NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958748171|ref|XP_038954135|]
View 

kelch domain-containing protein 4 isoform X2 [Rattus norvegicus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
35-321 1.16e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.56  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  35 PPPSPRLNASLSAHPEKdelILFGGEYFNGQktfMYNELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIF 113
Cdd:COG3055     8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 114 GGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTggPSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTfl 193
Cdd:COG3055    77 GGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 194 WSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskqrvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRS 273
Cdd:COG3055   149 WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR------------------------NGSGFSNTWTTLAPL---PTARA 198

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 274 GFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLYIYDAAKSRWFAA 321
Cdd:COG3055   199 GHA-AAVLGGKILVFGG----------ESGFSDEVEAYDPATNTWTAL 235
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
35-321 1.16e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.56  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  35 PPPSPRLNASLSAHPEKdelILFGGEYFNGQktfMYNELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIF 113
Cdd:COG3055     8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 114 GGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTggPSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTfl 193
Cdd:COG3055    77 GGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 194 WSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskqrvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRS 273
Cdd:COG3055   149 WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR------------------------NGSGFSNTWTTLAPL---PTARA 198

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 274 GFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLYIYDAAKSRWFAA 321
Cdd:COG3055   199 GHA-AAVLGGKILVFGG----------ESGFSDEVEAYDPATNTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 53-290 1.16e-19

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  53 ELILFGGEY--FNGQKTFMYNELYIYSIRK------GTWTKVDIPGPPP-RRCAHQavvVPQGGGQLWIFGGEFaSPDGE 123
Cdd:PLN02193  115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPstpkllGKWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 124 QFYHykdLWVLHLATKTWEQIRSTGGPSGRS--GHRMVAWKRQLILFGGFHESTRdyiyYSDVYTFSLDTFLWSKLSPSG 201
Cdd:PLN02193  191 IDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVE 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 202 PGPTPRSGCLMAV----------------------------------TPQGSIAIYGGYSKQRVKKDV-----DKGTQHS 242
Cdd:PLN02193  264 EGPTPRSFHSMAAdeenvyvfggvsatarlktldsynivdkkwfhcsTPGDSFSIRGGAGLEVVQGKVwvvygFNGCEVD 343

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 243 DMFLLKPedgGEDKwtWTRVNPSGVKPTVRSGFSVAVAPNHqILVFGG 290
Cdd:PLN02193  344 DVHYYDP---VQDK--WTQVETFGVRPSERSVFASAAVGKH-IVIFGG 385
Kelch_4 pfam13418
Galactose oxidase, central domain;
39-93 1.19e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 48.38  E-value: 1.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958748171  39 PRLNASLSAHPeKDELILFGGEYFNGQktfMYNELYIYSIRKGTWTKVdipGPPP 93
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTRL---GSLP 48
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
35-321 1.16e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.56  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  35 PPPSPRLNASLSAHPEKdelILFGGEYFNGQktfMYNELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIF 113
Cdd:COG3055     8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 114 GGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTggPSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTfl 193
Cdd:COG3055    77 GGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 194 WSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskqrvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRS 273
Cdd:COG3055   149 WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR------------------------NGSGFSNTWTTLAPL---PTARA 198

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 274 GFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLYIYDAAKSRWFAA 321
Cdd:COG3055   199 GHA-AAVLGGKILVFGG----------ESGFSDEVEAYDPATNTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 53-290 1.16e-19

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  53 ELILFGGEY--FNGQKTFMYNELYIYSIRK------GTWTKVDIPGPPP-RRCAHQavvVPQGGGQLWIFGGEFaSPDGE 123
Cdd:PLN02193  115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPstpkllGKWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 124 QFYHykdLWVLHLATKTWEQIRSTGGPSGRS--GHRMVAWKRQLILFGGFHESTRdyiyYSDVYTFSLDTFLWSKLSPSG 201
Cdd:PLN02193  191 IDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVE 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 202 PGPTPRSGCLMAV----------------------------------TPQGSIAIYGGYSKQRVKKDV-----DKGTQHS 242
Cdd:PLN02193  264 EGPTPRSFHSMAAdeenvyvfggvsatarlktldsynivdkkwfhcsTPGDSFSIRGGAGLEVVQGKVwvvygFNGCEVD 343

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 243 DMFLLKPedgGEDKwtWTRVNPSGVKPTVRSGFSVAVAPNHqILVFGG 290
Cdd:PLN02193  344 DVHYYDP---VQDK--WTQVETFGVRPSERSVFASAAVGKH-IVIFGG 385
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
19-290 1.68e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.90  E-value: 1.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  19 FQTLDAKKTQVTETPcPPPSPRLNASLSAHPEkDELILFGGEYFNGQKTFMYNELYIYSIRKGTWTKV-DIPGPpprRCA 97
Cdd:COG3055    40 FEVYDPATNTWSELA-PLPGPPRHHAAAVAQD-GKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLaPMPTP---RGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  98 HQAVVVpqgGGQLWIFGGEFASPdgeqfyHYKDLWVLHLATKTWEQIRSTggPSGRSGHR-MVAWKRQLILFGGFHestr 176
Cdd:COG3055   115 ATALLL---DGKIYVVGGWDDGG------NVAWVEVYDPATGTWTQLAPL--PTPRDHLAaAVLPDGKILVIGGRN---- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 177 dyiyysdvytFSLDTFLWSKLspsGPGPTPRSGcLMAVTPQGSIAIYGGYSkqrvkkdvdkgTQHSDMFLLKPEDGgedk 256
Cdd:COG3055   180 ----------GSGFSNTWTTL---APLPTARAG-HAAAVLGGKILVFGGES-----------GFSDEVEAYDPATN---- 230

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958748171 257 wTWTRVNPSgvkPTVRSGFsVAVAPNHQILVFGG 290
Cdd:COG3055   231 -TWTALGEL---PTPRHGH-AAVLTDGKVYVIGG 259
PLN02153 PLN02153
epithiospecifier protein
 37-318 1.27e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 75.41  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  37 PSPRLNASLSAhpEKDELILFGGEYFNGQKtfMYNELYIYSIRKGTWTKVDIPGPPPRrCAHQAVVVPQGGGQLWIFGGE 116
Cdd:PLN02153   20 PGPRCSHGIAV--VGDKLYSFGGELKPNEH--IDKDLYVFDFNTHTWSIAPANGDVPR-ISCLGVRMVAVGTKLYIFGGR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 117 FASPDGEQFYHYKDLwvlhlaTKTWE---QIRSTGGPSGRSGHRMVAWKRQLILFGGFHES--TRDYIYYSDVYTFSLDT 191
Cdd:PLN02153   95 DEKREFSDFYSYDTV------KNEWTfltKLDEEGGPEARTFHSMASDENHVYVFGGVSKGglMKTPERFRTIEAYNIAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 192 FLWSKLSPSGPGPTPRSGCLMAVTpQGSIAIYGGYSKQRVKKDVDKGTQHSDMFLlKPEDGgedkwTWTRVNPSGVKPTV 271
Cdd:PLN02153  169 GKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYGFATSILPGGKSDYESNAVQFF-DPASG-----KWTEVETTGAKPSA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958748171 272 RSGFSVAVAPNHqILVFGGVCDEEEEEHL-EGSFFNDLYIYDAAKSRW 318
Cdd:PLN02153  242 RSVFAHAVVGKY-IIIFGGEVWPDLKGHLgPGTLSNEGYALDTETLVW 288
Kelch_4 pfam13418
Galactose oxidase, central domain;
39-93 1.19e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 48.38  E-value: 1.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958748171  39 PRLNASLSAHPeKDELILFGGEYFNGQktfMYNELYIYSIRKGTWTKVdipGPPP 93
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTRL---GSLP 48
PLN02153 PLN02153
epithiospecifier protein
 141-333 7.31e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.53  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 141 WEQIRSTGG--PSGRSGHRMVAWKRQLILFGGfhESTRDYIYYSDVYTFSLDTFLWSKLSPSGPGPTPRSGCLMAVTPQG 218
Cdd:PLN02153    9 WIKVEQKGGkgPGPRCSHGIAVVGDKLYSFGG--ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 219 SIAIYGGYSKQRVKKDvdkgtqhsdmflLKPEDGGEDKWTW-TRVNPSGvKPTVRSGFSVAVAPNHqILVFGGVCDEEEE 297
Cdd:PLN02153   87 KLYIFGGRDEKREFSD------------FYSYDTVKNEWTFlTKLDEEG-GPEARTFHSMASDENH-VYVFGGVSKGGLM 152

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958748171 298 EHLEGsfFNDLYIYDAAKSRWfaAQLKGPKSEKKRR 333
Cdd:PLN02153  153 KTPER--FRTIEAYNIADGKW--VQLPDPGENFEKR 184
Kelch_3 pfam13415
Galactose oxidase, central domain;
51-103 9.79e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.74  E-value: 9.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958748171  51 KDELILFGGEYFNGQKtfMYNELYIYSIRKGTWTKVDiPGPPPRRCaHQAVVV 103
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT--RLNDLYVYDLDTNTWTQIG-DLPPPRSG-HSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
107-160 1.30e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958748171 107 GGQLWIFGGEFasPDGEQFYHykDLWVLHLATKTWEQIRSTggPSGRSGHRMVA 160
Cdd:pfam13415   1 GDKLYIFGGLG--FDGQTRLN--DLYVYDLDTNTWTQIGDL--PPPRSGHSATY 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 150-192 5.67e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 43.32  E-value: 5.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958748171 150 PSGRSGHRMVAWKRQLILFGGFheSTRDYIYYSDVYTFSLDTF 192
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
PLN02153 PLN02153
epithiospecifier protein
 37-207 3.74e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.13  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  37 PSPRLNASLSAhpEKDELILFGGEYFNGQKTF--MYNELYIYSIRKGTWTKVDIPGPPPRRCAHQAVVVPQGggQLWIFG 114
Cdd:PLN02153  125 PEARTFHSMAS--DENHVYVFGGVSKGGLMKTpeRFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQG--KIWVVY 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171 115 GeFAS---PDGEQFYHYKDLWVLHLATKTWEQIRSTGG-PSGRSGHRMVAWKRQLILFGGfhESTRDY-------IYYSD 183
Cdd:PLN02153  201 G-FATsilPGGKSDYESNAVQFFDPASGKWTEVETTGAkPSARSVFAHAVVGKYIIIFGG--EVWPDLkghlgpgTLSNE 277

                         170       180
                  ....*....|....*....|....
gi 1958748171 184 VYTFSLDTFLWSKLSPSGPGPTPR 207
Cdd:PLN02153  278 GYALDTETLVWEKLGECGEPAMPR 301
Kelch_3 pfam13415
Galactose oxidase, central domain;
162-214 1.15e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.97  E-value: 1.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958748171 162 KRQLILFGGFHESTRDYiyYSDVYTFSLDTFLWSKLspsGPGPTPRSGCLMAV 214
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
93-146 1.43e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.52  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958748171  93 PRRCaHQAVVVPqgGGQLWIFGGEfaSPDGEQfyhYKDLWVLHLATKTWEQIRS 146
Cdd:pfam13418   1 PRAY-HTSTSIP--DDTIYLFGGE--GEDGTL---LSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
95-144 3.93e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.47  E-value: 3.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958748171  95 RCAHQAVVVpqgGGQLWIFGGefaspDGEQFYHYKDLWVLHLATKTWEQI 144
Cdd:pfam13964   2 RTFHSVVSV---GGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEEL 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
83-184 6.44e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.31  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748171  83 WTKV-DIPGPPpRRCAHQAVVvpqgGGQLWIFGGEFASPDGEQFYHYKDLWVLHLATKTWEQIrSTGGPSGRSGHRMVAW 161
Cdd:PRK14131   64 WTKIaAFPGGP-REQAVAAFI----DGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVSL 137

                          90       100
                  ....*....|....*....|....
gi 1958748171 162 -KRQLILFGGFHESTRDYiYYSDV 184
Cdd:PRK14131  138 hNGKAYITGGVNKNIFDG-YFEDL 160
Kelch_4 pfam13418
Galactose oxidase, central domain;
152-202 1.66e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 1.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958748171 152 GRSGHRMVAW-KRQLILFGGFhesTRDYIYYSDVYTFSLDTFLWSKLSPSGP 202
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 269-312 2.75e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 35.62  E-value: 2.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958748171 269 PTVRSGFSVAVApNHQILVFGGVcdeeeeEHLEGSFFNDLYIYD 312
Cdd:pfam13854   1 PVPRYGHCAVTV-GDYIYLYGGY------TGGEGQPSDDVYVLS 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH