AMSFMRILFMLSIFGMSLHL-------QHLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRR--ITQMVVMTLRGICIL 190
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLptylvevRGLSlAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 191 TAVFVPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWI 268
Cdd:COG2271   264 LLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFL 341

                         170
                  ....*....|....*..
gi 1958642068 269 FYGGFSILNGFTVFLLP 285
Cdd:COG2271   342 LLAALALLAALLALLLL 358
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 11-285 1.48e-09

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 58.13  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  11 SFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILtrwlsesaRWLIVTnkpqkglkelrkvahmngmknsgdnltmevvr 90
Cdd:cd17379   132 TLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLY--------YWFIPK-------------------------------- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  91 tsmkreleaakarpsprdlfHTPILrkricamsfMRILFMLSIF--GMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYV 168
Cdd:cd17379   172 --------------------HTFIL---------MYAWFTSAVVyqGLIMRLGITGGNLYLDFFISALVELPAAFIILLT 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 169 FNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSG 248
Cdd:cd17379   223 IDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIG 302

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958642068 249 FFLAPLFMI-LASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17379   303 GIIAPFLLYrLAEIWLELPLIVFGVLALVAGGLVLLLP 340
Sugar_tr pfam00083
Sugar (and other) transporter;
12-292 1.76e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 58.44  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  12 FGSMILAGLAFQFQNWH-----HLQLAMSVPIFFFLIltrWLSESARWLIvtnkpQKGLKELRKVAHMNGMKNSGDNLTM 86
Cdd:pfam00083 153 LAYIFGLGLNKTSNSDGwriplGLQLVPALLLIIGLL---FLPESPRWLV-----EKGRLEEAREVLAKLRGVPDVDREL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  87 EVVRTSMKRELEAAKArpSPRDLFHTPILRKRI---CAMSFMR-------ILFMLSIFGMSLHLqhlsSNIMLLQFVVSA 156
Cdd:pfam00083 225 DEIKDSLEAGQEAEKA--SWKELFSTKTRRQRLligVMLQIFQqltginaIFYYSTTIFENLGL----SDSFLVTIIVGV 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 157 SSLLFSVIGPYVFNRMGRRITQMVVMTLRGIC--ILTAVFVPQE-----MQILRITVVTLAGAFSALSFG-VNRLHTNEL 228
Cdd:pfam00083 299 VNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICfvILGIVALLGVsksdwAGIVAIVFIALFIAFFAMGWGpVPWVIVSEL 378

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642068 229 LPTTLRATAIGVIGMFGN-SGFFLAPLFMILASYSPNLP-WIFYGGFSILNG-FTVFLLPETKNQPL 292
Cdd:pfam00083 379 FPLSVRSKAMALATAANWlANFLIGFLFPIITDAIGLGYtFFIFAGLLVLFIiFVFFFVPETKGRTL 445
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
96-288 6.69e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.43  E-value: 6.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  96 ELEAAKARPSPRDLFHtPILRKRICAMSFMRILFMLSIFGMSLHLQHLSSNIM--------LLQFVVSASSLLFSVIGPY 167
Cdd:COG2223   185 AGAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaatagLLAALFALLGALGRPLGGW 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 168 VFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNS 247
Cdd:COG2223   264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF-LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1958642068 248 GFFLAPLFM---ILASYSPNLPWIFYGGFSILNGFTVFLLPETK 288
Cdd:COG2223   343 GGFLGPLLFgalLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 114-281 7.34e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 56.07  E-value: 7.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 114 ILRKRICAMSFMRILFMLSIFGMSL-------HLQHLSSNIMLLQ-FVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLR 185
Cdd:cd17316   174 LLRRRTLLLILLWFFISFGYYGLTTflptylqTVLGLSPATSSLYlLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 186 GICILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAP--LFMILASYSP 263
Cdd:cd17316   254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGG 333

                         170
                  ....*....|....*...
gi 1958642068 264 NLPWIFYGGFSILNGFTV 281
Cdd:cd17316   334 TGVPALILALLAIVALIV 351
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 10-292 8.20e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 56.43  E-value: 8.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  10 GSFGSM--------ILAGLAF-QFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKvahMNGMKNS 80
Cdd:cd17358   129 GALGSLnqllvnigILLGYVLgSFLPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF---LRGKDAD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  81 GDNLTMEVvrTSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMR----------ILFMLSIFGMSLHLqhLSSNIMLL 150
Cdd:cd17358   206 ISKEAAEI--QEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLfqqlsginavIFYASSIFDEAGSG--LDPNTATI 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 151 qfVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGI-CILTAVF-----VPQEMQILRI-TVVTLAGAFSALSFGVNRL 223
Cdd:cd17358   282 --IIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIgLLALGLYfylqeHGALLSSVSWlPLVGLVIYIISFSIGLGPL 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642068 224 H---TNELLPTTLRATAIGVIGMFGNSGFFLAPL---FMILASYSPNLPWIFYG--GFSILngFTVFLLPETKNQPL 292
Cdd:cd17358   360 PwviMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKtfpFLTLAWGASGTFWIFAGicGLALV--FVLLFVPETKGKSL 434
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 171-285 1.36e-08

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 55.55  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 171 RMGRRITQMVVMTLRGICILTAVFVPQE-----MQILRITVVTLAGAFS-ALSFGVNRLHTNELLPTTLRATAIGVIGMF 244
Cdd:cd17377   233 WSGRRRTLAGFLFLGGIACLLVMFVPEKkdsgvFAVVNSTSLSLLGKLTiSAAFNIVYIYTSELYPTVVRNAGLGVCSMF 312

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958642068 245 GNSGFFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17377   313 SRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 88-284 3.29e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 3.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  88 VVRTSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMRILFMLSIFGM----SLHLQHL----SSNIMLLQFVVSASSL 159
Cdd:cd17325   170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepflPLYAAELgglsPAQIGLLFGAQGLASA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 160 LFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIG 239
Cdd:cd17325   250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL--LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642068 240 VIGMFGNSGFFLAPLF--MILASYSPNLPWIFYGGFSILNGFTVFLL 284
Cdd:cd17325   328 LFNTAFSLGMVLGPLLggFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 128-284 3.86e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 51.03  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 128 LFMLSIFGMSLhlqhlsSNIMLLQFVVSASSLLFSVIGPYV---FNRMGRRITQMVVMTLRGICILTAVFVPQEMqiLRI 204
Cdd:cd17319   204 TYLKQARGFSL------KQVGLLAAIPFLAGAIGMILGGRLsdrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV--VAV 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 205 TVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL---FMILASYSPNLPWIFYGGFSILNGFTV 281
Cdd:cd17319   276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLligYLVDATGSYTAAFLFLAAVALLAALLV 355


                  ...
gi 1958642068 282 FLL 284
Cdd:cd17319   356 LLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
119-293 8.70e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 119 ICAMSFMRILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQ- 197
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSl 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 198 -EMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFY--GGFS 274
Cdd:pfam07690  86 wLLLVLRV----LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLilAILS 161

                         170
                  ....*....|....*....
gi 1958642068 275 ILNGFTVFLLPETKNQPLP 293
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRP 180
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
95-252 1.36e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  95 RELEAAKARPSPRDLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQHL----SSNIMLLQFVVSASSLLFSVIGPYVFN 170
Cdd:COG2814   189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlglsASAAGLLLALFGLGGVLGALLAGRLAD 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 171 RMGRRITQMVVMTLRGICILTAVFVPQEMQILriTVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFF 250
Cdd:COG2814   269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLL--LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346


                  ..
gi 1958642068 251 LA 252
Cdd:COG2814   347 LA 348
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 2-289 2.78e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.41  E-value: 2.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   2 MSVIAPCAGSFGSMILAGLAFQF-----QNWHHLQLAMSVPIFFFLILTRWLSESARWL-IVTNKPQKGLKELRKvahmn 75
Cdd:cd17357   142 LGSLTQIGVTLGILLGQVFGLPSvlgteTLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKF----- 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  76 gMKNSGDNLTMEVVRTSMKRELEAAKARPSPRDLFHTPILRKR---ICAMSFMRIL--------FMLSIFGMSLHLQHLS 144
Cdd:cd17357   217 -LRGIEDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLRLPlllVLVVSASQQFsginaiffYSTFIFENAGFSPQLA 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 145 sniMLLQFVVSASSLLFSVIGPYVFNRMGRR---ITQMVVMTLrgICILTAVFV-----PQEMQILRITVVTLAGAFSAL 216
Cdd:cd17357   296 ---EWANLGIGIVNVLSTIVGPFLIEKVGRRpllLISLSVCAV--ALLLMSVFLflseqNSWMSYGCIVAIFLFIFFFAI 370

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642068 217 SFG-VNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL-FMILASYSPNLPWIFYGGFSILNG-FTVFLLPETKN 289
Cdd:cd17357   371 GLGpIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMaFPPLQSIGGGFVFIIFAIPCALFLlYLYRYLPETKG 446
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
116-288 6.06e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 116 RKRICAMSFMRILFMLSIFGMSLHL----QHLSSNIMLLQFVVSASSL---LFSVIGPYVFNRMGRRITQMVVMTLRGIC 188
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALpliaADLGASPAQAGLVVTAYLLgaaLGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 189 ILTAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF--MILASYSPNLP 266
Cdd:COG2814    89 SLLCALAPSLWLL--LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLggLLADLFGWRWV 166

                         170       180
                  ....*....|....*....|...
gi 1958642068 267 WIFYGGFSILNGF-TVFLLPETK 288
Cdd:COG2814   167 FLVNAVLALLALLlLLRLLPESR 189
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 127-276 8.97e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.65  E-value: 8.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 127 ILFMLSIFGMSLHLQHLSSNIMLLQFVVSASSLLFSVIGPYVFNRmGRRITQMVVMTLRGICILTAVFVPQEMQILRITV 206
Cdd:cd06174   221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR-LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL 299

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642068 207 VTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPL---FMILASYSPNLPWIFYGGFSIL 276
Cdd:cd06174   300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLlagFLLAATFGLTGAFLVLAVLLLL 372
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
119-284 2.40e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 119 ICAMSFMrILFMLSIFGMSLHLQ-HLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVP 196
Cdd:COG2223    13 AFFLAFG-VWYLWSVLAPPLAEEfGLSaAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 197 QEMQILRITVvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFYGGFS 274
Cdd:COG2223    92 SYWLLLLLGL--LLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAplLIAAFGWRNAFLILGILL 169

                         170
                  ....*....|
gi 1958642068 275 ILNGFTVFLL 284
Cdd:COG2223   170 LVVAVLAWLF 179
MFS_1 pfam07690
Major Facilitator Superfamily;
121-253 3.00e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.10  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 121 AMSFMRILFMLSIFGMSLHLQHLSSNIMLlqFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILT-AVFVPQEM 199
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLL--GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGlLLLSLTLS 290

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642068 200 QILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAP 253
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 119-291 3.42e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.87  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 119 ICAMSFMRIL-FMLSIFGMSLHLQHLSSNIMLLQFVVSASS---LLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVF 194
Cdd:cd17325     1 LSLALFLDMLgYGIIIPILPLYAESLGASVAQIGLIVAAYAlaqLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 195 V--PQEMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFM--ILASYSPNLPWIFY 270
Cdd:cd17325    81 AtsYWQLLLARF----LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGglLADALGYRAPFLVC 156

                         170       180
                  ....*....|....*....|..
gi 1958642068 271 GGFSILNG-FTVFLLPETKNQP 291
Cdd:cd17325   157 AALALLALvLALLLLPEPRPPP 178
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 119-292 7.53e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.65  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 119 ICAMSFMRILFMLSIFGMSLHL--QHLSSNIMLLQFVVSASSL---LFSVIGPYVFNRMGRRITQMVVMTLRGICILTAV 193
Cdd:COG0477    18 ALALGTFLEGLDFTIVNVALPSiaADLGASSAQLGWIVSAYLLgraIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 194 FVP--QEMQILRItvvtLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYG 271
Cdd:COG0477    98 LAPspELLIAARA----LQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173

                         170       180
                  ....*....|....*....|...
gi 1958642068 272 G--FSILNGFTVFLLPETKNQPL 292
Cdd:COG0477   174 NapLGLLALVLRLRLPESRGLLL 196
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 170-285 1.33e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 43.22  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 170 NRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLAGAFSALSFG-VNRLHTNELLPTTLRATAIGVIGMFGNSG 248
Cdd:cd17445   230 DRFGRRGILLLAMTLTGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAAsLSILFAAEVIPTVIRGSGLGLIMALGSLG 309

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958642068 249 FFLAPLFMILASYSPNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd17445   310 GLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 115-303 2.74e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.21  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 115 LRKRICAMSFMRILFMLSIFGMSLHL---QHLS-SNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICIL 190
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLhqqLGLSaSIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 191 TAVFVPQEMQIlrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF-MILASYSPNLP-WI 268
Cdd:cd17329    81 LLGFAHSPWLF--AIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFRLLfLA 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958642068 269 FYGGFSILNGFTVFLLPETKNQPLPDCIHDIGNDW 303
Cdd:cd17329   159 AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 9-287 3.69e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.90  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068   9 AGSFGSMILAGLAFQFQNWHHLQLAM----SVPIFFFLILTRWLSESARWLIVTNKPQKGlkelrkvahmngmknsgdnl 84
Cdd:cd17371   134 VGWLLATLLAALLFPLLPPEIAWRVLfllgALPALLVLFIRRFVKEPPQWQAARAARRHF-------------------- 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  85 tmevvrtsmkreleaaKARPSPRDLFHTPILRKRI--------CAMSFMRILFMLSIFGMSLHlqHLSSNIMLLQFVVSA 156
Cdd:cd17371   194 ----------------ADRPSLRELFSPPLLRTTLlasllatgALGGYYGITTWLPSYLTGER--GLSFEGSAGYLVVTI 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 157 S-SLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQILRITVVTLaGAFSALSFGVNRLHTNELLPTTLRA 235
Cdd:cd17371   256 LgGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPL-GFFASGPFSGMGAYLTELFPTAVRA 334

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642068 236 TAIGVIGMFGNSGFFLAPLF--MILASYSPNLPWIFYGGFS-ILNGFTVFLLPET 287
Cdd:cd17371   335 TAQGFCYNVGRIIGALFPFLvgFLATSGSLGTAIAVFAAVYyIAGLVLALLLPET 389
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 10-254 7.12e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.80  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  10 GSFGSMILAGLAFQFQNWHHL-QLAMSVPIFFFLILTRWLSESARWLIVtnkpQKGLKELRKVAHMNGMKNSGDNLTMEV 88
Cdd:TIGR00895 153 GAAVGGFLAGWLIPVFGWRSLfYVGGIAPLLLLLLLMRFLPESIDFLVS----KRPETVRRIVNAIAPQMQAEAQSALPE 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068  89 VRTSMKRELEAAKARPSPRDLFHTPILRKRICAMSFMRIL------FMLSIFGMSLHLqhlsSNIMLlqFVVSASSLLFS 162
Cdd:TIGR00895 229 QKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFltnwlpKLMVELGFSLSL----AATGG--ALFNFGGVIGS 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 163 VIGPYVFNRMGRRITqMVVMTLRGIcILTAVFVPQEMQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIG 242
Cdd:TIGR00895 303 IIFGWLADRLGPRVT-ALLLLLGAV-FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAI 380

                         250
                  ....*....|..
gi 1958642068 243 MFGNSGFFLAPL 254
Cdd:TIGR00895 381 GIGRLGAIIGPI 392
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 170-294 1.26e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.48  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 170 NRMGRRITQmvvmtLRGICILTAVFVPqeMQIL--------RITVVTLAGAFSalSFGVNR---LHTNELLPTTLRATAI 238
Cdd:TIGR00887 360 DIIGRKPIQ-----LMGFFILTVLFFV--LGFAynhlsthgFLAIYVLAQFFA--NFGPNAttfIVPGEVFPTRYRSTAH 430

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642068 239 GVIGMFGNSGFFLAPL-FMILASYS------PNLPW-----IFYGGFSILNGFTVFLLPETKNQPLPD 294
Cdd:TIGR00887 431 GISAASGKAGAIIGQFgFLYLAQHGdptkgyPTGIWmghvlEIFALFMFLGILFTLLIPETKGKSLEE 498
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 170-284 1.34e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.21  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 170 NRMGRRITQMVVMTLRGICILTaVFVPQEMQILrITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGF 249
Cdd:cd17372   254 DRLGRKASMASMLFTCCIFLLL-LLICQSPFIL-TVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGA 331

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958642068 250 FLAPLF-MILASYSPNLPWIFYGGFSILNGFTVFLL 284
Cdd:cd17372   332 ILCPFIaQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 107-285 3.29e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 107 RDLFHTPILRKRICAMSFMRILFMLSIFGMSLHLQ---HLSSNIM-LLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVM 182
Cdd:cd06173   202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKevlGGGAAGYgLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 183 TLRGICILTAVFVPQemQILRITVVTLAGAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYS 262
Cdd:cd06173   282 LLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359

                         170       180
                  ....*....|....*....|...
gi 1958642068 263 PNLPWIFYGGFSILNGFTVFLLP 285
Cdd:cd06173   360 LGLSAVFLLAGALLLLAALLLLL 382
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 145-286 3.74e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.71  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 145 SNIMLLQFVVSASSLLFSVIGPYVFNRMGRR-------ITQMVVMTLRGICILTAVfVPQEMQILRITVVTLAGAFSALS 217
Cdd:cd17315   214 TASILASIIVGVVNLLATLVAIRLVDKVGRRpllligfAGMAASLLLLAIAFLLPA-LAKAAGWLALLGILLYIAAFAMG 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642068 218 FG-VNRLHTNELLPTTLRATAIGV-IGMFGNSGFFLAPLFMI-LASYSPNLPWIFYGGFSILN-GFTVFLLPE 286
Cdd:cd17315   293 AGpVPWLLLSEIFPLRIRGKGMAIaTLVNWIFNFIVGLTFLImVSTIGLAGVFIFFAAVCLLAlVFVFFFVPE 365
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 127-276 3.87e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 127 ILFMLSIFgMSLHLQHLSSNIMLLQFVVSASSLLFSVI-GPYVFNRMGRRITQMVVMTLRGICILTAVFVPQemQILRIT 205
Cdd:cd17474   217 FLTYLPFL-LELLYGISPIIIGLLFAGWSVLLALGSLFvGRLLKKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLI 293

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642068 206 VVTLAGAFSALSF-GVNRLHTnELLPTTLRATAIGVIGMFGNSGFFLAPLFMILASYSPNLPWIFYGGFSIL 276
Cdd:cd17474   294 AIVLFGLGLGLNLpLLTTLVT-ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIA 364
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 146-286 8.25e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 37.63  E-value: 8.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 146 NIMLLQFVVSASSLLFSVIGPYVFNRMGRRItqMVVMTLRGIC---ILTAVFVPqeMQILRITVVTLAGAFSALSFGVNr 222
Cdd:cd17360   224 NAIWLSLIVAGTNFIFTIVGMYLIDKFGRRK--LLLISLFGVIvalVVLAVWLA--LVGLILYLAFFAPGMGPVPWTVN- 298

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642068 223 lhtNELLPTTLRATAIGVIGMfGNSGF--FLAPLFMILASY-SPNLPWIFYGGFSILNGFTV-FLLPE 286
Cdd:cd17360   299 ---SEIYPLWARGTGGGCAAA-VNWVFnlLVSQTFLTLTQAiGPYGTFLLFAGLAVLGLIFIyFCVPE 362
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 131-317 9.04e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.59  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 131 LSIFGMSLH--------LQHLSSNIM--LLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGICILTAVFVPQEMQ 200
Cdd:cd06173    10 LSALGDWIFtvalpwlvLQLTGSALLvgLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642068 201 ILRITVVTLA---GAFSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF--MILASYSPNLPWIFYGGFSI 275
Cdd:cd06173    90 LSLWLLLVLAfllGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALggLLVALLGPGGAFAINALSFL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958642068 276 LNGFTVFLLPETKNQPLPDCIHDIGNDWEESRQEMKEDPTIK 317
Cdd:cd06173   170 LSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLR 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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