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Conserved domains on  [gi|1958722156|ref|XP_038951993|]
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ras suppressor protein 1 isoform X4 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 1.91e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 1.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 114 LDLTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                         170
                  ....*....|..
gi 1958722156 194 VLPPELGNLDLT 205
Cdd:COG4886   264 DLPPLANLTNLK 275
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 1.91e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 1.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 114 LDLTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                         170
                  ....*....|..
gi 1958722156 194 VLPPELGNLDLT 205
Cdd:COG4886   264 DLPPLANLTNLK 275
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 2.04e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 2.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  31 LDVNGLFSLAH-----ITQLVLSHNKLTTVPPNVAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370  185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 106 GSlpALEVLDLTYNNLN--EHSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370  261 PS--ALQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958722156 169 LISLPKEIGelTQLKELHIQGNRLTV----LPPELGNLDLTGQKQVFKAENNP 217
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVlpetLPPTITTLDVSRNALTNLPENLP 387
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-206 3.72e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  39 LAHITQLVLSHNKLTTVPpNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTY 118
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 119 NNLNEHSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHI 187
Cdd:cd21340    78 NRISVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDA 149

                         170       180
                  ....*....|....*....|....*...
gi 1958722156 188 QGNRLTVLP---------PELGNLDLTG 206
Cdd:cd21340   150 SNNQISDLEelldllsswPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958722156  86 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 1.91e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 1.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 114 LDLTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                         170
                  ....*....|..
gi 1958722156 194 VLPPELGNLDLT 205
Cdd:COG4886   264 DLPPLANLTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-202 1.88e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 1.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  42 ITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNl 121
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 122 nehslpgNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
Cdd:COG4886   108 -------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180


                  .
gi 1958722156 202 L 202
Cdd:COG4886   181 L 181
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 2.04e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 2.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  31 LDVNGLFSLAH-----ITQLVLSHNKLTTVPPNVAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370  185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 106 GSlpALEVLDLTYNNLN--EHSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370  261 PS--ALQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958722156 169 LISLPKEIGelTQLKELHIQGNRLTV----LPPELGNLDLTGQKQVFKAENNP 217
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVlpetLPPTITTLDVSRNALTNLPENLP 387
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-200 2.25e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.11  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  38 SLAHITQL---VLSHNKLT-TVPPNVAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPAL 111
Cdd:PLN00113  183 SLTNLTSLeflTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 112 EVLDLtYNNLNEHSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113  263 QYLFL-YQNKLSGPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLW 340

                         170
                  ....*....|...
gi 1958722156 189 GNRLT-VLPPELG 200
Cdd:PLN00113  341 SNKFSgEIPKNLG 353
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
40-208 3.55e-13

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 68.65  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  40 AHITQLVLSHNKLTTVPPNVAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLP 102
Cdd:PRK15387  222 AHITTLVIPDNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 103 RG----------FGSLPAL--EVLDLTYNNLNEHSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 170
Cdd:PRK15387  302 PGlqelsvsdnqLASLPALpsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLP 378

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958722156 171 SLPkeigelTQLKELHIQGNRLT---VLPPELGNLDLTGQK 208
Cdd:PRK15387  379 ALP------SGLKELIVSGNRLTslpVLPSELKELMVSGNR 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-199 8.30e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 8.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  43 TQLVLSHNKLTTVPPNVAELKNLEVLNffNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRgfgSLP-ALEVLDLTYNNL 121
Cdd:PRK15370  181 TELRLKILGLTTIPACIPEQITTLILD--NNELKSLPENLQG--NIKTLYANSNQLTSIPA---TLPdTIQEMELSINRI 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 122 NE--HSLPgnffylTTLRALYLSDNDFEILPPDIGKltKLQILSLRDNDLISLPKEIGelTQLKELHIQGNRLTVLPPEL 199
Cdd:PRK15370  254 TElpERLP------SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL 323
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-202 2.47e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  40 AHITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLD 115
Cdd:PLN00113   69 SRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLD 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 116 LTyNNLNEHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI------------------------ 170
Cdd:PLN00113  147 LS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnls 225

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958722156 171 -SLPKEIGELTQLKELHIQGNRLT-VLPPELGNL 202
Cdd:PLN00113  226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-193 4.01e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 4.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  34 NGLFSLAHITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113  278 PSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 111 LEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113  358 LTVLDLSTNNLT-GEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436


                  ....*
gi 1958722156 189 GNRLT 193
Cdd:PLN00113  437 NNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 1.32e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  31 LDVNGLFSL-----AHITQLVLSHNKLTTVPPNVAElkNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370  248 LSINRITELperlpSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 106 GslPALEVLDLTYNNLNehSLPGNFfyLTTLRALYLSDNDFEILPPDIGKltKLQILSLRDNDLISLPKEIGelTQLKEL 185
Cdd:PRK15370  324 P--PGLKTLEAGENALT--SLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIM 393

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958722156 186 HIQGNRLTVLPPELGNLDLTG-QKQVFKAENNP 217
Cdd:PRK15370  394 QASRNNLVRLPESLPHFRGEGpQPTRIIVEYNP 426
PLN03150 PLN03150
hypothetical protein; Provisional
 78-144 3.38e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 62.53  E-value: 3.38e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958722156  78 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDN 144
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-208 8.37e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 8.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  41 HITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLT 117
Cdd:PLN00113  357 NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 118 YNNLnEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VL 195
Cdd:PLN00113  437 NNNL-QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEI 515

                         170
                  ....*....|....*....
gi 1958722156 196 PPELG------NLDLTGQK 208
Cdd:PLN00113  516 PDELSsckklvSLDLSHNQ 534
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-206 3.72e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  39 LAHITQLVLSHNKLTTVPpNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTY 118
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 119 NNLNEHSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHI 187
Cdd:cd21340    78 NRISVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDA 149

                         170       180
                  ....*....|....*....|....*...
gi 1958722156 188 QGNRLTVLP---------PELGNLDLTG 206
Cdd:cd21340   150 SNNQISDLEelldllsswPSLRELDLTG 177
PLN03150 PLN03150
hypothetical protein; Provisional
 58-217 3.90e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 3.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  58 NVAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVLDLTynNLNE 123
Cdd:PLN03150  350 THAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFIDGL--GLDN 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 124 HSL----PGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLP 196
Cdd:PLN03150  428 QGLrgfiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507

                         170       180
                  ....*....|....*....|.
gi 1958722156 197 PELGNLDLTGQKqvFKAENNP 217
Cdd:PLN03150  508 AALGGRLLHRAS--FNFTDNA 526
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-196 4.53e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 4.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  22 MSDRGISSMLDVNGLFSLAHitqLVLSHNKLTTVPpNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTL 101
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKV---LYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 102 pRGFGSLPALEVLDLTYNNL-NEHSL---PGNFFYL-TTLRALYLSDNDFEILPPdIGKLTKLQILSLRDNDLISLPK-- 174
Cdd:cd21340    84 -EGLENLTNLEELHIENQRLpPGEKLtfdPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEEll 161

                         170       180
                  ....*....|....*....|...
gi 1958722156 175 -EIGELTQLKELHIQGNRLTVLP 196
Cdd:cd21340   162 dLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 4.77e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 4.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  35 GLFSLAHITQLVLSHNKLTTVpPNVAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340    41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958722156 105 FGSLPALEVLDLTYNNLNEhslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340   116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-170 2.07e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  11 ESREKNQPEVDMSDRGISSML-DVNGLFSLAHITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQK 87
Cdd:PLN00113  445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  88 LKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 166
Cdd:PLN00113  525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAG 603


                  ....
gi 1958722156 167 NDLI 170
Cdd:PLN00113  604 NIDL 607
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958722156  86 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
64-121 3.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-193 1.10e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  19 EVDMSDRGISSMLDVNglfslAHITQLVLSHNKLTTVPPNVAELKNLEVlnfFNNQIEELPTQISSLQKLKHLNlgmNRL 98
Cdd:PRK15387  306 ELSVSDNQLASLPALP-----SELCKLWAYNNQLTSLPTLPSGLQELSV---SDNQLASLPTLPSELYKLWAYN---NRL 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  99 NTLPrgfgSLPA-LEVLDLTYNNLNehSLPgnfFYLTTLRALYLSDNDFEILP--PdigklTKLQILSLRDNDLISLPKE 175
Cdd:PRK15387  375 TSLP----ALPSgLKELIVSGNRLT--SLP---VLPSELKELMVSGNRLTSLPmlP-----SGLLSLSVYRNQLTRLPES 440

                         170
                  ....*....|....*...
gi 1958722156 176 IGELTQLKELHIQGNRLT 193
Cdd:PRK15387  441 LIHLSSETTVNLEGNPLS 458
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 22-193 1.62e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  22 MSDRGISSMLDvnGLFSLAHITQLVLSHNKLTtvPPNVAELKNLevlnffnnqieelpTQISSLQKLKHLN--LGMNRLN 99
Cdd:cd00116    65 RIPRGLQSLLQ--GLTKGCGLQELDLSDNALG--PDGCGVLESL--------------LRSSSLQELKLNNngLGDRGLR 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 100 TLPRGFGSL-PALEVLDLTYNNLNEHS---LPGNFFYLTTLRALYLSDND-----FEILPPDIGKLTKLQILSLRDNDL- 169
Cdd:cd00116   127 LLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLt 206

                         170       180
                  ....*....|....*....|....*...
gi 1958722156 170 ----ISLPKEIGELTQLKELHIQGNRLT 193
Cdd:cd00116   207 degaSALAETLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
109-169 3.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 3.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958722156 109 PALEVLDLTYNNLneHSL-PGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 169
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-115 9.84e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 9.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  32 DVNGLFSLAH-ITQLVLSHNKLTTVPPnVAELKNLEVLNFFNNQI---EELPTQISSLQKLKHLNLGMNRLNTLPRGFGS 107
Cdd:cd21340   111 DPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPKYRDK 189

                          90
                  ....*....|..
gi 1958722156 108 L----PALEVLD 115
Cdd:cd21340   190 IilasKSLEVLD 201
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 52-182 2.25e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.09  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156   52 LTTVPPNVAELknlevlnFFNN--QIEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNN 120
Cdd:PLN03210   773 MTMLSPSLTRL-------FLSDipSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPD 843

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958722156  121 LNehslpgnffylTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 182
Cdd:PLN03210   844 IS-----------TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-210 2.70e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156  32 DVNGLFSLAHITQLVLSHNKLTTVPPNvAELKNLEVLNFFNNQIEELptqisSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
Cdd:COG4886   242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLI 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958722156 112 EVLDLTYNNLNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                         170
                  ....*....|....*....
gi 1958722156 192 LTVLPPELGNLDLTGQKQV 210
Cdd:COG4886   396 TTAGVLLLTLALLDAVNTE 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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