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Conserved domains on  [gi|1958809592|ref|XP_038956403|]
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ralBP1-associated Eps domain-containing protein 2 isoform X8 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 262-357 9.69e-36

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


:

Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 129.32  E-value: 9.69e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592  262 PWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGY 341
Cdd:smart00027   1 PWAISPEDKAKYEQIFRSLDKNQDGTVTGAQAKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFALAMHLIYRKLNGY 80

                           90
                   ....*....|....*.
gi 1958809592  342 PLPEGLPPTLQPEYLQ 357
Cdd:smart00027  81 PIPASLPPSLIPPSKR 96
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 62-108 1.46e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00052:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 67  Bit Score: 42.98  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958809592  62 VADLFRASQLPPETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQA 108
Cdd:cd00052    21 ARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAIAMHLIALALN 67
EH super family cl42943
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 18-112 2.36e-04

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


The actual alignment was detected with superfamily member smart00027:

Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 40.34  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592   18 SDSEQQCYSELFARCAGAASggpgpgpleatrvapGILTAAAgpVADLFRASQLPPETLHQITELCGAKRVGYFGPTQFY 97
Cdd:smart00027   5 SPEDKAKYEQIFRSLDKNQD---------------GTVTGAQ--AKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFA 67

                           90
                   ....*....|....*
gi 1958809592   98 VALKLIAAAQAGLPV 112
Cdd:smart00027  68 LAMHLIYRKLNGYPI 82
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
379-584 4.39e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 379 ANQqsCDLN---------RMEKTSVKdMADFPVSTQDVTTGDD-KQALKSTVNESLPKDVSEDTAANSGLLPPPPALPPR 448
Cdd:PRK14971  335 CNQ--CDLNyrasknkrlLVELTLIQ-LAQLTQKGDDASGGRGpKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQP 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 449 PCPTQAEPASEADlyPQMNRAPSQAAESSPTKKDVPHAQPPSKPIRRKFRPENQTTEGqesaavvggaapAAMVKPHPTV 528
Cdd:PRK14971  412 SAPQSATQPAGTP--PTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLG------------PSTLRPIQEK 477

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809592 529 QKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKevhQERIALENQLEQLRPV 584
Cdd:PRK14971  478 AEQATGNIKEAPTGTQKEIFTEEDLQYYWQEFAGTRP---QEEKALKETMINCRPK 530
 
Name Accession Description Interval E-value
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 262-357 9.69e-36

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 129.32  E-value: 9.69e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592  262 PWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGY 341
Cdd:smart00027   1 PWAISPEDKAKYEQIFRSLDKNQDGTVTGAQAKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFALAMHLIYRKLNGY 80

                           90
                   ....*....|....*.
gi 1958809592  342 PLPEGLPPTLQPEYLQ 357
Cdd:smart00027  81 PIPASLPPSLIPPSKR 96
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 273-339 5.78e-23

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 92.28  E-value: 5.78e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958809592 273 YVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKN 339
Cdd:cd00052     1 YDQIFRSLDPDGDGLISGDEARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAIAMHLIALALN 67
EF-hand_4 pfam12763
Cytoskeletal-regulatory complex EF hand; This is an efhand family from the N-terminal of actin ...
 261-354 1.21e-10

Cytoskeletal-regulatory complex EF hand; This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.


Pssm-ID: 289529  Cd Length: 104  Bit Score: 58.54  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 261 EPWRIteeqrEYYVNQFRSLQPDpSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKNG 340
Cdd:pfam12763   5 EEWEI-----KKYWEIFSGLKPE-NNKLTGDQVSPVLKNSRLPDDQLAKIWDLADIDSDGKLDFEEFCIAMRLIFDLVNG 78

                          90
                  ....*....|....*.
gi 1958809592 341 -YP-LPEGLPPTLQPE 354
Cdd:pfam12763  79 nIAdVPDELPDWLVPG 94
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 62-108 1.46e-05

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 42.98  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958809592  62 VADLFRASQLPPETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQA 108
Cdd:cd00052    21 ARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAIAMHLIALALN 67
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 18-112 2.36e-04

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 40.34  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592   18 SDSEQQCYSELFARCAGAASggpgpgpleatrvapGILTAAAgpVADLFRASQLPPETLHQITELCGAKRVGYFGPTQFY 97
Cdd:smart00027   5 SPEDKAKYEQIFRSLDKNQD---------------GTVTGAQ--AKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFA 67

                           90
                   ....*....|....*
gi 1958809592   98 VALKLIAAAQAGLPV 112
Cdd:smart00027  68 LAMHLIYRKLNGYPI 82
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
379-584 4.39e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 379 ANQqsCDLN---------RMEKTSVKdMADFPVSTQDVTTGDD-KQALKSTVNESLPKDVSEDTAANSGLLPPPPALPPR 448
Cdd:PRK14971  335 CNQ--CDLNyrasknkrlLVELTLIQ-LAQLTQKGDDASGGRGpKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQP 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 449 PCPTQAEPASEADlyPQMNRAPSQAAESSPTKKDVPHAQPPSKPIRRKFRPENQTTEGqesaavvggaapAAMVKPHPTV 528
Cdd:PRK14971  412 SAPQSATQPAGTP--PTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLG------------PSTLRPIQEK 477

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809592 529 QKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKevhQERIALENQLEQLRPV 584
Cdd:PRK14971  478 AEQATGNIKEAPTGTQKEIFTEEDLQYYWQEFAGTRP---QEEKALKETMINCRPK 530
 
Name Accession Description Interval E-value
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 262-357 9.69e-36

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 129.32  E-value: 9.69e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592  262 PWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGY 341
Cdd:smart00027   1 PWAISPEDKAKYEQIFRSLDKNQDGTVTGAQAKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFALAMHLIYRKLNGY 80

                           90
                   ....*....|....*.
gi 1958809592  342 PLPEGLPPTLQPEYLQ 357
Cdd:smart00027  81 PIPASLPPSLIPPSKR 96
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 273-339 5.78e-23

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 92.28  E-value: 5.78e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958809592 273 YVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKN 339
Cdd:cd00052     1 YDQIFRSLDPDGDGLISGDEARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAIAMHLIALALN 67
EF-hand_4 pfam12763
Cytoskeletal-regulatory complex EF hand; This is an efhand family from the N-terminal of actin ...
 261-354 1.21e-10

Cytoskeletal-regulatory complex EF hand; This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.


Pssm-ID: 289529  Cd Length: 104  Bit Score: 58.54  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 261 EPWRIteeqrEYYVNQFRSLQPDpSSFISGSVAKNFFTKSKLSIAELSYIWELSDADCDGALTLPEFCAAFHLIVARKNG 340
Cdd:pfam12763   5 EEWEI-----KKYWEIFSGLKPE-NNKLTGDQVSPVLKNSRLPDDQLAKIWDLADIDSDGKLDFEEFCIAMRLIFDLVNG 78

                          90
                  ....*....|....*.
gi 1958809592 341 -YP-LPEGLPPTLQPE 354
Cdd:pfam12763  79 nIAdVPDELPDWLVPG 94
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 62-108 1.46e-05

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 42.98  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958809592  62 VADLFRASQLPPETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQA 108
Cdd:cd00052    21 ARPFLGKSGLPRSVLAQIWDLADTDKDGKLDKEEFAIAMHLIALALN 67
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 18-112 2.36e-04

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 40.34  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592   18 SDSEQQCYSELFARCAGAASggpgpgpleatrvapGILTAAAgpVADLFRASQLPPETLHQITELCGAKRVGYFGPTQFY 97
Cdd:smart00027   5 SPEDKAKYEQIFRSLDKNQD---------------GTVTGAQ--AKPILLKSGLPQTLLAKIWNLADIDNDGELDKDEFA 67

                           90
                   ....*....|....*
gi 1958809592   98 VALKLIAAAQAGLPV 112
Cdd:smart00027  68 LAMHLIYRKLNGYPI 82
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
379-584 4.39e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 379 ANQqsCDLN---------RMEKTSVKdMADFPVSTQDVTTGDD-KQALKSTVNESLPKDVSEDTAANSGLLPPPPALPPR 448
Cdd:PRK14971  335 CNQ--CDLNyrasknkrlLVELTLIQ-LAQLTQKGDDASGGRGpKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQP 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809592 449 PCPTQAEPASEADlyPQMNRAPSQAAESSPTKKDVPHAQPPSKPIRRKFRPENQTTEGqesaavvggaapAAMVKPHPTV 528
Cdd:PRK14971  412 SAPQSATQPAGTP--PTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLG------------PSTLRPIQEK 477

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809592 529 QKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKevhQERIALENQLEQLRPV 584
Cdd:PRK14971  478 AEQATGNIKEAPTGTQKEIFTEEDLQYYWQEFAGTRP---QEEKALKETMINCRPK 530
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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