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Conserved domains on  [gi|1958669484|ref|XP_038945648|]
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AP-5 complex subunit zeta-1 isoform X1 [Rattus norvegicus]

Protein Classification

SPG48 domain-containing protein( domain architecture ID 10631760)

SPG48 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPG48 pfam14764
AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the ...
 228-346 2.81e-53

AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterized by progressive spasticity in the lower limbs.


:

Pssm-ID: 464303  Cd Length: 118  Bit Score: 179.32  E-value: 2.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669484 228 LQKACLVEAVLVLDVLCRQDPSFLYRTLSCLKPLHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEAIYAQLLGSLPSE 307
Cdd:pfam14764   1 LQKACLVEAVLLLDELCRQDPSLVYRAFPCLKRLFQRLSSDLSQARALLPILQFFLNHGEAAAVDSEAVLQHFFTSVLSR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958669484 308 RFHSPTLAFEVIHFCTHNLALFDPHfLSLLRLSFPNLFK 346
Cdd:pfam14764  81 LFADPMLAFETIQFCRDNLELLLAN-TSLLPQYFPNLLK 118
 
Name Accession Description Interval E-value
SPG48 pfam14764
AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the ...
 228-346 2.81e-53

AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterized by progressive spasticity in the lower limbs.


Pssm-ID: 464303  Cd Length: 118  Bit Score: 179.32  E-value: 2.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669484 228 LQKACLVEAVLVLDVLCRQDPSFLYRTLSCLKPLHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEAIYAQLLGSLPSE 307
Cdd:pfam14764   1 LQKACLVEAVLLLDELCRQDPSLVYRAFPCLKRLFQRLSSDLSQARALLPILQFFLNHGEAAAVDSEAVLQHFFTSVLSR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958669484 308 RFHSPTLAFEVIHFCTHNLALFDPHfLSLLRLSFPNLFK 346
Cdd:pfam14764  81 LFADPMLAFETIQFCRDNLELLLAN-TSLLPQYFPNLLK 118
 
Name Accession Description Interval E-value
SPG48 pfam14764
AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the ...
 228-346 2.81e-53

AP-5 complex subunit, vesicle trafficking; This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterized by progressive spasticity in the lower limbs.


Pssm-ID: 464303  Cd Length: 118  Bit Score: 179.32  E-value: 2.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669484 228 LQKACLVEAVLVLDVLCRQDPSFLYRTLSCLKPLHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEAIYAQLLGSLPSE 307
Cdd:pfam14764   1 LQKACLVEAVLLLDELCRQDPSLVYRAFPCLKRLFQRLSSDLSQARALLPILQFFLNHGEAAAVDSEAVLQHFFTSVLSR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958669484 308 RFHSPTLAFEVIHFCTHNLALFDPHfLSLLRLSFPNLFK 346
Cdd:pfam14764  81 LFADPMLAFETIQFCRDNLELLLAN-TSLLPQYFPNLLK 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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