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Conserved domains on  [gi|1958746027|ref|XP_038953464|]
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WD repeat domain-containing protein 83 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-264 6.54e-55

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 6.54e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  16 KQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRkpEPVQTLDEARDGISSVKVS-DHEILA-GSVDG 173
Cdd:COG2319   233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSpDGKLLAsGSDDG 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 174 RVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQKYklDCCLSERDTHVV 251
Cdd:COG2319   311 TVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                         250
                  ....*....|...
gi 1958746027 252 SCSEDGKVFFWDL 264
Cdd:COG2319   389 SGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-264 6.54e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 6.54e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  16 KQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRkpEPVQTLDEARDGISSVKVS-DHEILA-GSVDG 173
Cdd:COG2319   233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSpDGKLLAsGSDDG 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 174 RVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQKYklDCCLSERDTHVV 251
Cdd:COG2319   311 TVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                         250
                  ....*....|...
gi 1958746027 252 SCSEDGKVFFWDL 264
Cdd:COG2319   389 SGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-264 6.30e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.68  E-value: 6.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVA 97
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRV 175
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 176 RRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQKYklDCCLSERDTHVVSC 253
Cdd:cd00200   160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASG 237

                         250
                  ....*....|.
gi 1958746027 254 SEDGKVFFWDL 264
Cdd:cd00200   238 SEDGTIRVWDL 248
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-262 9.56e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.72  E-value: 9.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAG----------SFDNSHLCSGGGDKTVVLWDVA 97
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASrsklsgicwnSYIKSQVASSNFEGVVQVWDVA 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  98 TGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSVRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEILAGSVDG 173
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 174 RVRRYDLRMGQVT-SDYVGSPITCTCFSRDGQCTLI-SSLDSTLRLLDKDTG------ELLGEYVGHKNQKYKLDccLSE 245
Cdd:PLN00181  641 KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVDSSTLVsSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFVG--LSV 718

                         250
                  ....*....|....*..
gi 1958746027 246 RDTHVVSCSEDGKVFFW 262
Cdd:PLN00181  719 SDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 2.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 2.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958746027   98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 3.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958746027  99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-264 6.54e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 6.54e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  16 KQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRkpEPVQTLDEARDGISSVKVS-DHEILA-GSVDG 173
Cdd:COG2319   233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSpDGKLLAsGSDDG 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 174 RVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQKYklDCCLSERDTHVV 251
Cdd:COG2319   311 TVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                         250
                  ....*....|...
gi 1958746027 252 SCSEDGKVFFWDL 264
Cdd:COG2319   389 SGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.96e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 1.96e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  15 RKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLW 94
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  95 DVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEILA-GSVD 172
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSpDGRLLAsGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 173 GRVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQKYKLdcCLSERDTH 249
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKT 344

                         250
                  ....*....|....*
gi 1958746027 250 VVSCSEDGKVFFWDL 264
Cdd:COG2319   345 LASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-264 6.30e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.68  E-value: 6.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVA 97
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRV 175
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 176 RRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQKYklDCCLSERDTHVVSC 253
Cdd:cd00200   160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN--SVAFSPDGYLLASG 237

                         250
                  ....*....|.
gi 1958746027 254 SEDGKVFFWDL 264
Cdd:cd00200   238 SEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-263 2.08e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.42  E-value: 2.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  13 LPRKQLKTLDCG-QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTV 91
Cdd:cd00200    38 LETGELLRTLKGhTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  92 VLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVSD--HEILAG 169
Cdd:cd00200   118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD--LRTGKCVATLTGHTGEVNSVAFSPdgEKLLSS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 170 SVDGRVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQKYKLDCclSER 246
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGheNGVNSVAFSPDGY-LLASgSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW--SPD 272

                         250
                  ....*....|....*..
gi 1958746027 247 DTHVVSCSEDGKVFFWD 263
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-264 4.64e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 4.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027   9 RAPELPRKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGD 88
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  89 KTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEIL 167
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSpDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 168 A-GSVDGRVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQKYKLdcCL 243
Cdd:COG2319   220 AsGSADGTVRLWDLATGKLLRTLTGhsGSVRSVAFSPDGR-LLASgSADGTVRLWDLATGELLRTLTGHSGGVNSV--AF 296

                         250       260
                  ....*....|....*....|.
gi 1958746027 244 SERDTHVVSCSEDGKVFFWDL 264
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
16-222 6.23e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 6.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  16 KQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  96 VATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKPepVQTLDEARDGISSVKVS--DHEILAGSVDG 173
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSpdGKTLASGSDDG 352

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958746027 174 RVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDT 222
Cdd:COG2319   353 TVRLWDLATGELLRTLTGhtGAVTSVAFSPDGR-TLASgSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-264 1.89e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.89e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027   8 PRAPELPRKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGG 87
Cdd:COG2319    19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  88 DKTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDcrSRKPEPVQTLDEARDGISSVKVS-DHEI 166
Cdd:COG2319    99 DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSpDGKL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 167 LA-GSVDGRVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQKYKLDcc 242
Cdd:COG2319   177 LAsGSDDGTVRLWDLATGKLLRTLTGhtGAVRSVAFSPDGK-LLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-- 253

                         250       260
                  ....*....|....*....|..
gi 1958746027 243 LSERDTHVVSCSEDGKVFFWDL 264
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
15-181 6.96e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 6.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  15 RKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLW 94
Cdd:COG2319   236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  95 DVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEILA-GSVD 172
Cdd:COG2319   316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSpDGRTLAsGSAD 393


                  ....*....
gi 1958746027 173 GRVRRYDLR 181
Cdd:COG2319   394 GTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-264 2.62e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 2.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  59 LLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDc 138
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 139 rSRKPEPVQTLDEARDGISSVKVSDHE--ILAGSVDGRVRRYDLRMGQVTSDYVG--SPITCTCFSRDGQCTLISSLDST 214
Cdd:cd00200    80 -LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958746027 215 LRLLDKDTGELLGEYVGHKNQKYKldCCLSERDTHVVSCSEDGKVFFWDL 264
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGEVNS--VAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
32-264 1.11e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  32 RFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGK 111
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 112 VNTVQFNEEATVILSGSIDSSVRCWDCRSrkPEPVQTLDEARDGISSVKVS-DHEILA-GSVDGRVRRYDLRMGQVTSDY 189
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSpDGKTLAsGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958746027 190 VG--SPITCTCFSRDGQcTLIS-SLDSTLRLLDKDTGELLGEYVGHKNQKYKLdcCLSERDTHVVSCSEDGKVFFWDL 264
Cdd:COG2319   159 TGhsGAVTSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
15-98 2.22e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  15 RKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLW 94
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                  ....
gi 1958746027  95 DVAT 98
Cdd:COG2319   400 DLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-262 9.56e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.72  E-value: 9.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAG----------SFDNSHLCSGGGDKTVVLWDVA 97
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASrsklsgicwnSYIKSQVASSNFEGVVQVWDVA 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  98 TGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSVRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEILAGSVDG 173
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 174 RVRRYDLRMGQVT-SDYVGSPITCTCFSRDGQCTLI-SSLDSTLRLLDKDTG------ELLGEYVGHKNQKYKLDccLSE 245
Cdd:PLN00181  641 KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVDSSTLVsSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFVG--LSV 718

                         250
                  ....*....|....*..
gi 1958746027 246 RDTHVVSCSEDGKVFFW 262
Cdd:PLN00181  719 SDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 2.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 2.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958746027   98 TGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-53 3.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958746027   14 PRKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 3.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958746027  99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
15-53 6.80e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 6.80e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958746027  15 RKQLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-95 1.02e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958746027   57 GTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
57-95 1.03e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958746027  57 GTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWD 95
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 44-189 2.18e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  44 GSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAG----------KVN 113
Cdd:PTZ00421  145 GADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclwakRKD 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 114 TVqfneeATVILSGSIDSSVRCWDCRsRKPEPVQTLDEARDGISSVKVSDHE----ILAGSVDGRVRRYDLRMGQVTSDY 189
Cdd:PTZ00421  225 LI-----ITLGCSKSQQRQIMLWDTR-KMASPYSTVDLDQSSALFIPFFDEDtnllYIGSKGEGNIRCFELMNERLTFCS 298
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-263 6.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 6.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958746027  222 TGELLGEYVGHKNqkYKLDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:smart00320   1 SGELLKTLKGHTG--PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 118-226 8.62e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 8.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 118 NEEATVILSGSIDSSVRCWDCRS-RKP--------EPVQTLDEARDGissvkvsdHEILAGSVDGRVRRYDLRMGQVTSD 188
Cdd:cd22857   189 KDDHRKIVTGTGYHQVRLYDTRAqRRPvvsvdfgeTPIKAVAEDPDG--------HTVYVGDTSGDLASIDLRTGKLLGC 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958746027 189 YVG---SPITCTcfSRDGQCTLISS--LDSTLRLLDKDTGELL 226
Cdd:cd22857   261 FKGkcgGSIRSI--ARHPELPLIAScgLDRYLRIWDTETRQLL 301
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 162-264 5.92e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 37.59  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027 162 SDH-EILAGSVDGRVRRYDLRMGQ--VTSDYVG-SPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGhKNQKY 237
Cdd:cd22857   190 DDHrKIVTGTGYHQVRLYDTRAQRrpVVSVDFGeTPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKG-KCGGS 268

                          90       100
                  ....*....|....*....|....*....
gi 1958746027 238 --KLDCCLSERdtHVVSCSEDGKVFFWDL 264
Cdd:cd22857   269 irSIARHPELP--LIASCGLDRYLRIWDT 295
PTZ00421 PTZ00421
coronin; Provisional
 24-142 7.27e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.57  E-value: 7.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746027  24 GQ-GAVRAVRFN-VDGNYCLTCGSDKTLKLWN-PLRGTLLRTYS------GHGYEVldAAGSFDNSH---LCSGGGDKTV 91
Cdd:PTZ00421   73 GQeGPIIDVAFNpFDPQKLFTASEDGTIMGWGiPEEGLTQNISDpivhlqGHTKKV--GIVSFHPSAmnvLASAGADMVV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958746027  92 VLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRK 142
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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