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Conserved domains on  [gi|1958676642|ref|XP_038948119|]
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rRNA N6-adenosine-methyltransferase ZCCHC4 isoform X2 [Rattus norvegicus]

Protein Classification

protein-lysine N-methyltransferase( domain architecture ID 6503)

protein-lysine N-methyltransferase such as human EEF1A lysine methyltransferase 1 that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
N6-adenineMlase super family cl10922
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 1-79 1.92e-10

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


The actual alignment was detected with superfamily member pfam10237:

Pssm-ID: 463014  Cd Length: 118  Bit Score: 57.17  E-value: 1.92e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676642   1 MRSLLLDIDFRYSQFylEESFCRYNMFNHHFFDgkaalevckAFLqeeEGKGVIMVTDPPFggLVEPLAVTFKKLIAMW 79
Cdd:pfam10237  49 INSLLLEYDKRFAVY--GPDFVFYDYNNPLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
 
Name Accession Description Interval E-value
N6-adenineMlase pfam10237
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 1-79 1.92e-10

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


Pssm-ID: 463014  Cd Length: 118  Bit Score: 57.17  E-value: 1.92e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676642   1 MRSLLLDIDFRYSQFylEESFCRYNMFNHHFFDgkaalevckAFLqeeEGKGVIMVTDPPFggLVEPLAVTFKKLIAMW 79
Cdd:pfam10237  49 INSLLLEYDKRFAVY--GPDFVFYDYNNPLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
 
Name Accession Description Interval E-value
N6-adenineMlase pfam10237
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 1-79 1.92e-10

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


Pssm-ID: 463014  Cd Length: 118  Bit Score: 57.17  E-value: 1.92e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676642   1 MRSLLLDIDFRYSQFylEESFCRYNMFNHHFFDgkaalevckAFLqeeEGKGVIMVTDPPFggLVEPLAVTFKKLIAMW 79
Cdd:pfam10237  49 INSLLLEYDKRFAVY--GPDFVFYDYNNPLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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