|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
1-439 |
2.77e-153 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 440.52 E-value: 2.77e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 1 MHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAegpvmnllsnrsrGIKDFSTRAAVYQWSTETQGIIFSSISYGII 80
Cdd:cd17318 4 LFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFYGYI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 81 LTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTS 160
Cdd:cd17318 71 LTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 161 IAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMiyddpmhhpcisvkekeyitssvaqqsssprrs 240
Cdd:cd17318 151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL--------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 241 ipikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLS 320
Cdd:cd17318 198 --------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 321 LITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTAGII 400
Cdd:cd17318 270 TTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGII 349
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1958704741 401 SSTTTGFLISQD-SESGWRNVFFLSAAVNMFGLIFYLIFG 439
Cdd:cd17318 350 SPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
1-454 |
1.23e-133 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 393.34 E-value: 1.23e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 1 MHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAEGPVmnllsnrsrgikdFSTRAAVYQWSTETQGIIFSSISYGII 80
Cdd:TIGR00894 24 LHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIKNPNFKWSGALQGLILSSHFYGQI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 81 LTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTS 160
Cdd:TIGR00894 91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 161 IAGSGAAFGSFIILCVGGLISQA-LGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVKEKEYITSSVAQQSSSPRR 239
Cdd:TIGR00894 171 MSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 240 SIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLL 319
Cdd:TIGR00894 251 SLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 320 SLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTAGI 399
Cdd:TIGR00894 331 SLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGL 410
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1958704741 400 ISSTTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYLIFGQAEIQNWAKERTLTR 454
Cdd:TIGR00894 411 IASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
1-439 |
2.53e-98 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 300.54 E-value: 2.53e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 1 MHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAEGPVMNLLSNRSRgikdfSTRAAVYQWSTETQGIIFSSISYGII 80
Cdd:cd17381 5 AFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEH-----NETGKKYDWDAETQGWILGSFFYGYI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 81 LTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTS 160
Cdd:cd17381 80 ITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 161 IAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpcisvkekeyitssvaqqsssprrs 240
Cdd:cd17381 160 ISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 241 ipikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLS 320
Cdd:cd17381 208 ---------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 321 LITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTAGII 400
Cdd:cd17381 279 TVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMV 358
|
410 420 430
....*....|....*....|....*....|....*....
gi 1958704741 401 SSTTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYLIFG 439
Cdd:cd17381 359 GPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
12-439 |
6.00e-74 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 236.85 E-value: 6.00e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 12 RVSLSIAIIAMVNSTQHQDPANASAEGPVMNllsnrsrgikdfstraavyqWSTETQGIIFSSISYGIILTLIPSGYLAG 91
Cdd:cd17382 15 RCNLGVAIVRMVNNFTDAYGGKVIVHKAEFN--------------------WTPETVGLIESSFFWGYLVTQIPGGFIAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 92 IFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSF 171
Cdd:cd17382 75 KFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 172 IILCVGGLISQALGWPFIFYIFGSIGCVCCVLWftmiyddpmhhpcisvkekeyitssvaqqsssprrsipikaMVRCLP 251
Cdd:cd17382 155 VGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-----------------------------------------MLVSMP 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 252 LWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLSLITVRKLFSSL 331
Cdd:cd17382 194 VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 332 GLLLPSLCAVALPFVTSSYIAtIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQ 411
Cdd:cd17382 274 GFGMEATFLLVVAFSHSPTVA-ISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKH 352
|
410 420
....*....|....*....|....*...
gi 1958704741 412 DSESGWRNVFFLSAAVNMFGLIFYLIFG 439
Cdd:cd17382 353 KTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
58-439 |
1.39e-60 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 201.63 E-value: 1.39e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 137
Cdd:cd17380 26 AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpc 217
Cdd:cd17380 106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 218 isvkekeyitssvaqqsssprrsipikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLhVNIRDSGVLSSLPFI 297
Cdd:cd17380 177 --------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 298 AASSCTILGGQMADFLLSRNLlSLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIpGTSNLCDSGFIINTLD 377
Cdd:cd17380 224 VMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVAL-GLSAFSSSGVLVNHQD 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958704741 378 VAPRYASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLIFG 439
Cdd:cd17380 302 IAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
61-439 |
3.28e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.58 E-value: 3.28e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 61 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWT 140
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 141 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFtmiyddpmhhpcisv 220
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF--------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 221 kekeyitssvaqqsssprrsipikamvrclplWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAAS 300
Cdd:COG2271 183 --------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 301 SCTILGGQMADFLLSRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAP 380
Cdd:COG2271 231 VGSLLGGWLSDRLGRRRKLVLAIG---------LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 381 -RYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIFG 439
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-437 |
2.28e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 109.20 E-value: 2.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 62 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGMSWTG 141
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 142 QFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDdpmhhpcisvk 221
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 222 ekeyitssvaqqsssprrsipikamvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASS 301
Cdd:cd17319 181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 302 CTILGGQMADFLLSRNllslitvRKLFSSLGLLLPSLCAVALPFVTSSYIAtIVLLILIPGTSNLCDSGFIINTLDVAPR 381
Cdd:cd17319 231 GMILGGRLSDRLLRGA-------RRLVIIIGLLLAAVGLLLAYLTTSPVVA-VILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958704741 382 -YASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLI 437
Cdd:cd17319 303 eAAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
58-436 |
2.92e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.80 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGM 137
Cdd:cd06174 23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG--RFLLGLGSGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQAL--GWPFIFYIFGSIGCVCCVLWFTMIYDDPMHH 215
Cdd:cd06174 101 IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 216 pcisvkekeyitSSVAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLP 295
Cdd:cd06174 181 ------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 296 FIAASSCTILGGQMADFLLSRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINT 375
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIGRKPLLLIGL---------LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958704741 376 LDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQDseSGWRNVFFLSAAVNMFGLIFYL 436
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
61-402 |
3.06e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 3.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 61 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMSWT 140
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 141 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPcisv 220
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 221 kekeyitssvAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYIsTVLHVNIRDSGVLSSLPFIAAS 300
Cdd:pfam07690 181 ----------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 301 SCTILGGQMADFLLSRNLLSLITVrklfsslgLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAP 380
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALL--------LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 1958704741 381 -RYASFLMGISRGFGLTAGIISS 402
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-438 |
9.70e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.63 E-value: 9.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--LLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpcisvkeKEYITS 228
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL--------------PEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 229 SVAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQ 308
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 309 MADFLlsrnllslitVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMG 388
Cdd:cd17325 258 LSDRI----------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1958704741 389 ISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIF 438
Cdd:cd17325 328 LFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
58-438 |
3.65e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.09 E-value: 3.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGM 137
Cdd:COG2223 32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLL--GLLLGIGGGG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPc 217
Cdd:COG2223 110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 218 isvkekeyitssvaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 297
Cdd:COG2223 189 ----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 298 AASSCTILGGQMADFLLSRNLLSLITVrklfsslgllLPSLCAVALPFVTSS-YIATIVLLILIPGTSNLCDSGFIINTL 376
Cdd:COG2223 253 LGALGRPLGGWLSDRIGGRRVLLIVFA----------LMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958704741 377 DVAPRYASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLIF 438
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
58-319 |
6.75e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.64 E-value: 6.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGM 137
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL--LAARFLQGLGAGA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPmhhpc 217
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 218 isvkekeyitssvaqQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 297
Cdd:COG2814 190 ---------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL 254
|
250 260
....*....|....*....|..
gi 1958704741 298 AASSCTILGGQMADFLLSRNLL 319
Cdd:COG2814 255 GGVLGALLAGRLADRFGRRRLL 276
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
69-410 |
3.99e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 76.65 E-value: 3.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLERSKLTSIAGSGAAF-GSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHhPCISVKEKEYIT 227
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPNE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 228 SSVAQQSSSPRRSIPIKAMVRCL----PLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCT 303
Cdd:TIGR00881 190 EPDGDAEKKEEELTKKQIFLQYVllnkVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 304 ILGGQMADFLLSRNLLSLITVRKLFSSLGLllpslcAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYA 383
Cdd:TIGR00881 270 LLAGWLSDKLFNGRRGPLAVFFMALIIVSL------LVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKA 343
|
330 340
....*....|....*....|....*...
gi 1958704741 384 SFLMGISRGF-GLTAGIISSTTTGFLIS 410
Cdd:TIGR00881 344 AGTAAGFVGFfAYLGGILAGLPLGYLAD 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
64-436 |
5.19e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 5.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQF 143
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--RALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 144 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCV-LWFTMIYDDPMHHPcisvke 222
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLPSLPPKKPG------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 223 keyITSSVAQQSSSPRRSIPIKAMVrclplwAIFMGFFSHFwlctIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSC 302
Cdd:cd17324 184 ---SLGLLSSLLLLLRNPRLRLAYL------ITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 303 TILGGQMADFLLSRNLLSLITVrklfsslglllPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRY 382
Cdd:cd17324 251 SPLAGRLADRGGRRALLIALLL-----------LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1958704741 383 ASFLMGISRGFGLTAGIISSTTTGFLISQDsesGWRNVFFLSAAVNMFGLIFYL 436
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHG---GWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
58-207 |
2.19e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.53 E-value: 2.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGM 137
Cdd:COG0477 41 AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTM 207
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
61-437 |
1.73e-10 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 62.64 E-value: 1.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 61 YQWSTETQGIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLF--TPLAADFGVILVIVIRTVQGMAQG 136
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYGLSKFV--MGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 137 MSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALG---WPFIFYIFGSIGCVCCVLWFTMIYDDPM 213
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 214 HH--PCISV----KEKEYITSSVAQQSSSPRrsIPIKAMVRCLPLWAI-FMGFFSHFwLCTIIITYLPTYISTVLHVNIR 286
Cdd:cd17345 191 SEglPPIEEykgdYPEEADGEEEEQELSAWE--IFVKYVLKNKLLWYIaIANVFVYL-VRYGILDWAPTYLSEVKGFSKA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 287 DSGVLSSLPFIAASSCTILGGQMADFLL--SRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILipgts 364
Cdd:cd17345 268 QAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTGIIFM---------ILVIVALIVYWLAPNVLVDLIALIAL----- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 365 nlcdsGFII---------NTLDVAPRYASflmGISRGF-GLTAGIISST--TTGFLISQDSeSGWRNVFFLSAAVNMFGL 432
Cdd:cd17345 334 -----GFLIygpvmliglQALELVPKKAA---GTAAGLtGLFGYLGGSVlaTALIGIIVDH-FGWNGGFIVLLASCILAI 404
|
....*
gi 1958704741 433 IFYLI 437
Cdd:cd17345 405 IFLAL 409
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
58-317 |
7.94e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 60.33 E-value: 7.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGM 137
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF--LVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 138 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLwFTMIYDDPMhhpc 217
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL-FWLFYREPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 218 isvkekeyITSSVAQQSSSPRRSipIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 297
Cdd:cd17475 176 --------AASAATESASTLLRS--LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQL 245
|
250 260
....*....|....*....|
gi 1958704741 298 AASSCTILGGQMADFLLSRN 317
Cdd:cd17475 246 GGALGRIGLGRVSDRVFGGR 265
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
69-438 |
9.52e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.90 E-value: 9.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSWTGQFTIW 146
Cdd:cd17312 41 GIIGSafLIAYAVGKFI--SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG--LNGLFQSMGWPPCVKLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 147 AKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHhpcisvkekeyi 226
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 227 tssvaqqsssprrsipikamvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILG 306
Cdd:cd17312 185 -------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 307 GQMADFLLSRNllslitvRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGF-IINTLDVAPRYA-S 384
Cdd:cd17312 240 GLLSDKLFGGR-------RAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIgGAAAQDIGRKEAaG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1958704741 385 FLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIF 438
Cdd:cd17312 313 TATGFVGLFGYLGASLAGLPLGYIIDH---YGWSTVFYFLISAALLSVLLLLSL 363
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-203 |
1.35e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.42 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVL--IIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 203
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-208 |
4.71e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 60 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSW 139
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--LLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958704741 140 TGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 208
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
53-215 |
2.05e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 53.15 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 53 DFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTV 130
Cdd:TIGR00711 31 DLGSSLSQVQWVI---------TSYMLANaISIPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL--ELMIIFRVI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 131 QGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGC-VCCVLWFTMIY 209
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVVVAFFILPR 179
|
....*.
gi 1958704741 210 DDPMHH 215
Cdd:TIGR00711 180 DKPAAS 185
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
82-203 |
2.67e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.58 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 82 TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTS 160
Cdd:cd17503 46 IMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958704741 161 IAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 203
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-285 |
5.21e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.44 E-value: 5.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVKekeyits 228
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAG------- 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958704741 229 svaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFShfwlctiIITYLPTYISTVLHVNI 285
Cdd:cd17489 185 -----TRAFRRLVEKKVLPPALILFLASIAYGA-------ISTFLPLYAAERGISNA 229
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
73-323 |
3.15e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.17 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 73 SSISY-GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAP 151
Cdd:cd17327 47 NTVFYvGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGL--IALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 152 PLERSKLTSI----AGSGAAFGSFI------ILCVGGLisqaLGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVK 221
Cdd:cd17327 125 REEQAKRIAFfyaaAGLGSIFGGLLaygvfkILGVGGL----AGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 222 EKEYITSSVAQ-QSSSPRRSIPIKAMVRCLPLWAIFMGFFSHF--WLCT-IIITYLPTYISTVLHVNIrDSGVLSSLPFI 297
Cdd:cd17327 201 EKELAVERLRAnQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFcsQITNnGISNFLPLILKSLGFYSL-QTNLLSVPIGA 279
|
250 260
....*....|....*....|....*.
gi 1958704741 298 AASSCTILGGQMADFLLSRNLLSLIT 323
Cdd:cd17327 280 LGAVSLLIAALLSDRFKKRGLFAIFA 305
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
83-203 |
3.24e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.18 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 83 LIPSGYLAGIFGAKQILGAGlliSSLLTLFTpLAADF--GVILVIVIRTVQGMAQGMSWTGQFTIWAK-WAPPLERSKLT 159
Cdd:cd17476 50 ILIFGRLGDIYGHKKMFVIG---SFWFAIWS-LIAGFspNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVF 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1958704741 160 SIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 203
Cdd:cd17476 126 SLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
83-203 |
4.84e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.32 E-value: 4.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 83 LIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIA 162
Cdd:cd17321 48 LLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW 125
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1958704741 163 GSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 203
Cdd:cd17321 126 GAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
58-208 |
6.46e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 58 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGA--KQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQ 135
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLF--LAGFGL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958704741 136 GMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 208
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
69-322 |
8.43e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 8.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLfTPLAADfGVILVIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV-AGLFLD-SLYALLASRALLGIGVAGIMTLATALIGD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQaLGWPFIFYIFG-SIGCVCCVLWFtmiyddpmhhpcisVKEKEYIT 227
Cdd:cd17473 116 YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVLLF--------------LPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 228 SSVAQQSSSPRRSIPIKamvrclPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGG 307
Cdd:cd17473 181 KSAASPGAATAAALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFG 254
|
250
....*....|....*
gi 1958704741 308 QMADFLLSRNLLSLI 322
Cdd:cd17473 255 RLKRRLGKRRLLAIG 269
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-438 |
2.33e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.39 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 59 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMS 138
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF--LLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 139 WTGQFTIwAKWAPPLERSKLTSIAGSGAAFGSFI-ILCVGGLISQALG--WPFIFYIFGSIGCVCCVLWFTMIYDDPMHH 215
Cdd:COG0738 114 DVAANPY-VAALGPETAASRLNLLHAFFSLGALLgPLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 216 PcisvkekeyitSSVAQQSSSPRRSIPIKAmvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLP 295
Cdd:COG0738 193 E-----------EEAAGSAASLKSLLKNPR------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 296 FIAASSCTILGGQMADFLLSRNLLSLITVrklfsslglllPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINT 375
Cdd:COG0738 256 WGGMTIGRFLGGFLLKRFGPVRLLRLSAL-----------LAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958704741 376 LDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAvnMFGLIFYLIF 438
Cdd:COG0738 325 LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLV--CYLLILLLAL 382
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
64-321 |
4.79e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.43 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQF 143
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 144 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVccVLWFTMIY-------------- 209
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLMRFlpesidflvskrpe 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 210 ---------DDPMHHPCISVKEKEyitSSVAQQSSSPRRSIPIKAMVRCLP-LW-AIFMGFFSHFWLctiiITYLPTYIS 278
Cdd:TIGR00895 206 tvrrivnaiAPQMQAEAQSALPEQ---KSTQGTKRSVFKALFQGKTARITVlLWlLYFMLLVGVYFL----TNWLPKLMV 278
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1958704741 279 TVLHVNIRDSGVLSSLPFIAASSCtILGGQMADFLLSRNLLSL 321
Cdd:TIGR00895 279 ELGFSLSLAATGGALFNFGGVIGS-IIFGWLADRLGPRVTALL 320
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-194 |
6.65e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.95 E-value: 6.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQFTIWAK 148
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA--RLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFG 194
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGG 176
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
64-433 |
9.07e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 9.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQF 143
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 144 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLI----SQALGWpFIFYIFGSIGCVCCVLWFtmiyddpmhhpcis 219
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGW-RILFLIGALPALLALLLR-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 220 vkekeyitssvaqqsssprrsipiKAMVRCLPLWAIFMGFFshfwlcTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAA 299
Cdd:cd17316 177 ------------------------RRTLLLILLWFFISFGY------YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 300 SSCTILGGQMADFllsrnllslITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVA 379
Cdd:cd17316 227 LVGALIAGLLSDR---------IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1958704741 380 P-RYASFLMGISRGFGLTAGIISSTTTGFLISqdSESGWRNVFFLSAAVNMFGLI 433
Cdd:cd17316 298 PtEVRATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
69-212 |
1.21e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 44.25 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDP 212
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
84-436 |
2.69e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 84 IPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAG 163
Cdd:cd17328 52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 164 SGAAFGSFIILCVGGLISQA-LGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVKEKEYITSSVAQqsssprrsip 242
Cdd:cd17328 130 FAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 243 IKAMVRCLPLWAIFMGFFshfwlCTIIITY-----LPTYISTVLHVNI----RDSGVLSSLPFIAASSCTILGGQMADFL 313
Cdd:cd17328 200 LKALAKNPSFILSTLGFT-----AVSFVTGalafwAPTFFLRAFGVGDlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 314 LSRNllslITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTL--DVAPRYASFLMGISR 391
Cdd:cd17328 275 RRKT----PRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILlyVVIPTRRSTASAIQI 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1958704741 392 ---------GFGLTAGIISS-TTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYL 436
Cdd:cd17328 351 llshllgdaGSPYLIGLISDlLRQNKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
69-207 |
3.19e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 3.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSWTGQFTIWAK 148
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF--LLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958704741 149 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTM 207
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-208 |
5.47e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQF 143
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--RFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958704741 144 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 208
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
87-192 |
6.88e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.79 E-value: 6.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 87 GYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVilVIVIRTVQGMAQGMSWTGqFTIWAKWAPPLERSKLTSIAGSGA 166
Cdd:cd17504 52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--LIAGRALQGIGGAVFPLA-FALVREEFPPERVPVAQGILSATF 128
|
90 100
....*....|....*....|....*.
gi 1958704741 167 AFGSFIILCVGGLISQALGWPFIFYI 192
Cdd:cd17504 129 GIGAGIGLPLGGWIVQHLGWRWIFWT 154
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
59-170 |
1.24e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 59 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMS 138
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF--LLGFGFGLL 313
|
90 100 110
....*....|....*....|....*....|..
gi 1958704741 139 WTGQFTIWAKWAPPLERSKLTSIAGSGAAFGS 170
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-324 |
1.26e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLER-SKLTSIAGSGAAFGSFIIlcvGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCisvkekeyit 227
Cdd:cd17333 114 EESSATRlNVLHGFFGLGALIGPLIA---TSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARN---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 228 ssvaQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGG 307
Cdd:cd17333 181 ----PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGG 256
|
250
....*....|....*..
gi 1958704741 308 QMADFLLSRNLLSLITV 324
Cdd:cd17333 257 PISRRIKPHTLLVLSGS 273
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
101-311 |
1.75e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 101 AGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAP-----PLERSKLTSIAGSGAAFGSFIILC 175
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 176 VGGLI------SQALGWPFIFYIFGSIGCVCCVLwftmiyddpmhhPCISVKEKEYitssVAQQSSSPRRSipIKAMVRC 249
Cdd:COG2211 166 LPPPLvaafggDAALGYRLTALIFAVLGLLAFLL------------TFFGTKERPV----PEEEKVSLKES--LKALLKN 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958704741 250 LPLWAIFMGFFShFWLCTIII-TYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMAD 311
Cdd:COG2211 228 RPFLLLLLAYLL-FFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK 289
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-201 |
1.88e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSisYGI--ILTLIPSGYLAGIFGA-KQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMsWT 140
Cdd:cd17490 29 SLSMIGIILGA--YGIsqMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPSPWGLLIA--RFLSGIAAAT-WV 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958704741 141 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFY---IFGSIGCVCC 201
Cdd:cd17490 104 SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLlaaLAGVLGFILS 167
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
62-277 |
1.89e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 62 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTG 141
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGF--AALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 142 QFTIWAKWAPPLERSKLTSIAGSGAAFGSFII-LCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPmhhpcisv 220
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGP-------- 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958704741 221 kekeyitssvaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYI 277
Cdd:cd06180 180 -------------SAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIA 223
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
64-438 |
3.47e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 64 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLA-ADFGVILVIVIRTVQGMAQGMSWTGQ 142
Cdd:pfam00083 44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkGKWSVYQLIVGRVLVGIGVGGASVLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 143 FTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVG---GLISQALGWPFIFY---IFGSIGCVCCVLW------------ 204
Cdd:pfam00083 124 PMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGlqlVPALLLIIGLLFLpesprwlvekgr 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 205 ---FTMIYDDPMHHPCISVKEKEYITSSVAQQSSSPRRSIPIKAMvrCLPLWAIFMGFFSHFW--LCTI-IITYLPTYIS 278
Cdd:pfam00083 204 leeAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFST--KTRRQRLLIGVMLQIFqqLTGInAIFYYSTTIF 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 279 TVLHVN--IRDSGVLSSLPFIAasscTILGGQMADFLLSRNLLSLITVrklfsSLGLLLPSLCAVALPFVTSSYIATIVL 356
Cdd:pfam00083 282 ENLGLSdsFLVTIIVGVVNFVF----TFIAIFLVDRFGRRPLLLLGAA-----GMAICFVILGIVALLGVSKSDWAGIVA 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 357 LILI--------PGTSNLCdsgFIINTLDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVN 428
Cdd:pfam00083 353 IVFIalfiaffaMGWGPVP---WVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA---IGLGYTFFIFAGLL 426
|
410
....*....|
gi 1958704741 429 MFGLIFYLIF 438
Cdd:pfam00083 427 VLFIIFVFFF 436
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
86-172 |
3.76e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.61 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 86 SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSG 165
Cdd:TIGR00898 147 FGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--RLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
|
....*..
gi 1958704741 166 AAFGSFI 172
Cdd:TIGR00898 225 FSLGLVL 231
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
87-209 |
3.81e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.47 E-value: 3.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 87 GYLAGIFGAKQILGAGL---LISSLLTLFTPlaadfGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAG 163
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIvifELGSLLCGLAP-----NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIG 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1958704741 164 SGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL----WFTMIY 209
Cdd:cd17502 126 AVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALlrtiLLSSIF 175
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-438 |
5.03e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 255 IFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLSLITVrklfsslgll 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 335 lPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYA-SFLMGISRGFGLTAGIISSTTTGFLISQds 413
Cdd:pfam07690 71 -LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180
....*....|....*....|....*
gi 1958704741 414 eSGWRNVFFLSAAVNMFGLIFYLIF 438
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
69-438 |
7.16e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 69 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGMSWTGQFTIWAK 148
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLL--AGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 149 WAPPLERSK----LTSIAGSGAAFGSFIilcvGGLISqALGWPFIFYIFGSIGCVCCVLWFTMIYDdpmhhpcisvkeke 224
Cdd:cd17474 115 LFEGGERAKamglYEAALGLGIAVGPLL----GGLLA-AISWRYPFFLLAALIPVAFLAILFLLPE-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 225 yiTSSVAQQSSSPRRSIPIKAMvRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIA-ASSCT 303
Cdd:cd17474 176 --PKEKAKSSSATKLRDLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLlALGSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958704741 304 ILGGQMADFLLSRNLLSLITVrklfsslgllLPSLCAVALPFVTSSYIATIVLLI--LIPGTSNLCDSGFIINTLDVAPR 381
Cdd:cd17474 253 FVGRLLKKRFGARRILVIGLL----------LYALSLLLLGFVPSLALLLIAIVLfgLGLGLNLPLLTTLVTELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958704741 382 yaSFLMGISRGFGLTAGIISSTTTGFLIsqdSESGWRNVFFLSAAVNMFGLIFYLIF 438
Cdd:cd17474 323 --GTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| |
