NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958746372|ref|XP_038953579|]
View 

sulfotransferase family 5A, member 1 isoform X1 [Rattus norvegicus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
98-316 3.01e-78

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 240.32  E-value: 3.01e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372  98 DTDVLLVTFPKSGTTWMQQVLSLIFCEGHLWPIHHLP---NWARMPWMEQA-------SFSSLLSKLNTSWPRLLTSHLN 167
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 168 AKGLSPALMKSKAKVVYMGRNPKDVLVSYYHFHQIAGFLPNPSSFEDFADEFLEGTGFFGSWFDHVKGWLGLQKDLTLLF 247
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958746372 248 VTYEELHQEPRSTIRKLSEFLGRTLGPKEEEIILEHSSFSFMSQSNMVNYSLLSKEIidqsqGKFLRKG 316
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKG 224
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
98-316 3.01e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 240.32  E-value: 3.01e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372  98 DTDVLLVTFPKSGTTWMQQVLSLIFCEGHLWPIHHLP---NWARMPWMEQA-------SFSSLLSKLNTSWPRLLTSHLN 167
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 168 AKGLSPALMKSKAKVVYMGRNPKDVLVSYYHFHQIAGFLPNPSSFEDFADEFLEGTGFFGSWFDHVKGWLGLQKDLTLLF 247
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958746372 248 VTYEELHQEPRSTIRKLSEFLGRTLGPKEEEIILEHSSFSFMSQSNMVNYSLLSKEIidqsqGKFLRKG 316
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKG 224
PLN02164 PLN02164
sulfotransferase
 94-322 4.63e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 78.04  E-value: 4.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372  94 FQFQDTDVLLVTFPKSGTTWMQqVLSLIFCEGHLWPIHHLPNWAR-----MPWME-QASFSSLLSKLNTSWPRLLTSHLN 167
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLK-ALTFAIANRSRFDDSSNPLLKRnphefVPYIEiDFPFFPSVDVLKDKGNTLFSTHIP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 168 AKGLSPALMKSKAKVVYMGRNPKDVLVSYYHF-HQIAGFLPNPSSFEDFADEFLEGTGFFGSWFDHVKG-WLGLQKDLT- 244
Cdd:PLN02164  154 YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQENPDr 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958746372 245 LLFVTYEELHQEPRSTIRKLSEFLGRTLGPKEEEIILEHSSFSFMSQSNMVNysllskeiIDQSQGKFLRKGRPS-WPN 322
Cdd:PLN02164  234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKN--------LEANKGEKDREDRPAvYAN 304
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
98-316 3.01e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 240.32  E-value: 3.01e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372  98 DTDVLLVTFPKSGTTWMQQVLSLIFCEGHLWPIHHLP---NWARMPWMEQA-------SFSSLLSKLNTSWPRLLTSHLN 167
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 168 AKGLSPALMKSKAKVVYMGRNPKDVLVSYYHFHQIAGFLPNPSSFEDFADEFLEGTGFFGSWFDHVKGWLGLQKDLTLLF 247
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958746372 248 VTYEELHQEPRSTIRKLSEFLGRTLGPKEEEIILEHSSFSFMSQSNMVNYSLLSKEIidqsqGKFLRKG 316
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKG 224
PLN02164 PLN02164
sulfotransferase
 94-322 4.63e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 78.04  E-value: 4.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372  94 FQFQDTDVLLVTFPKSGTTWMQqVLSLIFCEGHLWPIHHLPNWAR-----MPWME-QASFSSLLSKLNTSWPRLLTSHLN 167
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLK-ALTFAIANRSRFDDSSNPLLKRnphefVPYIEiDFPFFPSVDVLKDKGNTLFSTHIP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 168 AKGLSPALMKSKAKVVYMGRNPKDVLVSYYHF-HQIAGFLPNPSSFEDFADEFLEGTGFFGSWFDHVKG-WLGLQKDLT- 244
Cdd:PLN02164  154 YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQENPDr 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958746372 245 LLFVTYEELHQEPRSTIRKLSEFLGRTLGPKEEEIILEHSSFSFMSQSNMVNysllskeiIDQSQGKFLRKGRPS-WPN 322
Cdd:PLN02164  234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKN--------LEANKGEKDREDRPAvYAN 304
Sulfotransfer_3 pfam13469
Sulfotransferase family;
101-269 7.25e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 54.60  E-value: 7.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 101 VLLVTFPKSGTTWMQQVLSL---IFCEGHLWPIHhlPNWARMPWMEQASFSSLLSKlnTSWPRLLTSHL--NAKGLsPAL 175
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAhpdVRPPEETWFVI--PRILALLQAWGKSLEALARV--PSYARWLCDKSpsHLFHL-DLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746372 176 MK--SKAKVVYMGRNPKDVLVSyyHFHQIAGFLPNPssfedFADEFLEGTGFFGS-WFDHVKGWLGLQKDL---TLLFVT 249
Cdd:pfam13469  76 LKafPDAKFIHLHRDPVDTVIS--SYCSLFGFTLSS-----YSTAFLRDIGLALArWSRAYERLMAARARVppgRFLDVR 148

                         170       180
                  ....*....|....*....|
gi 1958746372 250 YEELHQEPRSTIRKLSEFLG 269
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH