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Conserved domains on  [gi|1958680791|ref|XP_038949513|]
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E3 ubiquitin-protein ligase CCNB1IP1 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GumC super family cl34566
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
66-153 2.37e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3206:

Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791  66 KQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEK---LMERNRQYQKLQGLYDSL--RLRNITIASQEG 140
Cdd:COG3206   305 AQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELeaeLRRLEREVEVARELYESLlqRLEEARLAEALT 384

                          90
                  ....*....|....*...
gi 1958680791 141 S-----LEPAMIPQSGVF 153
Cdd:COG3206   385 VgnvrvIDPAVVPLKPVS 402
 
Name Accession Description Interval E-value
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
66-153 2.37e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791  66 KQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEK---LMERNRQYQKLQGLYDSL--RLRNITIASQEG 140
Cdd:COG3206   305 AQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELeaeLRRLEREVEVARELYESLlqRLEEARLAEALT 384

                          90
                  ....*....|....*...
gi 1958680791 141 S-----LEPAMIPQSGVF 153
Cdd:COG3206   385 VgnvrvIDPAVVPLKPVS 402
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 45-122 6.01e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 41.42  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791   45 AVVHQERLYQEYNFSK-AENHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVL--EEYKKKFSDISEKLMERNRQYQKL 121
Cdd:smart00935   2 GVVDVQKILQESPAGKaAQKQLEKEFKKRQAELEKLEKELQKLKEKLQKDAATLseAAREKKEKELQKKVQEFQRKQQKL 81


                   .
gi 1958680791  122 Q 122
Cdd:smart00935  82 Q 82
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 78-132 1.06e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 39.86  E-value: 1.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958680791  78 SKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRN 132
Cdd:cd22887     1 ELESELQELEKRLAELEAELASLEEEIKDLEEELKEKNKANEILNDELIALQIEN 55
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 44-122 9.31e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 38.33  E-value: 9.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791  44 MAVVHQERLYQEYN-FSKAENHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKfsdISEKLMERNRQYQKLQ 122
Cdd:pfam03938   2 IGYVDMQKILEESPeGKAAQAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREE---KEQELQKKEQELQQLQ 78
 
Name Accession Description Interval E-value
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
66-153 2.37e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791  66 KQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEK---LMERNRQYQKLQGLYDSL--RLRNITIASQEG 140
Cdd:COG3206   305 AQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELeaeLRRLEREVEVARELYESLlqRLEEARLAEALT 384

                          90
                  ....*....|....*...
gi 1958680791 141 S-----LEPAMIPQSGVF 153
Cdd:COG3206   385 VgnvrvIDPAVVPLKPVS 402
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 45-122 6.01e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 41.42  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791   45 AVVHQERLYQEYNFSK-AENHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVL--EEYKKKFSDISEKLMERNRQYQKL 121
Cdd:smart00935   2 GVVDVQKILQESPAGKaAQKQLEKEFKKRQAELEKLEKELQKLKEKLQKDAATLseAAREKKEKELQKKVQEFQRKQQKL 81


                   .
gi 1958680791  122 Q 122
Cdd:smart00935  82 Q 82
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 78-132 1.06e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 39.86  E-value: 1.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958680791  78 SKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRN 132
Cdd:cd22887     1 ELESELQELEKRLAELEAELASLEEEIKDLEEELKEKNKANEILNDELIALQIEN 55
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
52-122 2.14e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.43  E-value: 2.14e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958680791  52 LYQEYN--FSKAENHLKQMEKIYtQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQ 122
Cdd:COG1340   165 LRAELKelRKEAEEIHKKIKELA-EEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQ 236
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 44-122 9.31e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 38.33  E-value: 9.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680791  44 MAVVHQERLYQEYN-FSKAENHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKfsdISEKLMERNRQYQKLQ 122
Cdd:pfam03938   2 IGYVDMQKILEESPeGKAAQAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREE---KEQELQKKEQELQQLQ 78
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
65-139 5.24e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 37.19  E-value: 5.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958680791  65 LKQMEKIyTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRlRNITIASQE 139
Cdd:COG4372    37 LFELDKL-QEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ-EELESLQEE 109
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 50-111 7.87e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 36.76  E-value: 7.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958680791  50 ERLYQEY--------NFSKAENHLKQMEKIY---TQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKL 111
Cdd:pfam06160 315 ERVQQSYtlneneleRVRGLEKQLEELEKRYdeiVERLEEKEVAYSELQEELEEILEQLEEIEEEQEEFKESL 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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