transcription initiation factor TFIID subunit 11 isoform X2 [Rattus norvegicus]
Protein Classification
TAF11 family protein( domain architecture ID 6730)
TAF11 family protein similar to TATA binding protein (TBP) associated factor 11 (TAF11), which is one of several TAFs that bind TBP and are involved in forming Transcription Factor IID (TFIID) complex
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| HFD_SF super family | cl45933 | histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ... |
108-136 | 3.32e-14 | ||
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10. The actual alignment was detected with superfamily member pfam04719: Pssm-ID: 480273 Cd Length: 86 Bit Score: 63.66 E-value: 3.32e-14
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| Name | Accession | Description | Interval | E-value | ||
| TAFII28 | pfam04719 | hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of ... |
108-136 | 3.32e-14 | ||
hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3. Pssm-ID: 428086 Cd Length: 86 Bit Score: 63.66 E-value: 3.32e-14
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| HFD_TAF11 | cd08048 | histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and ... |
113-136 | 5.83e-11 | ||
histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and similar proteins; TAF11, also called TATA Binding Protein (TBP) associated factor 11, TFIID subunit p30-beta, or transcription initiation factor TFIID 28 kDa subunit (TAF(II)28, TAFII-28, TAFII28), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone. TAF11 also directly interacts with TFIIA, acting as a bridging factor that stabilizes the TFIIA-TBP-DNA complex. Pssm-ID: 467028 Cd Length: 87 Bit Score: 55.25 E-value: 5.83e-11
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| TAF40 | COG5251 | Transcription initiation factor TFIID, subunit TAF11 [Transcription]; |
102-136 | 1.54e-06 | ||
Transcription initiation factor TFIID, subunit TAF11 [Transcription]; Pssm-ID: 227576 Cd Length: 199 Bit Score: 45.80 E-value: 1.54e-06
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| Name | Accession | Description | Interval | E-value | ||
| TAFII28 | pfam04719 | hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of ... |
108-136 | 3.32e-14 | ||
hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3. Pssm-ID: 428086 Cd Length: 86 Bit Score: 63.66 E-value: 3.32e-14
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| HFD_TAF11 | cd08048 | histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and ... |
113-136 | 5.83e-11 | ||
histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and similar proteins; TAF11, also called TATA Binding Protein (TBP) associated factor 11, TFIID subunit p30-beta, or transcription initiation factor TFIID 28 kDa subunit (TAF(II)28, TAFII-28, TAFII28), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone. TAF11 also directly interacts with TFIIA, acting as a bridging factor that stabilizes the TFIIA-TBP-DNA complex. Pssm-ID: 467028 Cd Length: 87 Bit Score: 55.25 E-value: 5.83e-11
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| TAF40 | COG5251 | Transcription initiation factor TFIID, subunit TAF11 [Transcription]; |
102-136 | 1.54e-06 | ||
Transcription initiation factor TFIID, subunit TAF11 [Transcription]; Pssm-ID: 227576 Cd Length: 199 Bit Score: 45.80 E-value: 1.54e-06
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