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Conserved domains on  [gi|1958807849|ref|XP_038955841|]
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plexin-B3 isoform X5 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 765.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRA 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  117 QELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  276 QGLIQAAFLAPD--TLLGAFSAG-----TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1958807849  429 GPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
RasGAP super family cl02569
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1317-1457 1.83e-96

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


The actual alignment was detected with superfamily member cd12791:

Pssm-ID: 470620 [Multi-domain]  Cd Length: 397  Bit Score: 316.40  E-value: 1.83e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLR 141
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 2.62e-32

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 121.27  E-value: 2.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTSGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1958807849  903 P-PGISAQHFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 1.01e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 107.70  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGDQPCPIQePVCPEAIICHTMPQMEPGEAVVFVVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1958807849  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 4.97e-24

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 97.73  E-value: 4.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  678 SPQLVPVGWESHVTLHIENLHYFRGLPALYYCWLELPGKLRKLPAFLEETSrnsgLIHCQAQQFHPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1958807849  758 RGEIQRLDNTGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 7.90e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 93.87  E-value: 7.90e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  522 PAQHPRQEHGQITLSVPGLPNLAmdEYFYCAFGDYN-SLAQVEEHHVVCATPPQDRMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1958807849  599 VLAATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-514 3.19e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.42  E-value: 3.19e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958807849  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGrAVQPNQWLWSYEDNHC 514
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKC 51
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1004-1135 8.86e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01181:

Pssm-ID: 472823  Cd Length: 99  Bit Score: 51.65  E-value: 8.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEFqvkalgvqaqdvnprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVE-------------------------------------- 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807849 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 4.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958807849 1165 GLNLGISKEEVQVHIGDGKCLVKTLTLTHLYCEPPQQAPQPTNgsgtlpqFVVQMGNVRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 6.34e-03

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 35.98  E-value: 6.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958807849   622 CRTCVSSLW-RCHWCPQSSHCVYGERCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 765.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRA 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  117 QELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  276 QGLIQAAFLAPD--TLLGAFSAG-----TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1958807849  429 GPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1317-1457 1.83e-96

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 316.40  E-value: 1.83e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLR 141
Sema smart00630
semaphorin domain;
44-436 1.34e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.91  E-value: 1.34e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849    44 FNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAecpQAQLTDNANQL-LLVSSRAQELVAC 122
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKG---KDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   123 GQ-VRQGVCEKRRLGDvtqvLYqaedpgdgqfvaantlgvttVGLVVPLPGRDlllvarglagklSAGVPPLTVRQLAGP 201
Cdd:smart00630   78 GTnAFQPVCRLRNLGE----LY--------------------VGTVADFSGSD------------PAIPRSLSVRRLKGT 121

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   202 QPFSSeglgRLVVGDFSDYNN-SYVGAFSDAHSAYFVFRRRGARAQTE---YRSYVARVCLGDV--------NLYSYVEV 269
Cdd:smart00630  122 SGVSL----RTVLYDSKWLNEpNFVYAFESGDFVYFFFRETAVEDDNCgkaVHSRVARVCKNDVggprsldkKWTSFLKA 197

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   270 PLTCHGQG-------LIQAAFLAP------DTLLGAFSAG-TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGmE 335
Cdd:smart00630  198 RLECSVPGedpfyfnELQAAFLLPpgsesdDVLYGVFSTSsNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPY-S 276

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   336 EATVEYGVTSRCVTLPPDSpESYPC----GDEHTPSPIAGRQPLEAQPLL---QLGQPISAVAALQTD---GHTIAFLGD 405
Cdd:smart00630  277 RGKVPYPRPGTCPNKPPSS-KDLPDetlnFIKSHPLMDEVVQPLTGRPLFvktDSNYLLTSIAVDRVAtdgNYTVLFLGT 355

                           410       420       430
                    ....*....|....*....|....*....|....*
gi 1958807849   406 TEGQLHKVFL----NSSHGQVYHSQQVGPPGSAIS 436
Cdd:smart00630  356 SDGRILKVVLsessSSSESVVLEEISVFPDGSPIS 390
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1317-1457 4.41e-70

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 244.80  E-value: 4.41e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGE-EGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVA 1395
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVTnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958807849 1396 SLLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLR 143
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 2.62e-32

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 121.27  E-value: 2.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTSGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1958807849  903 P-PGISAQHFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 1.01e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 107.70  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGDQPCPIQePVCPEAIICHTMPQMEPGEAVVFVVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1958807849  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 4.97e-24

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 97.73  E-value: 4.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  678 SPQLVPVGWESHVTLHIENLHYFRGLPALYYCWLELPGKLRKLPAFLEETSrnsgLIHCQAQQFHPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1958807849  758 RGEIQRLDNTGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 7.90e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 93.87  E-value: 7.90e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  522 PAQHPRQEHGQITLSVPGLPNLAmdEYFYCAFGDYN-SLAQVEEHHVVCATPPQDRMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1958807849  599 VLAATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 279-442 2.23e-14

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 72.69  E-value: 2.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  279 IQAAFLAP--------DTLLGAFSAGTSQA--QAALCAFPLADLDGSMEqaRRLCYTTGGQGPNGMEEATVEYGVTSRCV 348
Cdd:pfam01403    1 LQDVFVLKpgagdaldTVLYGVFTTQWSNSigGSAVCAFSLSDINAVFE--GPFKEQEKSDSKWLPYTGKVPYPRPGTCI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  349 TLP--PDSPESYPCGDEHTPSPIAGRQPLEAQPLL-QLGQPISAVAALQTDG----HTIAFLGDTEGQLHKVFLNSSHGQ 421
Cdd:pfam01403   79 NDPlrLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLvRTGVRLTSIAVDRVQAldgnYTVLFLGTDDGRLHKVVLVGSEES 158

                          170       180
                   ....*....|....*....|..
gi 1958807849  422 VYHSQ-QVGPPGSAISPDLLVD 442
Cdd:pfam01403  159 HIIEEiQVFPEPQPVLNLLLSS 180
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-514 3.19e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.42  E-value: 3.19e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958807849  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGrAVQPNQWLWSYEDNHC 514
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKC 51
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 824-914 1.32e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.78  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPdpsLYRISARIVCVTspaPNGTSGPVQVAIKSRP 903
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTV---ISVSSTTIVCTT---PPGTSGLVNVSVTVGG 72

                           90
                   ....*....|.
gi 1958807849  904 PGISAQHFTYQ 914
Cdd:pfam01833   73 GGISSSPLTFT 83
IPT smart00429
ig-like, plexins, transcription factors;
915-1001 4.14e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 63.59  E-value: 4.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   915 DPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGD--QPCPIQePVCPEAIICHTMPQME-PGEAVVFVV-FGHVE 990
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeAPCTFS-PSSSTAIVCKTPPYHNiPGSVPVRTVgLRNGG 79

                            90
                    ....*....|.
gi 1958807849   991 RKLLTTPFRYT 1001
Cdd:smart00429   80 VPSSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
824-913 2.85e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.28  E-value: 2.85e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   824 PSIDVIEPLTGPPEGGLAITILGSNLGqAFNDVRNAVTVAGQPCNPDPSLyriSARIVCVTSPAPNGT-SGPVQVAiKSR 902
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPgSVPVRTV-GLR 76

                            90
                    ....*....|...
gi 1958807849   903 PPGI--SAQHFTY 913
Cdd:smart00429   77 NGGVpsSPQPFTY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
464-514 1.87e-10

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 57.55  E-value: 1.87e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1958807849   464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGRAVQpnqwlwSYEDNHC 514
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ------NWLSGGC 46
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 916-1000 2.58e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 2.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNVSAFVGDQPCPIQEpVCPEAIIChTMPQMEPGEAVVFVVFGHVERKLL 994
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDsSDLKVTIGGTPCTVIS-VSSTTIVC-TTPPGTSGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1958807849  995 TTPFRY 1000
Cdd:pfam01833   79 PLTFTY 84
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1004-1135 8.86e-08

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 51.65  E-value: 8.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEFqvkalgvqaqdvnprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVE-------------------------------------- 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807849 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 4.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958807849 1165 GLNLGISKEEVQVHIGDGKCLVKTLTLTHLYCEPPQQAPQPTNgsgtlpqFVVQMGNVRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 6.34e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 35.98  E-value: 6.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958807849   622 CRTCVSSLW-RCHWCPQSSHCVYGERCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 765.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRA 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  117 QELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  276 QGLIQAAFLAPD--TLLGAFSAG-----TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1958807849  429 GPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 44-462 4.12e-174

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 527.19  E-value: 4.12e-174
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   44 FNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRAQELVACG 123
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  124 QVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVP-LPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQ 202
Cdd:cd11245     82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYfKDGLSLLFVGRGYTSSLSGGIPPITTRLLQEHG 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  203 P---FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTCHGQ--- 276
Cdd:cd11245    162 EmdaFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTADSTKRTYISRLCENDHHYYSYVELPLNCTVNqen 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  277 --GLIQAAFLAP-------DTLLGAFSAG-----TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGMEEATVEYG 342
Cdd:cd11245    242 tyNLVQAAYLAKpgkvlngKVLFGVFSADeastaAPDGRSALCMYPLSSVDARFERTRESCYTGEGLEDDKPETAYIEYN 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  343 VTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQV 422
Cdd:cd11245    322 VKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILTRNDMLTAVAVAVENGHTIAFLGDSGGQLHKVYLDPNHTDF 401

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1958807849  423 YhSQQVGPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11245    402 Y-STIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 37-462 3.37e-130

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 411.28  E-value: 3.37e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRA 116
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  117 QELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVV-PLPGRDLLLVARGLAGK-LSAGVPPLT 194
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAySKDGVPLLFVGRGYTSRgVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  195 VRQLAGPQP--------FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQT-EYRSYVARVCLGDVNLYS 265
Cdd:cd11275    161 TRNLRAHGDdatdshsiFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSrEYKTYISRICLDDSHYYS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  266 YVEVPLTCHGQ----GLIQAAFLAP--------------DTLLGAFSA-----GTSQAQAALCAFPLADLDGSMEQARRL 322
Cdd:cd11275    241 YVELPLLCQSKantySLLQAAYVTQpgerlaqgqldtdgEVLFAAFSAwqassGKLSEESALCAYPMDEVDRLTNWTRDV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  323 CYTTGGQGPNGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQ-LGQPISAVAALQTDGHTIA 401
Cdd:cd11275    321 CYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEwTEIRLTAVAVNVEDGHTIA 400

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958807849  402 FLGDTEGQLHKVFLNS-SHGQVYHSQQVgPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11275    401 FLGDSRGRLHKVYLGAgGDAHTYSSQSI-QQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1317-1457 1.83e-96

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 316.40  E-value: 1.83e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLR 141
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1317-1457 1.95e-84

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 282.20  E-value: 1.95e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMIKLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12787     81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLR 141
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 44-462 2.71e-84

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 281.91  E-value: 2.71e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   44 FNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRAQELVACG 123
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  124 QVRQGVCEKRRLGDVTQVLYQAEDPgdgqfVAANTLGVTTVGLV--VPLPGRDLLLVARGLAGKLS-AGVPPLTVRQLAG 200
Cdd:cd11236     82 SLYQGVCQLRNLSNISVVVERSSTP-----VAANDPNASTVGFVgpGPYNNENVLYVGATYTNNGYrDYRPAVSSRSLPP 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  201 PQPFSSEGLG---RLVVGDFSDYNNS--YVGAFSDAHSAYFVFRRR-GARAQTEYRSYVARVCLGDVNLYSYVEVPLTCH 274
Cdd:cd11236    157 DDDFNAGSLTggsAISIDDEYRDRYSikYVYGFSSGGFSYFVTVQRkSVDDESPYISRLVRVCQSDSNYYSYTEVPLQCT 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  275 GQG-----LIQAAFLAP---------------DTLLGAFSAG-----TSQAQAALCAFPLADLDgsmEQARRLCyttggq 329
Cdd:cd11236    237 GGDgtnynLLQAAYVGKagsdlarslgistddDVLFGVFSKSkgpsaEPSSKSALCVFSMKDIE---AAFNDNC------ 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  330 gpngmeeatveygvtsrcvtlppdspesypcgdehtpsPIAGRQPLEAQPLLQLGQPISaVAALQTDGHTIAFLGDTEGQ 409
Cdd:cd11236    308 --------------------------------------PLGGGVPITTSAVLSDSLLTS-VAVTTTRNHTVAFLGTSDGQ 348

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807849  410 LHKVFLNSSH-GQVYHSQQVGpPGSAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11236    349 LKKVVLESSSsATQYETLLVD-SGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
Sema smart00630
semaphorin domain;
44-436 1.34e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.91  E-value: 1.34e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849    44 FNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAecpQAQLTDNANQL-LLVSSRAQELVAC 122
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKG---KDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   123 GQ-VRQGVCEKRRLGDvtqvLYqaedpgdgqfvaantlgvttVGLVVPLPGRDlllvarglagklSAGVPPLTVRQLAGP 201
Cdd:smart00630   78 GTnAFQPVCRLRNLGE----LY--------------------VGTVADFSGSD------------PAIPRSLSVRRLKGT 121

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   202 QPFSSeglgRLVVGDFSDYNN-SYVGAFSDAHSAYFVFRRRGARAQTE---YRSYVARVCLGDV--------NLYSYVEV 269
Cdd:smart00630  122 SGVSL----RTVLYDSKWLNEpNFVYAFESGDFVYFFFRETAVEDDNCgkaVHSRVARVCKNDVggprsldkKWTSFLKA 197

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   270 PLTCHGQG-------LIQAAFLAP------DTLLGAFSAG-TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGmE 335
Cdd:smart00630  198 RLECSVPGedpfyfnELQAAFLLPpgsesdDVLYGVFSTSsNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPY-S 276

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   336 EATVEYGVTSRCVTLPPDSpESYPC----GDEHTPSPIAGRQPLEAQPLL---QLGQPISAVAALQTD---GHTIAFLGD 405
Cdd:smart00630  277 RGKVPYPRPGTCPNKPPSS-KDLPDetlnFIKSHPLMDEVVQPLTGRPLFvktDSNYLLTSIAVDRVAtdgNYTVLFLGT 355

                           410       420       430
                    ....*....|....*....|....*....|....*
gi 1958807849   406 TEGQLHKVFL----NSSHGQVYHSQQVGPPGSAIS 436
Cdd:smart00630  356 SDGRILKVVLsessSSSESVVLEEISVFPDGSPIS 390
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 45-461 2.61e-72

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 249.31  E-value: 2.61e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   45 NHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRAQELVACGQ 124
Cdd:cd11276      9 NHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSANKTLVVCGS 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  125 VRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPL-PGRD-LLLVARGLA----GKLsagvppLTVRQL 198
Cdd:cd11276     89 LFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLkPGNDrVFFVGKGNGsndnGKI------ISTRLL 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  199 agpqpfsSEGLGRLVVGDFSD-----------YNNSYVGAFSDAHSAYFVFRRRgARAQTEYRSYVARVCLGDVNLYSYV 267
Cdd:cd11276    163 -------QNYDDREVFENYIDaatvksayvsrYTQQFRYAFEDNNYVYFLFNQQ-LGHPDKNRTLIARLCENDHHYYSYT 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  268 EVPLTC------HGQglIQAAFLAP---------------DT-LLGAFSA-GTSQAQAALCAFPLADLDGSMEQARRLCY 324
Cdd:cd11276    235 EMDLNCrdganaYNK--CQAAYVSTpgkelaqnygnsilsDKvLFAVFSRdEKDSGESALCMFPLKSINAKMEANREACY 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  325 TTGGQGPNGMEEAtVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPL-EAQPLLQL-GQPISAVAALQTDGHTIAF 402
Cdd:cd11276    313 TGTIDDRDVFYKP-FHSQKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRgGLNLTAVTVAVENGHTVAF 391

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807849  403 LGDTEGQLHKVFLnSSHGQVYHSQQVGPPGsAISPDLLVDNSGDYLYVLTAQQVDRILV 461
Cdd:cd11276    392 LGTSDGRILKVHL-SPDPEEYNSILIEKNK-PVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1317-1457 4.41e-70

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 244.80  E-value: 4.41e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGE-EGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVA 1395
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVTnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958807849 1396 SLLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLR 143
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1317-1462 7.03e-65

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 226.07  E-value: 7.03e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPgeEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVP--ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVAS 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLKARQNE 1462
Cdd:cd12793     79 LLTVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGE 144
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 43-505 1.03e-55

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 203.24  E-value: 1.03e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   43 SFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQA-QLTDNANQLLLVSSRAQELVA 121
Cdd:cd11272     12 TFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVlTLTNNVNKLLIIDYSENRLLA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  122 CGQVRQGVCEKRRLGDVTqVLYQAEDPGDGQFVAANTLGvTTVGLVVPLPGRD-LLLVARGLAGKLSAgVPPLTVRQLag 200
Cdd:cd11272     92 CGSLYQGVCKLLRLDDLF-ILVEPSHKKEHYLSSVNKTG-TMYGVIVRSEGEDgKLFIGTAVDGKQDY-FPTLSSRKL-- 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  201 PQ-PFSSEGLGRLVVGDF---------------SDYNNSYVGAFSDAHSAYFVfrrrgaRAQTE--------------YR 250
Cdd:cd11272    167 PRdPESSAMLDYELHSDFvsslikipsdtlalvSHFDIFYIYGFASGNFVYFL------TVQPEtpegvsinsagdlfYT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  251 SYVARVCLGDVNLYSYVEVPLTCHGQG----LIQAAFLAP---------------DTLLGAFSAGTSQAQ-----AALCA 306
Cdd:cd11272    241 SRIVRLCKDDPKFHSYVSLPFGCVRGGveyrLLQAAYLSKpgevlarslnitaqeDVLFAIFSKGQKQYHhppddSALCA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  307 FPLADLDGSMEQARRLCYttggQGPNGMEEATVeYGVTSRCVTLPPDSPESYpCGDEhTPSPIAGRQPLEAQPLLQLGQP 386
Cdd:cd11272    321 FPIRAINAQIKERLQSCY----QGEGNLELNWL-LGKDVQCTKAPVPIDDNF-CGLD-INQPLGGSTPVEGVTLYTSSRD 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  387 -ISAVAALQTDGHTIAFLGDTEGQLHKVFLNSS-HGQV-YHSQQVGPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVAA 463
Cdd:cd11272    394 rLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPpHGGVqYEMVSVFKDGSPILRDMAFSIDHKYLYVMSERQVSRVPVES 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1958807849  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGRAVQPNQW 505
Cdd:cd11272    474 CEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEPFRF 515
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1317-1462 5.89e-53

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 190.90  E-value: 5.89e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQpgLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVL--LSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVAS 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYAFLKARQNE 1462
Cdd:cd12205     79 LLMVALQGKMEYATEILFDLLTDLIEKSVsKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGE 145
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1317-1462 9.80e-52

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 187.91  E-value: 9.80e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFF-PGHVGC--PLQPG-LEGPgeEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRC 1392
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlPSKDGAndVMITGkLDIP--EARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKV 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807849 1393 HVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVH-KNPKLMLRRTETMVEKLLTNWLSICLYAFLKARQNE 1462
Cdd:cd12792     79 YFASLLTVALHGKLEYYTDIMRTLLLELMEQYVHsKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGE 149
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1317-1457 3.51e-45

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 168.37  E-value: 3.51e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEegRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERD--RQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVAS 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958807849 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHK--NPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12790     79 LIMVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLK 141
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 45-462 3.17e-44

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 168.49  E-value: 3.17e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   45 NHLVLAPDQGKLYVGAVNHLFQLSP-ELEMESVAITGPVIDSPDC-VPFRDLAECP-QAQLTDNANQLLLVSSRAQELVA 121
Cdd:cd11247     12 NNFALDGGRGRLYLAAVNRLYQLSGlVLALEAEAAVGPVLDSPLChAPQLPQATCEhPRTLTDNYNKILQPDPEQGVLVV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  122 CGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQF-----VAANTLGVTTVGLVVPL---PGRDLLLVARGLAGKLSA----- 188
Cdd:cd11247     92 CGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLWPrggGGGLRLLVGATYTGYGSGffprn 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  189 ---------GVPPLTVRQLAG----------PQPFSSEGLGRLVVGDFSDYNNSYVGAF---SDAHSAYFVFRR--RGAR 244
Cdd:cd11247    172 rsledhrfeNTPEIAIRALNTrgdlaklftfDINPSDDNIFKIKQGAKARHKLSFVRAFlqhFLQPYAYLAMNGeaNAAG 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  245 AQTEYRSYVARVCLGDVNL----------YSYVEVPLTCHG-QGLIQAAFLA--PDTLLGAFSAGTSQAQAALCAFPLAD 311
Cdd:cd11247    252 KESQPPSLLARICLPGRAPpppgeakkltESYIQLGLRCEGaYTRLVSVFPArvEEEQLFAVFERAGGAPAALCAFRFAE 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  312 LDGSMEQARRLCYTTGGQGPNGMEEATVEyGVTSRC-----VTLppdSPESYPCGDEHTPSPIAGRQPLEAQPLLQlGQP 386
Cdd:cd11247    332 VEEPIRAARTACFVSPAAGVVTVLDSVVQ-GTGPACerklnIQL---QPEQLDCGAAHLQHPLAILQPLKATPVFR-APG 406

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807849  387 ISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDNSGD-YLYVLTAQQVDRILVA 462
Cdd:cd11247    407 LTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHVMQFDPSDStYLYLMTSHQMTRVKVA 483
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1318-1457 1.56e-42

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 161.19  E-value: 1.56e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1318 IPFLDYRTYAERAFFPgHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASL 1397
Cdd:cd12789      4 VPFLDYKHFALRTFFP-ESGGFTHIFTRDDPHDRDQTDKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASF 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1398 LSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLK 1457
Cdd:cd12789     83 LTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLR 142
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1317-1457 2.27e-42

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 161.31  E-value: 2.27e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1317 GIPFLDYRTYAERAFFPG----HVGCPLQPGLEGPGEEGR------------------RVTVCQGLTQLSNLLNSKLFLL 1374
Cdd:cd12788      2 GIPFLEYKHFVTRTFFPKcsslYEERYVLPSQENNSQGPRqvpethpllqewkipescRPNMEEGITLFSTLLNNKHFLV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1375 TLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYA 1454
Cdd:cd12788     82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161


                   ...
gi 1958807849 1455 FLK 1457
Cdd:cd12788    162 YLR 164
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 37-461 1.28e-41

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 160.52  E-value: 1.28e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQL-TDNANQLLLVSSR 115
Cdd:cd11271      7 FTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLGtTNNVNKLLLVDYA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  116 AQELVACGQVRQGVCEKRRLGDvtqvLYQAEDPGDGQ--FVAANTLGVTTVGLVVPLP-GRDLLLVARGLAGKlSAGVPP 192
Cdd:cd11271     87 ANRLIACGSASQGICQFLRLDD----LFKLGEPHHRKehYLSSVNESGTMSGVIIEVGnGQNKLFVGTPIDGK-SEYFPT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  193 LTVRQLAGPQ------------PFSSEGLG--RLVVGDFSDYNNSYVGAFSDAHSAYFV-------FRRRGARAQTEYRS 251
Cdd:cd11271    162 LSSRKLMANEenaemfgfvyqdEFVSSQLKipSDTLSKFPTFDIYYVYSFSSEQFVYYLtlqldtqLTSPDSTGEQFFTS 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  252 YVARVCLGDVNLYSYVEVPLTCHGQG----LIQAAFLA---------------PDTLLGAFSAGTSQ-----AQAALCAF 307
Cdd:cd11271    242 KIVRLCVDDPKFYSYVEFPIGCEQDGveyrLIQDAYLSkpgkalakqlgiserEDILFTVFSQGQKNrvkppKESVLCLF 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  308 PLADLDGSMEQARRLCYTtgGQGPNGME-EATVEYGvtsrCVTLPPDSPESYpCGDEHTpSPIAGRQPLEAQPL-LQLGQ 385
Cdd:cd11271    322 TLKKIKDKIKERIQSCYR--GEGKLSLPwLLNKELG----CINSPLQIDDNF-CGQDFN-QPLGGTVTIEGTPLfVDKED 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  386 PISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQ----VGPPGSAISPDLLVDNSGDYLYVLTAQQVDRILV 461
Cdd:cd11271    394 GMTSVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPSSRPALQyenvVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPV 473
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 36-461 4.77e-41

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 158.83  E-value: 4.77e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   36 RFSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQA-QLTDNANQLLLVSS 114
Cdd:cd11244      5 RGEPRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLLLIDY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  115 RAQELVACGQVRQGVCEKRRLGDvtqvLYQAEDPGDGQ---FVAANTLGvTTVGLVVP-LPGRDLLLVARGLAGKlSAGV 190
Cdd:cd11244     85 SENRLIACGSLYQGVCKLLRLED----LFKLGEPHHKKehyLSGVNESG-TMFGVIVSySNGDDKLFIGTAVDGK-SEYF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  191 PPLTVRQLagPQPFSSEGLGRLVVGD----------------FSDYNNSYVGAFSDAHSAYF-------VFRRRGARAQT 247
Cdd:cd11244    159 PTLSSRKL--TADEESDGMFAYVYHDefvssqikipsdtlsiIPDFDIYYVYGFSSGNFVYFltlqpetQLTPGDSTGEQ 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  248 EYRSYVARVCLGDVNLYSYVEVPLTCHGQG----LIQAAFLA---------------PDTLLGAFSAGTSQA-----QAA 303
Cdd:cd11244    237 FYTSKIVRLCKDDTKFYSYVEFPIGCTRDGveyrLLQAAYLSkpgkalaqalgisedEDVLFTIFSKGQKNRmkppdESA 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  304 LCAFPLADLDGSMEQARRLCYttggQGPNGMEEATVeYGVTSRCVTLPPDSPESYpCGDEHTpSPIAGRQPLEAQPLLQL 383
Cdd:cd11244    317 LCLFTLKQINLRIKERLQSCY----RGEGKLSLPWL-LNKDLPCINAPLQIDDNF-CGLDMN-QPLGGSDMVEGIPLFTD 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  384 GQP-ISAVAALQTDGHTIAFLGDTEGQLHKVFLNS-SHGQVYHSQQVGPPGSAISPDLLVDNSGDYLYVLTAQQVDRILV 461
Cdd:cd11244    390 DRDrMTSVAAYVYKGHSVVFVGTKSGKLKKIRVDGpPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVPV 469
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 37-461 8.35e-41

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 157.79  E-value: 8.35e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQA-QLTDNANQLLLVSSR 115
Cdd:cd11273      6 FVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLLVDYA 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  116 AQELVACGQVRQGVCEKRRLGDVTQV----------LYQAEDPgDGQfvaantlgvttVGLVVPLP-GRDLLLVARGLAG 184
Cdd:cd11273     86 GNRLVACGSIWQGVCQFLRLEDLFKLgephhrkehyLSGAQEP-DSM-----------AGVIVEQGkGPSKLFVGTAIDG 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  185 KlSAGVPPLTVRQLAGPQpfSSEGLGRLVVGD----------------FSDYNNSYVGAFSDAHSAYFVFRRRGArAQTE 248
Cdd:cd11273    154 K-SEYFPTLSSRKLISDE--DSADMFSLVYQDefvssqikipsdtlslYPAFDIYYVYGFVSASFVYFLTLQLDT-QQTL 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  249 --------YRSYVARVCLGDVNLYSYVEVPLTCHGQG----LIQAAFLA---------------PDTLLGAFSAG----- 296
Cdd:cd11273    230 ldtagekfFTSKIVRMCANDTEFYSYVEFPLGCSKDGveyrLVQAAHLAkpglllaqalgvpedEDVLFTIFSQGqknra 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  297 TSQAQAALCAFPLADLDGSMEQARRLCYTTGGQgpngmeeatveygvtsrcVTLPPDSPESYPCGDehTP---------- 366
Cdd:cd11273    310 SPPRETILCLFTLSNINAHIRERIQSCYRGEGT------------------LSLPWLLNKELPCIN--TPmqingnfcgl 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  367 ---SPIAGRQPLEAQPLL-QLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSH-GQVYHSQQVgPPGSAISPDLLV 441
Cdd:cd11273    370 vlnQPLGGLHVIEGLPLLaDSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQdAHLYETVPV-VDGSPILRDMVF 448

                          490       500
                   ....*....|....*....|
gi 1958807849  442 DNSGDYLYVLTAQQVDRILV 461
Cdd:cd11273    449 SPDHRYIYLLSEKQVSQLPV 468
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 40-464 1.04e-37

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 148.95  E-value: 1.04e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   40 PNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAEC-PQAQLTDNANQLLLVSSRAQE 118
Cdd:cd11274      9 TEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKMLLIDYKENR 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  119 LVACGQVRQGVCEKRRLGDVTQV---LYQAEDPGDGQFVAANTLGVTTVGLVVPlpgrDLLLVARGLAGKlSAGVPPLTV 195
Cdd:cd11274     89 LIACGSLYQGICKLLRLDDLFKLgepFHKKEHYLSGVNESGSVFGVIVSYSNLD----DKLFIATAVDGK-PEYFPTISS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  196 RQLAGPQP--------FSSEGLGRL---------VVGDFSDYnnsYVGAFSDAHSAYFVFRR--------RGARAQTeYR 250
Cdd:cd11274    164 RKLTKNSEadgmfayvFHDEFVASMikipsdtftIIPDFDIY---YIYGFSSGNFVYFLTLQpemisppgSTTKEQV-YT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  251 SYVARVCLGDVNLYSYVEVPLTCHGQG----LIQAAFLAP---------------DTLLGAFSAG-----TSQAQAALCA 306
Cdd:cd11274    240 SKLVRLCKEDTAFNSYVEVPIGCEKNGveyrLLQAAYLSKagailarslgvgpddDILFTVFSKGqkrkmKSLDESALCI 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  307 FPLADLDGSMEQARRLCYTtgGQGPNGMEEATV-EYGVTSRCVTLPPDSpesypCGDEHTpSPIAGRQPLEAQPLL-QLG 384
Cdd:cd11274    320 FVLKEINDRIKDRLQSCYR--GEGTLDLAWLKVkDIPCSSALLTIDDNF-----CGLDMN-APLGVSEMVRGLPVFtEDR 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  385 QPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQV--YHSQQVGPPGsAISPDLLVDNSGDYLYVLTAQQVDRILVA 462
Cdd:cd11274    392 DRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGTTKNAlqYETVQVVDTG-PILRDMAFSKDHEQLYIMSEKQLTRVPVE 470


                   ..
gi 1958807849  463 AC 464
Cdd:cd11274    471 SC 472
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 2.62e-32

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 121.27  E-value: 2.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTSGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1958807849  903 P-PGISAQHFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 1.01e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 107.70  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGDQPCPIQePVCPEAIICHTMPQMEPGEAVVFVVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1958807849  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 4.97e-24

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 97.73  E-value: 4.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  678 SPQLVPVGWESHVTLHIENLHYFRGLPALYYCWLELPGKLRKLPAFLEETSrnsgLIHCQAQQFHPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1958807849  758 RGEIQRLDNTGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 7.90e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 93.87  E-value: 7.90e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  522 PAQHPRQEHGQITLSVPGLPNLAmdEYFYCAFGDYN-SLAQVEEHHVVCATPPQDRMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1958807849  599 VLAATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 47-459 2.29e-19

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 93.25  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   47 LVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIdSPDCVPFRD-LAECPQAQLTDNANQLLLVSS-RAQELVACGQ 124
Cdd:cd11248     13 IVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTCQDcSSGADPGVPKDTDNMVLVLETyYDDYLYSCGS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  125 VRQGVCEKRRLGDVTQV------LY--QAEDPGDGQFVAANTLG--VTTV--GLVVplpgrdLLLVARGLAGKLSAGVPP 192
Cdd:cd11248     92 TQNGVCYRHVLEDGADIqsevhcLFskKNNSPSYCPDCVASPLGtkVTNVesGRTI------YFFVANSVNSSLAGSFPP 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  193 LTV---RQLAGPQPFSSEGLGRLVVGDFSD-YNNSYVGAFSDAHSAYF--VFRRRGARAQTEYRSYVARVCLGDVNLYSY 266
Cdd:cd11248    166 HSIsvrRLKEDGFGFLSDQSYLDVLPSLRDsYPIKYVYSFHSGPFVYFltVQRESLTKPSSAFHTRLVRLCSSDSEIWRY 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  267 VEVPLTCHGQ--------------GLIQAAFLAP---------------DTLLGAFS-----AGTSQAQAALCAFPLADL 312
Cdd:cd11248    246 REMPLECIFTpkrrrrsteedvvyNVLQAAHVSKvgadladelgasegdDILFGVFArskpdSGEPMPNSALCAFPIKYV 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  313 DGSMEQARRLCYTTggqgpnGMEEATVEYGVTSRCVTLPPDSPEsypCGDEHTPSPIAGRQPLEAQPLL--QLGQP-ISA 389
Cdd:cd11248    326 NDAIEKGVEKCCTS------GLEHFSGSLCHFQPCPTCPGESSS---CEATCKEYRTEVTKPYQRVDLFngQMSNVlLTS 396

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958807849  390 VAALQTDGHTIAFLGDTEGQLHKVFLNSShGQVYHS--QQVGPPgsaISPDLLVDNSGDYLYVLTAQQVDRI 459
Cdd:cd11248    397 ILVTTIGNHTVAHLGTSDGRVLQVVLSRS-GPIPHVnfSLDSQP---VSREVAVLSSNGSLLFVTGDKITKV 464
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 824-915 6.83e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 6.83e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPDPSlyrISARIVCVTSPAPNGTSGPVQVAIKSRP 903
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLNV---SSTEIVCRTPAAATPGEGPVEVTVDGAN 75

                           90
                   ....*....|....*
gi 1958807849  904 ---PGISAQHFTYQD 915
Cdd:cd00603     76 vsaRVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 916-1001 5.30e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.49  E-value: 5.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNVSAFVGDQPCPIqEPVCPEAIICHTMPQMEPGEAVVFVVFGHVERKLL 994
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGsPRVRVTVGGVPCKV-LNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSAR 79

                           90
                   ....*....|
gi 1958807849  995 TTP---FRYT 1001
Cdd:cd00603     80 VLSnttFTYV 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 824-915 7.01e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 71.34  E-value: 7.01e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNdVRnaVTV-AGQPCNPDPSlyrISARIVCVTSPAPNGTSGPVQVAIKSR 902
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN-LR--VTFgGGVPCSVLSV---SSTAIVCTTPPYANPGPGPVEVTVDRG 74

                           90
                   ....*....|....*
gi 1958807849  903 PPGI--SAQHFTYQD 915
Cdd:cd00102     75 NGGItsSPLTFTYVP 89
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 53-459 1.76e-14

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 77.98  E-value: 1.76e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   53 QGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAE---CPQAQLTDNANQLLLVSS-RAQELVACGQVRQG 128
Cdd:cd11278     35 KHHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCQDCSDkanLSNGVWKDNVNMALFVETyYDDQLISCGSVNRG 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  129 VCEKRRL-----GDV---TQVLYQAEDPGDGQfvAANTLGVTTVGLVVPLPGRDLLL---VARGLAGklsAGVPP----- 192
Cdd:cd11278    115 TCQRHVFphdhpADIqseVHCIYSPQIEEEPD--QCPDCVVSTLGSKVLVTVKDRFVnffVGNTINS---SYFPDhplhs 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  193 LTVRQLAGPQpfssEGLGRL-------VVGDFSD-YNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLY 264
Cdd:cd11278    190 ISVRRLKETQ----DGFEFLtdqsyidVLPEFRDsYPIKYVHAFESNNFVYFLTVQRESLDSQTFHTRIIRFCSIDSELR 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  265 SYVEVPLTC-------------HGQGLIQAAFLAP---------------DTLLGAFSAGTSQAQ-----AALCAFPLAD 311
Cdd:cd11278    266 SYMEMPLECiftekrrkrstkkEVFNILQAAYVSKpgaqlaremgaslndDILFGVFAQSKPDSAepmnrSAVCAVSIKT 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  312 LDGSMEQArrlcyttggQGPNGMEEATVEYGVTSR-CVTLPPDSPESYpCGDEHTPSPIAGRQPLEAQPLL--QLGQPIS 388
Cdd:cd11278    346 INEFFNKI---------VDKQNVKCLQHFYGKNHEhCFNRTFLRNASY-CEARRDEYRVEVTTALQRVDLFmgQFSNVLL 415

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807849  389 AVAALQTDGH-TIAFLGDTEGQLHKVFLNSSHGQVYHSQQVGPPgSAISPDLLVDNSGD---YLYVLTAQQVDRI 459
Cdd:cd11278    416 TSISVFTKGDlTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDS-HPVSPEVIVEHTLNqngYTLVITGKKITKI 489
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 279-442 2.23e-14

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 72.69  E-value: 2.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  279 IQAAFLAP--------DTLLGAFSAGTSQA--QAALCAFPLADLDGSMEqaRRLCYTTGGQGPNGMEEATVEYGVTSRCV 348
Cdd:pfam01403    1 LQDVFVLKpgagdaldTVLYGVFTTQWSNSigGSAVCAFSLSDINAVFE--GPFKEQEKSDSKWLPYTGKVPYPRPGTCI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  349 TLP--PDSPESYPCGDEHTPSPIAGRQPLEAQPLL-QLGQPISAVAALQTDG----HTIAFLGDTEGQLHKVFLNSSHGQ 421
Cdd:pfam01403   79 NDPlrLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLvRTGVRLTSIAVDRVQAldgnYTVLFLGTDDGRLHKVVLVGSEES 158

                          170       180
                   ....*....|....*....|..
gi 1958807849  422 VYHSQ-QVGPPGSAISPDLLVD 442
Cdd:pfam01403  159 HIIEEiQVFPEPQPVLNLLLSS 180
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 916-1001 7.63e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 7.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSA-FVGDQPCPIqEPVCPEAIICHTMPQMEPGEAVVFVVFGH--VERK 992
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtFGGGVPCSV-LSVSSTAIVCTTPPYANPGPGPVEVTVDRgnGGIT 79


                   ....*....
gi 1958807849  993 LLTTPFRYT 1001
Cdd:cd00102     80 SSPLTFTYV 88
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-514 3.19e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.42  E-value: 3.19e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958807849  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGrAVQPNQWLWSYEDNHC 514
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKC 51
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 824-914 1.32e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.78  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPdpsLYRISARIVCVTspaPNGTSGPVQVAIKSRP 903
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTV---ISVSSTTIVCTT---PPGTSGLVNVSVTVGG 72

                           90
                   ....*....|.
gi 1958807849  904 PGISAQHFTYQ 914
Cdd:pfam01833   73 GGISSSPLTFT 83
IPT smart00429
ig-like, plexins, transcription factors;
915-1001 4.14e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 63.59  E-value: 4.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   915 DPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGD--QPCPIQePVCPEAIICHTMPQME-PGEAVVFVV-FGHVE 990
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeAPCTFS-PSSSTAIVCKTPPYHNiPGSVPVRTVgLRNGG 79

                            90
                    ....*....|.
gi 1958807849   991 RKLLTTPFRYT 1001
Cdd:smart00429   80 VPSSPQPFTYV 90
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
 37-432 2.15e-11

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 68.09  E-value: 2.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   37 FSVPNA-SFNHLVLAPDQGKLYVGAVNHLFQLSpeleMESVAITGPVIDSPDCVPFRDLAECPQAQL-TDNANQLLLVSS 114
Cdd:cd11264      1 FTYPGVrDFSQLALDLNRNQLIVGARNYLFRLS----LHNVSLIQATEWGSDEDTRRSCQSKGKTEEeCQNYVRVLIVYG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  115 RaqELVACG-QVRQGVCEKRRLGDVTQVLYQAE-------DPGDGQFVAANTLGVTTVGLVVPLPGRDlLLVARGLagkl 186
Cdd:cd11264     77 K--KVFTCGtNAFSPVCTSRQVGNLSKVIERINgvarcpyDPRHNSTAVITSRGELYAATVIDFSGRD-PAIYRSL---- 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  187 sAGVPPLTVRQlagpqpFSSEGLGRlvvgdfsdynNSYVGAFSDAHSAYFVFRRRGAR---AQTEYrSYVARVCLGDV-- 261
Cdd:cd11264    150 -GSVPPLRTAQ------YNSKWLNE----------PNFIAAYDIGLFTYFFFRENAVEhdcGKTVY-SRVARVCKNDIgg 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  262 ------NLYSYVEVPLTCHGQGLI-------QAAFLAP--DTLLGAFSAG-TSQAQAALCAFPLADLdgsmeqarrlcyT 325
Cdd:cd11264    212 rflledTWTTFMKARLNCSRPGEIpfyynelQSTFYLPeqDLIYGVFTTNvNSIAASAVCAFNLSAI------------T 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  326 TGGQGPngmeeatVEYGVTSRCVTLPPDSP-ESYPCG--DEHTPSP-IAGRQPLEAQPLLQLG---QPISAVAALQTDG- 397
Cdd:cd11264    280 QAFNGP-------FRYQENPRSAWLPTANPiPNFQCGtlSDDSPNEnLTERSLQDAQRLFLMNdvvQPVTVDPLVTQDSv 352

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958807849  398 ----------------HTIAFLGDTEGQLHKVFLNSS---HGQVYHSQQVGPPG 432
Cdd:cd11264    353 rfsklvvdivqgkdtlYHVMYIGTEYGTILKALSTTNrslRSCYLEEMQILPPG 406
IPT smart00429
ig-like, plexins, transcription factors;
824-913 2.85e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.28  E-value: 2.85e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   824 PSIDVIEPLTGPPEGGLAITILGSNLGqAFNDVRNAVTVAGQPCNPDPSLyriSARIVCVTSPAPNGT-SGPVQVAiKSR 902
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPgSVPVRTV-GLR 76

                            90
                    ....*....|...
gi 1958807849   903 PPGI--SAQHFTY 913
Cdd:smart00429   77 NGGVpsSPQPFTY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
464-514 1.87e-10

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 57.55  E-value: 1.87e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1958807849   464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGRAVQpnqwlwSYEDNHC 514
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ------NWLSGGC 46
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 47-418 4.44e-09

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 60.56  E-value: 4.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   47 LVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPvIDSPDCvpfRDLAECPQA----QLTDNANQLLLVSSRAQELVAC 122
Cdd:cd11279     32 IVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGP-TGSPGC---QICALCPPGppgpSPEDTDNKVLVLDPEEPWLYSC 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  123 GQVRQGVC-----EKR----RLGDvTQVLYQAE--DPGDGQFVAANTLGvTTVgLVVPLPGRDLLLVARGLAGKLSAGVP 191
Cdd:cd11279    108 GSSLHGRCflhelESRgsavHIAS-TACLFSANanKPSDCPDCVASPLG-TRV-TVVEQSHTSYFYVASTLNSSVAASYS 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  192 P--LTVRQLAGPQPFSSEGLGRL-VVGDFSD-YNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYV 267
Cdd:cd11279    185 PrsVSIRRLKSDQDGFAPGFHSLtVLPKYLDsYPIHYVHSFTSGDFVYFLTVQPESPDSSAYHTRLVRLSAKEPELRDYR 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  268 EVPLTCH------------GQG----LIQAAFLAP---------------DTLLGAFS---AGTSQAQ--AALCAFPLAD 311
Cdd:cd11279    265 ELVLDCRfepkrrrrrrpaEREvpynVLQAAHAAPvgsklavelgisegqEVLFGVFAesqPGSPVPQknSAVCAFPISL 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  312 LDGSMEQARRLCYTTGGQgpNGMEEATVEYGVTSRCvtlpPDSPEsypcGDEHTPSPIAGRQPLEAQPLL--------QL 383
Cdd:cd11279    345 LNEAIDEGMEKCCSSSNS--DRLFRGLDFFQPQSYC----PHPPN----LSAAVSNTSCWNFPTLVSTSSfrvdlfngHL 414

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1958807849  384 GQP-ISAVAALQTDGHTIAFLGDTEGQLHKVFLNSS 418
Cdd:cd11279    415 SGVlLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRS 450
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 916-1000 2.58e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 2.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNVSAFVGDQPCPIQEpVCPEAIIChTMPQMEPGEAVVFVVFGHVERKLL 994
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDsSDLKVTIGGTPCTVIS-VSSTTIVC-TTPPGTSGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1958807849  995 TTPFRY 1000
Cdd:pfam01833   79 PLTFTY 84
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1004-1135 8.86e-08

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 51.65  E-value: 8.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEFqvkalgvqaqdvnprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVE-------------------------------------- 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807849 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 4.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958807849 1165 GLNLGISKEEVQVHIGDGKCLVKTLTLTHLYCEPPQQAPQPTNgsgtlpqFVVQMGNVRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 46-459 7.34e-05

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 47.02  E-value: 7.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849   46 HLVLAPDQGKLYVGAVNHLF-----QLSPELEMESVAitgpvidSPDcvpfrDLAECPQA--QLTDNANQLLLVSSRAQE 118
Cdd:cd11235      5 TKLLHEDRSTLYVGARDRVYlvdldSLYTEQKVAWPS-------SPD-----DVDTCYLKgkSKDDCRNFIKVLEKNSDD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  119 -LVACG-QVRQGVCEKRRLGDVTQVlyqaEDPGDGQFVAANTLGVTTVGLVVplpgrdlllvarglAGKLSAGVP----- 191
Cdd:cd11235     73 sLLVCGtNAFNPSCRNYNVETFELV----GKEESGRGKCPYDPDHNSTALFA--------------DGELYSGTSadflg 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  192 --PLTVRQLAGPQPFSSEGLGRLVVGDfsdynNSYVGAFSDAHSAYFVFRRRGARAQTEYR---SYVARVCLGDV----- 261
Cdd:cd11235    135 tdPVIYRTLGHNPPLRTEYHDSKWLNE-----PQFVGAFDIGDYVYFFFREIAVEYINCGKavySRVARVCKNDQggsrs 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  262 ---NLYSYVEVPLTCHGQGL-------IQAAFLAPDT------LLGAFSAGTSQ-AQAALCAFPLADLDGS-----MEQA 319
Cdd:cd11235    210 lekKWTTFLKARLNCSVPGEfpfyfneLQDVFDLPSPsnkekiFYAVFTTPYNSiPGSAVCAYSLSDIEAVfngpfKEQH 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  320 RRLCYTTGGQGPNGMEEATVEYGVTSRcvTLPPDS---PESYPCGDEHTPsPIAGRqPLEAQPLLQLGQPISAVAALQTD 396
Cdd:cd11235    290 SSNSAWLPVPDERVPEPRPGTCVDDSS--PLPDDTlnfIKSHPLMDEAVT-PILNR-PLFIKTDVNYRFTKIAVDRVQAK 365

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  397 G---HTIAFLGDTEGQLHKVFLNSSHGQ----VYHSQQVGPPGSAISpDLLVDNSGDYLYVLTAQQVDRI 459
Cdd:cd11235    366 LgqtYDVLFVGTDRGIILKVVSLPEQGLqasnILEEMPVGPPPEPIQ-TMQLSRKRRSLYVGSETGVLQV 434
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-988 1.35e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.22  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQ---TGGNVSAFVGDQPCpiqEPVCPEA-----IICHTMPQMEP-GEAVVFVVF 986
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPC---NPEPPEYsssekIVCTTGPAGNPvFNGPVEVTV 77


                   ..
gi 1958807849  987 GH 988
Cdd:cd01180     78 GH 79
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1000 1.63e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 39.32  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807849  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVS--AFVGDQ---PCPI---QEPVCPEAIICHTMPQMEPGEAVVFVVF- 986
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRirVKYGGVektSCKVrnsTLMTCPAPSLALLNRSPEPGERPVEFGLd 80

                           90
                   ....*....|....*..
gi 1958807849  987 GHVERKLLT---TPFRY 1000
Cdd:cd01181     81 GDNVQSLLIlnrTSFSY 97
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 6.34e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 35.98  E-value: 6.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958807849   622 CRTCVSSLW-RCHWCPQSSHCVYGERCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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