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Conserved domains on  [gi|1958694071|ref|XP_038951112|]
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zinc finger protein 844-like isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 86-123 1.35e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.36  E-value: 1.35e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958694071  86 SVTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNL 123
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
429-606 3.14e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 429 TSYSTLRAHERSHTG-EKPYVCKHCGKAFTQSSYLRIHKRT--HTGE--KPYIC--KQCGKAFARSSHLQIHKRSHTGEK 501
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 502 PYVCK--QCGKAFAQSS------YLHIHQRSHTgEKPYIC--KQCGKAFTRSSHLQIHKITHTGEKPYSCK--LCGKAFT 569
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958694071 570 HSNYLQIHRRIHTGEKPYVCKECGKAFARSTSLHIHE 606
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-414 8.14e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 339 HCGKAYSSYStlqAHERSHTGEKPFVCK--DCGKAYTSYSTLRAH---------------ERSHTG----EKPYVCKHCE 397
Cdd:COG5189   329 HGGERNIDTP---SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCD 405

                          90
                  ....*....|....*..
gi 1958694071 398 KAYTSYNTLRAHeRSHT 414
Cdd:COG5189   406 KRYKNLNGLKYH-RKHS 421
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-302 3.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958694071 268 KHEQFYAQEKPYVCKQCDKAFKYLSSLQNHkRTHT 302
Cdd:COG5189   388 KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 567-663 4.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 567 AFTHSNYLQIH---RRIHT-GEKPYVCK--ECGKAFARSTSLHIH--EGthsgekpfvckQCGKAFTLSSSLRRHDVVHS 638
Cdd:COG5189   326 KLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHmlHG-----------HQNQKLHENPSPEKMNIFSA 394

                          90       100
                  ....*....|....*....|....*
gi 1958694071 639 EEKPYICKCCGKTFDCYSSVQKHEK 663
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 6.22e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 321 NVQVHERNHTGEKPYVCKHCGKAYSS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG3767 super family cl01537
Uncharacterized low-complexity protein [Function unknown];
188-220 6.52e-03

Uncharacterized low-complexity protein [Function unknown];


The actual alignment was detected with superfamily member COG3767:

Pssm-ID: 442981 [Multi-domain]  Cd Length: 102  Bit Score: 36.63  E-value: 6.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958694071 188 CGEGTCGSHV-------CGEGTCGSHVCG-----EGTCGSHVCGG 220
Cdd:COG3767    56 CGEGKCGADKkkkkegkCGEGKCGADKKGdakaaEGKCGEGKCGA 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-430 7.00e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 406 LRAHERSHTGEKPFVCKDCGKAYTS 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 9.12e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 293 SLQNHKRTHTRERNYACKQCGKCFKR 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 86-123 1.35e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.36  E-value: 1.35e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958694071  86 SVTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNL 123
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
87-130 1.46e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 68.39  E-value: 1.46e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958694071   87 VTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNLHDIGQKL 130
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 87-123 2.61e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 2.61e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958694071  87 VTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNL 123
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
429-606 3.14e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 429 TSYSTLRAHERSHTG-EKPYVCKHCGKAFTQSSYLRIHKRT--HTGE--KPYIC--KQCGKAFARSSHLQIHKRSHTGEK 501
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 502 PYVCK--QCGKAFAQSS------YLHIHQRSHTgEKPYIC--KQCGKAFTRSSHLQIHKITHTGEKPYSCK--LCGKAFT 569
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958694071 570 HSNYLQIHRRIHTGEKPYVCKECGKAFARSTSLHIHE 606
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-470 2.16e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 387 GEKPYVCK--HCEKAYTSYNTLRAHeRSHtgekpfvcKDCGKAYTSYSTLRAHERSHTGEKPYVCKHCGKAFTQSSYLRI 464
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958694071 465 HkRTHT 470
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-514 3.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 489 HLQIHKRSHTGEKPYVCKQCGKAFAQ 514
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-414 8.14e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 339 HCGKAYSSYStlqAHERSHTGEKPFVCK--DCGKAYTSYSTLRAH---------------ERSHTG----EKPYVCKHCE 397
Cdd:COG5189   329 HGGERNIDTP---SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCD 405

                          90
                  ....*....|....*..
gi 1958694071 398 KAYTSYNTLRAHeRSHT 414
Cdd:COG5189   406 KRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-302 3.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958694071 268 KHEQFYAQEKPYVCKQCDKAFKYLSSLQNHkRTHT 302
Cdd:COG5189   388 KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 567-663 4.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 567 AFTHSNYLQIH---RRIHT-GEKPYVCK--ECGKAFARSTSLHIH--EGthsgekpfvckQCGKAFTLSSSLRRHDVVHS 638
Cdd:COG5189   326 KLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHmlHG-----------HQNQKLHENPSPEKMNIFSA 394

                          90       100
                  ....*....|....*....|....*
gi 1958694071 639 EEKPYICKCCGKTFDCYSSVQKHEK 663
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 6.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 321 NVQVHERNHTGEKPYVCKHCGKAYSS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG3767 COG3767
Uncharacterized low-complexity protein [Function unknown];
188-220 6.52e-03

Uncharacterized low-complexity protein [Function unknown];


Pssm-ID: 442981 [Multi-domain]  Cd Length: 102  Bit Score: 36.63  E-value: 6.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958694071 188 CGEGTCGSHV-------CGEGTCGSHVCG-----EGTCGSHVCGG 220
Cdd:COG3767    56 CGEGKCGADKkkkkegkCGEGKCGADKKGdakaaEGKCGEGKCGA 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-430 7.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 406 LRAHERSHTGEKPFVCKDCGKAYTS 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 350 LQAHERSHTGEKPFVCKDCGKAYTS 374
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 9.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 293 SLQNHKRTHTRERNYACKQCGKCFKR 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 86-123 1.35e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.36  E-value: 1.35e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958694071  86 SVTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNL 123
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
87-130 1.46e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 68.39  E-value: 1.46e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958694071   87 VTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNLHDIGQKL 130
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 87-123 2.61e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 2.61e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958694071  87 VTFEDVAVNFTLEEWTLLNPSQENLYRAVMRETIRNL 123
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
429-606 3.14e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 429 TSYSTLRAHERSHTG-EKPYVCKHCGKAFTQSSYLRIHKRT--HTGE--KPYIC--KQCGKAFARSSHLQIHKRSHTGEK 501
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 502 PYVCK--QCGKAFAQSS------YLHIHQRSHTgEKPYIC--KQCGKAFTRSSHLQIHKITHTGEKPYSCK--LCGKAFT 569
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958694071 570 HSNYLQIHRRIHTGEKPYVCKECGKAFARSTSLHIHE 606
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-654 8.50e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 8.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 305 RNYACKQCGKCFKRQSNVQVHERNHTGEKPYVCKH--CGKAYSSYSTLQAHERSHTGEKPFVCKDCG------KAYTSYS 376
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 377 TLRAHERSHTGEKPYVCKH-------------------CEKAYTSYNT--------------------------LRAHER 411
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnPLPGNNSSSVntpqsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 412 SHTGEKPFVCKDCGKAYTSYSTLRAHERSHTGEKPYVCKHCGKAFTQSSYLRIHKRT------HTGEKPYICKQCGKAFA 485
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 486 RSSHLQIHKRSHTG-EKPYVCKQCGKAFAQSSYLHIHQRS--HTGE--KPYIC--KQCGKAFTRSSHLQIHKITHTGEKP 558
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 559 YSCKL--CGKAFTHSN------YLQIHRRIHTgEKPYVC--KECGKAFARS--TSLHIHEGTHSGEKPFVCKQCGKAFTL 626
Cdd:COG5048   352 AKEKLlnSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDsnLSLHIITHLSFRPYNCKNPPCSKSFNR 430

                         410       420
                  ....*....|....*....|....*...
gi 1958694071 627 SSSLRRHDVVHSEEKPYICKCCGKTFDC 654
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-470 2.16e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 387 GEKPYVCK--HCEKAYTSYNTLRAHeRSHtgekpfvcKDCGKAYTSYSTLRAHERSHTGEKPYVCKHCGKAFTQSSYLRI 464
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958694071 465 HkRTHT 470
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-514 3.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 489 HLQIHKRSHTGEKPYVCKQCGKAFAQ 514
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-598 7.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 573 YLQIHRRIHTGEKPYVCKECGKAFAR 598
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-414 8.14e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 339 HCGKAYSSYStlqAHERSHTGEKPFVCK--DCGKAYTSYSTLRAH---------------ERSHTG----EKPYVCKHCE 397
Cdd:COG5189   329 HGGERNIDTP---SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCD 405

                          90
                  ....*....|....*..
gi 1958694071 398 KAYTSYNTLRAHeRSHT 414
Cdd:COG5189   406 KRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-458 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 434 LRAHERSHTGEKPYVCKHCGKAFTQ 458
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
274-496 1.17e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 274 AQEKPYVCKQCDKAFKYLSSLQNHKRThtrernyackqcgkcfkrqsnvqvheRNHTGE--KPYVCKH--CGKAYSSYST 349
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRS--------------------------VNHSGEslKPFSCPYslCGKLFSRNDA 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 350 LQAHERSHTGEKPFVCK--DCGKAYTSYSTLRAHERSHtgekpyvckhcekaytsyntlraHERSHTGEKPFVC--KDCG 425
Cdd:COG5048   339 LKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ-----------------------QYKDLKNDKKSETlsNSCI 395

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958694071 426 KAYTSYSTLRAHERSHTGEKPYVCK--HCGKAFTQSSYLRIHKRTHTgEKPYICKQCGKAFARSSHLQIHKRS 496
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-570 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 545 HLQIHKITHTGEKPYSCKLCGKAFTH 570
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-486 3.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 461 YLRIHKRTHTGEKPYICKQCGKAFAR 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-302 3.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958694071 268 KHEQFYAQEKPYVCKQCDKAFKYLSSLQNHkRTHT 302
Cdd:COG5189   388 KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 527-578 3.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958694071 527 GEKPYICK--QCGKAFTRSSHLQIHK-------ITH------------TGEKPYSCKLCGKAFTHSNYLQIHR 578
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 567-663 4.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 567 AFTHSNYLQIH---RRIHT-GEKPYVCK--ECGKAFARSTSLHIH--EGthsgekpfvckQCGKAFTLSSSLRRHDVVHS 638
Cdd:COG5189   326 KLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHmlHG-----------HQNQKLHENPSPEKMNIFSA 394

                          90       100
                  ....*....|....*....|....*
gi 1958694071 639 EEKPYICKCCGKTFDCYSSVQKHEK 663
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 415-498 5.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694071 415 GEKPFVCK--DCGKAYTSYSTLRAHeRSHtgekpyvcKHCGKAFTQSSYLRIHKRTHTGEKPYICKQCGKAFARSSHLQI 492
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958694071 493 HkRSHT 498
Cdd:COG5189   417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 447-469 6.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|...
gi 1958694071 447 YVCKHCGKAFTQSSYLRIHKRTH 469
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 6.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 321 NVQVHERNHTGEKPYVCKHCGKAYSS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG3767 COG3767
Uncharacterized low-complexity protein [Function unknown];
188-220 6.52e-03

Uncharacterized low-complexity protein [Function unknown];


Pssm-ID: 442981 [Multi-domain]  Cd Length: 102  Bit Score: 36.63  E-value: 6.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958694071 188 CGEGTCGSHV-------CGEGTCGSHVCG-----EGTCGSHVCGG 220
Cdd:COG3767    56 CGEGKCGADKkkkkegkCGEGKCGADKKGdakaaEGKCGEGKCGA 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-430 7.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 406 LRAHERSHTGEKPFVCKDCGKAYTS 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 350 LQAHERSHTGEKPFVCKDCGKAYTS 374
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....*
gi 1958694071 378 LRAHERSHTGEKPYVCKHCEKAYTS 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 9.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958694071 293 SLQNHKRTHTRERNYACKQCGKCFKR 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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