|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.78e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.78e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747931 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1530-1829 |
2.76e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1530 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1596
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1597 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1674
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1675 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1750
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747931 1751 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1829
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.22e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747931 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.04e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.64 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747931 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
693-929 |
5.90e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 693 QVENLSFKSRKCGDAFAEALCRSLPTMGSLKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVDLI 772
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 773 PCLRKLQKLDLSQNSFCMSTLLSSVKAAITCPTVRKLQVRESELifflspvpetatqqsgasDAQGEDSPKEGQSRNLQL 852
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI------------------GDEGAIALAEGLQGNKTL 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 853 R---LQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAV---SQLHiaqKLDLSDNGLSQTGVTYLLKA 926
Cdd:COG5238 323 HtlnLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLegnTTLR---ELNLGKNNIGKQGAEALIDA 399
|
...
gi 1958747931 927 VST 929
Cdd:COG5238 400 LQT 402
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
864-1058 |
2.12e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.44 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 864 AKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISL--L 941
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVnrI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 942 TNTVVLTFAQELRdqegsfkRGAQLTgfmspvtsELSqrsrrirLTHCGFLAEHTEKLCEALrvscQSHP-LDHLDLSDN 1020
Cdd:COG5238 305 GDEGAIALAEGLQ-------GNKTLH--------TLN-------LAYNGIGAQGAIALAKAL----QENTtLHSLDLSDN 358
|
170 180 190
....*....|....*....|....*....|....*...
gi 1958747931 1021 FLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSL 1058
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
984-1310 |
7.30e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 984 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1059
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1060 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1139
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1140 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1219
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1220 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1299
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747931 1300 SYPHIQEVSVS 1310
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.78e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.78e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747931 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1530-1829 |
2.76e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1530 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1596
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1597 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1674
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1675 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1750
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747931 1751 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1829
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.22e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747931 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1497-1807 |
4.48e-26 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 110.91 E-value: 4.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1497 ELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKED--TELLIGALQRTCRLKRLHLShlplETSSLDLLVQ 1574
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLS----DNALGPDGCG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1575 GLSNMTL---LQDLCLKHSQIGDMGTQHLA-AILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGD 1650
Cdd:cd00116 100 VLESLLRsssLQELKLNNNGLGDRGLRLLAkGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1651 PTALELAQRFP--PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEvslaennlaggvphfskrlpllkqINLVSCKIED 1728
Cdd:cd00116 180 AGIRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEV------------------------LNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1729 QAAKHLAT-NLTLCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLvHGSCVPVIRLWN 1807
Cdd:cd00116 236 AGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWV 314
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.04e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.64 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747931 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
693-929 |
5.90e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 693 QVENLSFKSRKCGDAFAEALCRSLPTMGSLKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVDLI 772
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 773 PCLRKLQKLDLSQNSFCMSTLLSSVKAAITCPTVRKLQVRESELifflspvpetatqqsgasDAQGEDSPKEGQSRNLQL 852
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI------------------GDEGAIALAEGLQGNKTL 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 853 R---LQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAV---SQLHiaqKLDLSDNGLSQTGVTYLLKA 926
Cdd:COG5238 323 HtlnLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLegnTTLR---ELNLGKNNIGKQGAEALIDA 399
|
...
gi 1958747931 927 VST 929
Cdd:COG5238 400 LQT 402
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
696-1050 |
1.06e-15 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 80.09 E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 696 NLSFKSRKCGDAFAEALCRSLPTMgslKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQL--KDPEVLSLVDLIP 773
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 774 CLRKLQKLDLSQNSFCmSTLLSSVKAAITCPTVRKLQVRESELifflspvPETATQQSGasdaqgeDSPKEGQSRNLQLR 853
Cdd:cd00116 79 KGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNNGL-------GDRGLRLLA-------KGLKDLPPALEKLV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 854 LQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTL 933
Cdd:cd00116 144 LGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 934 EELHIS--LLTNTVVLTFAQELRdqegsfkrgaqltgfmspvtsELSQRSRRIRLTHCGFLAEHTEKLCEALRVSCQshp 1011
Cdd:cd00116 224 EVLNLGdnNLTDAGAAALASALL---------------------SPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--- 279
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1958747931 1012 LDHLDLSDNFLKDKGVILLTQLLPRLGP-LKSLNLSRNDF 1050
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
864-1058 |
2.12e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.44 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 864 AKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISL--L 941
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVnrI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 942 TNTVVLTFAQELRdqegsfkRGAQLTgfmspvtsELSqrsrrirLTHCGFLAEHTEKLCEALrvscQSHP-LDHLDLSDN 1020
Cdd:COG5238 305 GDEGAIALAEGLQ-------GNKTLH--------TLN-------LAYNGIGAQGAIALAKAL----QENTtLHSLDLSDN 358
|
170 180 190
....*....|....*....|....*....|....*...
gi 1958747931 1021 FLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSL 1058
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
850-1190 |
3.18e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 850 LQLRLQKCQLRVHDAKalvELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNglsQTGVtyLLKAVST 929
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN---ETGR--IPRGLQS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 930 CGtleelhiSLLTNTVVLtfaQELRDQEGSFkrGAQLTGFMSPVTSELSQRSrrIRLTHCGFLAEHTEKLCEALRVScqS 1009
Cdd:cd00116 73 LL-------QGLTKGCGL---QELDLSDNAL--GPDGCGVLESLLRSSSLQE--LKLNNNGLGDRGLRLLAKGLKDL--P 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1010 HPLDHLDLSDNFLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSLVLCMSSLQWLFHLevSLESDCIFLRGAGtsr 1089
Cdd:cd00116 137 PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVL--DLNNNGLTDEGAS--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1090 dALAGGPEFPAGAQLLELSQrctsrsfclqeCQLESLNLAYLCDALEKC-PGPLEIQLSCKSLNDDSLKTLLQRLPQIPQ 1168
Cdd:cd00116 212 -ALAETLASLKSLEVLNLGD-----------NNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKES 279
|
330 340
....*....|....*....|..
gi 1958747931 1169 LSQLRLTHTVLSSRSPFLLADI 1190
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAES 301
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
520-635 |
2.83e-07 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 51.14 E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 520 HLNLQEFFAALYLMASDTVDKDTLINYVTLNSHWVLRTKA-------KPGLSDHLPTFLAGLASHTCHTFLCHLaQQDEA 592
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESLKSLldkalksKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958747931 593 WVGSRQATvIQVLRKLASRKLTGPKMVELYHYVAETQDLELAR 635
Cdd:pfam17776 80 SSEIKQEL-LQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1489-1783 |
2.44e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.99 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1489 QNILISSCELKSFRLTFSNVSTESPAHLASGLEhchhleELDFSNNSLCKEdTELLIGALQrtcRLKRLHL------SHL 1562
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLE------TLDLSNNMLSGE-IPNDIGSFS---SLKVLDLggnvlvGKI 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1563 PLEtssldllvqgLSNMTLLQDLCLKHSQ--------IGDM--------GTQHLAAILP----RLPGLRKLDLS-GNRIG 1621
Cdd:PLN00113 181 PNS----------LTNLTSLEFLTLASNQlvgqipreLGQMkslkwiylGYNNLSGEIPyeigGLTSLNHLDLVyNNLTG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1622 PaggmqLVKSLTHFKNLEEIILGNNTLGDPtalelaqrFPP------QLRVLCLTSSHLGPEgalcLAQALEQCPHIEEV 1695
Cdd:PLN00113 251 P-----IPSSLGNLKNLQYLFLYQNKLSGP--------IPPsifslqKLISLDLSDNSLSGE----IPELVIQLQNLEIL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1696 SLAENNLAGGVPHFSKRLPLLKQINLVSCKIEDQAAKHLA--TNLT----------------LCPA--LEKLLLSWNHLG 1755
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGkhNNLTvldlstnnltgeipegLCSSgnLFKLILFSNSLE 393
|
330 340
....*....|....*....|....*...
gi 1958747931 1756 DEMAAELAQVlpqmGQLKRVDLEKNQIT 1783
Cdd:PLN00113 394 GEIPKSLGAC----RSLRRVRLQDNSFS 417
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1607-1634 |
2.49e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 2.49e-03
10 20
....*....|....*....|....*...
gi 1958747931 1607 LPGLRKLDLSGNRIGPAGGMQLVKSLTH 1634
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
984-1310 |
7.30e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 984 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1059
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1060 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1139
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1140 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1219
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1220 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1299
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747931 1300 SYPHIQEVSVS 1310
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.78e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.78e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747931 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1530-1829 |
2.76e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1530 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1596
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1597 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1674
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1675 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1750
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747931 1751 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1829
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.22e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747931 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1497-1807 |
4.48e-26 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 110.91 E-value: 4.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1497 ELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKED--TELLIGALQRTCRLKRLHLShlplETSSLDLLVQ 1574
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLS----DNALGPDGCG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1575 GLSNMTL---LQDLCLKHSQIGDMGTQHLA-AILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGD 1650
Cdd:cd00116 100 VLESLLRsssLQELKLNNNGLGDRGLRLLAkGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1651 PTALELAQRFP--PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEvslaennlaggvphfskrlpllkqINLVSCKIED 1728
Cdd:cd00116 180 AGIRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEV------------------------LNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1729 QAAKHLAT-NLTLCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLvHGSCVPVIRLWN 1807
Cdd:cd00116 236 AGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWV 314
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1425-1702 |
1.31e-22 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 100.89 E-value: 1.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1425 WLQLEFPRQEdhseAMALRLAHCDLGTDHGLLMRQLVETCARLQQLSLSQVSF-SDDDGTRSrLLQNiLISSCelKSFRL 1503
Cdd:cd00116 15 ATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgRIPRGLQS-LLQG-LTKGC--GLQEL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1504 TFSNvsTESPAHLASGLEHCHH---LEELDFSNNSLCKEDTELLIGALQ-RTCRLKRLHLSHLPLETSSLDLLVQGLSNM 1579
Cdd:cd00116 87 DLSD--NALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLAKGLKdLPPALEKLVLGRNRLEGASCEALAKALRAN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1580 TLLQDLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQR 1659
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1958747931 1660 FP---PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEVSLAENNL 1702
Cdd:cd00116 245 LLspnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.04e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.64 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747931 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1442-1687 |
3.75e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 92.55 E-value: 3.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1442 LRLAHCDLGTDHGLLMRQlvetcaRLQQLSLSQVSFSDD--DGTRSRLLQNILISSCELKSFRLTFSNVSTESPAHLASG 1519
Cdd:COG5238 158 LLGLAARLGLLAAISMAK------ALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1520 LEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDMGTQH 1599
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIA 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1600 LAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRF--PPQLRVLCLTSSHLGPE 1677
Cdd:COG5238 312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLegNTTLRELNLGKNNIGKQ 391
|
250
....*....|
gi 1958747931 1678 GALCLAQALE 1687
Cdd:COG5238 392 GAEALIDALQ 401
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1516-1695 |
7.23e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 91.39 E-value: 7.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1516 LASGLEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDM 1595
Cdd:COG5238 256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1596 GTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRF-PPQLRVLCLTSSHL 1674
Cdd:COG5238 336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALqTNRLHTLILDGNLI 415
|
170 180
....*....|....*....|.
gi 1958747931 1675 GPEGAlclAQALEQCPHIEEV 1695
Cdd:COG5238 416 GAEAQ---QRLEQLLERIKSV 433
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1584-1818 |
4.65e-17 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 84.33 E-value: 4.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1584 DLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGgMQLVKSLTHFKNLEEIILGNNTLGDpTALELAQR---- 1659
Cdd:cd00116 57 CLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkd 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1660 FPPQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEVSLAENNlaggvphfskrlpllkqinlvsckIEDQAAKHLATNLT 1739
Cdd:cd00116 135 LPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNG------------------------IGDAGIRALAEGLK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1740 LCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGS-CVPVIRLWNNPIPACVAQSL 1818
Cdd:cd00116 191 ANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDL 270
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
693-929 |
5.90e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 693 QVENLSFKSRKCGDAFAEALCRSLPTMGSLKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVDLI 772
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 773 PCLRKLQKLDLSQNSFCMSTLLSSVKAAITCPTVRKLQVRESELifflspvpetatqqsgasDAQGEDSPKEGQSRNLQL 852
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI------------------GDEGAIALAEGLQGNKTL 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 853 R---LQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAV---SQLHiaqKLDLSDNGLSQTGVTYLLKA 926
Cdd:COG5238 323 HtlnLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLegnTTLR---ELNLGKNNIGKQGAEALIDA 399
|
...
gi 1958747931 927 VST 929
Cdd:COG5238 400 LQT 402
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
696-1050 |
1.06e-15 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 80.09 E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 696 NLSFKSRKCGDAFAEALCRSLPTMgslKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQL--KDPEVLSLVDLIP 773
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 774 CLRKLQKLDLSQNSFCmSTLLSSVKAAITCPTVRKLQVRESELifflspvPETATQQSGasdaqgeDSPKEGQSRNLQLR 853
Cdd:cd00116 79 KGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNNGL-------GDRGLRLLA-------KGLKDLPPALEKLV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 854 LQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTL 933
Cdd:cd00116 144 LGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 934 EELHIS--LLTNTVVLTFAQELRdqegsfkrgaqltgfmspvtsELSQRSRRIRLTHCGFLAEHTEKLCEALRVSCQshp 1011
Cdd:cd00116 224 EVLNLGdnNLTDAGAAALASALL---------------------SPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--- 279
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1958747931 1012 LDHLDLSDNFLKDKGVILLTQLLPRLGP-LKSLNLSRNDF 1050
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1596-1821 |
3.07e-15 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 78.94 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1596 GTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILG-NNTLGDPTALE-LAQRFP--PQLRVLCLTS 1671
Cdd:cd00116 11 KTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSlNETGRIPRGLQsLLQGLTkgCGLQELDLSD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1672 SHLGPEGALCLaQALEQCPHIEEVSLAENNLA-GGVPHFSKRL----PLLKQINLVSCKIEDQAAKHLATNLTLCPALEK 1746
Cdd:cd00116 91 NALGPDGCGVL-ESLLRSSSLQELKLNNNGLGdRGLRLLAKGLkdlpPALEKLVLGRNRLEGASCEALAKALRANRDLKE 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958747931 1747 LLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGSCVPVIRLWNNPIPACVAQSLQSQ 1821
Cdd:cd00116 170 LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1487-1811 |
3.63e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.98 E-value: 3.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1487 LLQNILISSCELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLplet 1566
Cdd:COG4886 31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1567 ssldllvQGLSNMTLLQDLCLKHSQIGDmgtqhLAAILPRLPGLRKLDLSGNRIGpaggmQLVKSLTHFKNLEEIILGNN 1646
Cdd:COG4886 107 -------EELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1647 TLGD-PTAL-ELaqrfpPQLRVLCLTSSHLGPegalcLAQALEQCPHIEEVSLAENNLAgGVPHFSKRLPLLKQINLVSC 1724
Cdd:COG4886 170 QLTDlPEELgNL-----TNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1725 KIEDqaakhlATNLTLCPALEKLLLSWNHLGDemaaelaqvLP---QMGQLKRVDLEKNQITACGAQLLAQGLVHGSCVP 1801
Cdd:COG4886 239 QLTD------LPELGNLTNLEELDLSNNQLTD---------LPplaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
|
330
....*....|
gi 1958747931 1802 VIRLWNNPIP 1811
Cdd:COG4886 304 LLLLLNLLEL 313
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
864-1058 |
2.12e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.44 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 864 AKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISL--L 941
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVnrI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 942 TNTVVLTFAQELRdqegsfkRGAQLTgfmspvtsELSqrsrrirLTHCGFLAEHTEKLCEALrvscQSHP-LDHLDLSDN 1020
Cdd:COG5238 305 GDEGAIALAEGLQ-------GNKTLH--------TLN-------LAYNGIGAQGAIALAKAL----QENTtLHSLDLSDN 358
|
170 180 190
....*....|....*....|....*....|....*...
gi 1958747931 1021 FLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSL 1058
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
850-1190 |
3.18e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 850 LQLRLQKCQLRVHDAKalvELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNglsQTGVtyLLKAVST 929
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN---ETGR--IPRGLQS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 930 CGtleelhiSLLTNTVVLtfaQELRDQEGSFkrGAQLTGFMSPVTSELSQRSrrIRLTHCGFLAEHTEKLCEALRVScqS 1009
Cdd:cd00116 73 LL-------QGLTKGCGL---QELDLSDNAL--GPDGCGVLESLLRSSSLQE--LKLNNNGLGDRGLRLLAKGLKDL--P 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1010 HPLDHLDLSDNFLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSLVLCMSSLQWLFHLevSLESDCIFLRGAGtsr 1089
Cdd:cd00116 137 PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVL--DLNNNGLTDEGAS--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1090 dALAGGPEFPAGAQLLELSQrctsrsfclqeCQLESLNLAYLCDALEKC-PGPLEIQLSCKSLNDDSLKTLLQRLPQIPQ 1168
Cdd:cd00116 212 -ALAETLASLKSLEVLNLGD-----------NNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKES 279
|
330 340
....*....|....*....|..
gi 1958747931 1169 LSQLRLTHTVLSSRSPFLLADI 1190
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAES 301
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1466-1661 |
9.80e-12 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 9.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1466 RLQQLSLSQVSFSDDDgtrSRLLQNILISSCELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKEDTELLI 1545
Cdd:COG5238 237 SLTTLDLSNNQIGDEG---VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1546 GALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGG 1625
Cdd:COG5238 314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
170 180 190
....*....|....*....|....*....|....*.
gi 1958747931 1626 MQLVKSLTHfKNLEEIILGNNTLGDPTALELAQRFP 1661
Cdd:COG5238 394 EALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
614-895 |
1.97e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 64.30 E-value: 1.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 614 TGPKMVELYHYVAETQDLELARFvaQSLPFDLSFHNFPLTRADLaslanilehrdGPIHLDFDGCPLePHCPEAL--VGC 691
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 692 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKMLGLTGSKITAQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVDL 771
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 772 IPCLRKLQKLDLSQN---SFCMSTLLSSVKAaitcptvrklqvreselifflspvpetatqqsgasdaqgedspkeGQSR 848
Cdd:cd00116 217 LASLKSLEVLNLGDNnltDAGAAALASALLS---------------------------------------------PNIS 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1958747931 849 NLQLRLQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRLV 895
Cdd:cd00116 252 LLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL 298
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
520-635 |
2.83e-07 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 51.14 E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 520 HLNLQEFFAALYLMASDTVDKDTLINYVTLNSHWVLRTKA-------KPGLSDHLPTFLAGLASHTCHTFLCHLaQQDEA 592
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESLKSLldkalksKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958747931 593 WVGSRQATvIQVLRKLASRKLTGPKMVELYHYVAETQDLELAR 635
Cdd:pfam17776 80 SSEIKQEL-LQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1518-1620 |
3.32e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 52.87 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1518 SGLEHCHHLEELDFSNNSLCKEDT----ELLIGALQRTcrLKRLHLSHLPLETssldllVQGLSNMTLLQDLCLKHSQIG 1593
Cdd:cd21340 84 EGLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNS--LRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQIS 155
|
90 100
....*....|....*....|....*..
gi 1958747931 1594 DMgtQHLAAILPRLPGLRKLDLSGNRI 1620
Cdd:cd21340 156 DL--EELLDLLSSWPSLRELDLTGNPV 180
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1519-1670 |
3.46e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 50.17 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1519 GLEHCHHLEELDFSNNSLCKedtellIGALQRTCRLKRLHLSHLPLETssldllVQGLSNMTLLQDLCLKHSQIgDMGTQ 1598
Cdd:cd21340 41 NLEFLTNLTHLYLQNNQIEK------IENLENLVNLKKLYLGGNRISV------VEGLENLTNLEELHIENQRL-PPGEK 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747931 1599 ------HLAAILPRlpgLRKLDLSGNRIgpaggmQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRFPPQLRVLCLT 1670
Cdd:cd21340 108 ltfdprSLAALSNS---LRVLNISGNNI------DSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
710-947 |
1.31e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.93 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 710 EALCRSLPTMGSLKMLGLTGSKITaqgisHLIQALPLCSQLEEVSLHDNQLKD-PEVLSLvdlipcLRKLQKLDLSQNSf 788
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDlPEELGN------LTNLKELDLSNNQ- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 789 cmstlLSSVKAAIT-CPTVRKLQVRESELIFFLSPVpetatqqsgasdaqgedspkeGQSRNLQ-LRLQKCQLRvhDAKA 866
Cdd:COG4886 194 -----ITDLPEPLGnLTNLEELDLSGNQLTDLPEPL---------------------ANLTNLEtLDLSNNQLT--DLPE 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 867 LVELfqkgPRLEEVDLSGNHLKDegcrlvTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISLLTNTVV 946
Cdd:COG4886 246 LGNL----TNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
|
.
gi 1958747931 947 L 947
Cdd:COG4886 316 L 316
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1604-1784 |
1.01e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1604 LPRLPGLRKLDLSGNRIGPAGGmqlvksLTHFKNLEEIILGNNtlgdptalelaqrfppQLRVLcltsshlgpEGalcla 1683
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN------LENLVNLKKLYLGGN----------------RISVV---------EG----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1684 qaLEQCPHIEEVSLAENNLAGGVP-HFSKR-----LPLLKQINLVSCKIEDqaakhlATNLTLCPALEKLLLSWNHLGDe 1757
Cdd:cd21340 86 --LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD- 156
|
170 180
....*....|....*....|....*..
gi 1958747931 1758 mAAELAQVLPQMGQLKRVDLEKNQITA 1784
Cdd:cd21340 157 -LEELLDLLSSWPSLRELDLTGNPVCK 182
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1489-1783 |
2.44e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.99 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1489 QNILISSCELKSFRLTFSNVSTESPAHLASGLEhchhleELDFSNNSLCKEdTELLIGALQrtcRLKRLHL------SHL 1562
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLE------TLDLSNNMLSGE-IPNDIGSFS---SLKVLDLggnvlvGKI 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1563 PLEtssldllvqgLSNMTLLQDLCLKHSQ--------IGDM--------GTQHLAAILP----RLPGLRKLDLS-GNRIG 1621
Cdd:PLN00113 181 PNS----------LTNLTSLEFLTLASNQlvgqipreLGQMkslkwiylGYNNLSGEIPyeigGLTSLNHLDLVyNNLTG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1622 PaggmqLVKSLTHFKNLEEIILGNNTLGDPtalelaqrFPP------QLRVLCLTSSHLGPEgalcLAQALEQCPHIEEV 1695
Cdd:PLN00113 251 P-----IPSSLGNLKNLQYLFLYQNKLSGP--------IPPsifslqKLISLDLSDNSLSGE----IPELVIQLQNLEIL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1696 SLAENNLAGGVPHFSKRLPLLKQINLVSCKIEDQAAKHLA--TNLT----------------LCPA--LEKLLLSWNHLG 1755
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGkhNNLTvldlstnnltgeipegLCSSgnLFKLILFSNSLE 393
|
330 340
....*....|....*....|....*...
gi 1958747931 1756 DEMAAELAQVlpqmGQLKRVDLEKNQIT 1783
Cdd:PLN00113 394 GEIPKSLGAC----RSLRRVRLQDNSFS 417
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1526-1783 |
8.30e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.45 E-value: 8.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1526 LEELDFSNNSLCKEDTELLIgalqrtcRLKRLHLSHL---------PLETSSLDLL--VQGLSNM---TLLQDLClKHSQ 1591
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVI-------QLQNLEILHLfsnnftgkiPVALTSLPRLqvLQLWSNKfsgEIPKNLG-KHNN 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1592 IG--DMGTQHLAAILPRL----PGLRKLDLSGNRIGPaggmQLVKSLTHFKNLEEIILGNNTLGDptalELAQRFP--PQ 1663
Cdd:PLN00113 358 LTvlDLSTNNLTGEIPEGlcssGNLFKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSG----ELPSEFTklPL 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1664 LRVLCLTSSHLGPEgalcLAQALEQCPHIEEVSLAENNLAGGVPHF--SKRL---------------------PLLKQIN 1720
Cdd:PLN00113 430 VYFLDISNNNLQGR----INSRKWDMPSLQMLSLARNKFFGGLPDSfgSKRLenldlsrnqfsgavprklgslSELMQLK 505
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958747931 1721 LVSCKIEDQAAKHLATnltlCPALEKLLLSWNHLGDEMAAELAQvLPQMGQLkrvDLEKNQIT 1783
Cdd:PLN00113 506 LSENKLSGEIPDELSS----CKKLVSLDLSHNQLSGQIPASFSE-MPVLSQL---DLSQNQLS 560
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1607-1634 |
2.49e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 2.49e-03
10 20
....*....|....*....|....*...
gi 1958747931 1607 LPGLRKLDLSGNRIGPAGGMQLVKSLTH 1634
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
713-789 |
4.09e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 4.09e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747931 713 CRSLPTMG-SLKMLGLTGSKITAqgishlIQALPLCSQLEEVSLHDNQLKDPEVLSlvDLIPCLRKLQKLDLSQNSFC 789
Cdd:cd21340 112 PRSLAALSnSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISDLEELL--DLLSSWPSLRELDLTGNPVC 181
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
984-1310 |
7.30e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 984 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1059
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1060 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1139
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1140 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1219
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747931 1220 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1299
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747931 1300 SYPHIQEVSVS 1310
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
