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Conserved domains on  [gi|1958694420|ref|XP_038951129|]
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coiled-coil domain-containing protein 66 isoform X4 [Rattus norvegicus]

Protein Classification

CCDC66 domain-containing protein( domain architecture ID 12172167)

CCDC66 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
378-531 5.66e-48

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


:

Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 167.66  E-value: 5.66e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420 378 PPAVQVKPSEKEQRARPVMDMSVSHGQKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRR 457
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958694420 458 KEEQEEELRLAREREEMQRQYEEDILKQKHKEEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELTQKGHDTSR 531
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
PTZ00121 super family cl31754
MAEBL; Provisional
184-517 9.65e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  184 ARENEPVPQRAQAASQQCEQKATVEsEWKPADIFSTLGERERDRSLLEARRAQWKKELDEqvaLKKKEkEASQKWPDPWK 263
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAE-EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE---AKKAA-EAKKKADEAKK 1517
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  264 PSEIL-CEKLQVLERSKEAGLLESPCITVKQEQQRKwIEELNKQvedDQQRKAEEKliysKGEEHDRWAVHFDSFKSHPG 342
Cdd:PTZ00121  1518 AEEAKkADEAKKAEEAKKADEAKKAEEKKKADELKK-AEELKKA---EEKKKAEEA----KKAEEDKNMALRKAEEAKKA 1589
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  343 SQSRLSSQLTPQHLESLCVSPDTQEladvsSVDTPPPAVQVKPSEKEQRarPVMDMSVSHGQKTNFLRSMTALLDPAQIE 422
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKK-----AEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  423 ERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRRkeeqeeeLRLAREREEMQRQYEEDILKQ---KHKEEIMTLKTNEL 499
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKE-------AEEAKKAEELKKKEAEEKKKAeelKKAEEENKIKAEEA 1735
                          330
                   ....*....|....*...
gi 1958694420  500 FHTMQRAQELAQRLKQEQ 517
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDE 1753
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
378-531 5.66e-48

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 167.66  E-value: 5.66e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420 378 PPAVQVKPSEKEQRARPVMDMSVSHGQKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRR 457
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958694420 458 KEEQEEELRLAREREEMQRQYEEDILKQKHKEEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELTQKGHDTSR 531
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
PTZ00121 PTZ00121
MAEBL; Provisional
184-517 9.65e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  184 ARENEPVPQRAQAASQQCEQKATVEsEWKPADIFSTLGERERDRSLLEARRAQWKKELDEqvaLKKKEkEASQKWPDPWK 263
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAE-EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE---AKKAA-EAKKKADEAKK 1517
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  264 PSEIL-CEKLQVLERSKEAGLLESPCITVKQEQQRKwIEELNKQvedDQQRKAEEKliysKGEEHDRWAVHFDSFKSHPG 342
Cdd:PTZ00121  1518 AEEAKkADEAKKAEEAKKADEAKKAEEKKKADELKK-AEELKKA---EEKKKAEEA----KKAEEDKNMALRKAEEAKKA 1589
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  343 SQSRLSSQLTPQHLESLCVSPDTQEladvsSVDTPPPAVQVKPSEKEQRarPVMDMSVSHGQKTNFLRSMTALLDPAQIE 422
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKK-----AEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  423 ERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRRkeeqeeeLRLAREREEMQRQYEEDILKQ---KHKEEIMTLKTNEL 499
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKE-------AEEAKKAEELKKKEAEEKKKAeelKKAEEENKIKAEEA 1735
                          330
                   ....*....|....*...
gi 1958694420  500 FHTMQRAQELAQRLKQEQ 517
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDE 1753
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
378-531 5.66e-48

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 167.66  E-value: 5.66e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420 378 PPAVQVKPSEKEQRARPVMDMSVSHGQKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRR 457
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958694420 458 KEEQEEELRLAREREEMQRQYEEDILKQKHKEEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELTQKGHDTSR 531
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
PTZ00121 PTZ00121
MAEBL; Provisional
184-517 9.65e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  184 ARENEPVPQRAQAASQQCEQKATVEsEWKPADIFSTLGERERDRSLLEARRAQWKKELDEqvaLKKKEkEASQKWPDPWK 263
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAE-EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE---AKKAA-EAKKKADEAKK 1517
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  264 PSEIL-CEKLQVLERSKEAGLLESPCITVKQEQQRKwIEELNKQvedDQQRKAEEKliysKGEEHDRWAVHFDSFKSHPG 342
Cdd:PTZ00121  1518 AEEAKkADEAKKAEEAKKADEAKKAEEKKKADELKK-AEELKKA---EEKKKAEEA----KKAEEDKNMALRKAEEAKKA 1589
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  343 SQSRLSSQLTPQHLESLCVSPDTQEladvsSVDTPPPAVQVKPSEKEQRarPVMDMSVSHGQKTNFLRSMTALLDPAQIE 422
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKK-----AEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  423 ERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRRkeeqeeeLRLAREREEMQRQYEEDILKQ---KHKEEIMTLKTNEL 499
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKE-------AEEAKKAEELKKKEAEEKKKAeelKKAEEENKIKAEEA 1735
                          330
                   ....*....|....*...
gi 1958694420  500 FHTMQRAQELAQRLKQEQ 517
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDE 1753
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
419-522 2.36e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.06  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420 419 AQIEERERRRQKQLEHQKAITAQVEENRRKKRLEEEQRRkeeqeeelrlaREREEM----QRQYEEDILKQKHKEEimtl 494
Cdd:pfam13868  59 EEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKL-----------QEREQMdeivERIQEEDQAEAEEKLE---- 123
                          90       100
                  ....*....|....*....|....*...
gi 1958694420 495 KTNELFHTMQRAQELAQRLKQEQRIREL 522
Cdd:pfam13868 124 KQRQLREEIDEFNEEQAEWKELEKEEER 151
PTZ00121 PTZ00121
MAEBL; Provisional
185-525 6.63e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  185 RENEPVPQRAQAASQQCEQKATVESEWKPADifstlgERERDRSLLEARRAQWKK--ELDEQVALKKKEKEASQKWPDPW 262
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAE------EDKKKADELKKAAAAKKKadEAKKKAEEKKKADEAKKKAEEAK 1444
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  263 KPSEiLCEKLQVLERSKEAGllespcitvKQEQQRKWIEELNKQVEddQQRKAEEklIYSKGEEHDRWAVHFDSFKSHPG 342
Cdd:PTZ00121  1445 KADE-AKKKAEEAKKAEEAK---------KKAEEAKKADEAKKKAE--EAKKADE--AKKKAEEAKKKADEAKKAAEAKK 1510
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  343 SQSRLSSQLTPQHLESLCVSPDTQELADVSSVDTPPPAVQVKPSEKEQRA---RPVMDMSVSHGQKTNFLRSMTAL--LD 417
Cdd:PTZ00121  1511 KADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAeekKKAEEAKKAEEDKNMALRKAEEAkkAE 1590
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958694420  418 PAQIEE-----RERRRQKQLEHQKAITAQVEENRRKKRLEEEQRRKEEQEEELRLAREREEMQRQYEEDILK---QKHKE 489
Cdd:PTZ00121  1591 EARIEEvmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKaaeEAKKA 1670
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1958694420  490 EIMTLKTNELfhtmqRAQELAQRLKQEQRIRELTQK 525
Cdd:PTZ00121  1671 EEDKKKAEEA-----KKAEEDEKKAAEALKKEAEEA 1701
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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