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Conserved domains on  [gi|1958653313|ref|XP_038956894|]
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secretion-regulating guanine nucleotide exchange factor isoform X9 [Rattus norvegicus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-279 1.08e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 133.56  E-value: 1.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184    96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184   173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 1958653313 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVA 279
Cdd:COG5184   238 dRATPVQVAG----LTGVVAIAAGGSHTCA 263
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-279 1.08e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 133.56  E-value: 1.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184    96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184   173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 1958653313 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVA 279
Cdd:COG5184   238 dRATPVQVAG----LTGVVAIAAGGSHTCA 263
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 1.29e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.60  E-value: 1.29e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-279 1.08e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 133.56  E-value: 1.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184    96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184   173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 1958653313 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVA 279
Cdd:COG5184   238 dRATPVQVAG----LTGVVAIAAGGSHTCA 263
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-244 1.95e-32

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 122.39  E-value: 1.95e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDfcKSGCIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   119 VWCWGDNSSGQLGDGTTTNRLTPVQVDA--GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   197 GLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAGL-TGVVAIAAGGSHTCALKSDGTVWC 272

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958653313 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQL 244
Cdd:COG5184   273 WGdnsygqLGDGTTTDRS-------------TPVKVPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQL 331
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 53-279 8.44e-25

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 101.59  E-value: 8.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  53 SVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 133 LGVPhGPRKCVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGT------GLASSGRRLCPGQnlplfltakepsrv 206
Cdd:COG5184    80 LGDG-TTTDRTTPVKVPGL-TGVVAVAAGYYHSCALKSDGTVWCWGDnssgqlGDGTTTNRLTPVQ-------------- 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958653313 207 TGLESSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF-LPLPQRVEAHyfqdEKVTAVWSGWTHLVA 279
Cdd:COG5184   144 VDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTdRPTPVQVGGL----SGVVAVAAGGDHSCA 213
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-134 6.62e-20

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 88.11  E-value: 6.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   220 VWCWGSNSSGQLGDGTTTDRATPVQVAGLTG---VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVP 296

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958653313  97 PLLgcPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLG 134
Cdd:COG5184   297 GLS--GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLG 332
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 104-276 1.34e-17

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 81.56  E-value: 1.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 104 RQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGTGlaS 183
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGL-SNVVAVAAGGDHTCALKADGTVWCWGNN--S 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313 184 SGrRLCPGQNLPlfltAKEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATFLPL-PQRVEAhyf 262
Cdd:COG5184    77 YG-QLGDGTTTD----RTTPVKVPGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLtPVQVDA--- 146

                         170
                  ....*....|....
gi 1958653313 263 QDEKVTAVWSGWTH 276
Cdd:COG5184   147 GLSGVVAIAAGGYH 160
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-86 1.17e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 61.53  E-value: 1.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFcksGCIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHT 86
Cdd:COG5184   270 VWCWGDNSYGQLGDGTTTDRSTPVKVPGL---SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTT 336
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 1.29e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.60  E-value: 1.29e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958653313  17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
68-116 4.52e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.67  E-value: 4.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958653313  68 GGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGCPIRQVACGWDFTIML 116
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
103-132 1.68e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 46.65  E-value: 1.68e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958653313 103 IRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
214-243 3.12e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 3.12e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958653313 214 VVCAVAGSDHSASLTDTGELYVWGRNKHGQ 243
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
119-167 7.60e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 39.42  E-value: 7.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958653313 119 KGQVLSCGSNAFGQLGVPHgPRKCVVPQAIECLRE-KVVCVAAGLRHALA 167
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGT-TENVLVPQKVEGLSGnKVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
51-80 2.57e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 2.57e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958653313  51 IKSVTGGGGHSVVVTDGGGLFVCGLNKDGQ 80
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
231-279 1.03e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 36.34  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958653313 231 GELYVWGRNKHGQLASLATFL-PLPQRVEAhyFQDEKVTAVWSGWTHLVA 279
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENvLVPQKVEG--LSGNKVVQVACGGDHTVA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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